Roberto Dominguez, Ph.D.

Professor

Ph.D. 1996 Institut Pasteur and Université Paris-Sud. Crystallography of Biological Macromolecules and Biochemistry

E-mail: droberto at mail . med . upenn . edu
Phone: (215) 573-4559

Publications (last 3 years)

Jampani N, Rivera-Santiago R, Li W, Lehman R, Dominguez R (2011) Structural analysis of Smooth muscle tropomyosin alpha andd beta isoforms. J Biol Chem [Epub ahead of print]

Namgoong S, Boczkowska M, Glista MJ, Winkelman JD, Rebowski G, Kovar DR, Dominguez R (2011) Mechanism of actin filament nucleation by Vibrio VopL and implications for tandem-W domain nucleation. Nature Struct Mol Biol 18:1060-1067

Jansen S, Collins A, Yang C, Rebowski G, Svitkina T*, Dominguez R* (2011) Mechanism of Actin Filament Bundling by Fascin. J Biol Chem 268:30087-30096

Pykalainen A, Boczkowska M, Zhao H, Saarikangas J, Rebowski G, Jansen M, Hakanen J, Koskela E, Peranen J, Vihinen H, Jokitalo E, Salminen M, Ikonen E, Dominguez R*, Lappalainen P* (2011) Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures. Nature Struct Mol Biol 18:902-907

Kast D & Dominguez R (2011) Arp you ready for actin in the nucleus? EMBO J 30:2097-2098

Dominguez R (2011) Tropomyosin: the gatekeeper's view of the actin filament revealed. Biophys J 100:797-798

Dominguez R & Holmes KC (2011) Actin Structure And Function. Annu Rev Biophys 40:169-186

Gorelik R, Yang C, Kameswaran V, Dominguez R, Svitkina T (2011) Mechanisms of plasma membrane targeting of formin mDia2 through its amino terminal domains. Mol Biol Cell 22:189-201

Rebowski G, Namgoong S, Boczkowska M, Leavis P, Navaza J, Dominguez R (2010) Structure of a Longitudinal Actin Dimer Assembled by Tandem W Domains - Implications for Actin Filament Nucleation. J Mol Biol 403:11-23

Dominguez R (2010) The WASP-Homology 2 Domain and Cytoskeleton Assembly. In Actin-based Motility: Cellular, Molecular and Physical Aspects Marie-France Carlier, Editor Spinger Dordrecht Heidelberg London New York 2010

Skwarek-Maruszewska A, Boczkowska M, Zajac A, Kremneva E, Svitkina T, Dominguez R*, Lappalainen P* (2010) Different Localizations and Cellular Behaviors of Leiomodin and Tropomodulin in Mature Cardiomyocyte Sarcomeres. Mol Biol Cell 21:3352-3361

Lee SH & Dominguez R (2010) Regulation of actin cytoskeleton dynamics in cells. Mol Cells 29:311-325

Baek K, Knodler A, Lee SH, Zhang X, Orlando K, Zhang J, Foskett TJ, Guo W, Dominguez R (2010) Structure-Function Study of the N-terminal Domain of Exocyst Subunit Sec3  J Biol Chem 285:10424-10433

Dominguez R (2010) Structural insights into de novo actin polymerization. Curr Opin Struct Biol 20:217-225

Kim HR, Graceffa P, Ferron F, Gallant C, Boczkowska M, Dominguez R, Morgan KG (2010) Actin Polymerization in Differentiated Vascular Smooth Muscle Cells Requires Vasodilator-Stimulated Phosphoprotein (VASP).  Am J Physiol Cell Physiol 298:C559-C571

Dominguez R (2009) Actin filament nucleation and elongation factors — Structure-function relationships. Crit Rev Biochem Mol Biol 44:351-366

Shvetsov A, Berkane E, Chereau D, Dominguez R, Reisler E (2009) The actin-binding domain of cortactin is dynamic and unstructed and affects lateral and longitudinal contacts in F-actin. Cell Motil Cytoskeleton 66:90-98