Publications
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| Wan, L., Dreyfuss, G. 2017. Splicing-Correcting Therapy for SMA. Cell., 170:5 | PubMed Citation |
| So, B. R., Wan, L., Zhang, Z., Li, P., Babiash, E., Duan, J., Younis, I., Dreyfuss, G. 2016. A U1 snRNP-specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange. Nat Struct Mol Bio, 23:225-30. | PubMed Citation |
| So, B.R.; Zhang, Z.; Dreyfuss, G. The SMN Complex: Organization and Function, In: Spinal Muscular Atrophy: Disease Mechanisms and Therapy, Sumner, C.J.; Paushkin, S.; Ko, C.-P. (Eds.). Academic Press, ISBN 0128036869. | PubMed Citation |
| Dreyfuss, G. 2015. On the occasion of the 20th anniversary of the RNA journal. RNA, 21:603-4. | PubMed Citation |
| Zhang, Z., Pinto, A.M., Wan, L., Wang, W., Berg, M.G., Oliva, I., Singh, L.N., Dengler, C., Wei, Z., and Dreyfuss, G. 2013. Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophy. PNAS, 110:19348-53. | PubMed Citation |
| Younis, I., Dittmar, K., Wang, W., Foley, S., Berg, M., Hu, K., Wei, Z., Wan, L., Dreyfuss, G. 2013. Minor introns are embedded molecular switches regulated by highly unstable U6atac snRNA. eLife, 2013;2:e00780. | PubMed Citation |
| Liu, X., Biswas, S., Berg, M.G., Antapli, C.M., Xie, F., Wang, Q., Tang, M.C., Tang, G.L., Zhang, L., Dreyfuss, G. and Cheng, Y.Q. 2013. Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkolderia thailandensis MSMB43. J Nat Prod., 76:685-693. | PubMed Citation |
| Berg, M.G., Singh, L.N., Kaida, D., Cho, S., Zhang, Z., Younis, I., Sherrill-Mix, S., Wan, L., and Dreyfuss, G. 2012. U1 snRNP determines mRNA length and regulates isoform expression. Cell., 150:53-64. |
PubMed Citation |
| Berg, M.G., Wan, L., Younis, I., Diem, M.D., Soo, M., Wang, C., and Dreyfuss, G. 2012. A quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis. Mol Cell Biol., 32:1271-83. |
PubMed Citation |
| Gruber, J.J., Olejniczak, S.H., Yong, J., La Rocca, G., Dreyfuss, G., and Thompson, C.B. 2012. Ars2 promotes proper replication-dependent histone mRNA 3' end formation. Mol Cell., 45:87-98. |
PubMed Citation |
| Zhang, R., So, B.R., Li, P., Yong, J., Glisovic, T., Wan, L., and Dreyfuss, G. 2011. Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly. Cell., 146:384-395. |
PubMed Citation |
| Kataoka, N., Diem, M.D., Yoshida, M., Hatai, C., Dobashi, I., Dreyfuss, G., Hagiwara, M., Ohno, M. 2011. Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with splicd mRNA. Sci Rep, 1:92. |
PubMed Citation |
| Kaida, D., Berg, M.G., Younis, I., Kasim, M., Singh, L.N., Wan, L., Dreyfuss, G. 2010. U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation. Nature, 468:664-668. |
PubMed Citation |
| Yong, J., Kasim, M., Bachorik, J., Wan, L., and Dreyfuss, G. 2010. Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis. Mol Cell., 38:551-562. |
PubMed Citation |
| Mei, Y., Yong, J., Liu, H., Shi, Y., Meinkoth, J., Dreyfuss, G., and Yang, X. 2010. tRNA Binds to Cytochrome c and Inhibits Caspase Activation. Mol Cell., 37:668-678. |
PubMed Citation |
| Younis, I., Berg, M., Kaida, D., Dittmar, K., Wang, C., and Dreyfuss, G. 2010. Rapid-response splicing reporter screens identify differential regulators of constitutive and alternative splicing. Mol Cell Biol., 30:1718-28. |
PubMed Citation |
| Cho, S., and Dreyfuss, G. 2010 A degron created by SMN2 exon 7 skipping is a principal contributor to spinal muscular atrophy severity. Genes Dev., 24:438-42. |
PubMed Citation |
| Gruber, J., Zatechka, S.D., Sabin, L.R., Yong, J., Lum, J.J., Kong, M., Zong, W.-X., Zhang, Z., Lau, C.-K., Rawlings, J., Cherry, S., Ihle, J.N., Dreyfuss, G. and Thompson, C.B. 2009. Ars2 links the nuclear cap binding complex to RNA interface and cell proliferation. Cell., 138:328-39. |
PubMed Citation |
| Lau, CK., Bachorick, JL., and Dreyfuss, G. 2009. Gemin5-snRNA interaction reveals an RNA-binding function for WD-repeat domains. Nat Struct Mol Biol., 6:486-91. |
PubMed Citation |
| Cooper, T., Wan, L., and Dreyfuss, G. 2009. RNA and disease. Cell., 136:777-793. |
PubMed Citation |
| Kataoka, N. and Dreyfuss, G. 2008. Preparation of efficient splicing extracts from whole cells, nuclei, and cytoplasmic fractions. Methods Mol Biol., 488:357-365 |
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| Wan, L., Ottinger, E., Cho, S., and Dreyfuss, G. 2008. Inactivation of the SMN complex by oxidative stress. Mol Cell., 31:244-254. |
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| Zhang, Z., Lotti, F., Dittmar, K., Younis, I., Wan, L., Kasim, M., and Dreyfuss, G. 2008. SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing. Cell., 133:585-600. |
PubMed Citation |
| Glisovic, T., Bachorik, J., Yong, J., and Dreyfuss, G. 2008. RNA-binding proteins and post-transcriptional gene regulation. FEBS Letters., 582:1977-1986. |
PubMed Citation |
| Diem, M., Chan, C., Younis, I., and Dreyfuss, G. 2007. PYM binds the cytoplasmic EJC and ribosomes to enhance translation of spliced mRNAs. Nat Struct Mol Biol., 14:1173-1179. |
PubMed Citation |
| Kolb, S.J., Battle, D.J., and Dreyfuss, G. 2007. Molecular functions of the SMN complex. J Child Neurol., 22:990-4. |
PubMed Citation |
| Battle, D.J., Kasim, M., Wang, J., and Dreyfuss, G. 2007. SMN-independent subunits of the SMN complex: Identification of a SNRNP assembly intermediate. J Biol Chem., 282:27953-9. |
PubMed Citation |
| Kim, E.K., Noh, K.T., Yoon, J.H., Cho, J.H., Yoon, K.W., Dreyfuss, G., and Choi, E.J. 2007. Positive regulation of ASK1-mediated c-Jun NH(2)-terminal kinase signaling pathway by the WD-repeat protein Gemin5. Cell Death Differ., 14:1518-28. |
PubMed Citation |
| Neumann, M., Igaz, L.M., Kwong, L.K., Nakashima-Yasuda, H., Kolb, S.J., Dreyfuss, G., Kretzschmar, H.A., Trojanowski, J.Q., and Lee, V.M. 2007. Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration. Acta Neuropathol (Berl)., 113:543-8. |
PubMed Citation |
| Battle, D.J., Kasim, M., Yong, J., Lotti, F., Lau, C.-K., Mouaikel, J., Zhang, Z., Han, K., Wan, L., Dreyfuss, G. 2006. The SMN Complex: An Assembly Machine for RNPs. Cold Spring Harb Symp Quant Biol., 71:313-20. |
PubMed Citation |
| Battle, D.J., Lau, C.-K., Wan, L., Deng, H., Lotti, F., and Dreyfuss, G. 2006. The Gemin5 protein of the SMN complex identifies snRNAs. Mol Cell., 23:273-9. |
PubMed Citation |
| Sumner, C.J., Kolb, S.J., Harmison, G.G., Jeffries, N.O., Schadt, K., Finkel, R.S., Dreyfuss, G., and Fischbeck, K.H. 2006. SMN mRNA and Protein Levels in Peripheral Blood: Biomarkers for SMA Clinical Trials. Neurol., 66:1067-73. |
PubMed Citation |
| Kolb, S.J., Gubitz, A.K., Olszewski, R.F., Ottinger, E., Sumner, C.J., Fischbeck, K.H., and Dreyfuss, G. 2006. A Novel Cell Immunoassay to Measure Survival of Motor Neurons Protein in Blood Cells. BMC Neurol., 6:6. |
PubMed Citation |
| Golembe, T., Yong, J., and Dreyfuss, G. 2005. Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPs. Mol Cell Biol., 25:10989-11004. |
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Ma, Y.L., Dostie, J., Dreyfuss, G. and Van Duyne, G. 2005. Crystal structure of Gemins6-7 heterodimer from the Survival of Motor Neurons complex has an Sm protein-like structure. Structure, 13:883-892. |
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Wan, L., Battle, D.J., Yong, J., Gubitz, A.K., Kolb, S.J., Wang, J. and Dreyfuss, G. 2005. The Survival of Motor Neurons Protein Determines the Capacity for snRNP Assembly: a Biochemical Deficiency in Spinal Muscular Atrophy. Mol Cell Biol., 25:5543-5551. |
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Feng, W., Gubitz, A.K., Wan, L., Battle, D.J., Dostie, J., Golembe, T.J., and Dreyfuss, G. 2005. Gemins Modulate the Expression and Activity of the SMN Complex. Hum Mol Gen., 14:1605-1611. |
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Golembe, T., Feng, W., and Dreyfuss, G. 2005. Lymphotropic Herpesvirus Saimiri uses the SMN complex to assemble Sm cores in its small RNAs. Mol Cell Biol., 25:602-611. |
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Gubitz, A., Feng, W., and Dreyfuss, G. 2004. The SMN Complex. Exper Cell Res., 296:51-56. |
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Yong, J., Wan, L. and Dreyfuss, G. 2004. Why do cells need an assembly machine for RNA-protein complexes? Trends Cell Biol., 15:226-232. |
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Yong, J., Golembe, T., Battle, D.J., Pellizzoni, L. and Dreyfuss, G. 2004. snRNAs contain specific SMN-binding domains that are essential for snRNP assembly. Mol Cell Biol., 24:2747-2756. |
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Kataoka, N. and Dreyfuss, G. 2004. A simple whole cell lysate system for in vitro splicing reveals a stepwise-assembly of the exon-exon junction complex. J Biol Chem., 279:7009-7013. |
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Chan, C., Dostie, J., Diem, M., Feng, W., Mann, M., Rappsilber, J. and Dreyfuss, G. 2004. eIF4A3 is a novel component of the Exon Junction Complex. RNA, 10:200-209. |
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Kawano, T., Kataoka, N., Dreyfuss, G. and Sakamoto, H. 2004. Ce-Y14 and MAG-1, components of the exon-exon junction complex, are required for embryogenesis and germline sexual switching in Caenorhabditis elegans. Mech Dev., 121:27-35. |
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Rappsilber, J., Friesen, W.J., Paushkin, S., Dreyfuss, G. and Mann, M. 2003. Detection of arginine dimethylated peptides by parallel precursor ion scanning mass spectrometry in positive ion mode. Anal Chem., 75:3107-3114. |
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Lau, C.-K., Diem, M.D., Dreyfuss, G. and Van Duyne, G.D. 2003. Structure of the Y14-Magoh core of the exon junction complex. Curr Biol., 13:933-941. |
PubMed Citation |
| Ambros, V., Barte, B., Bartel, D.P., Burge, C.B., Carrington, J.C., Chen, X., Dreyfuss, G., Eddy, SR., Griffiths-Jones, S., Marshall, M., Matzke, M., Ruvkun, G. and Tuschl, T. 2003. A uniform system for microRNA annotation. RNA, 9:277-279. |
PubMed Citation |
| Dostie, J., Mourelatos, Z., Yang, M., Sharma, A., and Dreyfuss, G. 2002. Numerous microRNPs in neuronal cells containing novel microRNAs. RNA, 9:180-186. |
PubMed Citation |
| Pellizzoni, L., Yong, J., and Dreyfuss, G. 2002. The SMN complex is a specificity factor essential for snRNP assembly. Science, 298:1775-1779. |
PubMed Citation |
| Massenet, S., Pellizzoni, L., Paushkin, S., Mattaj, I.W., and Dreyfuss, G. 2002. The SMN complex is associated with snRNPs throughout their cytoplasmic assembly pathway. Mol Cell Biol., 22:6533-6541. |
PubMed Citation |
| Baccon, J., Pellizzoni, L, Rappsilber, J., Mann, M., and Dreyfuss, G. 2002. Identification and characterization of Gemin7, a novel component of the Survival of Motor Neuron Complex. J Biol Chem., 277:31957-31962. |
PubMed Citation |
| Dostie, J. and Dreyfuss, G. 2002. Translation is required to remove Y14 from mRNAs in the cytoplasm. Curr Biol., 12:1060-1067. |
PubMed Citation |
| Paushkin, S., Gubitz, A.K., Massenet, S., and Dreyfuss, G. 2002. The SMN complex, an assemblyosome of RNPs. Curr Opin Cell Biol., 14:305-312. |
PubMed Citation |
| Mourelatos, Z., Dostie, J., Paushkin, S., Sharma, A., Charroux, B., Abel, L., Rappsilber, J., Mann, M. and Dreyfuss, G. 2002. miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev., 16:720-728. |
PubMed Citation |
| Yong, J.S., Pellizzoni, L. and Dreyfuss, G. 2002. Sequence-specific binding of SMN to U1 snRNA. EMBO J., 21:1188-1196. |
PubMed Citation |
| Pellizzoni, L., Baccon, J., Rappsilber, J., Mann, M., and Dreyfuss, G. 2002. Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component. J Biol Chem., 277:7540-7545. |
PubMed Citation |
| Gubitz, A.K., Mourelatos, Z., Mann, M., Abel, L., Rappsilber, J. and Dreyfuss, G. 2001. Gemin 5: A novel WD-40 repeat protein component of the SMN complex that binds Sm proteins. J Biol Chem., 277:5631-5636. |
PubMed Citation |
| Dreyfuss, G., Kim, V.N. and Kataoka, N. 2002. mRNA-binding proteins and the messages they carry. Nat Rev: Mol Cell Biol., 3:195-205. |
PubMed Citation |
| Friesen, W.J., Wyce, A., Paushkin, S., Abel, L., Rappsilber, J., Mann, M., and Dreyfuss G. 2002. A novel WD repeat protein component of the methylosome binds Sm proteins. J Biol Chem., 21:8289-8300. |
PubMed Citation |
| Kataoka, N., Diem, M.D., Kim, N.V., Yong, J., and Dreyfuss G. 2001. Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex. EMBO J., 20:6424-33. |
PubMed Citation |
| Kim, N.V. and Dreyfuss, G. 2001. Nuclear mRNA binding proteins couple pre-mRNA splicing and post-splicing events. Mol Cells., 12:1-10. |
PubMed Citation |
| Friesen, W.J., Paushkin, S., Wyce, A., Massenet, S., Pesiridis, G.S., Van Duyne, V., Rappsilber, J. Mann, M., and Dreyfuss, G. 2001. The methylosome: a 20S complex containing JBP1 and pICln produces dimethylarginine-modified Sm proteins. Mol Cell Biol., 24:8289-3. |
PubMed Citation |
| Kim, V.N., Kataoka, N., and Dreyfuss, G. 2001. Role of nonsense-mediated decay factor, hUpf3, in the splicing-dependent exon-exon junction complex. Science, 293:1832-6. |
PubMed Citation |
| Mourelatos, Z., Abel, L., Yong, J., Kataoka, N. and Dreyfuss, G. 2001. SMN interacts with a novel family of hnRNP and spliceosomal proteins. EMBO
J., 20:5443-52 |
PubMed Citation |
| Wang, J. and Dreyfuss, G. 2001. Characterization of functional domains of the SMN protein in vivo. J Biol Chem., 276:45387-93. |
PubMed Citation |
| Pellizzonni, L., Baccon, J., Charroux, B. and Dreyfuss, G., 2001. The Survival of Motor Neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1. Curr Biol., 11:1079-1088. |
PubMed Citation |
| Friesen, W.J., Massenet, S., Paushkin, S., Wyce, A., and Dreyfuss, G., 2001. SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets. Mol Cell., 7:1111-1117. |
PubMed Citation |
| Kim, N.V., Yong, J., Kataoka, N., Abel, L., Diem, M.D., and Dreyfuss, G. 2001. The Y14 protein communicates to the cytoplasm the position of exon-exon junctions. EMBO J., 20:2062-2068. |
PubMed Citation |
| Wan, L., Kim, J.K, Pollard, V.W., and Dreyfuss, G. 2001. Mutational definition of RNA-binding and protein-protein interaction domains of hnRNP C1. J Biol Chem., 276:7681-7688. |
PubMed Citation |
| Wang, J. and Dreyfuss, G. 2001. A cell system with targeted disruption of the SMN gene: Functional conservation of the SMN protein and dependence of Gemin2 on SMN. J Biol Chem., 276:9599-9605. |
PubMed Citation |
| Pellizzoni, L., Charroux, B., Rappsilber, J., Mann, M., and Dreyfuss, G. 2001. A functional interaction between the SMN complex and RNA polymerase II. J Cell Biol., 152:75-85. |
PubMed Citation |
| Wan, L., Dockendorff, T.C., Jongen, T.A. and Dreyfuss, G. 2000. Characterization of dFMR1, a Drosophila homolog of the fragile X mental retardation protein. Mol Cell Biol., 20:8536-8547. |
PubMed Citation |
| Mizukami, K., Kamma, H., Ishikawa, M., Dreyfuss, G. 2000. Immunohistochemical study of the hnRNP A2 and B1 in the rate forebrain. NeuroReport, 11:3099-3102. |
PubMed Citation |
| Kataoka, N., Yong, J., Kim, V.N., Velazquez, F., Perkinson, R.A., Wang, F. and Dreyfuss, G. 2000. Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm. Mol Cell., 6:673-682. |
PubMed Citation |
| Friesen, W.J. and Dreyfuss, G. 2000. Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN). J Biol Chem., 275:26370-26375. |
PubMed Citation |
| Paushkin, S., Charroux, B., Abel, L., Pellizzoni, L. and Dreyfuss, G. 2000. The SMN protein of Schizosacharomyces pombe: conservation of SMN interaction domains in divergent organisms. J Biol Chem., 275:23841-23846. |
PubMed Citation |
| Charroux, B., Pellizzoni, L., Perkinson, R.A., Yong, J.S., Shevchenko, A., Mann, M, and Dreyfuss, G. 2000. Gemin4: a novel component of the SMN complex that is found in both gems and nucleoli. J Cell Biol., 148:1177-1186. |
PubMed Citation |
| Nakielny, S. and Dreyfuss, G. 1999. Transport of proteins and RNAs in and out of the nucleus. Cell, 99:677-690. |
PubMed Citation |
| Swanson, M.S. and Dreyfuss, G. 1999. Preparation of heterogeneous nuclear ribonucleoprotein complexes. Methods Mol Biol., 118:299-308. |
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| Charroux, B., Pellizzoni, L., Perkinson, R.A., Shevchenko, A., Mann, M. and Dreyfuss, G. 1999. Gemin3: a novel DEAD box protein that interacts with SMN, the Spinal Muscular Atrophy gene product, and is a component of gems. J Cell Biol., 147:1181-1193. |
PubMed Citation |
| Fischer, U., Pollard, V.W., Luhrmann, R., Teufel, M., Michael, W.M., Dreyfuss, G, and Malim, M.H. 1999. Rev-mediated nuclear export of RNA is dominant over nuclear retention and is coupled to the Ran-GTPase cycle. Nucleic Acids Res., 27:4128-4134. |
PubMed Citation |
| Pellizzoni, L., Charroux, B. and Dreyfuss, G. 1999. Specific sequences in SMN and SIP1 mediate their interactions with each other and with Sm proteins. Proc Natl Acad Sci USA, 20:11167-11172. |
PubMed Citation |
| Dreyfuss, G. and Struhl, K. 1999. Multiprotein complexes, mechanistic connections and nuclear organization. Curr Opin Cell Biol., 11:303-306. |
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| Kataoka, N., Bachorik, J.L. and Dreyfuss, G. 1999. Transportin-SR, a nuclear import receptor for SR proteins. J Cell Biol., 145:1145-1152. |
PubMed Citation |
| Nakielny, S., Shaihk, S., Burke, B. and Dreyfuss, G. 1999. Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain. EMBO J., 18:1982-1995. |
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| Kamma, H., Horiguchi, H., Wan, L., Matsui, M., Fujiwara, M., Fujimoto, M., Yazawa, T. and Dreyfuss, G. 1999. Molecular characterization of the hnRNP A2/B1 proteins: tissue-specific expression and novel isoforms. Exp Cell Res., 246:399-411. |
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| Pellizzoni, L., Kataoka, N., Charroux, B. and Dreyfuss, G. 1998. A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing. Cell, 95:615-624. |
PubMed Citation |
| Siomi, M.C., Fromont, M., Rain, J.-C., Wan, L., Wang, F., Legrain, P. and Dreyfuss, G. 1998. Functional conservation of the transportin nuclear import pathway in divergent organisms. Mol Cell Biol., 18:4141-4148. |
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| Hassfeld, W., Chan, E.K.L., Mathison, D.A., Portman, D., Dreyfuss, G., Steiner, G. and Tan, E.M. 1998. Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P. Nucleic Acids Res., 15:439-45. |
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| Nakielny, S. and Dreyfuss, G. 1997. Import and export of the nuclear protein import receptor transportin by a mechanism independent of GTP hydrolysis. Curr Biol., 8:89-95. |
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| Siomi, M.C., Eder, P.S., Kataoka, N., Wan, L., Liu, Q. and Dreyfuss, G. 1997. Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. J Cell Biol., 138:1181-1192. |
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| Fischer, U., Liu, Q. and Dreyfuss, G. 1997. The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis. Cell, 90:1023-1029. |
PubMed Citation |
| Liu, Q., Fischer, U., Wang, F. and Dreyfuss, G. 1997. The spinal muscular atrophy disease gene product, SMN, and its associated protein, SIP1, are in a complex with spliceosomal snRNP proteins. Cell, 90:1013-1021. |
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| Siomi, H. and Dreyfuss, G. 1997. RNA-binding proteins as regulators of gene expression. Curr Opin Genet Dev., 7:345-353. |
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| Nakielny, S. and Dreyfuss, G. 1997. Nuclear export of proteins and RNAs. Curr Opin Cell Biol., 9:420-429. |
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| Lefebvre, S., Burlet, P., Liu, Q., Bertrandy, S., Clermont, O., Munnich, A., Dreyfuss, G. and Melki, J. 1997. Correlation between severity and SMN protein level in spinal muscular atrophy. Nat Genet., 16:265-269. |
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| Michael, W.M., Eder, P. and Dreyfuss, G. 1997. The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K protein. EMBO J., 16:3587-3598. |
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| Portman, D.S., O'Connor, J.P. and Dreyfuss, G. 1997. YRA1, an essential Saccharomyces cerevisiae gene, encodes a novel protein with RNA annealing activity. RNA, 3:527-537. |
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| Izaurralde, E., Jarmolowski, A., Beisel, C., Mattaj, I.W., Dreyfuss, G. and Fischer, U. 1997. A role for the M9-transport signal of hnRNP A1 in mRNA nuclear export. J Cell Biol., 137:27-35. |
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| Nakielny, S., Fischer, U., Michael, W.M. and Dreyfuss, G. 1997. RNA transport. Annu Rev Neurosci.,20:269-301. |
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| Waterhouse, H., Kumar, S., Song, Q., Strike, P., Sparrow, L., Dreyfuss, G., Alnemri, E.S., Litwack, G., Lavin, M., Watters, D. 1996. Heteronuclear ribonucleoproteins C1 and C2, components of the spliceosome, are specific targets of interleukin lbeta-converting enzyme-like proteases in apoptosis. J Biol Chem., 46:29335-29341. |
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| Svitkin, Y.V., Ovchinnikov, L.P., Dreyfuss, G. and Sonenberg, N. 1996. General RNA-binding proteins render translation cap-dependent. EMBO J., 15:7147-7155. |
PubMed Citation |
| Nakielny, S., Siomi, M., Siomi, H., Michael, W.M., Pollard, V. and Dreyfuss, G. 1996. Transportin: nuclear transport receptor of a novel nuclear protein import pathway. Exp Cell Res., 229:261-266. |
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| Liu, Q., Siomi, H., Siomi, M.C., Fischer, U., Zhang, Y., Wan, L., Dreyfuss G. 1996. Molecular characteriaction of the protein products of the fragile X syndrome gene and the survival of motor neurons gene. Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor Press, Vol. 61:689-697. |
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| Pollard, V.W., Michael, W.M., Nakielny, S., Siomi, M.C., Wang, F., Dreyfuss G. 1996. A novel receptor-mediated nuclear protein import pathway. Cell, 86:985-994. |
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| Dreyfuss, G., Hentze, M. and Lamond, A.I. 1996. Meeting Review - From Transcript to Protein. Cell, 85:963-972. |
PubMed Citation |
| Fischer, U., Michael, M., Lührmann, R. and Dreyfuss, G. 1996. Signal-mediated nuclear export pathways of proteins and RNAs. Trends Cell Biol., 6:290-293. |
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| Nakielny, S. and Dreyfuss, G. 1996. The hnRNP C proteins contain a nuclear retention sequence that can override nuclear export signals. J. Cell Biol., 134:1365-1373. |
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| Siomi, M.C., Zhang, Y., Siomi, H. and Dreyfuss, G. 1996. Specific sequences in the fragile X syndrome protein, FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interaction among them. Mol Cell Biol., 16:3825-3832. |
PubMed Citation |
| Michael, W.M. and Dreyfuss, G. 1996. Distinct domains in ribosomal protein L5 mediate 5 S rRNA binding and nucleolar localization. J Biol Chem., 27:11571-11574. |
PubMed Citation |
| Liu, Q. and Dreyfuss, G. 1996. A novel nuclear structure containing the survival of motor neurons protein. EMBO J., 15:3555-3565. |
PubMed Citation |
| Michael, W.M., Siomi, H., Choi, M., Píñol-Roma, S., Nakielny, S., Liu, Q. and Dreyfuss, G. 1995. Signal sequences that target nuclear import and nuclear export of pre-mRNA-binding proteins. Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor Press, Vol. 60:663-668. |
PubMed Citation |
| Michael, W.M., Choi, M. and Dreyfuss, G. 1995. A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway. Cell, 83:415-422. |
PubMed Citation |
| Kamma, H., Portman, D. and Dreyfuss, G. 1995. Cell-type-specific expression of hnRNP proteins. Exp Cell Res., 221:187-196. |
PubMed Citation |
| Zhang, Y., O'Connor, J.P., Siomi, M.C., Srinivasan, S., Dutra, A., Nussbaum, R. and Dreyfuss, G. 1995. The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. EMBO J., 14:5358-5366. |
PubMed Citation |
| Siomi, M.C., Siomi, H., Sauer, W.H., Srinivasan, S., Nussbaum, R.L. and Dreyfuss, G. 1995. FXR1, an autosomal homolog of the Fragile X mental retardation gene. EMBO J., 14:2401-2408. |
PubMed Citation |
| Liu, Q. and Dreyfuss, G. 1995. In vivo and in vitro arginine methylation of RNA-binding proteins. Mol Cell Biol., 15:2800-2808. |
PubMed Citation |
| Siomi, H. and Dreyfuss, G. 1995. A nuclear localization domain in the hnRNP A1 protein. J Cell Biol., 129:551-560. |
PubMed Citation |
| Bustelo, X.R., Suen, K-L., Michael, W.M., Dreyfuss, G. and Barbacid, M. 1995. Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins. Mol Cell Biol., 15:1324-1332. |
PubMed Citation |
| Matunis, M.J., Matunis, E.L. and Dreyfuss, G. 1994. Isolation and analysis of RNA-binding proteins. In: Methods Cell Biol., L.S.B. Goldstein and E.A. Fyrberg, (eds.), Academic Press, New York. |
|
| Görlach, M., Burd, C.G. and Dreyfuss, G. 1994. The determinants of RNA-binding specificity of the heterogeneous nuclear ribonucleoprotein C proteins. J Biol Chem., 269:23074-23078. |
PubMed Citation |
| Kiledjian, M., Burd, C.G., Görlach, M., Portman, D.S. and Dreyfuss, G. 1994. Structure and function of hnRNP proteins. In: RNA-protein interactions: Frontiers in Molecular Biology, pp. 127-149, K. Nagai and I. Mattaj (ed.) Oxford
University Press, Oxford. |
|
| Burd, C. and Dreyfuss, G. 1994. Conserved structures and diversity of functions of RNA-binding proteins. Science, 265:615-621. |
PubMed Citation |
| Weng, Z., Thomas, S.M., Rickles, R.J. Taylor, J.A., Brauer, A. W., Seidel-Dugan, C., Michael, W. M., Dreyfuss, G. and Brugge, J. S. 1994. Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains. Mol Cell Biol., 14:4509-4521. |
PubMed Citation |
| Görlach, M., Burd, C.G. and Dreyfuss, G. 1994. The mRNA poly(A)-binding protein: localization, abundance and RNA-binding specificity. Exp Cell Res., 211:400-407. |
PubMed Citation |
| Siomi, H., Choi, M., Siomi, M.C., Nussbaum, R.L. and Dreyfuss, G. 1994. Essential role for KH domains in RNA binding: impaired RNA binding by a mutation in the KH domain of FMR-1 that causes fragile X syndrome. Cell, 77:33-39. |
PubMed Citation |
| Matunis, E.L., Matunis, M.J., Kelley, R. and Dreyfuss, G. 1994. Essential role for an hnRNP protein in oogenesis: hrp 40 is absent from the germline in the dorsoventral mutant squid, Proc Natl Acad Sci USA., 91:2781-2784. |
PubMed Citation |
| Matunis, M.J., Xing, J. and Dreyfuss, G. 1994. The hnRNP F protein: unique primary structure, nucleic acid-binding properties, and subcellular localization. Nucleic Acids Res., 22:1059-1067. |
PubMed Citation |
| Burd, C.G. and Dreyfuss, G. 1994. RNA-binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing. EMBO J., 13:1197-1204. |
PubMed Citation |
| Portman, D. and Dreyfuss, G. 1994. RNA annealing activities in HeLa nuclei. EMBO J., 13:213-221. |
PubMed Citation |
| Takimoto, M., Tamonaga, T., Matunis, M., Abigan, M., Krutzsch, H., Dreyfuss, G. and Levens, D. 1993. Specific binding of heterogeneous ribonucleoprotein particle protein K to the human c-myc promoter, in vitro. J Biol Chem., 268:18249-18258. |
PubMed Citation |
| Soulard, M., Della Valle, V., Siomi, M.C., Píñol-Roma, S., Codogno, P., Bauvy, C., Belli, M., Lacroix, J.-C., Dreyfuss, G. and Larsen, C.J. 1993. hnRNP G: sequence and characterization of glycosylated RNA-binding protein. Nucleic Acids Res., 21:4210-4217. |
PubMed Citation |
| Matunis, M.J., Matunis, E.L. and Dreyfuss, G. 1993. PUB1: A major yeast poly(A)+ RNA-binding protein. Mol Cell Biol., 13:6114-6123. |
PubMed Citation |
| Piñol-Roma, S. and Dreyfuss, G. 1993. Cell cycle-regulated phosphorylation of the pre-mRNA-binding (heterogeneous nuclear ribonucleoprotein) C proteins. Mol Cell Biol., 13:5762-5770. |
PubMed Citation |
| Görlach, M., Burd, C.G., Portman, D.S. and Dreyfuss, G. 1993. The hnRNP proteins. Mol Biol Rep., 18:73-78. |
PubMed Citation |
| Siomi, H., Siomi, M.C., Nussbaum, R.L. and Dreyfuss, G. 1993. The protein product of the fragile X gene, FMR-1, has characteristics of an RNA binding protein. Cell, 74:291-298. |
PubMed Citation |
| Ishikawa, F., Matunis, M.J., Dreyfuss, G. and Cech, T.R. 1993. Nuclear Proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n. Mol Cell Biol. , 13:4301-4310. |
PubMed Citation |
| Dreyfuss, G., Matunis, M.J., Píñol-Roma, S. and Burd, C. 1993. hnRNP proteins and the biogenesis of mRNA. Annu Rev Biochem., 62:289-321. |
PubMed Citation |
| Piñol-Roma, S. and Dreyfuss, G. 1993. hnRNP proteins: Localization and transport between nucleus and cytoplasm. Trends Cell Biol., 3:151-155. |
PubMed Citation |
| Matunis, E.L., Matunis, M. J. and Dreyfuss, G. 1993. Association of individual hnRNP proteins and snRNPs with nascent transcripts in Drosophila. J Cell Biol., 121:219-228. |
PubMed Citation |
| Siomi, H., Matunis, M.J., Michael, W.M. and Dreyfuss, G. 1993. The pre-mRNA binding K protein contains a novel evolutionarily conserved motif. Nucleic Acids Res., 21:1193-1198. |
PubMed Citation |
| Datar, K.V., Dreyfuss, G. and Swanson, M.S. 1993. The human hnRNP M proteins: Identification of a methionine/arginine-rich repeat motif in ribonucleoproteins. Nucleic Acids Res., 21:439-446. |
PubMed Citation |
| Ludevid, L., Burd, C., Dreyfuss, G. and Pagès, M. 1992. RNA binding characteristics of a 16 kDa glycine-rich protien from maize. Plant J., 2:999-1003. |
PubMed Citation |
| Görlach, M., Wittekind, M., Beckman, R.A., Mueller, L. and Dreyfuss, G. 1992. Interaction of the RNA-binding domain of the hnRNP C proteins with RNA. EMBO J., 11:3289-3295. |
PubMed Citation |
| Wittekind, M., Görlach, M., Friedrichs, M., Dreyfuss, G. and Mueller, L. 1992. 1H, 13C, and 15N NMR assignments and global folding pattern of the RNA binding domain of the human hnRNP C proteins. Biochem., 31:6254-6265. |
PubMed Citation |
| Ghetti, A., Píol-Roma, S., Michael, W.M., Morandi, C. and Dreyfuss, G. 1992. hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs. Nucleic Acids Res., 20:3671-3678. |
PubMed Citation |
| Kiledjian, M. and Dreyfuss, G. 1992. Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box.EMBO J., 11:2655-2664. |
PubMed Citation |
| Bennett, M., Píñol-Roma, S., Staknis, D., Dreyfuss, G and Reed, R. 1992. Differential binding of heterogeneous nuclear ribonucleoproteins to mRNA precursors prior to spliceosome assembly in vitro. Mol Cell Biol., 12:3165-3175. |
PubMed Citation |
| Piñol-Roma, S. and Dreyfuss, G. 1992. Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm. Nature, 355:730-732. |
PubMed Citation |
| Matunis, E.L., Matunis, M.J. and Dreyfuss, G. 1992. Characterization of the major hnRNP proteins from Drosophila melanogaster. J Cell Biol., 116:257-269.. |
PubMed Citation |
| Matunis, M.J., Matunis, E.L. and Dreyfuss, G. 1992. Isolation of hnRNP complexes from Drosophila melanogaster. J Cell Biol.,116:245-255. |
PubMed Citation |
| Matunis, M.J., Michael, W.M. and Dreyfuss, G. 1992. Characterization and Primary Structure of the poly(C)-binding hnRNP K protein. Mol Cell Biol., 12:164-171. |
PubMed Citation |
| Burd, C. G., Matunis, E. L. and Dreyfuss, G. 1991. The multiple RNA binding domains of the poly(A)-binding protein have different RNA-binding activities. Mol Cell Biol. , 11:3419-3424. |
PubMed Citation |
| Piñol-Roma, S. and Dreyfuss, G. 1991. Transcription-dependent and transcription-independent nuclear transport of hnRNP proteins. Science, 253:312-314. |
PubMed Citation |
| Piñol-Roma, S., Swanson, M.S., Matunis, M. and Dreyfuss, G. 1990. Purification and characterization of hnRNP proteins by affinity chromatography. Methods Enzymol. , 181:326-331. |
PubMed Citation |
| Piñol-Roma, S., Choi, Y.D. and Dreyfuss, G. 1990. Immunological methods for the purification and characterization of hnRNP particles. Methods Enzymol., 181:317-325. |
PubMed Citation |
| Dreyfuss, G., Swanson, M.S. and Píñol-Roma, S. 1990. The composition, structure, and organization of proteins in heterogeneous nuclear ribonucleoprotein complexes. in: "The Eukaryotic Nucleus: Structure and Function." Strauss, P. and Wilson, S. (eds.) The Telford Press. Caldwell, NJ |
|
| Burd, C. G., Swanson, M. S., Görlach, M., and Dreyfuss, G. 1989. Primary structure of the A2, B1 and C2 hnRNP proteins: a diversity of RNA binding proteins is generated by small peptide inserts. Proc Natl Acad Sci USA, 86:9788-9792. |
PubMed Citation |
| Dreyfuss, G., Choi, Y.D. and Adam, S.A. 1989. The ribonucleoprotein structures along the pathway of mRNA formation. Endocr Res., 15:441-474. |
PubMed Citation |
| Piñol-Roma, S., Swanson, M.S., Gall, J. G. and Dreyfuss, G. 1989. A novel hnRNP protein with a unique distribution on nascent transcripts. J Cell Biol.,109:2575-2587. |
PubMed Citation |
| Bandziulis, R.J., Swanson, M.S. and Dreyfuss, G. 1989. RNA-binding proteins as developmental regulators. Genes Dev ., 3:431-437. |
PubMed Citation |
| Mortenson, E. and Dreyfuss, G. 1989. RNP in maize protein. Nature, 337:312. |
PubMed Citation |
| Lamb, R.A. and Dreyfuss, G. 1989. RNA Structure: Unwinding with a Vengeance. Nature, 337:19-20. |
PubMed Citation |
| Piñol-Roma, S., Adam, S.A., Choi, Y.D. and Dreyfuss, G. 1989. Ultraviolet-induced crosslinking of RNA to proteins in vivo. Methods Enzymol., 180:410-418. |
PubMed Citation |
| Swanson, M.S. and Dreyfuss, G. 1988. RNA binding specificity of hnRNP proteins: a subset bind to the 3' end of introns. EMBO
J., 7:3519-3529. |
PubMed Citation |
| Dreyfuss, G., Philipson, L. and Mattaj, I. 1988. Ribonucleoprotein particles in cellular processes. J Cell Biol., 106:1419-1425. |
PubMed Citation |
| Swanson, M.S. and Dreyfuss, G. 1988. Classification and purification of proteins of heterogeneous nuclear ribonucleoprotein particles by RNA binding specificities. Mol Cell Biol., 8:2237-2241. |
PubMed Citation |
| Dreyfuss, G., Swanson, M.S. and Píñol-Roma, S. 1988. Heterogeneous nuclear ribonucleoprotein particles and mRNA formation. Trends Biochem Sci., 13:86-91. |
PubMed Citation |
| Piñol-Roma, S., Choi, Y.D., Matunis, M. and Dreyfuss, G. 1988. Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins. Genes Dev., 2:215-227. |
PubMed Citation |
| Swanson, M.S., Pínol-Roma, S. and Dreyfuss, G. 1987. hnRNPs and mRNPs. Mol Biol Rep., 12:165-168. |
|
| Adam, S.A. and Dreyfuss, G. 1987. Adenovirus proteins associated with mRNA and hnRNA in infected HeLa cells. J Virol., 61:3276-3283. |
PubMed Citation |
| Swanson, M.S., Nakagawa, T.Y., LeVan, K. and Dreyfuss, G. 1987. Primary structure of human nuclear ribonucleoprotein particle C proteins: conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA, and pre-rRNA-binding proteins. Mol Cell Biol., 7:1731-1739. |
PubMed Citation |
| Dreyfuss, G. 1986. The structure and function of nuclear and cytoplasmic ribonucleoprotein particles. Annu Rev Cell Biol., (G. Palade, B. Alberts and J. Spudich, eds.) 2:459-498. |
PubMed Citation |
| Adam, S.A., Nakagawa, T.Y., Swanson, M.S., Woodruff, R. and Dreyfuss, G. 1986. mRNA polyadenylate binding protein: Gene isolation and sequencing and identification of a ribonucleoprotein (RNP) consensus sequence. Mol Cell Biol., 6:2932-2943. |
PubMed Citation |
| Choi, Y.D., Grabowski, P., Sharp, P.A. and Dreyfuss, G. 1986. Heterogeneous nuclear ribonucleoproteins: role in RNA splicing. Science, 231:1534-1539 |
PubMed Citation |
| Nakagawa, T., Swanson, M.S., Wold, B. and Dreyfuss, G. 1986. Molecular cloning of cDNA for the nuclear ribonucleoprotein particle C proteins: a conserved gene family. Proc Natl Acad Sci USA, 83:2007-2011 |
PubMed Citation |
| Adam, S.A., Choi, Y.D. and Dreyfuss, G. 1986. Interaction of mRNA with proteins in vesicular stomatitis virus-infected cells. J Virol., 57:614-622. |
PubMed Citation |
| Choi, Y.D. and Dreyfuss, G. 1984. Isolation of the hnRNA-ribonucleoprotein complex (hnRNP): a unique supramolecular assembly. Proc Natl Acad Sci USA, 81:7471-7475. |
PubMed Citation |
| Choi, Y.D. and Dreyfuss, G. 1984. Monoclonal antibody characterization of the C proteins of hnRNPs in vertebrate cells. J Cell Biol., 99:1997-2004. |
PubMed Citation |
| Dreyfuss, G., Choi, Y.D. and Adam, S.A. 1984. Characterization of hnRNA-protein complexes in vivo with monoclonal antibodies. Mol Cell Biol., 4:1104-1114. |
PubMed Citation |
| Dreyfuss, G., Adam, S.A. and Choi, Y.D. 1984. Physical change in cytoplasmic mRNPs in cells treated with inhibitors of transcription. Mol Cell Biol., 4:415-432. |
PubMed Citation |
| Boss, M.A., Dreyfuss, G. and Baltimore, D. 1981. Localization of the Abelson murine leukemia virus in a detergent insoluble subcellular matrix: architecture of the protein. J Virol., 40:472-481. |
PubMed Citation |
| Cervera, M., Dreyfuss, G. and Penman, S. 1981. Messenger RNA is translated when associated with the cytoskeletal framework in normal and VSV-infected HeLa cells. Cell,23:113-210. |
PubMed Citation |
| Burr, J., Dreyfuss, G., Penman, S. and Buchanan, J. 1980. Association of the src gene product of the
Rous Sarcoma Virus with cytoskeletal structures of chick embryo fibroblasts. Proc Natl Acad Sci USA, 77:3484-3488. |
PubMed Citation |
|
Dreyfuss, G., Schwartz, K.J. and Blout, E.T. 1978. Compartmentalization of cyclic AMP-dependent protein kinases in human erythrocytes. Proc Natl Acad Sci USA, 75:5926-5930. |
PubMed Citation |
| Dreyfuss, G., Schwartz, K.J., Blout, E.R., Barrio, J.R., Liu, F.T. and Leonard, N.H. 1978. Fluorescent photoaffinity labeling: Adenosine 3', 5'-cyclic monophosphate receptor sites. Proc Natl Acad Sci USA, 75:1199-1203. |
PubMed Citation |
