P. LESLIE DUTTON

1005 Stellar-Chance Labs
Dept. of Biochemistry & Biophysics
University of Pennsylvania
Philadelphia, PA  19104
Tel:  (215) 898-0991
Fax: (215) 573-2235
Email:  dutton@mail.med.upenn.edu

EDUCATION AND TRAINING

University of Wales, Biochemistry, Ph.D., 1967
University of Wales, Chemistry (Honors), B.Sc., 1963

RESEARCH AND PROFESSIONAL EXPERIENCE

2008 Member MRSEC Committee (NSF): Assembly of Nanoscale Protein Materials
1994- 2008 Chairman, Department of Biochemistry and Biophysics, University of Pennsylvania
1993-1994 Acting Chairman, Department of Biochemistry and Biophysics, University of  Pennsylvania
1991- Director, Johnson Research Foundation, University of Pennsylvania
1981-  Professor, Department of Biochemistry and Biophysics, University of Pennsylvania
1976 Associate Professor, Department of Biochemistry and Biophysics, University of Pennsylvania
1971 Assistant Professor, Johnson Research Foundation, University of Pennsylvania 
1968 Post Doctoral Fellow with Britton Chance, Johnson Research Foundation, University of Pennsylvania
1967 Post Doctoral Fellow with W. Charles Evans, Department of Biochemistry and Soil Science, University of Wales 

ADJUNCT APPOINTMENTS

2001- Visiting Senior Fellow, St. John’s College, Oxford
1995-1998 Visiting Professor, University College, London
1994- Visiting Professor, Imperial College, London
1975-1978

Visiting Scientist, Bell Research Laboratories, Murray Hill, New Jersey

HONORS AND AWARDS

2007 The First Sir William Dunn Scholar, Cambridge
2006 Randolph T. Major Medal: Merck & Company and The University of Connecticut
2002 Frontiers in Biological Chemistry Award: Max Planck Institute Mulheim, Germany
2001 Senior Visiting Fellowship, St. John's College, Oxford
1999 John Morgan Society
1995 IBM Partnership Award
1994 Keilin Medal of the Biochemical Society
1994 Peter Mitchell, Glynn Medal
1994 Fellow of the University College, University of Wales
1991 Eldridge Reeves Johnson Professor
1990 Fellow of the Royal Society
1989 U.S. national Institutes of health Merit Award
1976 Honorary MA, University of Pennsylvania
1974-1979 U.S. National Institutes of Health Research Career  Development Award  

SELECTED PUBLICATIONS

  1. Cerda, J.F., Koder, R.L.,  Lichtenstein, B.R., Moser, C.C., Miller, A-F., and Dutton, P.L.  Hydrogen Bond-free Flavin Redox Properties: Managing Flavins in Extreme Aprotic Solvents.  Organic and Biomolecular Chemistry, 6: 2204-2212,  2008.

  2. Jones, A.K., Lichtenstein, B.R., Dutton, A., Gordon, G., and Dutton, P. L.  Synthetic Hydrogenases: Incorporation of an Iron Carbonyl Thiolate into a Designed Peptide. J. Am. Chem. Soc. 129: 14844-14845, 2007.

  3. Koder, R.L., Valentine, K.G., Cerda, J, Noy, D., Wand, A.J., and Dutton, P.L.  Nativelike Structure in Designed Four a-helix Bundles Driven by Buried Polar Interactions. J. Am. Chem. Soc.  Vol 128, 45: 14450-14451, 2006

  4. Moser, C.C., Page, C.C., and Dutton, P.L.  Darwin at the Molecular Scale: Selection and Variance in Electron Tunneling Proteins Including Cytochrome c oxidase. Phil. Trans. R. Soc. B 361: 1295-1305, 2006.

  5. Koder, R.L., Dutton, P. L. Intelligent Design: the De Novo Engineering of Proteins with Specified Functions. Dalt. Trans, 3045-3051, 2006.

  6. Noy, D., Moser, C.C. and Dutton. P.L. Design and Engineering of Photosynthetic Light-Harvesting and Electron Transfer Using Length, Time, and Energy Scales. Biochim. Biophys. Acta. 1757: 90-105, 2006.

  7. Moser C.C., Page, C.C., and Dutton, P.L. Tunneling in PSII. Photochemical and Photobiological Sciences 4: 933-939, 2005.

  8. Noy, D., Discher, B.M., and Dutton, P.L., Design and Synthesis of Light Energy Harvesting Proteins (Chapter 2). In Energy Harvesting Materials. University of East Anglia Publishers, United Kingdom (Andrews, D.L. ed.)  27-64, 2005.

  9. Noy, D., Discher, B. M., Rubtsov, I., Hochstrasser, R., and Dutton, P.L.  Design of Amphiphilic Protein Maquettes: Enhancing Maquette Functionality through Binding of Extremely Hydrophobic Co Factors to Lipophilic Domains. Biochemistry,  44: 12344-12354, 2005.

  10. Discher, B., Noy, D.,  Strzalka, J., Ye, S., Moser, C.C., Lear, J., Blasie, J.K., and Dutton, P. L. Design of Amphiphilic Protein Maquettes: Controlling  Assembly, Membrane Insertion, and Cofactor Interactions.  Biochemistry,  44: 12329-12343, 2005.