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Zhang, Z., Pinto, A.M., Wan, L., Wang, W., Berg, M.G., Oliva, I., Singh, L.N., Dengler, C., Wei, Z., and Dreyfuss, G. 2013. Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophy. PNAS, 110:19348-53.PubMed Citation
Younis, I., Dittmar, K., Wang, W., Foley, S., Berg, M., Hu, K., Wei, Z., Wan, L., Dreyfuss, G. 2013. Minor introns are embedded molecular switches regulated by highly unstable U6atac snRNA. eLife, 2013;2:e00780.PubMed Citation
Liu, X., Biswas, S., Berg, M.G., Antapli, C.M., Xie, F., Wang, Q., Tang, M.C., Tang, G.L., Zhang, L., Dreyfuss, G. and Cheng, Y.Q. 2013. Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkolderia thailandensis MSMB43. J Nat Prod., 76:685-693.PubMed Citation
Berg, M.G., Singh, L.N., Kaida, D., Cho, S., Zhang, Z., Younis, I., Sherrill-Mix, S., Wan, L., and Dreyfuss, G. 2012. U1 snRNP determines mRNA length and regulates isoform expression. Cell., 150:53-64. PubMed Citation
Berg, M.G., Wan, L., Younis, I., Diem, M.D., Soo, M., Wang, C., and Dreyfuss, G. 2012. A quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis. Mol Cell Biol., 32:1271-83. PubMed Citation
Gruber, J.J., Olejniczak, S.H., Yong, J., La Rocca, G., Dreyfuss, G., and Thompson, C.B. 2012. Ars2 promotes proper replication-dependent histone mRNA 3' end formation. Mol Cell., 45:87-98. PubMed Citation
Zhang, R., So, B.R., Li, P., Yong, J., Glisovic, T., Wan, L., and Dreyfuss, G. 2011. Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly. Cell., 146:384-395. PubMed Citation
Kataoka, N., Diem, M.D., Yoshida, M., Hatai, C., Dobashi, I., Dreyfuss, G., Hagiwara, M., Ohno, M. 2011. Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with splicd mRNA. Sci Rep, 1:92. PubMed Citation
Kaida, D., Berg, M.G., Younis, I., Kasim, M., Singh, L.N., Wan, L., Dreyfuss, G. 2010. U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation. Nature, 468:664-668. PubMed Citation
Yong, J., Kasim, M., Bachorik, J., Wan, L., and Dreyfuss, G. 2010. Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis. Mol Cell., 38:551-562. PubMed Citation
Mei, Y., Yong, J., Liu, H., Shi, Y., Meinkoth, J., Dreyfuss, G., and Yang, X. 2010. tRNA Binds to Cytochrome c and Inhibits Caspase Activation. Mol Cell., 37:668-678. PubMed Citation
Younis, I., Berg, M., Kaida, D., Dittmar, K., Wang, C., and Dreyfuss, G. 2010. Rapid-response splicing reporter screens identify differential regulators of constitutive and alternative splicing. Mol Cell Biol., 30:1718-28. PubMed Citation
Cho, S., and Dreyfuss, G. 2010 A degron created by SMN2 exon 7 skipping is a principal contributor to spinal muscular atrophy severity. Genes Dev., 24:438-42. PubMed Citation
Gruber, J., Zatechka, S.D., Sabin, L.R., Yong, J., Lum, J.J., Kong, M., Zong, W.-X., Zhang, Z., Lau, C.-K., Rawlings, J., Cherry, S., Ihle, J.N., Dreyfuss, G. and Thompson, C.B. 2009. Ars2 links the nuclear cap binding complex to RNA interface and cell proliferation. Cell., 138:328-39. PubMed Citation
Lau, CK., Bachorick, JL., and Dreyfuss, G. 2009. Gemin5-snRNA interaction reveals an RNA-binding function for WD-repeat domains. Nat Struct Mol Biol., 6:486-91. PubMed Citation
Cooper, T., Wan, L., and Dreyfuss, G. 2009. RNA and disease. Cell., 136:777-793. PubMed Citation
Kataoka, N. and Dreyfuss, G. 2008. Preparation of efficient splicing extracts from whole cells, nuclei, and cytoplasmic fractions. Methods Mol Biol., 488:357-365 PubMed Citation
Wan, L., Ottinger, E., Cho, S., and Dreyfuss, G. 2008. Inactivation of the SMN complex by oxidative stress. Mol Cell., 31:244-254. PubMed Citation
Zhang, Z., Lotti, F., Dittmar, K., Younis, I., Wan, L., Kasim, M., and Dreyfuss, G. 2008. SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing. Cell., 133:585-600. PubMed Citation
Glisovic, T., Bachorik, J., Yong, J., and Dreyfuss, G. 2008. RNA-binding proteins and post-transcriptional gene regulation. FEBS Letters., 582:1977-1986. PubMed Citation
Diem, M., Chan, C., Younis, I., and Dreyfuss, G. 2007. PYM binds the cytoplasmic EJC and ribosomes to enhance translation of spliced mRNAs. Nat Struct Mol Biol., 14:1173-1179. PubMed Citation
Kolb, S.J., Battle, D.J., and Dreyfuss, G. 2007. Molecular functions of the SMN complex. J Child Neurol., 22:990-4. PubMed Citation
Battle, D.J., Kasim, M., Wang, J., and Dreyfuss, G. 2007. SMN-independent subunits of the SMN complex: Identification of a SNRNP assembly intermediate. J Biol Chem., 282:27953-9. PubMed Citation
Kim, E.K., Noh, K.T., Yoon, J.H., Cho, J.H., Yoon, K.W., Dreyfuss, G., and Choi, E.J. 2007. Positive regulation of ASK1-mediated c-Jun NH(2)-terminal kinase signaling pathway by the WD-repeat protein Gemin5. Cell Death Differ., 14:1518-28. PubMed Citation
Neumann, M., Igaz, L.M., Kwong, L.K., Nakashima-Yasuda, H., Kolb, S.J., Dreyfuss, G., Kretzschmar, H.A., Trojanowski, J.Q., and Lee, V.M. 2007. Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration. Acta Neuropathol (Berl)., 113:543-8. PubMed Citation
Battle, D.J., Kasim, M., Yong, J., Lotti, F., Lau, C.-K., Mouaikel, J., Zhang, Z., Han, K., Wan, L., Dreyfuss, G. 2006. The SMN Complex: An Assembly Machine for RNPs. Cold Spring Harb Symp Quant Biol., 71:313-20. PubMed Citation
Battle, D.J., Lau, C.-K., Wan, L., Deng, H., Lotti, F., and Dreyfuss, G. 2006. The Gemin5 protein of the SMN complex identifies snRNAs. Mol Cell., 23:273-9. PubMed Citation
Sumner, C.J., Kolb, S.J., Harmison, G.G., Jeffries, N.O., Schadt, K., Finkel, R.S., Dreyfuss, G., and Fischbeck, K.H. 2006. SMN mRNA and Protein Levels in Peripheral Blood: Biomarkers for SMA Clinical Trials. Neurol., 66:1067-73. PubMed Citation
Kolb, S.J., Gubitz, A.K., Olszewski, R.F., Ottinger, E., Sumner, C.J., Fischbeck, K.H., and Dreyfuss, G. 2006. A Novel Cell Immunoassay to Measure Survival of Motor Neurons Protein in Blood Cells. BMC Neurol., 6:6. PubMed Citation
Golembe, T., Yong, J., and Dreyfuss, G. 2005. Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPs. Mol Cell Biol., 25:10989-11004. PubMed Citation
Ma, Y.L., Dostie, J., Dreyfuss, G. and Van Duyne, G. 2005. Crystal structure of Gemins6-7 heterodimer from the Survival of Motor Neurons complex has an Sm protein-like structure. Structure, 13:883-892. PubMed Citation
Wan, L., Battle, D.J., Yong, J., Gubitz, A.K., Kolb, S.J., Wang, J. and Dreyfuss, G. 2005. The Survival of Motor Neurons Protein Determines the Capacity for snRNP Assembly: a Biochemical Deficiency in Spinal Muscular Atrophy. Mol Cell Biol., 25:5543-5551. PubMed Citation
Feng, W., Gubitz, A.K., Wan, L., Battle, D.J., Dostie, J., Golembe, T.J., and Dreyfuss, G. 2005. Gemins Modulate the Expression and Activity of the SMN Complex. Hum Mol Gen., 14:1605-1611. PubMed Citation
Golembe, T., Feng, W., and Dreyfuss, G. 2005. Lymphotropic Herpesvirus Saimiri uses the SMN complex to assemble Sm cores in its small RNAs. Mol Cell Biol., 25:602-611. PubMed Citation
Gubitz, A., Feng, W., and Dreyfuss, G. 2004. The SMN Complex. Exper Cell Res., 296:51-56. PubMed Citation
Yong, J., Wan, L. and Dreyfuss, G. 2004. Why do cells need an assembly machine for RNA-protein complexes? Trends Cell Biol., 15:226-232. PubMed Citation
Yong, J., Golembe, T., Battle, D.J., Pellizzoni, L. and Dreyfuss, G. 2004. snRNAs contain specific SMN-binding domains that are essential for snRNP assembly. Mol Cell Biol., 24:2747-2756. PubMed Citation
Kataoka, N. and Dreyfuss, G. 2004. A simple whole cell lysate system for in vitro splicing reveals a stepwise-assembly of the exon-exon junction complex. J Biol Chem., 279:7009-7013. PubMed Citation
Chan, C., Dostie, J., Diem, M., Feng, W., Mann, M., Rappsilber, J. and Dreyfuss, G. 2004. eIF4A3 is a novel component of the Exon Junction Complex. RNA, 10:200-209. PubMed Citation
Kawano, T., Kataoka, N., Dreyfuss, G. and Sakamoto, H. 2004. Ce-Y14 and MAG-1, components of the exon-exon junction complex, are required for embryogenesis and germline sexual switching in Caenorhabditis elegans. Mech Dev., 121:27-35. PubMed Citation
Rappsilber, J., Friesen, W.J., Paushkin, S., Dreyfuss, G. and Mann, M. 2003. Detection of arginine dimethylated peptides by parallel precursor ion scanning mass spectrometry in positive ion mode. Anal Chem., 75:3107-3114. PubMed Citation
Lau, C.-K., Diem, M.D., Dreyfuss, G. and Van Duyne, G.D. 2003. Structure of the Y14-Magoh core of the exon junction complex. Curr Biol., 13:933-941. PubMed Citation
Ambros, V., Barte, B., Bartel, D.P., Burge, C.B., Carrington, J.C., Chen, X., Dreyfuss, G., Eddy, SR., Griffiths-Jones, S., Marshall, M., Matzke, M., Ruvkun, G. and Tuschl, T. 2003. A uniform system for microRNA annotation. RNA, 9:277-279. PubMed Citation
Dostie, J., Mourelatos, Z., Yang, M., Sharma, A., and Dreyfuss, G. 2002. Numerous microRNPs in neuronal cells containing novel microRNAs. RNA, 9:180-186. PubMed Citation
Pellizzoni, L., Yong, J., and Dreyfuss, G. 2002. The SMN complex is a specificity factor essential for snRNP assembly. Science, 298:1775-1779. PubMed Citation
Massenet, S., Pellizzoni, L., Paushkin, S., Mattaj, I.W., and Dreyfuss, G. 2002. The SMN complex is associated with snRNPs throughout their cytoplasmic assembly pathway. Mol Cell Biol., 22:6533-6541. PubMed Citation
Baccon, J., Pellizzoni, L, Rappsilber, J., Mann, M., and Dreyfuss, G. 2002. Identification and characterization of Gemin7, a novel component of the Survival of Motor Neuron Complex. J Biol Chem., 277:31957-31962. PubMed Citation
Dostie, J. and Dreyfuss, G. 2002. Translation is required to remove Y14 from mRNAs in the cytoplasm. Curr Biol., 12:1060-1067. PubMed Citation
Paushkin, S., Gubitz, A.K., Massenet, S., and Dreyfuss, G. 2002. The SMN complex, an assemblyosome of RNPs. Curr Opin Cell Biol., 14:305-312. PubMed Citation
Mourelatos, Z., Dostie, J., Paushkin, S., Sharma, A., Charroux, B., Abel, L., Rappsilber, J., Mann, M. and Dreyfuss, G. 2002. miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev., 16:720-728. PubMed Citation
Yong, J.S., Pellizzoni, L. and Dreyfuss, G. 2002. Sequence-specific binding of SMN to U1 snRNA. EMBO J., 21:1188-1196. PubMed Citation
Pellizzoni, L., Baccon, J., Rappsilber, J., Mann, M., and Dreyfuss, G. 2002. Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component. J Biol Chem., 277:7540-7545. PubMed Citation
Gubitz, A.K., Mourelatos, Z., Mann, M., Abel, L., Rappsilber, J. and Dreyfuss, G. 2001. Gemin 5: A novel WD-40 repeat protein component of the SMN complex that binds Sm proteins. J Biol Chem., 277:5631-5636. PubMed Citation
Dreyfuss, G., Kim, V.N. and Kataoka, N. 2002. mRNA-binding proteins and the messages they carry. Nat Rev: Mol Cell Biol., 3:195-205. PubMed Citation
Friesen, W.J., Wyce, A., Paushkin, S., Abel, L., Rappsilber, J., Mann, M., and Dreyfuss G. 2002. A novel WD repeat protein component of the methylosome binds Sm proteins. J Biol Chem., 21:8289-8300. PubMed Citation
Kataoka, N., Diem, M.D., Kim, N.V., Yong, J., and Dreyfuss G. 2001. Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex. EMBO J., 20:6424-33. PubMed Citation
Kim, N.V. and Dreyfuss, G. 2001. Nuclear mRNA binding proteins couple pre-mRNA splicing and post-splicing events. Mol Cells., 12:1-10. PubMed Citation
Friesen, W.J., Paushkin, S., Wyce, A., Massenet, S., Pesiridis, G.S., Van Duyne, V., Rappsilber, J. Mann, M., and Dreyfuss, G. 2001. The methylosome: a 20S complex containing JBP1 and pICln produces dimethylarginine-modified Sm proteins. Mol Cell Biol., 24:8289-3. PubMed Citation
Kim, V.N., Kataoka, N., and Dreyfuss, G. 2001. Role of nonsense-mediated decay factor, hUpf3, in the splicing-dependent exon-exon junction complex. Science, 293:1832-6. PubMed Citation
Mourelatos, Z., Abel, L., Yong, J., Kataoka, N. and Dreyfuss, G. 2001. SMN interacts with a novel family of hnRNP and spliceosomal proteins. EMBO J., 20:5443-52 PubMed Citation
Wang, J. and Dreyfuss, G. 2001. Characterization of functional domains of the SMN protein in vivo. J Biol Chem., 276:45387-93. PubMed Citation
Pellizzonni, L., Baccon, J., Charroux, B. and Dreyfuss, G., 2001. The Survival of Motor Neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1. Curr Biol., 11:1079-1088. PubMed Citation
Friesen, W.J., Massenet, S., Paushkin, S., Wyce, A., and Dreyfuss, G., 2001. SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets. Mol Cell., 7:1111-1117. PubMed Citation
Kim, N.V., Yong, J., Kataoka, N., Abel, L., Diem, M.D., and Dreyfuss, G. 2001. The Y14 protein communicates to the cytoplasm the position of exon-exon junctions. EMBO J., 20:2062-2068. PubMed Citation
Wan, L., Kim, J.K, Pollard, V.W., and Dreyfuss, G. 2001. Mutational definition of RNA-binding and protein-protein interaction domains of hnRNP C1. J Biol Chem., 276:7681-7688. PubMed Citation
Wang, J. and Dreyfuss, G. 2001. A cell system with targeted disruption of the SMN gene: Functional conservation of the SMN protein and dependence of Gemin2 on SMN. J Biol Chem., 276:9599-9605. PubMed Citation
Pellizzoni, L., Charroux, B., Rappsilber, J., Mann, M., and Dreyfuss, G. 2001. A functional interaction between the SMN complex and RNA polymerase II. J Cell Biol., 152:75-85. PubMed Citation
Wan, L., Dockendorff, T.C., Jongen, T.A. and Dreyfuss, G. 2000. Characterization of dFMR1, a Drosophila homolog of the fragile X mental retardation protein. Mol Cell Biol., 20:8536-8547. PubMed Citation
Mizukami, K., Kamma, H., Ishikawa, M., Dreyfuss, G. 2000. Immunohistochemical study of the hnRNP A2 and B1 in the rate forebrain. NeuroReport, 11:3099-3102. PubMed Citation
Kataoka, N., Yong, J., Kim, V.N., Velazquez, F., Perkinson, R.A., Wang, F. and Dreyfuss, G. 2000. Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm. Mol Cell., 6:673-682. PubMed Citation
Friesen, W.J. and Dreyfuss, G. 2000. Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN). J Biol Chem., 275:26370-26375. PubMed Citation
Paushkin, S., Charroux, B., Abel, L., Pellizzoni, L. and Dreyfuss, G. 2000. The SMN protein of Schizosacharomyces pombe: conservation of SMN interaction domains in divergent organisms. J Biol Chem., 275:23841-23846. PubMed Citation
Charroux, B., Pellizzoni, L., Perkinson, R.A., Yong, J.S., Shevchenko, A., Mann, M, and Dreyfuss, G. 2000. Gemin4: a novel component of the SMN complex that is found in both gems and nucleoli. J Cell Biol., 148:1177-1186. PubMed Citation
Nakielny, S. and Dreyfuss, G. 1999. Transport of proteins and RNAs in and out of the nucleus. Cell, 99:677-690. PubMed Citation
Swanson, M.S. and Dreyfuss, G. 1999. Preparation of heterogeneous nuclear ribonucleoprotein complexes. Methods Mol Biol., 118:299-308. PubMed Citation
Charroux, B., Pellizzoni, L., Perkinson, R.A., Shevchenko, A., Mann, M. and Dreyfuss, G. 1999. Gemin3: a novel DEAD box protein that interacts with SMN, the Spinal Muscular Atrophy gene product, and is a component of gems. J Cell Biol., 147:1181-1193. PubMed Citation
Fischer, U., Pollard, V.W., Luhrmann, R., Teufel, M., Michael, W.M., Dreyfuss, G, and Malim, M.H. 1999. Rev-mediated nuclear export of RNA is dominant over nuclear retention and is coupled to the Ran-GTPase cycle. Nucleic Acids Res., 27:4128-4134. PubMed Citation
Pellizzoni, L., Charroux, B. and Dreyfuss, G. 1999. Specific sequences in SMN and SIP1 mediate their interactions with each other and with Sm proteins. Proc Natl Acad Sci USA, 20:11167-11172. PubMed Citation
Dreyfuss, G. and Struhl, K. 1999. Multiprotein complexes, mechanistic connections and nuclear organization. Curr Opin Cell Biol., 11:303-306.
Kataoka, N., Bachorik, J.L. and Dreyfuss, G. 1999. Transportin-SR, a nuclear import receptor for SR proteins. J Cell Biol., 145:1145-1152. PubMed Citation
Nakielny, S., Shaihk, S., Burke, B. and Dreyfuss, G. 1999. Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain. EMBO J., 18:1982-1995. PubMed Citation
Kamma, H., Horiguchi, H., Wan, L., Matsui, M., Fujiwara, M., Fujimoto, M., Yazawa, T. and Dreyfuss, G. 1999. Molecular characterization of the hnRNP A2/B1 proteins: tissue-specific expression and novel isoforms. Exp Cell Res., 246:399-411. PubMed Citation
Pellizzoni, L., Kataoka, N., Charroux, B. and Dreyfuss, G. 1998. A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing. Cell, 95:615-624. PubMed Citation
Siomi, M.C., Fromont, M., Rain, J.-C., Wan, L., Wang, F., Legrain, P. and Dreyfuss, G. 1998. Functional conservation of the transportin nuclear import pathway in divergent organisms. Mol Cell Biol., 18:4141-4148. PubMed Citation
Hassfeld, W., Chan, E.K.L., Mathison, D.A., Portman, D., Dreyfuss, G., Steiner, G. and Tan, E.M. 1998. Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P. Nucleic Acids Res., 15:439-45. PubMed Citation
Nakielny, S. and Dreyfuss, G. 1997. Import and export of the nuclear protein import receptor transportin by a mechanism independent of GTP hydrolysis. Curr Biol., 8:89-95. PubMed Citation
Siomi, M.C., Eder, P.S., Kataoka, N., Wan, L., Liu, Q. and Dreyfuss, G. 1997. Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. J Cell Biol., 138:1181-1192. PubMed Citation
Fischer, U., Liu, Q. and Dreyfuss, G. 1997. The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis. Cell, 90:1023-1029. PubMed Citation
Liu, Q., Fischer, U., Wang, F. and Dreyfuss, G. 1997. The spinal muscular atrophy disease gene product, SMN, and its associated protein, SIP1, are in a complex with spliceosomal snRNP proteins. Cell, 90:1013-1021. PubMed Citation
Siomi, H. and Dreyfuss, G. 1997. RNA-binding proteins as regulators of gene expression. Curr Opin Genet Dev., 7:345-353. PubMed Citation
Nakielny, S. and Dreyfuss, G. 1997. Nuclear export of proteins and RNAs. Curr Opin Cell Biol., 9:420-429. PubMed Citation
Lefebvre, S., Burlet, P., Liu, Q., Bertrandy, S., Clermont, O., Munnich, A., Dreyfuss, G. and Melki, J. 1997. Correlation between severity and SMN protein level in spinal muscular atrophy. Nat Genet., 16:265-269. PubMed Citation
Michael, W.M., Eder, P. and Dreyfuss, G. 1997. The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K protein. EMBO J., 16:3587-3598. PubMed Citation
Portman, D.S., O'Connor, J.P. and Dreyfuss, G. 1997. YRA1, an essential Saccharomyces cerevisiae gene, encodes a novel protein with RNA annealing activity. RNA, 3:527-537. PubMed Citation
Izaurralde, E., Jarmolowski, A., Beisel, C., Mattaj, I.W., Dreyfuss, G. and Fischer, U. 1997. A role for the M9-transport signal of hnRNP A1 in mRNA nuclear export. J Cell Biol., 137:27-35. PubMed Citation
Nakielny, S., Fischer, U., Michael, W.M. and Dreyfuss, G. 1997. RNA transport. Annu Rev Neurosci.,20:269-301. PubMed Citation
Waterhouse, H., Kumar, S., Song, Q., Strike, P., Sparrow, L., Dreyfuss, G., Alnemri, E.S., Litwack, G., Lavin, M., Watters, D. 1996. Heteronuclear ribonucleoproteins C1 and C2, components of the spliceosome, are specific targets of interleukin lbeta-converting enzyme-like proteases in apoptosis. J Biol Chem., 46:29335-29341. PubMed Citation
Svitkin, Y.V., Ovchinnikov, L.P., Dreyfuss, G. and Sonenberg, N. 1996. General RNA-binding proteins render translation cap-dependent. EMBO J., 15:7147-7155. PubMed Citation
Nakielny, S., Siomi, M., Siomi, H., Michael, W.M., Pollard, V. and Dreyfuss, G. 1996. Transportin: nuclear transport receptor of a novel nuclear protein import pathway. Exp Cell Res., 229:261-266. PubMed Citation
Liu, Q., Siomi, H., Siomi, M.C., Fischer, U., Zhang, Y., Wan, L., Dreyfuss G. 1996. Molecular characteriaction of the protein products of the fragile X syndrome gene and the survival of motor neurons gene. Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor Press, Vol. 61:689-697. PubMed Citation
Pollard, V.W., Michael, W.M., Nakielny, S., Siomi, M.C., Wang, F., Dreyfuss G. 1996. A novel receptor-mediated nuclear protein import pathway. Cell, 86:985-994. PubMed Citation
Dreyfuss, G., Hentze, M. and Lamond, A.I. 1996. Meeting Review - From Transcript to Protein. Cell, 85:963-972. PubMed Citation
Fischer, U., Michael, M., Lührmann, R. and Dreyfuss, G. 1996. Signal-mediated nuclear export pathways of proteins and RNAs. Trends Cell Biol., 6:290-293. PubMed Citation
Nakielny, S. and Dreyfuss, G. 1996. The hnRNP C proteins contain a nuclear retention sequence that can override nuclear export signals. J. Cell Biol., 134:1365-1373. PubMed Citation
Siomi, M.C., Zhang, Y., Siomi, H. and Dreyfuss, G. 1996. Specific sequences in the fragile X syndrome protein, FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interaction among them. Mol Cell Biol., 16:3825-3832. PubMed Citation
Michael, W.M. and Dreyfuss, G. 1996. Distinct domains in ribosomal protein L5 mediate 5 S rRNA binding and nucleolar localization. J Biol Chem., 27:11571-11574. PubMed Citation
Liu, Q. and Dreyfuss, G. 1996. A novel nuclear structure containing the survival of motor neurons protein. EMBO J., 15:3555-3565. PubMed Citation
Michael, W.M., Siomi, H., Choi, M., Píñol-Roma, S., Nakielny, S., Liu, Q. and Dreyfuss, G. 1995. Signal sequences that target nuclear import and nuclear export of pre-mRNA-binding proteins. Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor Press, Vol. 60:663-668. PubMed Citation
Michael, W.M., Choi, M. and Dreyfuss, G. 1995. A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway. Cell, 83:415-422. PubMed Citation
Kamma, H., Portman, D. and Dreyfuss, G. 1995. Cell-type-specific expression of hnRNP proteins. Exp Cell Res., 221:187-196. PubMed Citation
Zhang, Y., O'Connor, J.P., Siomi, M.C., Srinivasan, S., Dutra, A., Nussbaum, R. and Dreyfuss, G. 1995. The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. EMBO J., 14:5358-5366. PubMed Citation
Siomi, M.C., Siomi, H., Sauer, W.H., Srinivasan, S., Nussbaum, R.L. and Dreyfuss, G. 1995. FXR1, an autosomal homolog of the Fragile X mental retardation gene. EMBO J., 14:2401-2408. PubMed Citation
Liu, Q. and Dreyfuss, G. 1995. In vivo and in vitro arginine methylation of RNA-binding proteins. Mol Cell Biol., 15:2800-2808. PubMed Citation
Siomi, H. and Dreyfuss, G. 1995. A nuclear localization domain in the hnRNP A1 protein. J Cell Biol., 129:551-560. PubMed Citation
Bustelo, X.R., Suen, K-L., Michael, W.M., Dreyfuss, G. and Barbacid, M. 1995. Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins. Mol Cell Biol., 15:1324-1332. PubMed Citation
Matunis, M.J., Matunis, E.L. and Dreyfuss, G. 1994. Isolation and analysis of RNA-binding proteins. In: Methods Cell Biol., L.S.B. Goldstein and E.A. Fyrberg, (eds.), Academic Press, New York.
Görlach, M., Burd, C.G. and Dreyfuss, G. 1994. The determinants of RNA-binding specificity of the heterogeneous nuclear ribonucleoprotein C proteins. J Biol Chem., 269:23074-23078. PubMed Citation
Kiledjian, M., Burd, C.G., Görlach, M., Portman, D.S. and Dreyfuss, G. 1994. Structure and function of hnRNP proteins. In: RNA-protein interactions: Frontiers in Molecular Biology, pp. 127-149, K. Nagai and I. Mattaj (ed.) Oxford University Press, Oxford.
Burd, C. and Dreyfuss, G. 1994. Conserved structures and diversity of functions of RNA-binding proteins. Science, 265:615-621. PubMed Citation
Weng, Z., Thomas, S.M., Rickles, R.J. Taylor, J.A., Brauer, A. W., Seidel-Dugan, C., Michael, W. M., Dreyfuss, G. and Brugge, J. S. 1994. Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains. Mol Cell Biol., 14:4509-4521. PubMed Citation
Görlach, M., Burd, C.G. and Dreyfuss, G. 1994. The mRNA poly(A)-binding protein: localization, abundance and RNA-binding specificity. Exp Cell Res., 211:400-407. PubMed Citation
Siomi, H., Choi, M., Siomi, M.C., Nussbaum, R.L. and Dreyfuss, G. 1994. Essential role for KH domains in RNA binding: impaired RNA binding by a mutation in the KH domain of FMR-1 that causes fragile X syndrome. Cell, 77:33-39. PubMed Citation
Matunis, E.L., Matunis, M.J., Kelley, R. and Dreyfuss, G. 1994. Essential role for an hnRNP protein in oogenesis: hrp 40 is absent from the germline in the dorsoventral mutant squid, Proc Natl Acad Sci USA., 91:2781-2784. PubMed Citation
Matunis, M.J., Xing, J. and Dreyfuss, G. 1994. The hnRNP F protein: unique primary structure, nucleic acid-binding properties, and subcellular localization. Nucleic Acids Res., 22:1059-1067. PubMed Citation
Burd, C.G. and Dreyfuss, G. 1994. RNA-binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing. EMBO J., 13:1197-1204. PubMed Citation
Portman, D. and Dreyfuss, G. 1994. RNA annealing activities in HeLa nuclei. EMBO J., 13:213-221. PubMed Citation
Takimoto, M., Tamonaga, T., Matunis, M., Abigan, M., Krutzsch, H., Dreyfuss, G. and Levens, D. 1993. Specific binding of heterogeneous ribonucleoprotein particle protein K to the human c-myc promoter, in vitro. J Biol Chem., 268:18249-18258. PubMed Citation
Soulard, M., Della Valle, V., Siomi, M.C., Píñol-Roma, S., Codogno, P., Bauvy, C., Belli, M., Lacroix, J.-C., Dreyfuss, G. and Larsen, C.J. 1993. hnRNP G: sequence and characterization of glycosylated RNA-binding protein. Nucleic Acids Res., 21:4210-4217. PubMed Citation
Matunis, M.J., Matunis, E.L. and Dreyfuss, G. 1993. PUB1: A major yeast poly(A)+ RNA-binding protein. Mol Cell Biol., 13:6114-6123. PubMed Citation
Piñol-Roma, S. and Dreyfuss, G. 1993. Cell cycle-regulated phosphorylation of the pre-mRNA-binding (heterogeneous nuclear ribonucleoprotein) C proteins. Mol Cell Biol., 13:5762-5770. PubMed Citation
Görlach, M., Burd, C.G., Portman, D.S. and Dreyfuss, G. 1993. The hnRNP proteins. Mol Biol Rep., 18:73-78. PubMed Citation
Siomi, H., Siomi, M.C., Nussbaum, R.L. and Dreyfuss, G. 1993. The protein product of the fragile X gene, FMR-1, has characteristics of an RNA binding protein. Cell, 74:291-298. PubMed Citation
Ishikawa, F., Matunis, M.J., Dreyfuss, G. and Cech, T.R. 1993. Nuclear Proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n. Mol Cell Biol. , 13:4301-4310. PubMed Citation
Dreyfuss, G., Matunis, M.J., Píñol-Roma, S. and Burd, C. 1993. hnRNP proteins and the biogenesis of mRNA. Annu Rev Biochem., 62:289-321. PubMed Citation
Piñol-Roma, S. and Dreyfuss, G. 1993. hnRNP proteins: Localization and transport between nucleus and cytoplasm. Trends Cell Biol., 3:151-155. PubMed Citation
Matunis, E.L., Matunis, M. J. and Dreyfuss, G. 1993. Association of individual hnRNP proteins and snRNPs with nascent transcripts in Drosophila. J Cell Biol., 121:219-228. PubMed Citation
Siomi, H., Matunis, M.J., Michael, W.M. and Dreyfuss, G. 1993. The pre-mRNA binding K protein contains a novel evolutionarily conserved motif. Nucleic Acids Res., 21:1193-1198. PubMed Citation
Datar, K.V., Dreyfuss, G. and Swanson, M.S. 1993. The human hnRNP M proteins: Identification of a methionine/arginine-rich repeat motif in ribonucleoproteins. Nucleic Acids Res., 21:439-446. PubMed Citation
Ludevid, L., Burd, C., Dreyfuss, G. and Pagès, M. 1992. RNA binding characteristics of a 16 kDa glycine-rich protien from maize. Plant J., 2:999-1003. PubMed Citation
Görlach, M., Wittekind, M., Beckman, R.A., Mueller, L. and Dreyfuss, G. 1992. Interaction of the RNA-binding domain of the hnRNP C proteins with RNA. EMBO J., 11:3289-3295. PubMed Citation
Wittekind, M., Görlach, M., Friedrichs, M., Dreyfuss, G. and Mueller, L. 1992. 1H, 13C, and 15N NMR assignments and global folding pattern of the RNA binding domain of the human hnRNP C proteins. Biochem., 31:6254-6265. PubMed Citation
Ghetti, A., Píol-Roma, S., Michael, W.M., Morandi, C. and Dreyfuss, G. 1992. hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs. Nucleic Acids Res., 20:3671-3678. PubMed Citation
Kiledjian, M. and Dreyfuss, G. 1992. Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box.EMBO J., 11:2655-2664. PubMed Citation
Bennett, M., Píñol-Roma, S., Staknis, D., Dreyfuss, G and Reed, R. 1992. Differential binding of heterogeneous nuclear ribonucleoproteins to mRNA precursors prior to spliceosome assembly in vitro. Mol Cell Biol., 12:3165-3175. PubMed Citation
Piñol-Roma, S. and Dreyfuss, G. 1992. Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm. Nature, 355:730-732. PubMed Citation
Matunis, E.L., Matunis, M.J. and Dreyfuss, G. 1992. Characterization of the major hnRNP proteins from Drosophila melanogaster. J Cell Biol., 116:257-269.. PubMed Citation
Matunis, M.J., Matunis, E.L. and Dreyfuss, G. 1992. Isolation of hnRNP complexes from Drosophila melanogaster. J Cell Biol.,116:245-255. PubMed Citation
Matunis, M.J., Michael, W.M. and Dreyfuss, G. 1992. Characterization and Primary Structure of the poly(C)-binding hnRNP K protein. Mol Cell Biol., 12:164-171. PubMed Citation
Burd, C. G., Matunis, E. L. and Dreyfuss, G. 1991. The multiple RNA binding domains of the poly(A)-binding protein have different RNA-binding activities. Mol Cell Biol. , 11:3419-3424. PubMed Citation
Piñol-Roma, S. and Dreyfuss, G. 1991. Transcription-dependent and transcription-independent nuclear transport of hnRNP proteins. Science, 253:312-314. PubMed Citation
Piñol-Roma, S., Swanson, M.S., Matunis, M. and Dreyfuss, G. 1990. Purification and characterization of hnRNP proteins by affinity chromatography. Methods Enzymol. , 181:326-331. PubMed Citation
Piñol-Roma, S., Choi, Y.D. and Dreyfuss, G. 1990. Immunological methods for the purification and characterization of hnRNP particles. Methods Enzymol., 181:317-325. PubMed Citation
Dreyfuss, G., Swanson, M.S. and Píñol-Roma, S. 1990. The composition, structure, and organization of proteins in heterogeneous nuclear ribonucleoprotein complexes. in: "The Eukaryotic Nucleus: Structure and Function." Strauss, P. and Wilson, S. (eds.) The Telford Press. Caldwell, NJ
Burd, C. G., Swanson, M. S., Görlach, M., and Dreyfuss, G. 1989. Primary structure of the A2, B1 and C2 hnRNP proteins: a diversity of RNA binding proteins is generated by small peptide inserts. Proc Natl Acad Sci USA, 86:9788-9792. PubMed Citation
Dreyfuss, G., Choi, Y.D. and Adam, S.A. 1989. The ribonucleoprotein structures along the pathway of mRNA formation. Endocr Res., 15:441-474. PubMed Citation
Piñol-Roma, S., Swanson, M.S., Gall, J. G. and Dreyfuss, G. 1989. A novel hnRNP protein with a unique distribution on nascent transcripts. J Cell Biol.,109:2575-2587. PubMed Citation
Bandziulis, R.J., Swanson, M.S. and Dreyfuss, G. 1989. RNA-binding proteins as developmental regulators. Genes Dev ., 3:431-437. PubMed Citation
Mortenson, E. and Dreyfuss, G. 1989. RNP in maize protein. Nature, 337:312. PubMed Citation
Lamb, R.A. and Dreyfuss, G. 1989. RNA Structure: Unwinding with a Vengeance. Nature, 337:19-20. PubMed Citation
Piñol-Roma, S., Adam, S.A., Choi, Y.D. and Dreyfuss, G. 1989. Ultraviolet-induced crosslinking of RNA to proteins in vivo. Methods Enzymol., 180:410-418. PubMed Citation
Swanson, M.S. and Dreyfuss, G. 1988. RNA binding specificity of hnRNP proteins: a subset bind to the 3' end of introns. EMBO J., 7:3519-3529. PubMed Citation
Dreyfuss, G., Philipson, L. and Mattaj, I. 1988. Ribonucleoprotein particles in cellular processes. J Cell Biol., 106:1419-1425. PubMed Citation
Swanson, M.S. and Dreyfuss, G. 1988. Classification and purification of proteins of heterogeneous nuclear ribonucleoprotein particles by RNA binding specificities. Mol Cell Biol., 8:2237-2241. PubMed Citation
Dreyfuss, G., Swanson, M.S. and Píñol-Roma, S. 1988. Heterogeneous nuclear ribonucleoprotein particles and mRNA formation. Trends Biochem Sci., 13:86-91. PubMed Citation
Piñol-Roma, S., Choi, Y.D., Matunis, M. and Dreyfuss, G. 1988. Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins. Genes Dev., 2:215-227. PubMed Citation
Swanson, M.S., Pínol-Roma, S. and Dreyfuss, G. 1987. hnRNPs and mRNPs. Mol Biol Rep., 12:165-168.
Adam, S.A. and Dreyfuss, G. 1987. Adenovirus proteins associated with mRNA and hnRNA in infected HeLa cells. J Virol., 61:3276-3283. PubMed Citation
Swanson, M.S., Nakagawa, T.Y., LeVan, K. and Dreyfuss, G. 1987. Primary structure of human nuclear ribonucleoprotein particle C proteins: conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA, and pre-rRNA-binding proteins. Mol Cell Biol., 7:1731-1739. PubMed Citation
Dreyfuss, G. 1986. The structure and function of nuclear and cytoplasmic ribonucleoprotein particles. Annu Rev Cell Biol., (G. Palade, B. Alberts and J. Spudich, eds.) 2:459-498. PubMed Citation
Adam, S.A., Nakagawa, T.Y., Swanson, M.S., Woodruff, R. and Dreyfuss, G. 1986. mRNA polyadenylate binding protein: Gene isolation and sequencing and identification of a ribonucleoprotein (RNP) consensus sequence. Mol Cell Biol., 6:2932-2943. PubMed Citation
Choi, Y.D., Grabowski, P., Sharp, P.A. and Dreyfuss, G. 1986. Heterogeneous nuclear ribonucleoproteins: role in RNA splicing. Science, 231:1534-1539 PubMed Citation
Nakagawa, T., Swanson, M.S., Wold, B. and Dreyfuss, G. 1986. Molecular cloning of cDNA for the nuclear ribonucleoprotein particle C proteins: a conserved gene family. Proc Natl Acad Sci USA, 83:2007-2011 PubMed Citation
Adam, S.A., Choi, Y.D. and Dreyfuss, G. 1986. Interaction of mRNA with proteins in vesicular stomatitis virus-infected cells. J Virol., 57:614-622. PubMed Citation
Choi, Y.D. and Dreyfuss, G. 1984. Isolation of the hnRNA-ribonucleoprotein complex (hnRNP): a unique supramolecular assembly. Proc Natl Acad Sci USA, 81:7471-7475. PubMed Citation
Choi, Y.D. and Dreyfuss, G. 1984. Monoclonal antibody characterization of the C proteins of hnRNPs in vertebrate cells. J Cell Biol., 99:1997-2004. PubMed Citation
Dreyfuss, G., Choi, Y.D. and Adam, S.A. 1984. Characterization of hnRNA-protein complexes in vivo with monoclonal antibodies. Mol Cell Biol., 4:1104-1114. PubMed Citation
Dreyfuss, G., Adam, S.A. and Choi, Y.D. 1984. Physical change in cytoplasmic mRNPs in cells treated with inhibitors of transcription. Mol Cell Biol., 4:415-432. PubMed Citation
Boss, M.A., Dreyfuss, G. and Baltimore, D. 1981. Localization of the Abelson murine leukemia virus in a detergent insoluble subcellular matrix: architecture of the protein. J Virol., 40:472-481. PubMed Citation
Cervera, M., Dreyfuss, G. and Penman, S. 1981. Messenger RNA is translated when associated with the cytoskeletal framework in normal and VSV-infected HeLa cells. Cell,23:113-210. PubMed Citation
Burr, J., Dreyfuss, G., Penman, S. and Buchanan, J. 1980. Association of the src gene product of the Rous Sarcoma Virus with cytoskeletal structures of chick embryo fibroblasts. Proc Natl Acad Sci USA, 77:3484-3488. PubMed Citation
Dreyfuss, G., Schwartz, K.J. and Blout, E.T. 1978. Compartmentalization of cyclic AMP-dependent protein kinases in human erythrocytes. Proc Natl Acad Sci USA, 75:5926-5930. PubMed Citation
Dreyfuss, G., Schwartz, K.J., Blout, E.R., Barrio, J.R., Liu, F.T. and Leonard, N.H. 1978. Fluorescent photoaffinity labeling: Adenosine 3', 5'-cyclic monophosphate receptor sites. Proc Natl Acad Sci USA, 75:1199-1203. PubMed Citation