Department of Psychiatry
Penn Behavioral Health

Center for Studies of Addiction

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Addiction Treatment and Medication Development Division

Recent Publications

 

PUBLISHED MANUSCRIPTS:

2009

  • Anton, R.F., Oroszi, G., O’Malley, S., Couper, D., Swift, R., Pettinati, H.M., & Goldman, D.  (2009).  Response to the Letter to the Editor.  Archives of General Psychiatry.
  • Bloch, P.J., Nall, A.H., Weller, A.E., Ferraro, T.N., Berrettini, W.H., Kampman, K.M., Pettinati, H.M., Dackis, C.A., O’Brien, C.P., Oslin, D.W., & Lohoff, F.W. (2009).  Association analysis between polymorphisms in dopamine D3 receptor (DRD3) gene and cocaine dependence.
  • Lohoff, F.W., Bloch, P.J., Ferraro, T.N., Berrettini, W.H., Pettinati, H.M., Dackis, C.A., O’Brien, C.P., Kampman, K.M., & Oslin, D.W. (2009).  Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence.
  • Oroszi, G., Anton, R.F., O¹Malley, S., Swift, R., Pettinati, H., Couper, D.,
    Yuan, Q., & Goldman, D. (2009). OPRM1 Asn40Asp predicts response to
    naltrexone: A haplotype-based approach. Alcoholism: Clinical and
    Experimental Research, 33(3), 383-393.

 

  • Pettinati, H.M., Gastfriend, D.R., Dong, Q., Kranzler, H.R., & O’Malley, S. (2009).  Effect of extended release naltrexone (XR-NTX) on quality of life in alcohol dependent patients. Alcoholism:Clinical and Experimental Research, 33(2), 350-356.

 

2008

  1. Ahmadi, J., Kampman, K., Dackis, T., Sparkman, T., & Pettinati, H. (2008). Cocaine withdrawal symptoms identify Type B cocaine dependent patients. American Journal on Addictions, 17, 60-64.
  2. Anton, R.F., Oroszi, G., O’Malley, S., Couper, D., Swift, R., Pettinati, H.M., & Goldman, D., (2008). An evaluation of u-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: Results from the combined pharmacotherapies and behavioral interventions for alcohol dependence (COMBINE) Study. Archives of General Psychiatry, 65(2),135-144.
  3. Ciraulo, D.A., Dong, Q., Silverman, B.L., Gastfriend, D.R., & Pettinati, H.M. (2008). Early treatment response in alcohol dependence with extended-release naltrexone. Journal of Clinical Psychiatry, 69, 190-195.
  4. Donovan, D.M., Anton, R.F., Miller, W., Longabaugh, R., Hosking, J.D., & Youngblood, M., for the COMBINE Study Research Group. (2008). Combined pharmacotherapies and behavioral interventions for alcohol dependence (The COMBINE Study): Examination of post-treatment drinking outcomes. Journal on Studies of Alcohol and Drugs, 69: 5-13.
  5. Dundon, W.D., Pettinati, H. M., Lynch, K. G., Xie, H., Varillo, K.M., Makadon, C., & Oslin, D. W. (2008). The therapeutic alliance in medical-based interventions impacts outcomes in treating alcohol dependence. Drug and Alcohol Dependence, 95, 230-236.
  6. Ernst, D.B., Pettinati, H.M., Weiss, R.D., Donovan, D.M., & Longabaugh, R. (2008). An intervention for treating alcohol dependence: Relating elements of medical management to patient outcomes with implications for primary care. Annals of Family Medicine, 6(5), 435-440.
  7. Fairbairn, C.E., Dundon, W.D., Xie, H., Plebani, J.G., Kampman, K.M., & Lynch, K.G. (2008). Study blinding and correlations between perceived group assignment and outcome in a cocaine pharmacotherapy trial. American Journal on Addictions, 17: 387-391.
  8. Gariti, P., Levin, S., Whittingham, T, Barou, D., Kampman, K.M., Lynch, K., Halbert, C.H., & Alterman, A. (2008). Why do those who request smoking treatment fail to attend the first appointment? Journal of Substance Abuse Treatment, 35(1):62-67.
  9. Johnson, B.A., Rosenthal, N., Capece, J.A., Weigand, F., Mao, L., Beyers, K., McKay, A., Ait-Daoud, N., Addolorato, G., Anton, R.F., Ciraulo, D.A., Kranzler, H.R., Mann, K., O’Malley, S.S., Swift, R.M., & the Topiramate for Alcoholism Study Group (2008). Improvement of physical health and quality of life of alcohol dependent individuals with topiramate treatment. Archives of Internal Medicine, 168(11), 1188-1199.
  10. Kampman, K.M. The search for medications to treat stimulant dependence. NIDA's Addiction Science & Clinical Practice, 4(2):28-35, 2008.
  11. Lohoff, F.W., Bloch, P.J., Weller, A.E., Nall, A.H., Doyle, G.A., Buono, R.J., Ferraro, T.N., Kampman, K.M., Pettinati, H.M., Dackis, C.A., Oslin ,D.W., O'Brien, C.P., & Berrettini, W.H. (2008). Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence. Neuroscience Letters, 440(3):280-283.
  12. Oslin, D.W, Lynch, K.G, Pettinati, H.M., Kampman, K.M., Gariti, P., Gelfand, L., Ten Have, T., Wortman, S., Dundon, W., Dackis, C, Volpicelli, J.R., & O'Brien, C.P. (2008) .A placebo-controlled randomized clinical trial of naltrexone in the context of different levels of psychosocial intervention. Alcohol Clinical and Experimental Research, 32(7):1299-1308.
  13. Pettinati, H.M., Kampman. K.M., Lynch, K.G., Suh, J.J., Dackis, C.A., Oslin, D.W., & O’Brien, C.P. (2008). Gender differences with high dose naltrexone in cocaine and alcohol dependent patients. Journal of Substance Abuse Treatment 34: 378-390.
  14. Pettinati, H.M., Kampman, K.M., Lynch, K.G., Xie, H., Dackis, C., Rabinowitz, A.R., & O’Brien, C.P. (2008). A double blind, placebo-controlled trial that combines disulfiram and naltrexone for treating co-occurring cocaine and alcohol dependence. Addictive Behaviors, 33, 651-667.
  15. Schnoll, R.A., Wileyto, E.P., Pinto, A., Leone, F., Gariti, P., Siegel, S., Perkins, K.A., Dackis, C., Heitjan, D.F., Berrettini, W., & C. Lerman. (2008). A placebo controlled trial of modafinil for nicotine dependence. Drug and Alcohol Dependence 98:86-93.
  16. Suh, J.J., Pettinati, H.M., Kampman. K.M., & O’Brien, C.P. (2008). Gender differences in predictors of treatment attrition with high dose naltrexone in cocaine and alcohol dependence. American Journal on Addictions 17:463-468.
  17. Tirado, C.F., Goldman, M., Kampman, K.M., & O’Brien, C.P. (2008). Atomoxetine for treatment of marijuana dependence: A report on the efficacy and high incidence of GI adverse events in a pilot study. Drug and Alcohol Dependence, 4(1-3): 254-257.
  18. Weiss, R.D., O’Malley, S.S., Hosking, J.D., LoCastro, J.S., Swift, R., for the COMBINE Study Research Group. (2008). Do patients with alcohol dependence respond to placebo? Results from the COMBINE Study*. Journal of Studies on Alcohol and Drugs, 69, 878-884.
  19. Zweben, A, Pettinati, H.M., Weiss, R.D., Youngblood, M., Cox, C.E., Mattson, M.E., Gorroochurn, P., & Ciraulo, D. (2008). Relationship between medication adherence and treatment outcomes: The COMBINE Study. Alcoholism:Clinical and Experimental Research, 32(9), 1-9.

2007

  1. Dixon, L.B., Adler, D.A., Berlant, J.L., Dulit, R.A., Goldman, B., Hackman, A.L., Oslin, D.W., Siris, S.G., Sonis, W.A., & Valenstein, M. (2007). Psychiatrists and primary caring: What are our boundaries of responsibility? Psychiatric Services 58(5), 600-602.
  2. Franklin, T.R., Wang, Z., Wang, J., Sciortino, N., Harper, D., Li, Y, Ehrman, R., Kampman, K., O'Brien, C.P., Detre, J.A., & Childress, A.R. (2007). Limbic activation to cigarette smoking is independent of nicotine withdrawal: A perfusion fMRI study. Neuropsychopharmacology, 32, 2301-2309.
  3. Gastfriend, D.R., Garbutt, J.C., Pettinati, H.M., & Forman, R.F. (2007). Reduction in heavy drinking as a treatment outcome in alcohol dependence. Journal of Substance Abuse Treatment, 33, 71-80.
  4. Johnson, B.A., Rosenthal, N., Capece, J.A., Wiegand, F., Mao, L., Beyers, K., McKay, A., Ait-Daoud, N., Anton, R.F., Ciraulo, D.A., Kranzler, H.R., Mann, K., O’Malley, S.S., & Swift, R.M., for the Topiramate for Alcoholism Advisory Board, and the Topiramate for Alcoholism Study Group. (2007). Topiramate for treating alcohol dependence; Journal of the American Medical Association, 298(14), 1641-1656.
  5. Kampman, K.M., Pettinati, H.M., Lynch, K.G., Whittingham, T., Macfadden, W., Dackis, C., Tirado, C., Oslin, D.W., Sparkman, T., & O’Brien, C.P. (2007). A double-blind, placebo-controlled, pilot trial of quetiapine for the treatment of Type A and Type B Alcoholism. Journal of Clinical Psychopharmacology, 27(4), 344-351.
  6. Kampman, K.M., Wilkins, C.R. (2007). New developments in the treatment of alcohol dependence: The impact on clinical practice. Counselor, 8(3), 12-18.
  7. Kirchner, J.E., Zubritsky, C., Cody, M., Coakley, E., Chen, H., Ware, J.H., Oslin, D.W., Sanchez, H.A., Durai, U.N., Miles, K.M., Llorente, M.D., Costantino, G., & Levkoff, S. (2007). Alcohol consumption among older adults in primary care. Journal of General Internal Medicine 22(1), 92-97.
  8. Mavandadi, S., Ten Have, T.R., Katz, I. R., Durai, U.N., Krahn, D.D., Llorente, M.D., Kirchner, J.E., Olsen, E.J., Van Stone, W.W., Cooley, S.L., & Oslin, D.W. (2007). Effect of depression treatment on depressive symptoms in older adulthood: The moderating role of pain. Journal of the American Geriatrics Society 55(2), 202-211.
  9. Murphy, S.A., Lynch, K.G., Oslin, D., McKay, J.R., TenHave, T. (2007). Developing adaptive treatment strategies in substance abuse research. Drug & Alcohol Dependence 88 Suppl 2, S24-30.
  10. Murphy, S.A., Oslin, D.W., Rush, A.J., Zhu, J., McAts. (2007). Methodological challenges in constructing effective treatment sequences for chronic psychiatric disorders. Neuropsychopharmacology 32(2), 257-262.
  11. Pettinati, H.M. (2007). Letter to the Editor in regard to Timko, DeBenedetti, Moos and Moos (2006). “Predictors of 16-year mortality among individuals initiating help-seeking for an alcoholic use disorder”. Alcoholism: Clinical and Experimental Research, 31(3), 512.
  12. Pettinati, H.M. & Gallis, T. (2007). Advances and challenges in treating alcohol dependence with pharmacotherapy. Psychiatric Times, CMEducator, 68-71.
  13. Suh, J.J., Gallis, T., Kampman, K.M., & Pettinati, H.M. (2007). Reply to Comments by Dr. Beresford on “The status of disulfiram: A half century later.” Journal of Psychopharmacology, 27(4), 417-418.
  14. Zanjani, F., Saboe, K., Oslin, D., Zanjani, F., & Saboe, K., (2007). Age difference in rates of mental health/substance abuse and behavioral care in HIV-positive adults. AIDS Patient Care & STDS, 21(5), 347-355.

2006

  1. Ahmadi, J., Kampman, K., Dackis, C. (2006). Outcome predictors in cocaine dependence treatment trials. American Journal of Addictions 15(6): 434-9.
  2. Dahl, J.P., Cubells, J.F., Ray, R., Weller, A.E., Lohoff, K.M., Ferraro, F.W., Oslin, D.W., Kampman, K.M., Tang, Y., Gelernter, J., Kranzler, H.R., O’Brien, C.P., Berrentini, W.H.  (2006). Analysis of the variation in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence. Addiction Biology, 11(1): 76-83.
  3. Dahl, J.P., Weller, A.E., Kampman, K.M., Oslin, D.W., Lohoff, F.W., Ferraro, T.N., O’Brien, C.P., Berrettini, W.H.  Confirmation of the association between a polymorphism in the promoter region of the prodynorphan gene and cocaine dependence. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 139B:106-108.
  4. Kampman, K.M., Dackis, C., Lynch, K.G., Pettinati, H.M., Tirado, C., Gariti, P., Sparkman, T., Atzram, M., O'Brien, C.P.  (2006). A double-blind, placebo-controlled trial of amantadine and propranolol for the treatment of cocaine dependent patients with severe cocaine withdrawal symptoms. Drug and Alcohol Dependence, 85(2): 129-137.
  5. O’Brien, C.P., Dackis, C.A., Kampman, K. (2006). Does modafinil produce euphoria?  American Journal of Psychiatry, 163(6): 1109.
  6. Oslin, D.W., Berrettini, W.H., et al. (2006). Targeting treatments for alcohol dependence: The pharmacogenetics of naltrexone. Addiction Biology, 11(3-4): 397-403.
  7. Oslin, D.W.  Detoxification and Substance Abuse Treatment, Treatment Improvement Protocol (TIP) Series # 19 (revision).  Consensus Panel member.  Norman Miller, Consensus Panel Chair.  U.S. Department of Health and Human Services Publication Number (SMA) 2006.
  8. Pettinati, H.M. (2006).  Improving medication adherence in alcohol dependence.  Journal of Clinical Psychiatry, 67 (Supplement 14), 23-30.
  9. Pettinati, H.M., O'Brien, C.P., Rabinowitz, A.R, Wortman, S.M, Oslin, D.W., Kampman, K.M., Dackis, C.A. (2006). The status of naltrexone in the treatment of alcohol dependence: Specific effects on heavy drinking. Journal of Clinical Psychopharmacology, 26, 610-625.
  10. Pettinati, H.M. & Rabinowitz, A.R. (2006).  New pharmacotherapies for treating neurobiology of alcohol and drug addiction.  Psychiatry 2006, 3(5) 14-16.
  11. Suh, J.J., Pettinati, H.M., Kampman, K.M., & O’Brien, C.P. (2006).  The status of disulfiram: A half of a century later.  Journal of Psychopharmacology, 26, 290-302.
  12. Weller, A.E., Dahl, J.P., Lohoff, F.W., Kampman, K.M., Oslin, D.W., Dackis, C., Ferraro, T.N., O'Brien C.P. and Berrettini, W.H. (2006). No association between polymorphisms in the prostate apoptosis factor-4 gene and cocaine dependence. Psychiatric Genetics 16, 193-196.

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ABSTRACTS / PRESENTATIONS:

2008

  1. Franklin, T., Lohoff, F., Wang, Z., Li, Y., Kampman, K., Cruz, J., Jens, W., Berrentini, W., O'Brien, C.P., & Childress, A.R. (June, 2008) DAT genotype underlies the intensity and direction of corticolimbic activation to smoking cues. Presented at the College on Problems of Drug Dependence Annual Meeting, San Juan Puerto Rico.
  2. Kampman, K., Gromov, I., Sirota, A., Siverman, B., Illeperuma, A., & Gastfrend, D. (April, 2008). Long-term Safety and Tolerability of Extended-Release Naltrexone in Alcohol and/or Opioid-Dependent Patients: A Randomized, Active-Controlled Study Presented at American Psychiatric Association Annual meeting.
  3. Kampman, K.M., Pettinati, H.M., Lynch, K.G., Dackis, C., Sharkoski, T., Kirchner, K., Xie, H., & O’Brien, C.P. (June, 2008). Initiating acamprosate within versus post-detoxification in the treatment of alcohol dependence. Presented at the College on Problems of Drug Dependence Annual Meeting, San Juan Puerto Rico.
  4. Levin, S.C., Dundon, W.D., Xie, H., Prout, M.F., & Pettinati, H.M. (2008). The efficacy of sertraline for babor type a alcohol dependence: a replication. Alcoholism: Clinical and Experimental Research; 32 (s1), p259A, a996.
  5. Pettinati, H.M., Bogenschutz, M.P., & Tonigan, J.S. (2008). Alcohol subtypes as predictors for treatment response: results from the combine study. Alcoholism: Clinical and Experimental Research; 32 (s1), pg281A, a032.
  6. Pettinati, H.M., Stedman, M., Brown, E.S., Kotz, M., Calabrese, J., Borsody, M., & Raines, S. (2008). A double-blind, placebo-controlled study of quetiapine adjunct therapy with traditional mood stabilizers in bipolar i patients with alcohol dependence. Alcoholism: Clinical and Experimental Research; 32 (s1), p260A, a998.
  7. Plebani, J.G., Pettinati, H.M., Kampman, K.M., Dundon, W.D., & Lynch K.G. (2008) The relationship between gender, relapse to drinking and subsequent depression in a pharmacotherapy trial for comorbid depression and alcohol dependence. Alcoholism: Clinical and Experimental Research; 32 (s1), p193A, a731.
  8. Solodky, H.K., Dundon, W.D., Xie, H., Sorensen L.C., & Pettinati H.M. (2008). Age of onset does not predict Babor typology or outcome in depressed alcoholics. Alcoholism: Clinical and Experimental Research; 32 (s1), p122A, a448.
  9. Sorensen, L.C., Dundon, W.D., Xie, H., Solodky, H.K., & Pettinati H.M. (2008). Naltrexone improves drinking outcome in Babor type a and b alcohol dependence in a sample of depressed, alcohol dependent outpatients. Alcoholism: Clinical and Experimental Research; 32 (s1), p260A, a999.
  10. Zaharakis, N., Courtright, L., Prasad, D., Stoeckle, J., Sorensen, L., Kampman, K., Pettinati, H.M., Lynch, K., & Oslin D.W. (2008). Design and implementation of an adaptive treatment trial for alcohol dependence. Alcoholism: Clinical and Experimental Research; 32 (s1), p258A, a991.

2007

  1. Chakravorty, S., Pettinati, H.M., Dundon, W., Zaharakis, N., Kampman, K. & Oslin, D.W. (July, 2007). The relationship between sleep disturbances and alcohol craving. Poster presented at the annual meeting of the Research Society on Alcoholism, Chicago, IL.
  2. Dundon, W. (July, 2007). The treatment of late life major depression complicated by alcohol dependence. In: Pharmacological treatments of comorbid alcohol and psychiatric disorders: Four recent clinical trials. Helen Pettinati and William Dundon (Chairs). Symposium conducted at the annual meeting of the Research Society on Alcoholism, Chicago, IL.
  3. Kampman, K., Lynch, K., Pettinati, H.M., Dackis, C., Dundon, W., Varillo, K., Fairbairn, C., Yama, M. & O’Brien, C.P. (June, 2007). The measurement of craving in cocaine pharmacotherapy trials: What do we learn from it? Poster presented at the annual meeting of College on Problems of Drug Dependence, Quebec City, Quebec, Canada.
  4. Kampman, K.M., Pettinati, H.M., Lynch, K., Xie, H., & O’Brien, C.P. (Dec. 2007). Secondary efficacy and safety measures in a pilot trial of quetiapine for the treatment of Type A and Type B alcoholism. Poster presented at the annual meeting of the American College of Neuropsychopharmacology, Boca Raton, FL.
  5. Kampman, K.M., Pettinati, H., Lynch, K., Xie, H., & O’Brien, C. (December, 2007) Secondary efficacy and safety measures in a pilot trial of quetiapine for the treatment of type a and type b alcoholism. Presented at the American College of Neuropsychopharmacology Annual Meeting, Hollywood, Florida.
  6. Pettinati, H.M. (July, 2007). Sertraline for alcohol dependence and depression. In: Pharmacological treatments of comorbid alcohol and psychiatric disorders: Four recent clinical trials. Helen Pettinati and William Dundon (Chairs). Symposium conducted at the annual meeting of the Research Society on Alcoholism, Chicago, IL.
  7. Pettinati, H.M. (July, 2007). Variation in the mu-opiate receptor gene (oprm1) predicts response to naltrexone: Results from the COMBINE study. In: Pharmacogenetics of naltrexone: Meaningful genetic variation in the opioid system. David W. Oslin (Chair). Symposium conducted at the annual meeting of the Research Society on Alcoholism, Chicago, IL.
  8. Plebani, J., Kampman, K., Pettinati, H.M., Dackis, C., O’Brien, C.P., Varillo, K., Yama, M., & Fairbairn, C. (June, 2007). Implications of early in-treatment cocaine abstinence in high CSSA patients. Poster presented at the annual meeting of College on Problems of Drug Dependence, Quebec City, Quebec, Canada.
  9. Tirado, C.F., Goldman, M., Kampman, K., & O’Brien, C.P. (June, 2007). Atomoxetine for treatment of marijuana dependence: Limited efficacy and high incidence of GI adverse events in a pilot study. Poster presented at the College on Problems of Drug Dependence Annual Meeting, Quebec City, Quebec.
  10. Zweben, A., & Pettinati, H.M. (Chairs) (July, 2007). The COMBINE STUDY: Secondary Analyses – Dedicated to the Memory of Jim Hosking. Workshop conducted at the annual meeting of the Research Society on Alcoholism, Chicago, IL.

2006

  1. Kampman, K.M., & Pettinati, H.M. A randomized, placebo-controlled trial of quetiapine for the treatment of alcohol dependence. (presented at the American Psychiatric Association Annual Scientific Meeting, Toronto, Ontario, March 2006).
  2. Kampman, K.M., Pettinati, H.M., Macfadden, W., Lynch, K.G., Whittingham, T., Dackis, C.A., & Varillo, K. A pilot trial of quetiapine for the treatment of alcohol dependence. (presented at the College on Problems of Drug Dependence Annual Meeting, Scottsdale Arizona, June 2006).
  3. Starosta, A.N., Rha, C., Whittingham, T., DiDonato, D., Lynch, K., Kampman, K., & Dackis, C. Factors involved in predicting the success of modafinil for the treatment of cocaine dependence. (presented at the College on Problems of Drug Dependence Annual Meeting, Scottsdale Arizona, June 2006).

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BOOK CHAPTERS:

2009

  1. Pettinati, H.M. & Plebani, J.G. (2009). Depression and substance use disorders in women. In: Brady, K. et al (eds) Women and Addiction: A Comprehensive Handbook. New York, Guilford Press.

2008

  1. Kampman, K.M. (2008). Antiepileptic Drugs in the Treatment of Drug Use Disorders, in Antiepileptic Drugs to Treat Psychiatric Disorders. Edited by McElroy, S.L., Keck, P.E., Post, R.M., New York, Informa Healthcare, 263-270.
  2. O’Brien, C.P., Kampman, K.M. (2008). Opioids, Antagonists and Partial Agonists, in The American Psychiatric Publishing Textbook of Substance Abuse Treatment. Edited by Galanter, M., Kleber, H.D., Washington D.C., American Psychiatric Publishing, 325-329.

2006

  1. Blow, F.C., and Oslin, D.W.  Substance Use and Abuse. In Mellow A. (ed.). Review of Psychiatry. APA Press, in press.
  2. Oslin, D.W.  Substance Abuse. In Calhoun, K. and Eibling, D.E. (eds). Geriatric Otolaryngology, Marcel Dekker, 2006.
  3. Oslin D.W.  Addictions.  Psychiatry for Neurologists.  Jeste, D.V., Friedman, J.H. (eds). Humana Press, 2006.
  4. Oslin D.W. Substance Abuse.  Geriatric Otolaryngology. Calhoun, K.H., and Eibling, D.E. (ed). Taylor and Francis, NY, 2006.
  5. Steen, T.A. and Dackis, C.A.  Treatment of cocaine dependence, in Smith, H. and Passik, S. (Eds.) Pain and Chemical Dependency Textbook, Oxford University Press, New York, in press.
  6. Zanjani, F. and Oslin, D.W.  Substance use and abuse assessment. Handbook of Geriatric Assessment. Gallo, J.J., Bogner, H.R. Fulmer, T., Paveza, G.J. (ed). Jones and Bartlett, Boston, 2006.

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