Penn Cardiovascular Institute - Heart Research at Penn Contact | Cardiovascular Division | Patient Care
Home About Research Education Patient Care Members Clinical Trials News Events Funding Gifts
Penn Cardiovascular Institute
Building Bridges, Accelerating Discovery, Advancing Care
Established in 2005, the Penn Cardiovascular Institute (Penn CVI) promotes transformational research in cardiovascular biology and medicine. Leveraging the expertise of scientists and clinicians across the University of Pennsylvania and the Health System through interdisciplinary research programs, the Penn CVI seamlessly integrates research, education and patient care. Learn more »

In the News »

Penn Scientists Receive $16.7M NationaI Heart Lung Blood Institute Award for Stem Cell Research
October 7, 2009

Two Penn researchers have been awarded $16.7 million for collaborative stem cell research projects. Edward Morrisey, PhD, Professor of Medicine and Cell and Developmental Biology and Scientific Director of the Penn Institute for Regenerative Medicine and Mortimer Poncz, MD, Professor of Pediatrics, Children’s Hospital of Philadelphia received the funding from the National Heart Lung Blood Institute (NHLBI) as part of a $170 million effort to create the NHLBI Progenitor Cell Biology Consortium, which will bring together "hubs" of investigators from the heart, lung, blood, and technology research fields.

Poncz and Fred Hutchinson Cancer Research Center, Seattle (Dr. Beverly Torok-Storb, PhD) will study the specialization of blood-forming cell lines, develop molecular interventions that will drive the formation of blood cells toward desired lines, and establish new, functional platelets that potentially may be used for the targeted delivery of bioactive proteins.

Morrisey and Fred Hutchinson Cancer Research Center (Dr. Irwin Bernstein, MD) endeavor to determine how certain signaling pathways - ordered sequences of biochemical reactions inside cells - affect cardiac and blood-forming cell development and cardiac regeneration and repair. The team will also study whether these pathways may be harnessed for therapeutic applications.

Research »

"Dysfunctional Corin I555(P568) Allele Is Associated With Impaired Brain Natriuretic Peptide Processing and Adverse Outcomes in Blacks With Systolic Heart Failure: Results From the Genetic Risk Assessment in Heart Failure Substudy"
Circulation: Heart Failure, November 2009

Related:
CVI Complex Genetics Initiative »

"A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium"
Nature Genetics, November 2009

Related:
CVI Complex Genetics Initiative »

"Gata4 and Gata5 cooperatively regulate cardiac myocyte proliferation in mice"
Journal of Biological Chemistry, November 2009

Related:
Molecular Cardiology Research Center,
Gruber Lab »

Journal of Clinical Investigation "Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers"
Journal of Clinical Investigation, November 2009

Related:
"Staying Off the Beating Track"
Penn researchers investigation into source of atrial fibrillation featured in Science »

Proceedings of the National Academy of Science "Myocardin is required for cardiomyocyte survival and maintenance of heart function"
Proceedings of the National Academy of Science, November 2009

Related:
Molecular Cardiology Research Center,
Parmacek Lab »

"Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway"
Journal of Biological Chemistry, November 2009

Related:
CVI Complex Genetics Initiative »

Journal of Clinical Endocrinology and Metabolism "Higher Serum Testosterone Concentration in Older Women is Associated with Insulin Resistance, Metabolic Syndrome, and Cardiovascular Disease"
Journal of Clinical Endocrinology and Metabolism, October 2009

Related:
Penn Diabetes Heart Study »

"Inpp5f Is a Polyphosphoinositide Phosphatase That Regulates Cardiac Hypertrophic Responsiveness"
Circulation Research, October 2009

Related:
Molecular Cardiology Research Center, Epstein Lab »

Free Radical Biology and Medicine "Inflammation induces fibrinogen nitration in experimental human endotoxemia"
Free Radical Biology and Medicine, October 2009

Related:
Prevention, Atherosclerosis & Lipids Research »

Journal of Clinical Investigation "MicroRNA-modulated targeting of vascular smooth muscle cells"
Journal of Clinical Investigation, September 2009

Related:
Molecular Cardiology Research Center
Parmacek Lab »

Circulation "Antiarrhythmics After Ablation of Atrial Fibrillation (5A Study)"
Circulation, E-Pub, September 2009

Related:
Cardiac Electrophysiology Research Program »

Circulation Research "Chronic endoplasmic reticulum stress activates unfolded protein response in arterial endothelium in regions of susceptibility to atherosclerosis"
Circulation Research, September 2009

Related:
Penn Institute for Medicine and Engineering »

New England Journal of Medicine "MADIT-CRT:
Breathtaking or Time to Catch Our Breath?"
New England Journal of Medicine, September 2009

Related:
Wall Street Journal features Penn’s Dr. Jessup »

Circulation "Lecithin: cholesterol acyltransferase and atherosclerosis: another high-density lipoprotein story that doesn't quite follow the script"
Circulation, August 2009

Related:
Institute for Translational Medicine and Therapeutics »

Journal of Clinical Investigation "Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway"
Journal of Clinical Investigation, August 2009

Related:
Molecular Cardiology Research Center, Morrisey Lab »

Developmental Cell "Wnt2/2b and ß-Catenin Signaling Are Necessary and Sufficient to Specify Lung Progenitors in the Foregut"
Developmental Cell, August 2009

Related:
How to Make a Lung:
Cell-Regeneration Molecules Essential Signals for Early Lung Development »

Annals of Biomedical Engineering "Hemodynamically driven stent strut design"
Annals of Biomedical Engineering, August 2009

Related:
Institute for Medicine and Engineering »

Science "Multiscale Mechanics of Fibrin Polymer:
Gel Stretching with Protein Unfolding and Loss of Water"
Science, August 2009

Related:
Penn Researchers Show That Protein Unfolding is Key for Understanding Blood Clot Mechanics »

Circulation "Neuregulin-1{beta} Is Associated With Disease Severity and Adverse Outcomes in Chronic Heart Failure"
Circulation, July 2009

Related:
Penn Heart Failure Study »

New England Journal of Medicine "Cardiomyocyte Renewal"
New England Journal of Medicine, July 2009

Related:
Penn Researchers Receive $2 Million Grant to Study Cardiac Muscle Cell Development »

Circulation "Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure"
Circulation July 2009

Related:
Penn Heart Failure Study »

Journal of Clinical Investigation "Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development"
Journal of Clinical Investigation, June 2009

Related:
Molecular Cardiology Research Center, Epstein Lab »

Diabetes "Apolipoprotein B but not Low-Density Lipoprotein Cholesterol is Associated with Coronary Artery Calcification in Type 2 Diabetic Caucasians"
Diabetes, June 2009

Related:
Penn Diabetes Heart Study »

Developmental Biology "BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis"
Developmental Biology, May 2009

Related:
Molecular Cardiology Research Center, Parmacek Lab »

JAMA "Aspirin for the prevention of cardiovascular events in patients with peripheral artery disease: a meta-analysis of randomized trials"
JAMA, May 2009

Related:
Penn Vascular Research Center »

Clinical Endocrinology "Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in nondiabetic Caucasians"
Clinical Endocrinology, May 2009

Related:
Institute for Diabetes,Obesity & Metabolism - Cardiovascular Metabolism Unit »

Proceedings of the National Academy of Sciences "Cardiomyocyte Cyclooxygenase-2 Influences Cardiac Rhythm and Function"
Proceedings of the National Academy of Sciences, April 2009

Related:
Molecular Cardioloy Research Center - Patel Lab »

Journal of Thoracic and Cardiovascular Surgery "Early planned institution of biventricular mechanical circulatory support results in improved outcomes compared with delayed conversion of a left ventricular assist device to a biventricular assist device"
Journal of Thoracic and Cardiovascular Surgery, April 2009

Related:
Cardiovascular Research ~ Harrison Dept. of Surgical Research ~ Woo Lab »

"Evidence for co-regulation of myocardial gene expression by MEF2 and NFAT in human heart failure (PDF)"
Circulation: Cardiovascular Genetics, March 2009

Related:
Penn Heart Failure Study »

Nature Genetics "Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants"
Nature Genetics, February 2009

Related:
Complex Genetics Initiative »

Penn Complex Genetics Initiative Personalized Medicine for the Heart

Over the next five years 100,000 adults seeking patient care at the University of Pennsylvania Health System will be invited to join the Genetics of Cardiovascular and Metabolic Phenotypes Study, a DNA bank being designed to investigate the genes involved in cardiovascular disease. The study, part of the Complex Genetics Initiative, hopes to learn about the genetic causes of these diseases and how different people respond to the same medications and treatments.

About the Complex Genetics Initiative »


6 ABC News Health Check Video - Jan. 7, 2009 New Heart Valves Without Open Surgery

The Hospital of the University of Pennsylvania is one of a handful of medical centers participating in the PARTNER trial - a new procedure (Download PDF) that could change the lives of more than 120,000 heart patients. The procedure gives patients new heart valves, but without a major incision, and without general anesthesia.

About the PARTNER Trial »

Search Options »
Upcoming Events » [ view full calendar ]
Recent Articles » « Back   Next »
                               
Penn’s Recovery Act Awards from
the National Heart Lung Blood Institute
(Sept. 2009 / .xls )


CVI PubMed

Penn Heart and Vascular Research on Apple iTunes University
CVI iTunes

Making History: Give to Penn Heart and Vascular Research