Center for Therapeutic Effectiveness Research Center for Therapeutic Effectiveness Research Center for Therapeutic Effectiveness Research Center for Therapeutic Effectiveness Research Center for Therapeutic Effectiveness Research


Welcome to the Center for Therapeutic Effectiveness Research (CTER). The mission of CTER is to improve the effectiveness of existing therapeutics (including medications, devices, vaccines, and care plans) through clinical research.


New Round of PCOR Pilot Funding!

Funds Available for Patient Centered Outcomes Research Pilot Studies

Application deadline: May 8, 2015

The Perelman School of Medicine of the University of Pennsylvania is providing pilot funds for studies in patient centered outcomes research (PCOR). For purposes of this funding announcement, the working definition for PCOR is that which is provided by the Patient-Centered Outcomes Research Institute (PCORI) on its website

The goal of this pilot grant program is to advance PCOR at Penn and assist Penn faculty in preparing applications for PCORI and/or NIH funding. Applications will be viewed most favorably that address PCORI’s national priorities and research agenda and respond to specific PCORI funding opportunities

The focus of the pilot should be related to at least one of the following: research methods, patient engagement, or the collection of pilot data leading to a large-scale intervention.

Some examples include:

  • Developing, assessing, and/or applying novel study designs for adapting therapeutic approaches based on patient response
  • Examining how the communication of genetic risk information affects health behavior
  • Quantifying the effectiveness of patient-centered components of a hospital-based initiative to improve transitions of care
  • Methods to use patient portals (e.g., myPennMedicine) to improve patient engagement and communication
  • Developing improvements in mixed-methods approaches


Grant Term: Up to one year beginning as early as July 1, 2015. Unexpended funds must be returned at the end of the funding period.

Budget: Applications for funds up to $40,000 in total direct costs per project will be considered to cover appropriate direct expenses. Salary support for faculty is not allowable. No indirect costs will be covered.

Eligibility: The principal investigator must be a full-time Penn faculty member or trainee from any Penn school. The PI must have a primary appointment at the University of Pennsylvania, UPHS, or the VA, and funds are limited to non-CHOP personnel. If the principal investigator does not hold the rank of assistant professor or above at Penn, a full-time Penn faculty member at this rank must agree to serve as faculty mentor. PIs will be expected to acknowledge PSOM support, as appropriate, in resultant presentations and publications.

Evaluation criteria:

  • applicability to PCOR research
  • scientific merit, creativity, and innovation
  • the degree to which the project is responsive to PCORI’s national priorities and research agenda
  • prospects for future extramural funding
  • clinical and/or public health significance
  • feasibility

Application Instructions

Use the following format:

    • Cover letter that must include the following: PI name, academic degree, rank/title, address, phone and email; mentor’s name if applicable; title of study; study site; signature of approval of your department chair or their surrogate.
    • Abstract, 250 words maximum
    • Research proposal including: Specific aims, Significance, Innovation, Approach, and Plans for Future Funding (not to exceed a total of 5 pages combined, single space, 11 inch font, ½ inch margins.)
    • Budget and brief budget justification
    • Investigator(s) biosketch(s) (NIH format)
    • Human Subjects (NIH format)
    • References

    Deadline for applications is May 8, 2015 and selected applicants will be notified in June, 2015.

    Send Cover letter and a PDF application by May 8, 2015 to
Please direct any questions to
Become a member of CTER!

We welcome applications for membership as a core faculty, trainee, or adjunct faculty.

Criteria for membership includes participation in CTER activities (e.g., working groups, brainstorming sessions, seminars, retreats) and the following:

Core Faculty: Standing or Associated Faculty of the University of Pennsylvania with research interests aligned with the objectives of CTER.

Trainee: Postdoctoral (Ph.D. or M.D.) trainees interested in participating in faculty-led CTER research projects or embarking upon their own mentored research.

Adjunct Faculty: Faculty of other universities or employees of non-academic organizations (e.g., non-profit, industry) who engage in collaborative work with CTER.


CTER Pilot Study Funds Awarded

We are pleased to announce the recipients of the first round of CTER pilot study funding. From many excellent submissions, the review committee selected the following six projects for one-year funding:

Integrating Depression Services into Type 2 Diabetes Mellitus Management; Dr. Hillary Bogner, Epidemiology and Biostatistics/Family Medicine and Community Health, Perelman School of Medicine

A Trial of Telemedical Implementation of Early Goal Directed Therapy for Cases of Severe Sepsis; Dr. Brendan Carr, Epidemiology and Biostatistics/Emergency Medicine, Perelman School of Medicine

The Patient-Centered Transition Project; Dr. Shreya Kangovi, Department of Medicine, Perelman School of Medicine

Improving Treatment Access to Pregnant Women with Depression; Dr. Deborah Kim, Department of Psychiatry, Perelman School of Medicine

Remote Observed Dosing to Increase Suboxone Compliance (RODISC); Dr. Jennifer Plebani, Department of Psychiatry, Perelman School of Medicine

Pilot Study of Cognitive-Behavioral Therapy by Technology to Reduce Stress in Family Caregivers of Heart Failure Patients; Dr. Barbara Riegel, School of Nursing