Overview

The Cullen Laboratory applies Neural Engineering principles and technologies to the area of Neurotrauma.  A biomedical engineering approach is used to better understand the causative mechanisms of neural injury as well as to develop cutting-edge neural tissue engineering-based treatments to promote regeneration and restore function.

CBIR Logo

Funding

The Cullen Laboratory was founded in 2009 with significant support from the Department of Neurosurgery at the University of Pennsylvania. Our research has received additional funding from the Department of Veterans Affairs, the National Institutes of Health, the Department of Defense, the University Research Foundation at the University of Pennsylvania, and Axonia Medical, Inc.

Contact Information

D. Kacy Cullen, Ph.D
105E Hayden Hall, 3320 Smith Walk
Philadelphia, PA 19104
dkacy@mail.med.upenn.edu

Apply to join the Cullen Lab

CBIR Logo

Neurosurgery

News and Events

  • Dr. Cullen and colleague Dr. Douglas Smith were awarded a 3-year grant from the Department of Defense Joint Warfighter Medical Research Program to advance their work for "Repair of Segmental Nerve Defects Using Tissue-Engineered Nerve Grafts."
  • Dr. Cullen was invited to give a research talk at the Center for Translational Injury Research at the University of Texas Health Science Center in Houston, TX. He presented “Tissue Engineered Nerve Grafts for Peripheral and Central Nervous System Repair”.
  • The Cullen Lab was awarded a one-year pilot grant through the Penn Medicine Neuroscience Center to explore "Neuromodulation of Brain Circuits Using Transplantable Micro-Tissue Engineered Neural Networks."
  • James Harris, Ph.D., was awarded an NIH NRSA Postdoctoral Fellowship on the "Brain Injury Training Grant" through Penn's Center for Brain Injury & Repair. Dr. Harris' project is on "Mechanisms of Biophysical Responses and Neurodegeneration following Concomitant Blast and Inertial Traumatic Brain Injury."
  • Dr. Cullen gave a lecture at the American Society for Peripheral Nerve Annual Meeting in Kauai, Hawaii in January. The talk was titled "Tissue Engineered Grafts Accelerate Peripheral Nerve Repair By Direct Axon-Induced Axon Regeneration."
  • Laura Struzyna was a Poster Award Finalist at the Tissue Engineering and Regenerative Medicine International Society Annual Meeting in Atlanta, Georgia in November. Her poster was titled "Tissue Engineered Grafts Accelerate Peripheral Nerve Repair By Direct Axon-Induced Axon Regeneration."
  • Dr. Cullen gave an Invited Lecture at the Department of Biomedical Engineering at the Georgia Institute of Technology in May. He presented "Tissue Engineering Strategies to Restore Neural Circuitry and Create Living Scaffolds for Targeted Axonal Regeneration."
  • Dr. Cullen and collaborator Dr. Douglas Smith were awarded funding from the Department of Defense through the Rutgers - Cleveland Clinic Consortium of the Armed Forces Inst. of Regenerative Medicine. This project will investigate the efficacy of novel tissue engineered constructs encased in custom-built nerve guidance tubes to promote nerve regeneration following major peripheral nerve injury.
  • Bioengineering Ph.D. Candidate, Laura Struzyna, was selected for a prestigious 3-year Graduate Research Fellowship through the National Science Foundation based on her proposal for "Tissue Engineered Constructs for Neural Regeneration."

View more news. →