Publications

38. Struzyna LA, Wolf JA, Mietus CJ, Chen HI, Smith DH, Cullen DK. Rebuilding Brain Circuitry with Living Micro-Tissue Engineered Neural Networks (in review).

37. Struzyna LA, Katiyar KS, Cullen DK. Living Scaffolds for Neuroregeneration, Current Opinion in Solid State & Material Science (in press). PDF

36. Harris JP, Browne KD, Wolf JA, Cullen DK. Linking Macro- to Micro-Biomechanics in Closed-Head Traumatic Brain Injury Base on Acute Biophysical Disruptions and Evolving Neurodegeneration, Conf Proc 17th U.S. National Congress on Theoretical and Applied Mechanics (2014). PDF

35. Meng X, Cullen DK, Tofighi MR, Rosen A. Telemetry-Based Neuromonitoring System Measuring Dynamic Intracranial Pressure Following Closed-Head Rotational Injury in Swine, IEEE Life Sciences Newsletter February (2013). LINK

34. Cullen DK and Smith DH. Bionic Connections: Living Bridges to Connect Bionic Limbs to the Nervous System. Scientific American 308(1): 52-57 (2013).

33. Ross JD, Cullen DK, LaPlaca MC, DeWeerth SP. 3-D Image Processing Techniques for Rapid Automated Segmentation of Neuronal Somata with Dense Neurite Outgrowth (in review).

32. Meng X, Bronw KD, Huang SM, Mietus CJ, Cullen DK, Tofighi MR Rosen A. Dynamic Evaluation of a Digital Wireless Intracranial Pressure Sensor for the Assessment of Traumatic Brain Injury in a Swine Model, Trans on Microwave Theory and Technology (2012). PDF

31. Cullen DK, Tang-Schomer MD, Struzyna LA, Patel AR, Johnson VE, Wolf JA, Smith DH. Micro-Tissue Engineered Constructs with Living Axons for Targeted Tract Reconstruction, Tissue Engineering Part A 18(21-22)(2012). PMID: 22702955. PDF

30. Meng X, Brown KB, Huang SM, Cullen DK, Tofighi MR, Rosen A. Dynamic Study of Wireless Intracranial Pressure Monitoring of Rotational Head Injury in Swine Model, Electronics Letters 48(7):363-364 (2012). PDF

29. Cullen DK, Browne KD, Xu Y, Adeeb S, Wolf JA, McCarron RM, Yang S, Chavko M, Smith DH. Blast-Induced Color Change in Photonic Crystals Corresponds with Brain Pathology, J Neurotrauma 28:2307-2318 (2011). PMID: 22023510. PDF

28. Cullen DK, Vernekar VN, LaPlaca MC. Trauma-Induced Plasmalemma Disruptions in 3-D Neural Cultures are Dependent on Strain Modality and Rate, J Neurotrauma 28:2219-2233 (2011). PMID: 22023556. PDF

27. Higgins AZ, Cullen DK, LaPlaca MC, Karlsson JOM. Effects of Freezing Profile Parameters on the Survival of Cryopreserved Rat Embryonic Neural Cells, J Neuroscience Methods 201(1):9-16 (2011). PMID: 21816171. PDF

26. Cullen DK and Pfister BJ. Transformative Research in Neural Engineering, Critical Reviews in Biomedical Engineering 39(3):181-183 (2011). PMID: 21967301. PDF

25. Cullen DK, Wolf JA, Smith DH, Pfister BJ. Neural Tissue Engineering for Neuroregeneration and Biohybridized Interface Microsystems In Vivo (Part 2), Critical Reviews in Biomedical Engineering 39(3):241-259 (2011). PMID: 21967304. PDF

24. Cullen DK, Wolf JA, Vernekar VN, Vukasinovic J, LaPlaca MC. Neural Tissue Engineering and Biohybridized Microsystems for Neurobiological Investigation In Vitro (Part 1), Critical Reviews in Biomedical Engineering 39(3):201-240 (2011). PMID: 21967303. PDF

23. Morrison B III, Cullen DK, LaPlaca MC. In Vitro Models for Biomechanical Studies of Neural Tissues. Neural Tissue Mechanics, L. Bilston, ed. (2011). PDF

22. Cullen DK and Pfister BJ. State of the Art and Future Challenges in Neural Engineering: Strategies for Nervous System Repair, Critical Reviews in Biomedical Engineering 39(2):79-80 (2011). PMID: 21488816. PDF

21. Pfister BJ, Gordon T, Loverde JR, Kochar AS, Mackinnon SE, Cullen DK. Biomedical Engineering Strategies for Peripheral Nerve Repair: Surgical Applications, State of the Art, and Future Challenges, Critical Reviews in Biomedical Engineering 39(2):81-124 (2011). PMID: 21488817. PDF

20. Cullen DK and Pfister BJ. State of the Art and Future Challenges in Neural Engineering: Neural Interfaces, Critical Reviews in Biomedical Engineering 39(1):1-3 (2011). PMID 21488811. PDF

19. Cullen DK, Xu Y, Reneer DV, Browne KD, Geddes JW, Yang S, Smith DH. Color Changing Photonic Crystals Detect Blast Exposure, NeuroImage 54S1:S37-S44 (2011). PMID: 21040795. Featured in Science (Editor’s Choice), Technology Review, UPI, Newsworks, Wired, The Engineer. PDF

18. Cullen DK, Gilroy ME, Irons HR, LaPlaca MC. Synapse-to-Neuron Ratio is Inversely Related to Neuronal Density in Mature Neuronal Cultures, Brain Research 1359:44-55 (2010) (cover article). PMID 20800585. PDF

17. LaPlaca MC, Vernekar VN, Shoemaker JT, Cullen DK. Three-Dimensional Neuronal Cultures. Methods in Bioengineering: 3D Tissue Engineering, Berthiaume F and Morgan J, eds. (2010). PDF

16. LaPlaca MC, Prado GR, Cullen DK, Simon CM. Plasma Membrane Damage as a Marker of Neuronal Injury, Conf Proc IEEE Eng Med Biol Soc 2009:1113-6 (2009). PMID: 19964751. PDF

15. Vukasinovic J, Cullen DK, LaPlaca MC, Glezer A. A Microperfused Incubator for Tissue Mimetic 3-D Cultures, Biomedical Microdevices 11(6):1155 (2009). PMID 19562488. PDF

14. Huang JH, Cullen DK (co-first author), Browne KD, Groff R, Zhang J, Pfister BJ, Zager EL, Smith DH. Long-Term Survival and Integration of Transplanted Engineered Nervous Tissue Constructs Promotes Peripheral Nerve Regeneration, Tissue Engineering Part A 15(7):1677-85 (2009). PMID: 19231968. PDF

13. Vernekar VN, Cullen DK, Fogleman N, Choi Y, Garcia AJ, Allen MG, Brewer GJ, LaPlaca MC. SU-8 2000 Rendered Cytocompatible for Neuronal BioMEMS Applications, J Biomed Mater Res A 89(1):138-151 (2009). PMID: 18431778. PDF

12. Cullen DK, Patel AR, Doorish JF, Smith DH, Pfister BJ. Developing a Tissue Engineered Neural-Electrical Relay Using Encapsulated Neuronal Constructs on Conducting Polymer Fibers, J Neural Engineering 5(4):374-384 (2008) (cover article). PMID: 18827311. PDF

11. Kameswaran N, Cullen DK, Pfister BJ, Ranalli NJ, Huang JH, Zager EL, Smith DH. A Novel Neuro-Prosthetic Interface with the Peripheral Nervous System Using Artificially Engineered Axonal Tracts, Neurological Res 30(10):1063-7 (2008). PMID: 19079981. PDF

10. Irons HR, Cullen DK, Shapiro NP, Lambert NA, Lee RH, LaPlaca MC. 3-D Neural Constructs: A Novel Platform for Neurophysiological Investigation, J Neural Engineering 5(3):333-341 (2008). PMID: 18756031. PDF

9. Cullen DK, Stabenfeldt SE, Simon CM, Tate CC, LaPlaca MC. In Vitro Neural Injury Model for Optimization of Tissue Engineered Constructs, J Neurosci Res 85(16):3642-51 (2007). PMID: 17671988. PDF

8. Cullen DK, Simon CM, LaPlaca MC. Strain Rate-Dependent Induction of Reactive Astrogliosis and Cell Death in 3-D Neuronal-Astrocytic Co-Cultures, Brain Res 1158:103-115 (2007) (cover article). PMID: 17555726. PDF

7. LaPlaca MC, Simon CM, Prado GR, Cullen DK. CNS Injury Biomechanics and Experimental Models, Prog Brain Res 161:13-26 (2007). PMID: 17618967. PDF

6. Cullen DK, Vukasinovic J, Glezer A, LaPlaca MC. Microfluidic Engineered High Cell Density 3-D Neural Cultures, J Neural Engineering 4(2):159-172 (2007). PMID: 17409489. Selected as “Highlights of 2007”. PDF

5. Cullen DK, Lessing MC, LaPlaca MC. Collagen-Dependent Neurite Outgrowth and Response to Dynamic Deformation in 3-D Neuronal Cultures, Ann Biomed Engineering 35(5):835-846 (2007). PMID: 17385044. PDF

4. LaPlaca MC, Prado GR, Cullen DK, Irons HR. High Rate Shear Insult Delivered to Cortical Neurons Produces Heterogeneous Membrane Permeability Alterations, Conf Proc IEEE Eng Med Biol Soc 1:2384-7 (2006). PMID: 17946956. PDF

3. Cullen DK and LaPlaca MC. Neuronal Response to High Rate Shear Deformation Depends on Heterogeneity of the Local Strain Field, J Neurotrauma 23(9):1304-1319 (2006). PMID: 16958583. PDF

2. Cullen DK, Vukasinovic J, Glezer A, LaPlaca MC. High Cell Density 3-D Neural Co-Cultures Require Continuous Medium Perfusion for Survival, Conf Proc IEEE Eng Med Biol Soc 1:636-9 (2006). PMID 17946846. PDF

1. LaPlaca MC, Cullen DK, McLoughlin JJ, Cargill RS. High Rate Shear Strain of 3-D Neural Cell Cultures: A New In Vitro Traumatic Brain Injury Model, J Biomech 38(5):1093-1105 (2005). PMID: 15797591. PDF

Contact Information

D. Kacy Cullen, Ph.D
105E Hayden Hall, 3320 Smith Walk
Philadelphia, PA 19104
dkacy@mail.med.upenn.edu

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News and Events

  • The Cullen Lab's research in TBI was featured in the Fall issue of Penn Medicine Magazine (p. 15-17). PDF
  • Dr. Cullen and colleague Dr. Douglas Smith were awarded a 3-year grant from the Department of Defense Joint Warfighter Medical Research Program to advance their work for "Repair of Segmental Nerve Defects Using Tissue-Engineered Nerve Grafts."
  • Dr. Cullen was invited to give a research talk at the Center for Translational Injury Research at the University of Texas Health Science Center in Houston, TX. He presented “Tissue Engineered Nerve Grafts for Peripheral and Central Nervous System Repair”.
  • The Cullen Lab was awarded a one-year pilot grant through the Penn Medicine Neuroscience Center to explore "Neuromodulation of Brain Circuits Using Transplantable Micro-Tissue Engineered Neural Networks."
  • James Harris, Ph.D., was awarded an NIH NRSA Postdoctoral Fellowship on the "Brain Injury Training Grant" through Penn's Center for Brain Injury & Repair. Dr. Harris' project is on "Mechanisms of Biophysical Responses and Neurodegeneration following Concomitant Blast and Inertial Traumatic Brain Injury."
  • Dr. Cullen gave a lecture at the American Society for Peripheral Nerve Annual Meeting in Kauai, Hawaii in January. The talk was titled "Tissue Engineered Grafts Accelerate Peripheral Nerve Repair By Direct Axon-Induced Axon Regeneration."
  • Laura Struzyna was a Poster Award Finalist at the Tissue Engineering and Regenerative Medicine International Society Annual Meeting in Atlanta, Georgia in November. Her poster was titled "Tissue Engineered Grafts Accelerate Peripheral Nerve Repair By Direct Axon-Induced Axon Regeneration."
  • Dr. Cullen gave an Invited Lecture at the Department of Biomedical Engineering at the Georgia Institute of Technology in May. He presented "Tissue Engineering Strategies to Restore Neural Circuitry and Create Living Scaffolds for Targeted Axonal Regeneration."
  • Dr. Cullen and collaborator Dr. Douglas Smith were awarded funding from the Department of Defense through the Rutgers - Cleveland Clinic Consortium of the Armed Forces Inst. of Regenerative Medicine. This project will investigate the efficacy of novel tissue engineered constructs encased in custom-built nerve guidance tubes to promote nerve regeneration following major peripheral nerve injury.
  • Bioengineering Ph.D. Candidate, Laura Struzyna, was selected for a prestigious 3-year Graduate Research Fellowship through the National Science Foundation based on her proposal for "Tissue Engineered Constructs for Neural Regeneration."

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