Malgorzata Boczkowska, Ph.D.

Senior Research Investigator
Ph.D. 2001 - Polish Academy of Science, Lodz, Poland. Organic Chemistry

E-mail: malgora at mail . med . upenn . edu
Phone: (215) 573-0983


Boczkowska M, Rebowski G, Dominguez R (2015) The chalenges of polydisperse SAXS data analysis: Two SAXS studies of PICK1 produce different structural models. Stucture 23:1967-1968. DOI:10.1016/j.str.2015.10.007

Boczkowska M, Rebowski G, Kremneva E, Lappalainen P, Dominguez R (2015) How Leiomodin and Tropomodulin use a common fold for different actin assembly functions. Nature Commun 6:8314. DOI:10.1038/ncomms9314

Madasu Y, Yang C, Boczkowska M, Bethoney KA, Zwolak A, Rebowski G, Svitkina T, and Dominguez R (2015) PICK1 is implicated in organelle motility in an Arp2/3 complex-independent manner. Mol. Biol. Cell E14-10-1448. [Epub ahead of print]

Kast DJ, Yang C, Disanza A, Boczkowska M, Madasu Y, Scita G, Svitkina T and Dominguez R (2014) Molecular mechanism of IRSp53 regulation by autoinhibition and activation by Cdc42. Nature Struct Mol Biol. 4:413-22. doi: 10.1038/nsmb.2781

Boczkowska M, Rebowski G, Kast DJ, Dominguez R (2014) Structural analysis of the transitional state of Arp2/3 complex activation by two actin-bound WCAs. Nature Commun 5:3308. DOI:10.1038/ncomms4308

Boczkowska M, Rebowski G, Dominguez R (2013) GMF interacts with Arp2/3 complex in a nucleotide state-dependent manner. J Biol Chem 288:25683-25688

Namgoong S, Boczkowska M, Glista MJ, Winkelman JD, Rebowski G, Kovar DR, Dominguez R (2011) Mechanism of actin filament nucleation by Vibrio VopL and implications for tandem-W domain nucleation. Nature Struct Mol Biol 18: 1060-1067

Pykalainen A, Boczkowska M, Zhao H, Saarikangas J, Rebowski G, Jansen M, Hakanen J, Koskela E, Peranen J, Vihinen H, Jokitalo E, Salminen M, Ikonen E, Dominguez R*, Lappalainen P* (2011) Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures. Nature Struct Mol Biol 18: 902-907

Rebowski G, Namgoong S, Boczkowska M, Leavis P, Navaza J, Dominguez R (2010) Structure of a Longitudinal Actin Dimer Assembled by Tandem W Domains - Implications for Actin Filament Nucleation. J Mol Biol 403:11-23

Kim H.R., Graceffa P, Ferron, F, Gallant C, Boczkowska M, Dominguez R, Morgan KG. (2010). Actin Polymerization in Differentiated Vascular Smooth Muscle Cells Requires Vasodilator-Stimulated Phosphoprotein (VASP). Am J Physiol Cell Physiol.; 298(3):C559-71

Skwarek-Maruszewska A., Boczkowska M, Zajac A, Kremneva E., Svitkina T, Dominguez R. & Lappalainen P. (2010) Different Localizations and Cellular Behaviors of Leiomodin and Tropomodulin in Mature Cardiomyocyte Sarcomeres. Mol.Biol.Cell. 21:3352-3361

Rebowski G.,* Boczkowska M.,* Hayes D.B., Guo L., Irving T.C. & Dominguez R. (2008). X-ray scattering study of actin polymerization nuclei assembled by tandem Wdomains. Proc.Natl.Acad.Sci 105:10785-10790.

Boczkowska M,* Rebowski G,* Petoukhov MV, Hayes DB, Svergun DI & Dominguez R. (2008). X-ray Scattering Study of Activated Arp2/3 Complex with Bound Actin-WCA. Structure 16:695-704.

Chereau D,* Boczkowska M,* Skwarek-Maruszewska A, Fujiwara I, Hayes DB, Rebowski G, Lappalainen P, Pollard TD & Dominguez R. (2008). Leiomodin Is an Actin Filament Nucleator in Muscle Cells. Science 320:239-243.

Guga P, Boczkowska M, Janicka M, Maciaszek A, Kuberski S, Stec WJ (2007). Unusual thermal stability of RNA/[RP-PS]-DNA/RNA triplexes containing a homopurine DNA strand. Biophys. J. 92:2507-2515.

Puig M., Grajkowski A, Boczkowska M, Ausín C, Beaucage SL, Verthelyi D. (2006). Use of thermolytic protective groups to prevent G-tetrad formation in CpG ODN type D: structural studies and immunomodulatory activity in primates. Nucleic Acids Res. 34:6488-6495.

Boczkowska M, Guga P, Stec WJ. (2002). Stereodefined phosphorothioate analogues of DNA: relative thermodynamic stability of the model PS-DNA/DNA and PS-DNA/RNA complexes. Biochemistry 41:12483-12487.

Rebowski G, Wójcik M, Boczkowska M, Gendaszewska E, Soszyński M, Bartosz G, Niewiarowski W. (2001). Antisense hairpin loop oligonucleotides as inhibitors of expression of multidrug resistance-associated protein 1: their stability in fetal calf serum and human plasma. Acta Biochim Pol.; 48(4):1061-76.

Boczkowska M, Guga P, Karwowski B, Maciaszek A. (2000). Effect of P-chirality of internucleotide bonds on B-Z conversion of stereodefined self-complementary phosphorothioate oligonucleotides of the [PS]-d(CG)4 and [PS]-d(GC)4 series. Biochemistry 39:11057-11064.

Kobylanska A, Pluskota E, Swiatkowska M, Wojcik M, Cierniewska-Cieslak A, Krakowiak A, Boczkowska M, Pawlowska Z., Okruszek A, Koziolkiewicz M, Cierniewski CS, Stec WJ. (1999) Inhibition of plasminogen activator inhibitor release in endothelial cell cultures by antisense oligodeoxyribonucleotides with a 5'-end lipophilic modification. Acta Biochim. Pol. 46:679-691.

Nawrot B, Boczkowska M, Wojcik M, Sochacki M, Kazmierski S, Stec WJ. (1998). Novel internucleotide 3'-NH-P(CH3)(O)-O-5' linkage. Oligo(deoxyribonucleoside methanephosphonamidates); synthesis, structure and hybridization properties. Nucleic Acids Res. 26:2650-2658.

Koziolkiewicz M, Krakowiak A, Kwinkowski M, Boczkowska M, Stec WJ. (1995). Stereodifferentiation--the effect of P chirality of oligo(nucleoside phosphorothioates) on the activity of bacterial RNase H. Nucleic Acids Res. 23:5000-5005.