Research Interests:

Dr. Domchek is a medical oncologist specializing in breast cancer genetics, prevention and treatment. As part of the Breast Cancer Risk Evaluation Program, Dr. Domchek has served as the site principal investigator on screening studies performed through the Cancer Genetics Network. To date, 100 women have joined the ovarian cancer screening study through this mechanism, and an additional 27 women at genetic risk for breast cancer participated in a CGN-sponsored MRI screening study. In addition to her work in the genetics clinic, Dr. Domchek is interested in the use of novel therapeutics, particularly immunotherapy-based, in the treatment of breast cancer. Dr. Domchek is the principal investigator of Protocol 11102 at the University of Pennsylvania, "Phase I study of telomerase based peptide vaccination for patients with advanced breast cancer".

Recent Representative Publications:
Domchek SM and Weber BL. Advances in breast cancer biology. (2002). Current Opinions in Oncology; 14, 589-593.

Domchek SM. (2003). Chemoprevention in BRCA1 and BRCA2 mutation carriers, Seminars in Breast Disease, 6:30-33.

Bendell JC, Domchek SM, Burstein HJ, Harris LN, Younger J, Kuter I, Bunnell C, Rue M, Gelman R, Winer EP. (2003). Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast cancer. Cancer 97, 2972-7.

Domchek SM, Eisen A, Calzone K, Stopfer J, Blackwood A, Weber BL. (2003). Application of breast cancer risk prediction models in clinical practice. Journal of Clinical Oncology 21, 593-601.

Armstrong, K., Quistberg, D. A., Micco, E., Domchek, S., and Guerra, C. (2006). Prescription of tamoxifen for breast cancer prevention by primary care physicians. Arch Intern Med 166, 2260-5.

Halbert, C. H., Kessler, L., Stopfer, J. E., Domchek, S., and Wileyto, E. P. (2006). Low rates of acceptance of BRCA1 and BRCA2 test results among African American women at increased risk for hereditary breast-ovarian cancer. Genet Med 8, 576-82.

Halbert, C. H., Kessler, L., Wileyto, E. P., Weathers, B., Stopfer, J., Domchek, S., Collier, A., and Brewster, K. (2006). Breast cancer screening behaviors among African American women with a strong family history of breast cancer. Prev Med 43, 385-8.

Narod, S. A., Lubinski, J., Ghadirian, P., Lynch, H. T., Moller, P., Foulkes, W. D., Rosen, B., Kim-Sing, C., Isaacs, C., Domchek, S., and Sun, P. (2006). Screening mammography and risk of breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study. Lancet Oncol 7, 402-6.

Brooks, G. A., Stopfer, J. E., Erlichman, J., Davidson, R., Nathanson, K. L., and Domchek, S. M. (2006). Childhood cancer in families with and without BRCA1 or BRCA2 mutations ascertained at a high-risk breast cancer clinic. Cancer Biol Ther 5, 1098-102.

Domchek, S. M., Armstrong, K., and Weber, B. L. (2006). Clinical management of BRCA1 and BRCA2 mutation carriers. Nat Clin Pract Oncol 3, 2-3.

Domchek, S. M., Friebel, T. M., Neuhausen, S. L., Wagner, T., Evans, G., Isaacs, C., Garber, J. E., Daly, M. B., Eeles, R., Matloff, E., Tomlinson, G. E., Van't Veer, L., Lynch, H. T., Olopade, O. I., Weber, B. L., and Rebbeck, T. R. (2006). Mortality after bilateral salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers: a prospective cohort study. Lancet Oncol 7, 223-9.

Domchek, S. M., Stopfer, J. E., and Rebbeck, T. R. (2006). Bilateral risk-reducing oophorectomy in BRCA1 and BRCA2 mutation carriers. J Natl Compr Canc Netw 4, 177-82.

Domchek, S. M., and Weber, B. L. (2006). Clinical management of BRCA1 and BRCA2 mutation carriers. Oncogene 25, 5825-31.
Brewster, K., Wileyto, E. P., Kessler, L., Collier, A., Weathers, B., Stopfer, J. E., Domchek, S., and Halbert, C. H. (2007). Sociocultural predictors of breast cancer risk perceptions in African American breast cancer survivors. Cancer Epidemiol Biomarkers Prev 16, 244-8.

Domchek, S. M., and Rebbeck, T. R. (2007). Prophylactic oophorectomy in women at increased cancer risk. Curr Opin Obstet Gynecol 19, 27-30.

Kotsopoulos, J., Ghadirian, P., El-Sohemy, A., Lynch, H. T., Snyder, C., Daly, M., Domchek, S., Randall, S., Karlan, B., Zhang, P., Zhang, S., Sun, P., and Narod, S. A. (2007). The CYP1A2 genotype modifies the association between coffee consumption and breast cancer risk among BRCA1 mutation carriers. Cancer Epidemiol Biomarkers Prev 16, 912-6.

Kotsopoulos, J., Lubinski, J., Lynch, H. T., Klijn, J., Ghadirian, P., Neuhausen, S. L., Kim-Sing, C., Foulkes, W. D., Moller, P., Isaacs, C., Domchek, S., Randall, S., Offit, K., Tung, N., Ainsworth, P., Gershoni-Baruch, R., Eisen, A., Daly, M., Karlan, B., Saal, H. M., Couch, F., Pasini, B., Wagner, T., Friedman, E., Rennert, G., Eng, C., Weitzel, J., Sun, P., and Narod, S. A. (2007). Age at first birth and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat.

McLaughlin, J. R., Risch, H. A., Lubinski, J., Moller, P., Ghadirian, P., Lynch, H., Karlan, B., Fishman, D., Rosen, B., Neuhausen, S. L., Offit, K., Kauff, N., Domchek, S., Tung, N., Friedman, E., Foulkes, W., Sun, P., and Narod, S. A. (2007). Reproductive risk factors for ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control study. Lancet Oncol 8, 26-34.

Tchou, J., Ward, M. R., Volpe, P., Palma, M. D., Medina, C. A., Sargen, M., Sonnad, S. S., Godwin, A. K., Daly, M., Winchester, D. J., Garber, J., Weber, B. L., Domchek, S., and Nathanson, K. L. (2007). Large Genomic Rearrangement in BRCA1 and BRCA2 and Clinical Characteristics of Men with Breast Cancer in the United States. Clin Breast Cancer 7, 627-33.