BIOSKETCH LEE SOLOMON

1004 Stellar-Chance Labs
Dept. of Biochemistry & Biophysics
University of Pennsylvania
Philadelphia, PA  19104
Tel:  (215) 898-5668
Fax: (215) 573-2235
Email: solomoan@mail.med.upenn.edu

EDUCATION

B.A./M.S. –combined- SUNY at Buffalo, Buffalo, NY
Biological Sciences 2001-2006

PRINCIPAL RESEARCH INTERESTS

Understanding the physical chemistry of protein-cofactor assembly by using protein maquettes and a variety of heme-b analogues
Understanding ways to modulate the redox potential of a cofactor within a protein maquette by means of alternative cofactor placement, protein surface charge, and effects on ligand bond strength
Understanding how the assembly and redox potential work to modulate the lifetime and stability of the heme-oxygen bound state

SELECTED PUBLICATIONS

Koder, R. L., Anderson, J. L. R., Solomon, L. A., Reddy, K. S., Moser, C. C., & Dutton, P. L. Design and engineering of an O2 transport protein. Nature 458, 305-309, 2009.