CorLab | Advanced Cardiovascular Imaging Lab
Who We Are
We are a research group in the Department of Radiology at the University of Pennsylvania and our main interests are the development of new imaging technologies for cardiovascular disease.
Principal Investigator: Walter RT Witschey, PhD
The prevalence of heart failure continues to increase as the adult population ages, so understanding the role of hypertension and obesity to the development of heart failure is a number one priority in cardiovascular medicine.
To disentangle the relationships between the multiple organ systems implicated in heart failure, non-invasively in humans, and to understand how differences emerge in cardiovascular disease, it’s necessary to have methods that can probe disease holistically, at multiple locations, and to measure the relevant quantities at each organ, such as arterial flow, pressure and contractility.
It’s not enough simply to know these parameters, but also to measure their concurrent activity to understand their dynamic and integrated response. Major breakthroughs for heart failure treatment will arise from uncovering these complex relationships in patients.
The main focus of our group is the development of effective ways to non-invasively characterize the relationships between brain, heart and arteries in cardiovascular disease and the progression to heart failure.
To elucidate the pathogenesis of heart failure, our group develops magnetic resonance imaging (MRI) approaches that establish relationships between the different organs implicated in heart disease. Our major areas of interest are the determinants of cardiac contractile function, arrhythmias, and autonomic nervous system control of the heart.
Our group uses a multidisciplinary approach, integrating techniques from RF and electromagnetic engineering, computer vision and nuclear spin physics with a special emphasis on the real-time and nonlinear dynamics of the cardiovascular system.
Our work is supported by the National Institutes of Health, National Heart Lung and Blood Institute (R00 HL108157), the McCabe foundation and the Institute for Translational Medicine and Therapeutics at the University of Pennsylvania.
Congratulations to Anya Hall for a wonderful poster presentation at the bioengineering research symposium. He will be heading off to medical school at the University of Miami!
April 18, 2018
Congratulations to Avanti Gulhane who received the SCMR travel award to the annual meeting in Barcelona, Spain this year. She presented two studies:
- "Determination of Conducting Channels from LGE CMR in patients with Myocardial Infarction-Comparison with Electroanatomic Mapping for Ventricular Tachycardia Ablation"
- "Evaluation of LGE-CMR for predicting ventricular tachycardia (VT) ablation sites in Nonischemic cardiomyopathy (NICM) –comparison with electroanatomic maps (EAM)"
The first study was recognized in the "Best of Moderated" electronic poster session.
March 9, 2018
Congratulations to Srikant Iyer, Brianna Moon, and Eileen Hwuang whose abstracts were accepted at the Joint Annual Meeting ISMRM-ESMRMB 2018 in Paris, France (June 16-21, 2018).
"Quantitative susceptibility mapping Accelerated Reconstruction Technique (QUART): A novel Split Bregman based approach for rapid reconstruction of quantitative susceptibility maps" (electronic poster on June 20, 4:15pm)
"Accelerated free breathing 3D cardiac T1rho mapping in humans using compressed sensing and improved k-space reordering" (electronic poster on June 20, 2:45pm)
"Magnetic susceptibility of hemorrhagic myocardial infarction: correlation with tissue iron and comparison with relaxation time MRI" (oral on June 18, 4:15pm)
"Background-suppressed pulsed arterial spin labeling of placental perfusion at 1.5T" (electronic poster on June 20, 10:15am)
"Characterization of uterine artery geometry in normal pregnancy with time-of-flight angiography" (electronic poster on June 20, 10:15am)
February 19, 2018