Research Interests:
Genomic Characterization of Cancers of the Head and Neck, Thyroid and Lung

Novel Drug Target Discovery
Use of Genetic Testing in Diagnosis, Prognostication and Treatment of Cancer

Current Research Interests:
Tobacco Related Cancers: 
Head and Neck Squamous Cell Cancer, Lung Cancer, Esophageal Cancer.Thyroid Cancer

Recent Representative Publications:
Sataymoorthy, K., Li, G., Gerrero, R. Brose, M.S., Volpe, P., Weber, B.L., van Belle, P., Elder, D.E., and Herlyn, M. Constitutive MAP kinase activation in melanoma is mediated by both BRAF Mutations and Autocrine Growth Factor Stimulation. Cancer Research 63:756-759 (2003).

Brose, M.S., (3 additional authors), and Weber, B.L. Characterization of two novel BRCA1 germline mutations involving the splice donor sites of exon 3 and exon 17. GeneticTesting 8(2) 133-138 (2004).
Edwards, R. H., Ward, M. R., Wu, H., Medina, C. A., Brose, M. S., Volpe, P., Nussen-Lee, S., Haupt, H. M., Martin, A.-M., Herlyn, M., Lessin, S. R., Weber, B. L.. Absence of BRAF Mutations in UV-protected Mucosal Melanomas. Journal of Medical Genetics (2004) 41:270-272.

Huang, J., Brose, M.S., (3 additional authors), and Weber, B. L. Germline CHEK21100delC mutations in breast cancer patients with multiple primary cancers. J. Med.Genet (2004) 41:e120.

Baloch, ZW, Puttaswamy, K., Brose, M. and LiVolsi ,VA, Lack of BRAF mutations in hyalinizing trabecular neoplasm., Cytojournal. (2006) Jul 25;3:17.

Sparano, A, Quesnelle, K., Kumar, M., Sewell, D., Feldman, M., Wang, Y., Sylvester, A., Weinstein, G., Brose, M. Genome-wide profiling of OSCC by array-based comparative genomic hybridization. Laryngoscope. (2006) May ;116:735-741

Edwards, R.H., Gimmotty, P., Medina, A, Letrero, R.., Brose, M.S., Rappaport, E. Nathanson, K.N., M. Herlyn, Spittle, C.S. Application of a BRAF Pyrosequencing Assay for Mutation Detection and Copy Number Analysis in Malignant Melanoma. The Journal of Molecular Diagnostics (2007) 9(4):464-471.

O’Donnell, R. K., Mick R., Feldman M., Hino S., Wang Y., Brose, M.S., and Muschel, R. J. Comprehensive dysfunction of the dendritic cell response in primary oral squamous cell carcinomas. Cancer Letters (2007) 255: 145-152.

Vachani, A., Nebozhyn, M., Singhal, S., Alila, L., Wakeam, E., Muschel, R., Powell, C., Gaffney, P., Singh, B., Brose, M.S, Kucharczuk, J., Kaiser, L., Marron, J. S., Showe, M.J, Albelda, S., Showe, L.: Identification of 10 Gene Classifier for Head and Neck Squamous Cell Carcinoma and Lung Squamous Cell Carcinoma: Towards a Distinction between Primary and Metastatic Squamous Cell Carcinoma of the Lung Clinical Cancer Research (2007) 13: 2905-2915.

Tsygankova, O.M., Prendergast, G.P., Puttaswamy, K., Wang, Y., Feldman, M.D., Wang, H., Brose, M.S., and Meinkoth, J.L. Downregulation of Rap1GAP contributes to Ras transformation. Molec. Cell. Biol. (2007) 19: 6647-6658.

Edwards, R.H., Spittle, C.S., Quesnelle, K., Rooney, R., Gimotty, P.A., Hammond, R., Brose, M., Lessin S.R, Herlyn, M. Characterization of UV-induced signaling patterns in melanocytes and malignant melanoma. Society for Investigative Dermatology (in press 2007).