Research Interests:
Dr. Storey's research interests have focused primarily on the biochemistry of mammalian sperm function and the mechanism by which sperm establish binding to the egg zona pellucida. His work has provided a foundation for many subsequent investigations by others dealing with the analysis of specific forms of male infertility, the development of techniques for the evaluation of sperm function and the development of new approaches to contraception. His early work on sperm mitochondrial function and the localization of the enzymes of glycolysis has had a significant impact on present studies relating to the regulation of sperm function and the development of the assisted reproductive technologies. His laboratory was the first to demonstrate that the physiological acrosome reaction was induced by the zona pellucida subsequent to the binding of the sperm to this unique extracellular matrix. This work has led to a basic understanding of the fertilization process in mammals. His work on sperm lipid peroxidation has identified the mechanisms by which sperm viability is compromised and has led to the development of new media to extend such viability. Finally, his most recent work on sperm cryopreservation has provided the basis for the development of new media for cryopreservation of sperm from rare genetic strains of mice.

Dr. Storey has served the scientific community in numerous ways. He has served on the editorial board of several journals, has been a member of the Reproductive Biology Study Section, served as the Chair of the Gordon Research Conference on Fertilization and Activation of Development, and has been a member of multiple professional and scientific societies, including the Executive Council of the American Society of Andrology. Perhaps on of the most significant impacts that Bayard has had on the scientific community has been his total commitment to the mentoring of students, post-docs and junior faculty. The contributions by Bayard to the scientific community have been acknowledged by young investigators, his scientific peers and by the American Society of Andrology with his election as the 2000 Distinguished Andrologist.

Dr. Storey's active laboratory research was discontinued in 1999 pursuant to a move from 3rd floor John Morgan Bldg to 13th floor BRB II/III. Writeup of research results from the laboratory continued until early 2001. Areas of research covered in those studies may be inferred from the list of publications below. Present activity includes acting as reviewer for J Andrology, Biology of Reproduction, Human Reproducton Update, Cryobiology, Reproduction, Molecular Reproduction & Development, Molecular Human Reproduction; collaboration with colleagues on papers and grant applications.

Selected Publications:
Storey, B.T.: Biochemistry of the induction and prevention of lipoperoxidative damage in human spermatozoa. Mol. Human Reprod. 3: 203-213, 1997.

Noiles, E.E., Thompson, K.A., and Storey, B.T.: Water permeability, Lp, of the mouse sperm plasma membrane and its activation energy are strongly dependent on interaction of the plasma membrane within the sperm cytoskeleton. Cryobiology 35: 79-92, 1997.

Storey, B.T., Alvarez, J.G., and Thompson, K.A.: Human sperm glutathione reductase activity in situ reveals limitation in the glutathione antioxidant system due to supply of NADPH. Mol. Reprod. Dev. 49: 400-407, 1998

Storey, B.T., Noiles, E.E., and Thompson, K.A.: Comparison of glycerol, other polyols, trehalose, and raffinose to provide a defined cryoprotectant medium for mouse sperm cryopreservation. Cryobiology 37: 46-68, 1998.

Rockwell, P.L., and Storey, B.T.: Determination of the intracellular dissociation constant, KD, of the fluo-3 Ca2+ complex in mouse sperm for use in estimating intracellular Ca2+ concentrations. Mol. Reprod. Dev. 54: 418-428, 1999.

Rockwell, P.L., Storey, B.T.: Kinetics of onset of mouse sperm acrosome reaction induced by solubilized zona pellucida: fluorimetric determination of loss of pH gradient between acrosomal lumen and medium monitored by Dapoxyl (2-aminoethyl) sulfonamide and of intracellular Ca2+ changes monitored by fluo-3. Mol. Reprod. Dev. 55: 335-349, 2000.

Travis, A.J., Jorgez, C.J., Merdiushev, T., Jones, B.H., Dess, D.M., Diaz-Cueto, L., Storey, B.T., Kopf, G.S., Moss, S.B.: Functional relationships between capacitation-dependent cell signaling and compartmentalized metabolite pathways in murine spermatozoa. J. Biol. Chem.: 276: 7630-7636, 2001.

Thompson, K.A., Richa, J., Liebhaber, S.A., Storey, B.T.: Dialysis addition of trehalose/glycerol cryoprotectant allows recovery of cryopreserved mouse sperm with satisfactory fertilizing ability as assessed by yield of live young. J. Androl. 22: 339-344, 2001.

Selak, M.A., Storey, B.T., Peterside, I., Simmons, R.A.: Impaired oxidative phosphorylation in skeletal muscle of intrauterine growth-retarded rats. Am. J. Physiol. Endocrinol. Metab. 285: E130-E137, 2003.

Galantino-Homer, H.L., Florman, H.M., Storey, B.T., Dobrinski, I., Kopf, G.S.: Bovine sperm capacitation: assessment of phosphodiesterase activity and intracellular alkalinization on capacitation-associated protein tyrosine phosphorylation. Mol. Reprod. Dev. 67: 487-500, 2004.