CRISPR Cas9 Mouse Targeting Core

The CRISPR Mouse Targeting Core in partnership with the Transgenic and Chimeric mouse facility offers a variety of services, including:

  • targeting design
  • gRNA preparation
  • Cas9 mRNA generation
  • DNA preparation
  • Mouse one-cell embryo microinjection
  • genotyping/screening for targeted mice

The CRISPR/Cas9 technology offered in this core has revolutionized the way genome editing is performed in several organisms. In particular, it has significantly reduced the time and the cost required to generate genetically engineered mice, allowing scientists to test more precise hypotheses in vivo.

Contact Us

Core Director
Jorge Henao-Mejia, MD, PhD
215-898-2212
jhena@pennmedicine.upenn.edu