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Below find a selection of Penn CVI member’s research publications.
Each links to an abstract in PubMed, the U.S. National Library of Medicine,
unless otherwise noted.

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2009 Articles
November
Dysfunctional Corin I555(P568) Allele Is Associated With Impaired Brain Natriuretic Peptide Processing and Adverse Outcomes in Blacks With Systolic Heart Failure: Results From the Genetic Risk Assessment in Heart Failure Substudy
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
Gata4 and Gata5 cooperatively regulate cardiac myocyte proliferation in mice
Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers
Atherosclerotic plaque development
Myocardin is required for cardiomyocyte survival and maintenance of heart function
MicroRNAs as Novel Myocardial Biomarkers
Targeted detoxification of selected reactive oxygen species in the vascular endothelium
Saddle shape of the mitral annulus reduces systolic strains on the P2 segment of the posterior mitral leaflet
Left ventricle to right ventricle size discrepancy in the fetus: the presence of critical congenital heart disease can be reliably predicted
Quantitative analysis of chest compression interruptions during in-hospital resuscitation of older children and adolescents
October
Inpp5f Is a Polyphosphoinositide Phosphatase That Regulates Cardiac Hypertrophic Responsiveness
Lipoprotein-associated phospholipase A(2) and atherosclerosis
Magnetically responsive biodegradable nanoparticles enhance adenoviral gene transfer in cultured smooth muscle and endothelial cells
N-Terminal Pro-Brain Natriuretic Peptide as a Biomarker for Hypertensive Disorders of Pregnancy
Higher Serum Testosterone Concentration in Older Women is Associated with Insulin Resistance, Metabolic Syndrome, and Cardiovascular Disease
Inflammation induces fibrinogen nitration in experimental human endotoxemia
Macrophage reverse cholesterol transport in mice expressing ApoA-I Milano
Fish oil promotes macrophage reverse cholesterol transport in mice
Relationship of late potentials to the ventricular tachycardia circuit defined by entrainment
Validation of diagnostic codes for outpatient-originating sudden cardiac death and ventricular arrhythmia in Medicaid and Medicare claims data
Safety and efficacy of pacemaker reuse in underdeveloped nations: a case series
Natural history of symptomatic intracranial arterial stenosis
Consensus conference on intracranial atherosclerotic disease: rationale, methodology, and results
Pre-Fontan cardiac magnetic resonance predicts post-Fontan length of stay and avoids ionizing radiation
Qualitative echocardiographic assessment of aortic valve regurgitation with quantitative cardiac magnetic resonance: a comparative study
Adherence to sleep apnea therapy and use of lipid-lowering drugs: a study of the healthy user effect
D-dimer, magnetic resonance imaging diffusion-weighted imaging, and ABCD2 score for transient ischemic attack risk stratification
September
Hand-carried echocardiography for assessment of left ventricular filling and ejection fraction in the surgical intensive care unit
Cell-cycle control by physiological matrix elasticity and in vivo tissue stiffening
Endothelial cell specific adhesion molecule (ESAM) localizes to platelet-platelet contacts and regulates thrombus formation in vivo
Mesenchymal cell transplantation and myocardial remodeling after myocardial infarction
Experimental Endotoxemia Induces Adipose Inflammation and Insulin Resistance in Humans
Patient satisfaction is comparable to early discharge versus overnight observation after elective percutaneous coronary intervention
Association of a unique cardiovascular risk profile with outcomes in Hispanic patients referred for percutaneous coronary intervention (from the National Heart, Lung, and Blood Institute Dynamic Registry)
Fenfluramine disrupts the mitral valve interstitial cell response to serotonin
MicroRNA-modulated targeting of vascular smooth muscle cells
Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes
Chronic endoplasmic reticulum stress activates unfolded protein response in arterial endothelium in regions of susceptibility to atherosclerosis
MADIT-CRT - Breathtaking or Time to Catch Our Breath? [ New England Journal of Medicine ~ Editorial ]
In vivo dynamic deformation of the mitral valve annulus
Antiarrhythmics After Ablation of Atrial Fibrillation (5A Study)
New Endpoint for Ablation of Ventricular Tachycardia: Change in QRS Morphology with Pacing at Protected Isthmus as Index of Isthmus Block
Noninvasive quantification of systemic-to-pulmonary collateral flow: a major source of inefficiency in patients with superior cavopulmonary connections
Risk factors and comorbidities associated with obesity in children and adolescents after the arterial switch operation and Ross procedure
Arterial load and ventricular-arterial coupling: physiologic relations with body size and effect of obesity
August
Monitoring unfractionated heparin in pediatric patients with congenital heart disease having cardiac catheterization or cardiac surgery
Electroanatomic substrate and ablation outcome for suspected epicardial ventricular tachycardia in left ventricular nonischemic cardiomyopathy
Hemodynamically driven stent strut design
Identification of the Active Form of Endothelial Lipase, a Homodimer in a Head-to-Tail Conformation
Chronic Endoplasmic Reticulum Stress Activates Unfolded Protein Response in Arterial Endothelium in Regions of Susceptibility to Atherosclerosis
Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway
Wnt2/2b and -Catenin Signaling Are Necessary and Sufficient to Specify Lung Progenitors in the Foregut
Fenfluramine Disrupts the Mitral Valve Interstitial Cell Response to Serotonin
Membrane Cholesterol Is a Biomechanical Regulator of Neutrophil Adhesion
Lipoprotein-associated phospholipase A2 and atherosclerosis
Learning before burning: the importance of anatomy to the electrophysiologist
Epicardial substrate and outcome with epicardial ablation of ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathy/dysplasia
Electrophysiologic substrate underlying postinfarction ventricular tachycardia: characterization and role in catheter ablation
Ventricular arrhythmias and sudden death in adults after a Mustard operation for transposition of the great arteries
Antegrade thoracic stent grafting during repair of acute DeBakey I dissection prevents development of thoracoabdominal aortic aneurysms
Plasma Levels of Receptor for Advanced Glycation End-Products(sRAGE), Blood Transfusion, and Risk of Primary Graft Dysfunction
Impact of pulmonary artery pressure on exercise function in severe COPD
Phenotypic delineation of Emanuel syndrome (supernumerary derivative 22 syndrome): Clinical features of 63 individuals
Aspirin reduces the prothrombotic activity of C-reactive protein
Comparison of echocardiographic and cardiac magnetic resonance imaging measurements of functional single ventricular volumes, mass, and ejection fraction (from the Pediatric Heart Network Fontan Cross-Sectional Study)
High-resolution mapping and analysis of copy number variations in the human genome: A data resource for clinical and research applications
Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture
Red blood cells-coupled tPA prevents impairment of cerebral vasodilatory responses and tissue injury in pediatric cerebral hypoxia/ischemia through inhibition of ERK MAPK activation
Anchoring fusion thrombomodulin to the endothelial lumen protects against injury-induced lung thrombosis and inflammation
Barriers to adherence and hypertension control in a racially diverse representative sample of elderly primary care patients
Lecithin: Cholesterol Acyltransferase and Atherosclerosis. Another High-Density Lipoprotein Story That Doesn't Quite Follow the Script.
Multiscale Mechanics of Fibrin Polymer: Gel Stretching with Protein Unfolding and Loss of Water
A Translational Medicine perspective of the development of torcetrapib:
Does the failure of torcetrapib development cast a shadow on future development of lipid modifying agents, HDL elevation strategies or CETP as a viable molecular target for atherosclerosis? A case study of the use of biomarkers and Translational Medicine in atherosclerosis drug discovery and development.
July
Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure
Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction
Soluble p-selectin and the risk of primary graft dysfunction after lung transplantation
Preoperative Takotsubo Cardiomyopathy Identified in the Operating Room Before Induction of Anesthesia
BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis
Incremental Pacing for the Diagnosis of Complete Cavotricuspid Isthmus Block During Radiofrequency Ablation of Atrial Flutter
High-Frequency Ultrasound for Evaluation of Intimal Thickness
Brown fat in humans: turning up the heat on obesity
Magnetically Responsive Biodegradable Nanoparticles Enhance Adenoviral Gene Transfer in Cultured Smooth Muscle and Endothelial Cells
Soluble urokinase receptor conjugated to carrier red blood cells binds latent pro-urokinase and alters its functional profile
Wide variation in clinicians' assessment of New York Heart Association/World Health Organization functional class in patients with pulmonary arterial hypertension
Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A
Cardiomyocyte-specific loss of neurofibromin promotes cardiac hypertrophy and dysfunction
Neuregulin-1{beta} Is Associated With Disease Severity and Adverse Outcomes in Chronic Heart Failure
Gene profiling of human adipose tissue during evoked inflammation in vivo
Cardiomyocyte Renewal
Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis
Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer
Update on strategies to increase HDL quantity and function
Prediction of periventricular leukomalacia. Part I: Selection of hemodynamic features using logistic regression and decision tree algorithms
Prediction of periventricular leukomalacia. Part II: Selection of hemodynamic features using computational intelligence
June
Negative regulation of activated alpha-2 integrins during thrombopoiesis
Atherosclerotic plaque development
15(S)-lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism
15(S)-lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism
Growth factors, matrices, and forces combine and control stem cells
Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development
Red yeast rice for dyslipidemia in statin-intolerant patients: a randomized trial
Apolipoprotein B but not Low-Density Lipoprotein Cholesterol is Associated with Coronary Artery Calcification in Type 2 Diabetic Caucasians
Magnetically Responsive Biodegradeable Nanoparticles Enhance Adenoviral Gene Transfer in Cultured Smooth Muscle and Endothelial Cells
Aortic size in acute type A dissection: implications for preventive ascending aortic replacement
Ventricular premature depolarizations triggered by incremental dose isoproterenol infusion: common electrocardiographic features
Filamentous polymer nanocarriers of tunable stiffness that encapsulate the therapeutic enzyme catalase
Time-varying myocardial stress and systolic pressure-stress relationship: role in myocardial-arterial coupling in hypertension
New insights into myocardial glucose metabolism: surviving under stress
Clinical review: The extrapancreatic effects of glucagon-like peptide-1 and related peptides
Interleukin-18 predicts atherosclerosis progression in SIV-infected and uninfected rhesus monkeys (Macaca mulatta) on a high-fat/high-cholesterol diet
Hospitals with and without percutaneous coronary intervention capability: considerations for treating acute coronary syndromes
Serotonin Transporter Polymorphisms in Patients With Portopulmonary Hypertension
Analyzing the "speckled band" to predict response to CRT: a Sherlockian conundrum
Endoplasmic Reticulum Stress Regulates Adipocyte Resistin Expression
Diagnosing the mechanism of supraventricular tachycardia: restoring the luster of a fading art.
Skeletal muscle microvascular flow in progressive peripheral artery disease: assessment with continuous arterial spin-labeling perfusion magnetic resonance imaging
May
Aspirin for the prevention of cardiovascular events in patients with peripheral artery disease: a meta-analysis of randomized trials
Effects of aspirin on clot structure and fibrinolysis using a novel in vitro cellular system
Transillumination of the fingers for vascular anomalies: a novel method for evaluating hereditary hemorrhagic telangiectasia
Images in cardiovascular medicine. Partial anomalous left pulmonary artery
Dominant Frequency Mapping of Atrial Fibrillation: Comparison of Contact and Noncontact Approaches
Genomics, transcriptional profiling, and heart failure
A series of cationic sterol lipids with gene transfer and bactericidal activity
Interethnic differences in the accuracy of anthropometric indicators of obesity in screening for high risk of coronary heart disease
EBV PCR in the diagnosis and monitoring of posttransplant lymphoproliferative disorder: results of a two-arm prospective trial
Glucagon-like Peptide-1 and Myocardial Protection: More than Glycemic Control
INTERMACS: Interval Analysis of Registry Data
BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis
Aspirin for the prevention of cardiovascular events in patients with peripheral artery disease: a meta-analysis of randomized trials
Genetic risk factors for portopulmonary hypertension in patients with advanced liver disease
Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in nondiabetic Caucasians
CD59 but not DAF deficiency accelerates atherosclerosis in female ApoE knockout mice
Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis
Defective pulmonary vascular remodeling in Smad8 mutant mice
Lipoprotein-Associated Phospholipase A2 and C-Reactive Protein for Risk-Stratification of Patients With TIA
Percutaneous closure of patent foramen ovale and atrial septal defect in adults: the impact of clinical variables and hospital procedure volume on in-hospital adverse events
Von Willebrand disease and other bleeding disorders in women: Consensus on diagnosis and management from an international expert panel
Evaluating the association between all components of the metabolic syndrome and pre-eclampsia
Ventricular arrhythmias and sudden death in adults after a Mustard operation for transposition of the great arteries
April
Aortic root dilation in patients with 22q11.2 deletion syndrome
Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary hypertension
Disruption of SEMA4D Ameliorates Platelet Hypersensitivity in Dyslipidemia and Confers Protection Against the Development of Atherosclerosis
Early goal-directed hemodynamic optimization combined with therapeutic hypothermia in comatose survivors of out-of-hospital cardiac arrest
Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function
Activation dependent stabilization of the human thromboxane receptor: Role of reactive oxygen species
Cardiomyogenic differentiation potential of human adipose precursor cells
Assessment of left ventricular systolic function by echocardiography
'Recirculating cardiac delivery' method of gene delivery should be called 'non-recirculating' method
Arrhythmogenic potential of pulmonary venous tissue: triggers for atrial fibrillation identified within the remnant of a vein
Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial

About the CUPID Clinical Trial »
Atheroprotective lipoprotein effects of a niacin-simvastatin combination compared to low- and high-dose simvastatin monotherapy
Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans
Early planned institution of biventricular mechanical circulatory support results in improved outcomes compared with delayed conversion of a left ventricular assist device to a biventricular assist device
Caffeine restores myocardial cytochrome oxidase activity and improves cardiac function during sepsis
March
Gene therapy in large animal models of human cardiovascular genetic disease
Echocardiography-guided interventions
A national analysis of the relationship between hospital factors and post-cardiac arrest mortality
Stem cells by the shore: Meeting summary of the 2008 MDI Stem Cell Symposium
Allogeneic mesenchymal precursor cell therapy to limit remodeling after myocardial infarction: the effect of cell dosage
Gene therapy in large animal models of human cardiovascular genetic disease
Endothelin receptor blockade in the management of pulmonary arterial hypertension: Selective and dual antagonism
The Extra-Pancreatic Effects of GLP-1 and Related Peptides
Inflammation impairs reverse cholesterol transport in vivo
Structural and functional consequences of the milano mutation (R173C) in human apolipoprotein A-I
Evidence for co-regulation of myocardial gene expression by MEF2 and NFAT in human heart failure [ PDF ]
Negative regulation of activated {alpha}2 integrins during thrombopoiesis
Soluble P-Selectin and the Risk of Primary Graft Dysfunction After Lung Transplantation
Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support
Increased thymus- and decreased parathyroid-fated organ domains in Splotch mutant embryos
Embryonic stem cell grafting in normal and infarcted myocardium: serial assessment with MR imaging and PET dual detection
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
Body mass index and hypertension hemodynamic subtypes in the adult US population
Off-pump, minimally invasive and robotic coronary revascularization yield improved outcomes over traditional on-pump CABG
Determinants of right ventricular ejection fraction in pulmonary arterial hypertension
February
Supercharged blood coagulation
Stem cells by the shore: Meeting summary of the 2008 MDI stem cell symposium.
Serum alkaline phosphatase reflects post-Fontan hemodynamics in children
S447X variant of the lipoprotein lipase gene, lipids, and risk of coronary heart disease in 3 prospective cohort studies
Endocarditis with massive aortic root abscess and atrioventricular septal destruction
Intracoronary delivery of mesenchymal stem cells at high flow rates after myocardial infarction improves distal coronary blood flow and decreases mortality in pigs
Selective PKC beta inhibition with ruboxistaurin and endothelial function in type-2 diabetes mellitus.
Estimation of the warfarin dose with clinical and pharmacogenetic data
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
Plasma cytokines and chemokines in primary graft dysfunction post-lung transplantation
Effect of pulmonary vein isolation on the distribution of complex fractionated electrograms in humans
Outcomes using extracorporeal life support for adult respiratory failure due to status asthmaticus
Effects of cholesteryl ester transfer protein inhibition on apolipoprotein (apo) A-II-containing HDL subspecies and ApoA-II metabolism
Managing diabetic dyslipidemia: beyond statin therapy
January
Heterotaxy syndrome with mirror image anomalies in identical twins
Application of appropriateness criteria in outpatient transthoracic echocardiography
Ventricular premature depolarizations triggered by incremental dose isoproterenol infusion: common electrocardiographic features
The Clinical Utility of Entrainment Pacing
Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism
Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway
Small-molecule inhibitors of integrin {alpha}2{beta}1 that prevent pathological thrombus formation via an allosteric mechanism
Diabetes reduces bone marrow and circulating porcine endothelial progenitor cells, an effect ameliorated by atorvastatin and independent of cholesterol
Fibrin gels and their clinical and bioengineering applications
Dermal filler injection: a novel approach for limiting infarct expansion
Very mild hypothermia during ischemia and reperfusion improves postinfarction ventricular remodeling
Characterization of the phrenic nerve course within the epicardial substrate of patients with nonischemic cardiomyopathy and ventricular tachycardia
Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects
Emerging role of FDG-PET/CT in assessing atherosclerosis in large arteries
Combining Thrombolysis in Myocardial Infarction risk score and clear-cut alternative diagnosis for chest pain risk stratification
Diagnosis of heart failure
Adipose inflammation, insulin resistance, and cardiovascular disease

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Journal Links

American Journal of Cardiology
BioMed Central
Blood
Cardiosource (American College of Cardiology)
Cell
Circulation (American Heart Association)
Development
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Journal of Cardiothoracic Surgery
Journal of Cardiovascular Magnetic Resonance
Journal of Clinical Investigation
Lipids Online
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Nature
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Pacing and Clinical Electrophysiology
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