| MORNING SESSION |
All lectures held in BRB Auditorium |
| 8:00-8:30 AM |
Continental Breakfast - BRB Lobby - Invited Speakers and Registrants |
| 8:30-8:45 AM |
Opening Remarks
Mark L. Kahn, M.D., co-organizer
Associate Professor of Medicine
University of Pennsylvania |
| 8:45-9:20 AM |
"A Combinatorial Transcriptional Code for Endothelial Development"
Brian Black, Ph.D.
Professor and Associate Director,
Cardiovascular Research Institute
University of California, San Francisco |
| 9:30-9:50 AM |
Short Talk:
"Blood Flow Reprograms Lymphatic Vessels to Blood Vessels Through Shear-Mediated Down-Regulation of the PROX1 Transcription Factor"
Chiu-Yu Chen,
Pre-Doctoral Student, Mark L. Kahn Lab |
| 10:00-10:20 AM |
Short Talk:
"Role of rushhour in Cardiac Neural Crest Cell Migration and Heart Valve Morphogenesis in Zebrafish"
Santanu Banerjee, Ph.D.,
Post Doctoral Researcher, Michael Granato Lab |
| 10:20-10:30 AM |
Break |
| 10:30-11:10 AM |
"Novel Regulators of Angiogenesis - New Insights from the Zebrafish"
Brant Weinstein, Ph.D.
Senior Investigator and Deputy Chief,
Program in Genomics of Differentiation
National Institute of Child Health and Human Development |
| 11:15-11:35 AM |
Short Talk:
"Loss-of-Function Mutations in Endothelial Lipase are Associated with Elevated HDL Cholesterol in Humans"
Andrew Edmondson,
Pre-Doctoral Student, Daniel Rader Lab |
| 12:00-1:40 PM |
Lunch and Poster Session Judging - BRB Lobby
Invited speakers and registrants |
| AFTERNOON SESSION |
All lectures held in BRB Auditorium |
| 1:40-1:45 PM |
Remarks and Introductions
Edward E. Morrisey, Ph.D., co-organizer
Associate Professor of Medicine
University of Pennsylvania |
| 1:45-2:25 PM |
"Epigenetic Regulation of Smooth Muscle Differentiation in Development and Disease"
Gary K. Owens, Ph.D.
Professor of Molecular Physiology and Biological Physics;
Director, Robert M. Berne Cardiovascular Research Center;
Director, M.D./Ph.D. (NIH MST Program)
University of Virginia School of Medicine |
| 2:30-2:50 PM |
Short Talk:
"Wnt Signaling Regulates Smooth Muscle Precursor Development in the Lung via a Tenascin-C/platelet Derived Growth Factor Receptor Pathway"
Ethan David Cohen, Ph.D.,
Post Doctoral Researcher, Edward Morrisey Lab |
| 3:00-3:40 PM |
"BMP Signaling in Endothelial Cells and Angiogenesis"
Cam Patterson, M.D., M.B.A., F.A.C.C., F.A.H.A.
Chief, Division of Cardiology;
Director Caroline Cardiovascular Biology Center;
Associate Chair for Research, Department of Medicine;
Professor of Medicine in Cardiology, Pharmacology, and Cell and Developmental Biology
University of North Carolina at Chapel Hill |
| 2:30-2:50 PM |
Short Talk:
"Conformational Activation of Zymogen-like Thrombin Variants by Tight Binding Ligands"
Anuja Khan, Ph.D.,
Post Doctoral Researcher, Sriram Krishnaswamy Lab |
| 4:10-4:30 PM |
Short Talk:
"Genetic Variation in ISL1 Confers Genetic Susceptibility for Human Congenital Heart Disease"
Peter J. Gruber, M.D., Ph.D.,
Assistant Professor, Department of Surgery,
The Children’s Hospital of Philadelphia |
| 4:40-5:15 PM |
"Redox Regulation of Cardiac Hypertrophy"
Junichi Sadoshima, M.D., Ph.D.
Professor and Vice Chair;
Department of Cell Biology and Molecular Medicine;
Associate Director, Cardiovascular Research Institute
University of Medicine and Dentistry of New Jersey |
| 5:20-5:30 PM |
Closing Remarks
Michael S. Parmacek, M.D.,
Director, Penn Cardiovascular Institute;
Chief, Division of Cardiovascular Medicine
University of Pennsylvania |
| 5:30-6:30 PM |
Reception – BRB Lobby
Invited Speakers and Registrants |
Opening Remarks:
Edward E. Morrisey, Ph.D. »
and Mark L. Kahn, M.D. » |
"Protease-Activated Receptors in Vascular Biology and Beyond"
Dr. Shaun Coughlin »
Director, Cardiovascular Research Institute, Professor of Medicine and Cellular and Molecular Pharmacology,
University of California, San Francisco |
"Identifying Novel Genetic Determinants of Hemostatic Balance"
Dr. David Ginsburg »
James V. Neel Distinguished University Professor, Department of Human Genetics,
Physician and Chief- Division of Medical Genetics, Department of Internal Medicine, University of Michigan |
"NHLBI Strategic Initiatives: The Frontiers of Cardiovascular Research"
Dr. Elizabeth Nabel »
Director, National Heart Lung Blood Institute, NIH Senior Investigator, Genome Technology Branch,
NHGRI Division of Intramural Research |
Breakout Session A: Cardiac Development and Stem Cells
"A population of melanocyte-like cells in the heart and pulmonary veins are a source of triggers for atrial arrythmogenesis"
Mark D. Levin, M.D., University of Pennsylvania, Vickas V. Patel Lab »
"Wnt signaling regulates morphogenesis of the inflow tract and atrioventricular canal during cardiac development"
Ying Tian, Ph.D., University of Pennsylvania, Edward E. Morrisey Lab »
"Large-scale candidate gene association with human heart failure"
Thomas A. Cappola, MD, Assistant Professor of Medicine, University of Pennsylvania »
"Rushour controls cardiac neural crest cell migration and heart valve morphogenesis in zebrafish"
Santanu Banerjee, Ph.D., University of Pennsylvania, Michael Granato Lab »
Breakout Session B: Vascular Development and Thrombosis
"Heart of glass receptor and cerebral cavernous malformation proteins regulate the formation and integrity of the cardiovascular system"
Ben Kleaveland, University of Pennsylvania, Mark L. Kahn Lab »
"Genome Wide Association Studies of Coronary Artery Disease"
Muredach P. Reilly, MD, Associate Professor of Medicine, University of Pennsylvania »
"Von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia and pulmonary hypertension"
Michele Hickey, University of Pennsylvania, M. Celeste Simon Lab »
"Venom-Derived factor V from the common brown snake P. Textilis is expressed as a constitutively active cofactor"
Mettine Bos, Ph.D., University of Pennsylvania, Rodney L. Camire Lab - CHOP » |
"Chromatin remodeling in heart development"
Dr. Benoit Bruneau »
Associate Investigator, Gladstone Institute of Cardiovascular Disease, University of California at San Francisco |
"Decoding the endothelial genome"
Dr. Nathan Lawson »
Associate Professor, Programs in Gene Function and Expression and Molecular, University of Massachusetts Medical School |
"Control of Cardiac Mycocyte Differentiation by GATA4 and GATA6"
Dr. Stephen Duncan »
Marcus Professor of Human and Molecular Genetics, Director, Program in Regenerative Medicine;
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin |
"The Molecular and Genetic Basis of Congenital Heart Disease"
Dr. Michael Parmacek »
Director, Penn Cardiovascular Institute,
Chief, Division of Cardiovascular Medicine, University of Pennsylvania |
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