Brain-Behavioral Vulnerabilities Laboratory
Clinical Trials
The Brain-Behavioral Vulnerabilities Laboratory is currently recruiting for a number of "active" clinical trials, as indicated below. The "pending" studies are not yet recruiting, but funding is in place.
COCAINE TRIALS
Study Name: The CURE-Cocaine
Diagnosis or Problem: Cocaine Dependence
Age: 18-60 years
Study Involves: A 7-10 day inpatient stay followed by weekly outpatient drug counseling and psychosocial treatment; Participation in up to 4 fMRI scans that occur before, during, and after the treatment period
Duration: 12 weeks of treatment plus 12 weeks of follow-up
Study Status: Active - recruiting patients
Study Name: Real Time
Diagnosis or Problem: Cocaine Dependence
Age: 18-60 years
Study Involves: A 7-10 day inpatient stay, 4 fMRI scans plus 8 weeks of behavioral therapy
Duration: 8 weeks of treatment
Study Status: Active - recruiting patients
Study Name: Extinction
Diagnosis or Problem: Cocaine Dependence
Age: 18-60 years
Study Involves: A 7-10 day inpatient stay, 3 fMRI scans plus 8 weeks of behavioral therapy
Duration: 8 weeks of treatment
Study Status: On Hold – Not actively recruiting
MARIJUANA TRIALS
Study Name: The CURE-Marijuana
Diagnosis or Problem: Marijuana Dependence
Age: 18-60 years
Study Involves: Baclofen or placebo (double-blind), plus weekly outpatient drug counseling and psychosocial treatment; Participation in up to 4 fMRI scans that occur before, during, and after the treatment period
Duration: 12 weeks of treatment plus 12 weeks of follow-up
Study Status: Active - recruiting patients
NICOTINE TRIALS
Study Name: Effects of Varenicline on Smoking Behavior (VSMK)
Diagnosis or Problem: Nicotine dependence
Age: 18-60 years
Study Involves: Varenicline or placebo (double-blind), 2 fMRI scans, plus weekly monitoring meetings
Duration: 8 weeks of treatment (including 2 fMRI scans) plus 1 week of follow-up
Study Status: Active - recruiting patients
Study Name: Acute Baclofen-Affect Regulation Task (AB-ART)
Diagnosis or Problem: Nicotine Dependence
Age: 18-60 years
Study Involves: 1 small dose of baclofen
Duration: 2 fMRI scans
Study Status: Closed
Study Name: Use of SPECT to examine DAT genotype in smokers (DDAT)
Diagnosis or Problem: Nicotine dependence
Age: 18-60 years
Study Involves: 2 SPECT scans (one sated and one withdrawal session)
Duration: 4 visits (including 2 SPECT scans)
Study Status: Not yet recruiting
OPIATE TRIALS
Study Name: The CURE-Prescription Opiates
Diagnosis or Problem: Prescription Opiate Dependence
Age: 18-60 years
Study Involves: Three injections of naltrexone (Vivitrol) plus weekly outpatient drug counseling and psychosocial treatment; Participation in up to 4 fMRI scans that occur before, during, and after the treatment period
Duration: 12 weeks of treatment plus 12 weeks of follow-up
Study Status: Active - recruiting patients
Study Name: Biomarkers of Disease and Response to Treatment in Opioid Addiction (XRNT/XRM)
Diagnosis: Opioid dependence
Age: 18-55 years
Study Involves: Three monthly injections of naltrexone (Vivitrol) plus weekly psychosocial treatment; Participation in up to 3 fMRI scans throughout treatment
Duration: 3 months of treatment plus 1 month of follow-up
Study status: Active - recruiting participants
HEALTHY CONTROL TRIALS
Study Name: Brain Substrates of Affect Regulation (BSAR)
Diagnosis: N/A
Age: 30-49 years (African-American males only)
Study Involves: 1 fMRI scan
Duration: 4 visits (including 1 fMRI scan)
Study status: Active - recruiting participants
