Department of Psychiatry

Penn Behavioral Health

Publications by PI

Click on the Investigator's name to see published work. 

An-Li Wang, PhD

Wang AL , Ruparel K, Strasser AA, Blady SJ, Lynch KG, Loughead JW, Romer D, Cappella JN, Lerman C and Langleben DD. Content matters: neuroimaging investigation of brain and behavioral impact of televised anti-tobacco public service announcements. Journal of Neuroscience 33(17):7420-7427 (2013) 

Wang AL , Romer D, Elman I, Turetsky BI, Gur RC & Langleben DD. Emotional graphic cigarette warning labels reduce the electrophysiological brain response to smoking cues. Addiction Biology , 20(2):368-76. doi: 10.1111/adb.12117 (2013) 

Romer D, Jamieson P, Bushman B, Bleakley A, Wang AL, Langleben DD, Jamieson K. Parental Desensitization to Violence and Sex in Movies. Pediatrics , 134(5):877-84. doi: 10.1542/peds.2014-1167 (2014) 

Seelig D*, Wang AL*, Romer D, Jagannathan K, Loughead JW, Childress, AR, Langleben, DD Low message sensation health promotion videos are better remembered and activate areas of the brain associated with memory encoding . PLoS ONE, 19;9(11):e113256. doi: 10.1371/journal.pone.0113256 (2014) * *authors contributed equally. 

Wang AL, Lowen BS, Romer D, Jagannathan K, Langleben, DD. Emotional reaction facilitates the brain and behavioral impact of graphic cigarette warning labels in smokers . Tobacco Control , 2015 Jan 6. pii: tobaccocontrol-2014-051993. doi: 10.1136/tobaccocontrol-2014-051993 . 

Wang AL, Elman I, Lowen BS, Blady JS, Lynch GK, O’Brien PC and Langleben DD Neural correlates of adherence to extended-release naltrexonepharmacotherapy in heroin dependence. Translational Psychiatry . 2015 Mar 17;5:e531. doi: 10.1038/tp.2015.20. 

Langleben DD, Wang AL, Hakun JG, Seelig D, Barndollar RK, Bilker WB, Busch EL, Ruparel K, Gur RC. Poly graph and fMRI in lie detection: a controlled blind comparison using the Concealed Information Test . J Clin Psychiatry. 2016 Oct;77(10):1372-1380. doi: 10.4088/JCP.15m09785. 

Wang AL, Bissey B, Davis-Vogel A, Shapira D, Giorno M and Langleben DD. A Neuroimaging Investigation of the Effects of Personal Relevance on the Effectiveness of HIV-prevention videos in African American Men Who Have Sex With Men. J Neuroimmune Pharmacol (2015) 10 (Suppl 1):S1-S55 

Shi ZH, Wang AL and Langleben DD. Keeping your spaceship safe: A complex relation between addiction, gender, and avoidance behavior. J Clin Psychiatry. 2016 Mar;77(3):395-7. doi: 10.4088/JCP.16com10752. 

Wang AL, Lowen BS, Elman I, Shi ZH, Bissey B, Metzger DS and Langleben DD. Targeting modulates brain and behavioral impact of safe sex video ads. Soc Cogn Affect Neurosci. 2016 Oct;11(10):1650-7. doi: 10.1093/scan/nsw070. 

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Kevin Lynch, PhD

Leiby, BE, Ten Have, TR, Lynch, KG, and Sammel, M. Bayesian multivariate growth curve latent class models for mixed outcomes, Statistics in Medicine, 33(20), 3434–3452, 2014. PMC3676449

Ertefaie A, Wu T, Lynch KG, Nahum-Shani I, Identifying the Set of Best Dynamic Treatment Regimes, Biostatistics, 17(1), 135-148, 2016.

Lu X, Nahum-Shani I, Kasari C, Lynch KG, Oslin DW, Pelham WE, Fabiano G, Almirall D, Comparing Dynamic Treatment Regimes using Repeated Measures, Statistics in Medicine, 35(10), 1595-1615, 2016.

Taylor CM, Ross ME, Frioux SM, Wood JN, Griffis HM, Harb GC, Mi L, Song L, Lynch KG, Rubin DM, Maltreatment of Infants and Toddlers during Deployment Periods of Active Duty Army Soldiers, American Journal of Public Health, 106(1), 153-158, 2016.

Lu X, Lynch KG, Oslin DW, Murphy SA, Comparing Treatment Policies with Assistance from the Structural Nested Mean Model, Biometrics, 72(1):10-19, 2016.

Greeson JM, Gettes DR, Spitsin S, Dubé B, Benton TD, Lynch KG, Douglas SD, Evans DL, Selective Serotonin Reuptake Inhibitor Decreases HIV Receptor and Coreceptor Expression in Immune Cells, Biological Psychiatry, 80(1), 33-9, 2016.

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Martin Cheatle, PhD

Cheatle, M.D., Pain and addiction. In: Interventions for Addiction: Comprehensive Addictive Behaviors and Disorders. Elsevier Inc., San Diego: Academic Press, pp. 503–515, 2013.

Cheatle, M.D., O’Brien, C.P., Mathai, K., Hansen, M., Grasso, M., Yi, P., Aberrant behaviors in a primary care-based cohort of chronic pain patients identified as misusing prescription opioids. Journal of Opioid Management 9(5): 315-324, 2013.

Cheatle, M.D., Wasser, T., Foster, C., Olugbodi, A., Bryan, J., Prevalence of suicidal ideation in patients with chronic noncancer pain referred to a behaviorally based pain program. Pain Physician, 17 (3): E359-E367, 2014.

Cheatle, M.D., Comer, D., Wunsch, M., Skoufalos, A., Reddy, Y. Treating pain in addicted patients: Recommendations from an expert panel. Population Health Management,17(2): 79-89, 2014

Cheatle, M.D., Baker, C. Improving opioid practices and reducing patient risk in the primary care setting. Journal of Pain Research, 7: 301-311, 2014.

Cheatle, M.D. Pain, depression and suicide: Assessment and intervention in the primary care setting. Current Pain Perspectives, Journal of Family Practice, 63 (6): S6-S11, 2014.

Cheatle, M.D., Psychological dependence and prescription opioid misuse and abuse. Pain Medicine, 15 (4): 541-543, 2014.

Cheatle, M.D. Suicidal ideation in patients with chronic pain: The risk/benefit of pharmacotherapy. Pain, 155 (12): 2446-2447, 2014.

Cheatle, M.D., Shmuts, R. Benzodiazepine and opioid use in patients with chronic pain: balancing risk and benefit. Pain Medicine, 16(2): 219-221, 2015.

Cheatle, M.D., Gallagher, R.M., Biopsychosocial factors in pain medicine. In M.S. Wallace and P. Staats (Eds.), Pain Medicine and Management: Just the facts 2ed. New York: McGraw-Hill, pp. 337-348, 2015.

Fine, P., Cheatle, M.D., Common Adverse Effects and Complications of Long-Term Opioid Therapy. Pain Medicine, 16 Suppl 1: S 1-2, 2015

Dhingra, L., Perlman, D.C., Masson, C., Chen, J., McKnight, C., Jordan, A.E., Wasser, T., Portenoy, R.K., Cheatle, M.D. Longitudinal Analysis of Pain and Illicit Drug Use Behaviors in Outpatients on Methadone Maintenance. Drug and Alcohol Dependence, 149: 285-289, 2015.

Wachholtz, A., Foster, S., Cheatle, M.D. Psychophysiology of pain and opioid use: Implications for managing pain in patients with an opioid use disorder. Drug and Alcohol Dependence, 146:1-6, 2015.

Peppin, J.F., Cheatle, M.D., Kirsh, K., McCarberg, W. The complexity model: A novel approach to improve chronic pain care. Pain Medicine, 16 (4): 653-666, 2015.

Cheatle, M.D. Prescription opioid misuse, abuse, morbidity and mortality: balancing effective pain management and safety. Pain Medicine 16 Suppl 1: S 3-8, 2015.

Cheatle, M.D., Webster, L.R. Opioid therapy and sleep disorders: Risks and mitigation strategies. Pain Medicine 16 Suppl 1: S 22-26, 2015.

Cheatle, M.D. Biopsychosocial approach to assessing and managing patients with chronic pain. Medical Clinics of North America 100 (1): 43-53, 2016.

Cheatle, M.D., Foster, S., Pinkett, A., Lesneski, M., Qu, D., Dhingra, L. Assessing and Managing Sleep Disturbance in Patients with Chronic Pain. Anesthesiology Clinics, 34 (2): 379-393, 2016.

Cheatle, M.D. Facing the challenge of pain management and opioid misuse. Expert Review of Clinical Pharmacology, 9 (6): 751-754, 2016.

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Teresa Franklin, PhD

Wetherill, R.R., Young, K.A., Jagannathan, K., Shin, J., O’Brien, C.P., Childress,  A.R., Franklin, T.R.:  The impact of sex on brain responses to smoking cues: A perfusion fMRI study. Biology of Sex Differences April 29, 2013 4(1): 9. doi: 10.1186/2042-6410-4-9. E- Publication, Paper Version, In Press.

Wetherill, R.R., Childress, A.R., Jagannathan, K., Bender, J., Young, K.A., Suh, J.J., O’Brien, C.P., Franklin, T.R.: Neural responses to subliminally presented cannabis and other emotionally evocative cues in cannabis-dependent individuals. Psychopharmacology AOL November 02, 231(7):1397-407, 2014.

Wetherill, R.R., Jagannathan, K., Shin, J., Franklin, T.R.: Sex Differences in Resting State Neural Networks of Nicotine-Dependent Cigarette Smokers. Addictive Behaviors (AOL January 23, 2014; http://www.sciencedirect.com/science/article/pii/S0306460314000070).

Young, K., Franklin, T.R., Roberts, D., Jagannathan, K., Suh, J.J., Wetherill, R.R., Wang, Z., Kampman, K., O’Brien, C.P., Childress, AR.: Nipping cue reactivity in the bud: Baclofen prevents limbic activation elicited by subliminal drug cues.Journal of Neuroscience 34(14):5038 –5043, 2014.

Franklin, T.R. and Wetherill, R.R., Jagannathan, K., Johnson, B., Mumma, J., Hager, N., Rao, H., Childress, AR.: The effects of chronic cigarette smoking on gray matter volume: Influence of sex. PLoS ONE 9(8): e104102. doi:10.1371/journal.pone.0104102, 2014

Franklin, T.R., Jagannathan, K., Wetherill, R.R., Johnson, B., Kelly, S., Langguth, J., Mumma, J., Childress, AR.: Influence of menstrual cycle phase on neural and craving responses to appetitive smoking cues in naturally cycling females. Nicotine and Tobacco Research Apr;17(4):390-7, 2015

Goldman, M., Ehrman, R.N., Suh, J.J., Hurt, H., Marquez, K., Franklin, T.R., O’Brien, C.P., Childress AR.: “Spiders-No, Puppies-Go", Introducing a novel Go NoGo task tested in inner city adolescents at risk for poor impulse control. Journal of Adolescence, 2014 Nov 24;38C:45-48. doi: 10.1016/j.adolescence.2014.10.007.[Epub ahead of print] PMID:5460679

Franklin, T.R., Wetherill, R.R., Jagannathan, K., Hager, N., O’Brien, C.P., Childress, AR.: Limitations of the use of the MP-RAGE to identify neural changes in the brain:  Recent cigarette smoking alters gray matter indices in the striatum. Frontiers in Human Neuroscience, 2015 Jan 28;8:1052.

Wang, Z., Franklin, T.R., A Hyper-connected but Less Efficient Small-world Network in the Substance-Dependent Brain. Drug and Alcohol Dependence, 2015, Jul (152): 102-108.

Wetherill, R.R., Jagannathan, K., Hager, N., Childress, A.R., Rao, H., Franklin, T.R., Sex Differences in Associations Between Cannabis Craving and Neural Responses to Cannabis Cues: Implications for Treatment. Experimental and Clinical Psychopharmacology, 2015, 23(4), 238–246.

 Wetherill, R.R., Jagannathan, K., Hager, N., Childress, A.R., Rao, H., Franklin, T.R., Cannabis, cigarettes, and their co-occurring use: disentangling differences  in gray matter volume. International Journal of Neuropsychopharmacology,  2015;
doi: 10.1093/ijnp/pyv061

Wetherill, R.R., Fang, Z., Jagannathan, K., Childress, A.R., Rao, H., Franklin, T.R.,    Cannabis, cigarettes, and their co-occurring use: disentangling differences in default mode network functional connectivity. Drug and Alcohol Dependence, 2015;153, 116-123.

Wetherill, RR, Franklin, TR, Allen, S.S., Ovarian hormones, menstrual cycle phase, and smoking: a review with recommendations for future studies.    Current Addiction Reports, 2016; 3(1), 1-8.

Wetherill, R.R., Jagannathan, K., Hager, N., Maron, M., Franklin, T.R., Influence of menstrual cycle phase on resting-state functional connectivity in naturally-cycling, cigarette-dependent women. Biology of Sex Differences, 2016 May 10;7:24, 1-9.

Regier, P.S., Monge, Z.A., Franklin, T.R., Wetherill, R.R., Teitelman, A., Jagannathan, K., Suh, J.J., Wang, Z., Young, K.A., Gawrysiak, M., Langleben,         D.D.,    Kampman, K.M., O’Brien, C.P., Childress AR., Emotional, physical and sexual abuse are associated with a heightened limbic response to cocaine cues. Addiction Biology,  2016 Sep 22. doi: 10.1111/adb.12445. [Epub ahead of print].

Wetherill R. R., Hager, N., Guthier, E., Franklin T.R. A Method to Standardize and  Quantify Lifetime Cannabis Consumption. Cannabis and Cannabinoid Research. September 2016, 1(1): 216-217. doi:10.1089/can.2016.0025.

Wetherill R.R., Hager, N., Jagannathan, K., Mashhoon, Y., Pater H., Childress. AR, and Franklin, T.R. Early Versus Late Onset of Cannabis Use: Differences in Striatal Response to Cannabis Cues. Cannabis and Cannabinoid Research. October 2016, 1(1): 229-233. oi:10.1089/can.2016.0026.

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Reagan Wetherill, PhD

Wetherill RR, Jagannathan K, Lohoff FW, Ehrman R., O’Brien CP, Childress AR, Franklin TR: Neural correlates of attentional bias for smoking cues: modulation by variance in the dopamine transporter gene. Addiction Biology 19:294-304, 2014. 

Wetherill RR, Childress AR, Jagannathan K, Bender J, Young KA, Suh JJ, O’Brien CP, Franklin TR: Neural responses to subliminally presented cannabis and other emotionally evocative cues in cannabis-dependent individuals. Psychopharmacology 231:1397-1407, 2014.

Wetherill RR, Jagannathan K, Shin J, Franklin TR: Sex differences in resting state neural networks of nicotine-dependent cigarette smokers. Addictive Behaviors 39:789-792, 2014.

Young KA, Franklin TR, Roberts DC, Jagannathan K, Suh JJ, Wetherill RR, Wang Z, Kampman KM., O’Brien CP, Childress AR: Nipping cue reactivity in the bud: baclofen prevents limbic activation elicited by subliminal drug cues. Journal of Neuroscience 34:5038-5043, 2014.

Franklin TR, Wetherill RR, Jagannathan K, Johnson B, Mumma J, Rao H, Childress AR: The effects of chronic cigarette smoking on gray matter volume: influence of sex. PLOS One 9, e104102, 2014.

Kranzler HR, Wetherill RR, Feinn R, Pond T, Gelernter J, Covault J: Post-treatment effects of topiramate treatment for heavy drinking. Alcoholism: Clinical and Experimental Research 38, 3017-3023, 2014.

Franklin TR, Wetherill RR, Jagannathan K, Hager N, O’Brien CP, Childress AR: Limitations of the use of the MP-RAGE to identify morphometric biomarkers: recent cigarette smoking alters gray matter indices in the ventral striatum, Frontiers in Human Neuroscience 8, 1-3, 2015.

Franklin TR, Jagannathan K, Wetherill RR, Johnson B, Kelly S, Langguth J, Mumma J, Childress AR: Influence of menstrual cycle phase on neural and craving responses to appetitive smoking cues in naturally cycling females, Nicotine and Tobacco Research 17, 390-397, 2015.

Wetherill RR, Jagannathan K, Hager N, Childress AR, Rao H, Franklin TR: Cannabis, cigarettes, and their co-occurring use: disentangling differences in gray matter volume, International Journal of Neuropsychopharmacology 18, pyv061, 2015.

Wetherill RR, Fang Z, Jagannathan K, Childress AR, Rao H, Franklin TR: Cannabis, cigarettes, and their co-occurring use: disentangling differences in default mode network functional connectivity, Drug and Alcohol Dependence 153, 116-123, 2015.

Wetherill RR, Jagannathan K, Hager N, Childress AR, Franklin TR: Sex differences in associations between cannabis craving and neural responses to cannabis cues: implications for treatment, Experimental and Clinical Psychopharmacology 23, 238-246, 2015.

Kranzler HR, Armeli S, Wetherill RR, Feinn R, Tennen H, Gelernter J, Covault J, Pond T: Self-efficacy mediates the effects of topiramate and GRIK1 genotype on drinking, Addiction Biology 21, 450-459, 2016.

Wetherill RR, Allen SS, Franklin TR: Ovarian hormones, menstrual cycle phase, and smoking: a review with recommendations for future studies, Current Addiction Reports, 3, 1-8, 2016.

Wetherill RR, Fromme K: Alcohol-induced blackouts: A review of recent clinical research with practical implications and recommendations for future studies, Alcoholism: Clinical and Experimental Research 40, 922-935, 2016.

Wetherill RR, Jagannathan K, Hager N, Maron M, Franklin TR: Influence of menstrual cycle phase on resting-state functional connectivity in naturally cycling, cigarette-dependent women, Biology of Sex Differences 7, 24, 2016.

Regier PS, Monge ZA, Franklin TR, Wetherill RR, Teitelman A, Jagannathan K, Suh JJ, Wang Z, Young KA, Gawrysiak M, Langleben DD, Kampman KM, O’Brien CP, Childress AR: Emotional, physical and sexual abuse are associated with a heightened limbic response to cocaine cues, Addiction Biology in press.

Wetherill RR, Hager N, Guthier E, Franklin TR: Gram years: a method to standardize and quantify lifetime cannabis use, Cannabis and Cannabinoid Research 1, 216-217, 2016.

Wetherill RR, Hager N, Jagannathan K, Mashhoon Y, Pater H, Childress AR, Franklin TR: Early versus late onset of cannabis use: differences in striatal response to cannabis cues, Cannabis and Cannabinoid Research 1, 229-233, 2016.

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James McKay, PhD

McKay, J.R., Van Horn, D., Lynch, K.G., Ivey, M., Cary, M.S., Drapkin, M., Coviello, D., & Plebani, J.G. (2013).  An adaptive approach for identifying cocaine dependent patients who benefit from extended continuing care. Journal of Consulting and Clinical Psychology, 81, 1063-1073. PMCID: PMC3938091

McKay, J.R., Van Horn, D.H.A., Lynch, K.G., Ivey, M., Cary, M.S., Drapkin, M., & Coviello, D. (2014).  Who benefits from extended continuing care?  Addictive Behaviors, 39, 660-668. PMCID: PMC3925615

Petry, N.M., DePhilippis, D., Rash, C.J., Drapkin, M., & McKay, J.R. (2014). Nationwide dissemination of contingency management: The Veterans Administration initiative.  American Journal of Addictions, 23, 205-210. PMCID: PMC3986725

Van Horn, D.H.A., Rennert, L., Lynch, K.G., & McKay, J.R. (2014).  Social network correlates of participation in telephone continuing care for alcohol dependence. American Journal on Addictions, 23, 447-452. PMCID: PMC4139454

McKay, J.R., Drapkin, M., Van Horn, D.H.A., Lynch, K.G., Oslin, D.W., DePhilippis, D., Ivey, M., Cacciola, J.S. (2015).  Effect of patient choice in an adaptive sequential randomization trial of treatment for alcohol and cocaine dependence.  Journal of Consulting and Clinical Psychology, 83, 1021-1032.  

McKay, J.R. (2015).  The use of new communication technologies to evaluate and intervene in substance dependence.  Current Behavioral Neuroscience Reports, 2, 23-29. PMCID: In progress

Van Horn, D.H.A., Drapkin, M., Lynch, K.G., Rennert, L., Goodman, J.D., Thomas, T., Ivey, M.S., & McKay, J.R. (2015).  Treatment choices and subsequent attendance by substance-dependent patients who disengage from intensive outpatient treatment. Addiction Research and Theory, 23, 391-403.

McCollister, K., Yang, K., & McKay, J.R. (2016).  Cost-effectiveness analysis of a continuing care intervention for cocaine-dependent adults.  Drug and Alcohol Dependence, 158, 38-44.

Shepard, D.S., Daley, M.C., Neuman, M.J., Blaakman, A.P., & McKay, J.R. (2016).  Telephone-based continuing care counseling in substance abuse treatment: Economic analysis of a randomized trial.  Drug and Alcohol Dependence, 159, 109-116.

Hagen, E., Erga, A.H., Hagen, K., Nesvag, S.M., McKay, J.R., Lundervold, A.J., & Walderhaug, E. (2016).  Assessment of executive function in patients with substance use disorder: A comparison of inventory- and performance-based assessment.  Journal of Substance Abuse Treatment, 66, 1-8.

McKay, J.R., Knepper, Deneke, E., O’Reilly, C., & DuPont, R. (2016).  An initial evaluation of a comprehensive continuing care intervention for patients with substance use disorders:  My First Year of Recovery (MyFYR).  Journal of Substance Abuse Treatment, 67, 50-54.

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