Department of Psychiatry

Penn Behavioral Health

Novel Interventions in Criminal Justice Populations Division

Research Areas

A large randomized trial of oral naltrexone in probationers with opiate dependence has recently been completed. The Division concluded a pilot multi-site trial of depot (injectable) naltrexone.  Currently, the Division is the lead site for a large scale multi-site study.  In this study, a total of 308 opiate-dependent patients who are on probation or parole were randomized to receive either monthly depot naltrexone injections or treatment-as-usual in an effort to study relapse in this population.  The Division is also beginning a clinical trial of depot naltrexone in the management of repeat DUI offenders.


Cornish, J.W., Metzger, D., Woody, G.E., Wilson, D., McLellan, A.T., Vandergrift, B. and O’Brien, C.P.:  Naltrexone pharmacotherapy for opioid dependent federal probationers.  Journal of Substance Abuse Treatment, 14(6):529-534, 1997.

O’Brien, C.P. and Cornish, J.W.:  Naltexone for probationers and parolees.  Journal of Substance Abuse Treatment, 31:107-11, 2006.

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