Perelman School of Medicine at the University of Pennsylvania

Drapkin Lab

  • Welcome to the lab
  • Fimbria with cancer

    Initiation of high-grade serous carcinoma from the fimbria of the fallopian tube.

  • Diagram

    Tubal precursor lesions to high-grade serous ovarian carcinoma.

  • Close Up

    Animal models for ovarian cancer.

  • Mechanism of Action

    Copy number alterations in ovarian cancer compared to other cancers.

About Our Lab

The Drapkin laboratory focuses on developing a comprehensive understanding of the genetic, molecular and physiological factors that drive the development of cancer, with a special focus on gynecologic malignancies.  Recent work from our group and others has implicated the fallopian tube (FT) secretory cell as the likely cell-of-origin for a majority of high-grade serous ovarian carcinomas. This new concept of ovarian tumorigenesis has been a paradigm shift in the field and the Drapkin lab has been at the forefront in developing novel experimental platforms that address the role of the FT epithelium and its susceptibility to neoplastic transformation. These platforms include genetically engineered mouse (GEM) models, fallopian tube-derived cell lines, and patient-derived tumor xenografts.  The lab is currently focused on utilizing these models to interrogate how genetic and epigenetic alterations influence lineage dependencies, genomic instability, DNA repair, replicative stress, and metabolism. The goal is to define selective vulnerabilities that can guide novel therapeutic approaches and biomarker development. > read more

Fallopian Tube Epithelium (FTE)-Based Model Systems