The Dreyfuss Laboratory is interested in RNA-binding proteins and their complexes with RNAs (RNPs), the key mediators of post-transcriptional gene regulation, and their role in disease. Our current research focuses on the SMN complex, an RNP assembly machine; spinal muscular atrophy, the motor neuron degenerative disease caused by SMN deficiency; splicing regulation; and high-throughput technologies for research and drug discovery.