Jerome F. Strauss, III, M.D., Ph.D.
Address:
Sanger Hall, 1101 East Marshall Street, Room 1-071
P.O. Box 980565
Richmond, Virginia 23298
Phone: (804) 828-9788
Fax: (804) 828-7628
E-Mail: jfstrauss@vcu.edu
Current Position:
- Dean, School of Medicine, Virginia Commonwealth University
and Executive Vice President for Medical Affairs, VCU Health System
Adjunct Professor of Obstetrics and Gynecology, University of Pennsylvania
Education:
- B.A., Brown University, 1969
- M.D., University of Pennsylvania, 1974
- Ph.D., Molecular Biology, University of Pennsylvania, 1975
- House Officer, Obstetrics and Gynecology, Hospital of the University of Pennsylvania
- M.D., University of Pennsylvania, 1974
Past Positions:
1977-1982, Assistant Professor, Department of Obstetrics and Gynecology, Pathology and Laboratory Medicine, and Physiology, University of Pennsylvania
1982-1985, Associate Professor of Obstetrics and Gynecology, Pathology and Laboratory Medicine, and Physiology, University of Pennsylvania
1985-2005, Professor of Obstetrics and Gynecology, Pathology and Laboratory Medicine, and Physiology, University of Pennsylvania
1987-2005, Associate Chairman, Department of Obstetrics and Gynecology, University of Pennsylvania
1992-2005 Luigi Mastroianni, Jr. Professor and founding Director, Center for Research on Reproduction and Women's Health, University of Pennsylvania School of Medicine
Membership:
- American Association for the Advancement of Science (AAAS)
- American Association of Pathologists; American Fertility Society
- American Physiological Society
- Endocrine Society;
- Institute of Medicine, National Academy of Sciences
- Society for Gynecologic Investigation
- Society for the Study of Reproduction
- American Association of Pathologists; American Fertility Society
Research Interests:
Dr. Strauss's laboratory has three primary interests: 1) the regulation of steroid hormone synthesis in ovary and placenta; 2) polycystic ovary syndrome; 3) the biology of fetal membranes.
Studies on the control of steroid hormone synthesis are currently focused on the role of proteins that govern the uptake of lipoprotein-carried cholesterol from the circulation and proteins involved in the distribution cholesterol to and within various intracellular organelles. On-going work explores the role and function of the very low density lipoprotein receptor in placental cholesterol metabolism. Work on intracellular sterol transport addresses sterol efflux from lysosomes and endosomes, sterol transport through the cytoplasm and intra-mitochondrial sterol translocation. Diseases caused by defects in the intracellular trafficking of cholesterol, including Niemann-Pick type C disease and congenital lipoid adrenal hyperplasia, serve as models to explore the roles of specific proteins.
The genetic basis of polycystic ovary syndrome and the regulation of thecal androgen synthesis are being investigated as part of the National Cooperative Program in Infertility Research.
Studies on fetal membranes focus on the activation of collagenolytic enzymes and programmed cell death in the amniotic epithelium at term. The rat amnion and human fetal membranes are under investigation. Genetic factors contributing to premature rupture of the fetal membranes are being sought.
Recent Representative Publications:
Okamura, Y., Watari, M., Jerud, E.S., Young, D.W., Ishizaka, S.T., Rose, J., Chow, J.C., Strauss III, J.F. The EDA domain of fibronectin activates Toll-like receptor 4. Journal of Biological Chemistry 276: 10229-10233, 2001.
Christenson, L., Stouffer, R.L., Strauss, III, J.F. Quantitative analysis of the hormone-induced hyperacetylation of histone 3 associated with the steroidogenic acute regulatory protein (StAR) gene promoter. Journal of Biological Chemistry 276: 27392-27399, 2001.
Fujimoto, T., Parry, S., Urbanek, M., Sammel, M., Macones, G., Kuivaniemi, H., Romero, R., Strauss III, J.F. A single nucleotide polymorphism in the matrix metalloproteinase-1 (MMP-1) promoter influences amnion cell MMP-1 expression and risk for preterm premature rupture of the fetal membranes. Journal of Biological Chemistry 277: 6296-6302, 2002.
Sapiro, R., Kostetskii, I., Olds-Clarke, P., Gerton, G.L., Radice, G.L., Strauss III, J.F. Male infertility, impaired sperm motility, and hydrocephalus in mice deficient in sperm-associated antigen 6. Molecular and Cellular Biology 22: 6298-6305.
Search for abstracts and other papers by this author using the Public Medline database.
This page was last modified on October 19, 2005.
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