Perelman School of Medicine at the University of Pennsylvania

Eckmann Lab

Our Publications

 
2017 | 2016 |  2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 19981996 | 1995 | 1992 | 1990 | 1988PATENTS

 

2017

Ramakrishnan N, Roychoudhury A, Eckmann DM, Ayyaswamy PS, Baumgart T, Pucadyil T, Shivprasad P, Weaver V, Radhakrishnan R. Excess area dependent scaling behavior of nano-sized membrane tethers. Accepted to Physical Biology, 2017.

Jang DH, Seeger S, Grady ME, Shofer FS, Eckmann DM. Mitochondrial dynamics and respiration within cells with increased open pore cytoskeletal meshes. Accepted to Bilogy Open, 2017.

Yu H-Y, Jabeen Z, Eckmann DM, Ayyaswamy PS, Radhakrishnan R. Microstructure of flow-driven suspension of hardspheres in cylindrical confinement: a dynamical density functional theory and Monte Carlo study. Accepted to Langmuir, 2017.

Ranganathan A, Campo J, Myerson J, Shuvaev V, Zern B, Muzykantov, V, Eckmann DM. Fluorescence microscopy imaging calibration for quantifying nanocarrier binding to cells during shear flow exposure. Journal of Biomedical Nanotechnology, 2017; 13: 737-745.

Kandel J, Picard M, Wallace DC, Eckmann DM. MtDNA 3243A>G heteroplasmy is associated with changes in cytoskeletal protein expression and cell mechanics. Journal of the Royal Society Interface, 2017; 14: 20170071.

Lee HS, Myers C, Zaidel L, Nalam PC, Caporizzo MA, Daep C, Eckmann DM, Masters JG, Composto RJ. Competitive adsorption of polyelectrolytes onto and into pellicle coated hydroxyapatite investigated by QCM-D and force spectroscopy. ACS Applied Materials & Interfaces, 2017; 9: 13079-13091.

Ramakrishnan N, Wang Y, Eckmann DM, Ayyaswamy PS, Radhakrishnan R. Motion of a nano-ellipsoid in a cylindrical vessel flow: Brownian and hydrodynamic interactions. Journal of Fluid Mechanics, 2017; 821: 117-152.

Nalam PC, Lee HS, Bhatt N, Carpick RW, Eckmann DM, Composto RJ. Nanomechanics of pH-responsive, drug-loaded bi-layered polymer grafts. ACS Applied Materials & Interfaces, 2017; 9: 12936-12948.

Grady ME, Parrish E, Seeger S, Caporizzo, MA, Composto RJ*, Eckmann DM*. Intracellular nanoparticle dynamics affected by cytoskeletal integrity. Soft Matter, 2017; 13: 1873-1880. *Equal contributions as senior author.

Jang DH, Kelly M, Hardy K, Lambert DS, Shofer FS, Eckmann DM. A preliminary study in the alterations of mitochondrial respiration in patients with carbon monoxide poisoning measured in blood cells. Clinical Toxicology, 2017; 55: 579-584.

Barel O, Malicdan MC, Ben-Zeev B, Kandel J, Pri-Chen H, Stephen J, Castro IG, Metz J, Atawa O, Moshkovitz S, Ganelin E, Barshack I, Polak-Charcon S, Nass D, Marek-Yagel D, Amariglio N, Shalva N, Vilboux T, Ferreira C, Pode-Shakked B, Heimer G, Hoffmann C, Yardeni T, Nissenkorn A, Avivi C, Eyal E, Kol N, Saar EG, Wallace DC, Gahl WA, Rechavi G, Schrader M, Eckmann DM, Anikster Y. Deleterious variants in TRAK1 disrupt mitochondrial movement and cause fatal encephalopathyBrain, 2017; 140: 568–581.

Jang DH, Greenwood JC, Spyres MB, Eckmann DM. Measurement of mitochondrial respiration and motility in acute care: Sepsis, trauma, and poisoningJournal of Intensive Care Medicine, 2017; 32: 86-94.

Radhakrishnan R, Yu H-Y, Eckmann DM, Ayyaswamy PS. Computational models for nanoscale biofluid dynamics inspired by non-equilibrium thermodynamicsASME Journal of Heat Transfer, 2017; 139: 033001-1-9.

 

2016

Farokhirad S, Bradley RP, Sarkar A, Shih A, Telesco S, Liu Y, Venkatramani R, Eckmann DM, Ayyaswamy PS and Radhakrishnan R. Computational Methods Related to Molecular Structure and Reaction Chemistry of Biomaterials. Chapter in Comprehensive Biomaterials II (P Ducheyne, Ed.), Elsevier, Oxford, UK, 2016

Yu H-Y, Eckmann DM, Ayyaswamy PS and Radhakrishnan R.Effect of wall-mediated hydrodynamic fluctuations on the kinetics of a Brownian nanoparticle. Royal Society Proceedings A, 2016; 472: 20160397-1-12.

Vitoshkin H, Yu H-Y, Eckmann DM, Ayyaswamy PS and Radhakrishnan R. Nanoparticle stochastic motion and hydrodynamic interactions close to a cylindrical wall. Physical Review Fluids, 2016; DOI:1: 054104-1-12

Kandel J, Angelin AA, Wallace DC and Eckmann DM. Mitochondrial respiration is sensitive to cytoarchitectural breakdown. Integrative Biology, 2016; 8: 1170-1182.

Ramakrishnan N, Tourdot RW, Eckmann DM, Ayyaswamy PS, Muzykantov VN and Radhakrishnan R. Biophysically inspired model for functionalized nanocarrier adhesion to cell surface: roles of protein expression and mechanical factors. R. Soc. Open Sci., 2016; DOI: 10.1098/rsos.160260.

Zhang Y, Barocas V, Clancy CE, Eckmann DM, Einstein D, Garbey M, Jin Y, Kassab GS, Lochner DR, McCulloch A, Tay RTS, Trayanova N. Multi-scale modeling of the cardiovascular system: disease development, progression, and clinical intervention.  Annals of Biomedical Engineering, 2016; 44: 2642–2660.

Clancy CE, An G, Cannon WR, Klassen T, Liu Y, May CC, Ortoleva P, Popel A, Sluka JP, Vicini P, Zhou X, Eckmann DM. Multi-scale modeling in the clinic: drug design and development. Annals of Biomedical Engineering, 2016; 44: 2591-2610.

Myerson J, Anselmo AC, Liu Y, Mitragotri S, Eckmann DM, Muzykantov VR. Non-affinity factors modulating vascular targeting of nanocarriers. Advanced Drug Delivery Reviews, 2016; 99(A):97-112.

Grady ME, Composto RJ, Eckmann DM. Cell elasticity with altered cytoskeletal architectures across multiple cell types. Journal of Mechanical Behavior of Biomedical Materials. 2016; 61:197-207.

 

2015

Caporizzo MA, Roco CM, Ferrer MCC, Grady ME, Parrish EP, Eckmann DM, Composto RJ. Strain-rate Dependence of Elastic Modulus Reveals Silver Nanoparticle Induced Cytotoxicity. Nanobiomedicine. 2015; 2:9. doi: 10.5772/61328

Sarkar A, Eckmann DM, Ayyaswamy PS, Radhakrishnan R. Hydrodynamic interactions of deformable polymeric nanocarriers and the effect of crosslinking. Soft Matter. 2015; 11(29):5955-69.

Lee HS, Stachelek SJ, Tomczyk N, Finley MJ, Composto RJ, Eckmann DM. Correlating macrophage morphology and cytokine production resulting from biomaterial contact. J Biomed Mater Res Part A 2013; 101A:203–212.

Chacko AM, Han J, Greineder CF, Zern BJ, Mikitsh JL, Nayak M, Menon D, Johnston IH, Eckmann DM, Davies PF, Muzykantov VR. Collaborative Enhancement of Endothelial Targeting of Nanocarriers by Modulating Platelet-Endothelial Cell Adhesion Molecule-1/CD31 Epitope Engagement. ACS Nano. 2015; 9(7):6785-93.

Han J, Shuvaev VV, Davies PF, Eckmann DM, Muro S, Muzykantov VR. Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1. Journal of Controlled Release: Official Journal of the Controlled Release Society. 2015; 210:39-47.

Kandel J, Chou P, Eckmann DM. Automated detection of whole-cell mitochondrial motility and its dependence on cytoarchitectural integrity. Biotechnology and Bioengineering. 2015; 112(7):1395-405.

Yu HY, Eckmann DM, Ayyaswamy PS, Radhakrishnan R. Composite generalized Langevin equation for Brownian motion in different hydrodynamic and adhesion regimes. Physical review. E, Statistical, Nonlinear, and Soft Matter Physics. 2015; 91(5):052303.

Lee HS, Dastgheyb SS, Hickok NJ, Eckmann DM, Composto RJ. Targeted release of tobramycin from a pH-responsive grafted bilayer challenged with S. aureus. Biomacromolecules. 2015; 16(2):650-9.

 

2014

Eckmann DM, Composto RJ, Tsourkas A, Muzykantov VR. Nanogel Carrier Design for Targeted Drug Delivery. Journal of Materials Chemistry. B, Materials for Biology and Medicine. 2014; 2(46):8085-8097.

Kandel J, Lee HS, Sobolewski P, Tomczyk N, Composto RJ, Eckmann DM. Chemically grafted fibronectin for use in QCM-D cell studies. Biosensors & Bioelectronics. 2014; 58:249-57.

Ferrer MC, Dastgheyb S, Hickok NJ, Eckmann DM, Composto RJ. Designing nanogel carriers for antibacterial applications. Acta biomaterialia. 2014; 10(5):2105-11

Liu J, Ayyaswamy PS, Eckmann DM, Radhakrishnan R. Modelling of Binding Free Energy of Targeted Nanocarriers to Cell Surface. Heat and Mass Transfer. 2014; 50(3):315-321.

Ferrier RC Jr, Lee HS, Hore MJ, Caporizzo M, Eckmann DM, Composto RJ. Gold nanorod linking to control plasmonic properties in solution and polymer nanocomposites. Langmuir : the ACS Journal of Surfaces and Colloids. 2014; 30(7):1906-14.

Ferrer MC, Shuvaev VV, Zern BJ, Composto RJ, Muzykantov VR, Eckmann DM. Icam-1 targeted nanogels loaded with dexamethasone alleviate pulmonary inflammation. PloS One. 2014; 9(7):e102329.

Klinger AL, Kandel J, Pichette B, Eckmann DM. Pefluorocarbon inhibition of bubble induced Ca2+ transients in an in vitro model of vascular gas embolism. Experimental Biology and Medicine. 2014; 239(1):116-22.

Eckmann DM, Eckmann YY, Tomczyk N. Dose response of surfactants to attenuate gas embolism related platelet aggregation. Heat and Mass Transfer. 2014; 50:323-331.

Eckmann DM. Miller’s Anesthesia. 8th Edition ed. Miller RD, editor. Philadelphia, PA: Elsevier; 2014. Chapter 71, Anesthesia for Bariatric Surgery.

 

2013

Lee HS, Tomczyk N, Kandel J, Composto RJ, Eckmann DM. Hemocompatibility of Chitosan/poly(acrylic acid) Grafted Polyurethane Tubing. Journal of Materials Chemistry. B, Materials for Biology and Medicine. 2013; 1(46)

Dastgheyb SS, Eckmann DM, Composto RJ, Hickok NJ. Photo-activated porphyrin in combination with antibiotics: therapies against Staphylococci. Journal of Photochemistry and pPhotobiology. B, Biology. 2013; 129:27-35.

Ferrer MC, Eckmann UN, Composto RJ, Eckmann DM. Hemocompatibility and biocompatibility of antibacterial biomimetic hybrid films. Toxicology and Applied Pharmacology. 2013; 272(3):703-12.

Eckmann DM, Armstead SC. Surfactant reduction of cerebral infarct size and behavioral deficit in a rat model of cerebrovascular arterial gas embolism. Journal of Applied Physiology. 2013; 115(6):868-76.

Eckmann DM, Tsai IY, Tomczyk N, Weisel JW, Composto RJ. Hyaluronan and dextran modified tubes resist cellular activation with blood contact. Colloids and Surfaces. B, Biointerfaces. 2013; 108:44-51.

Radhakrishnan R, Uma B, Liu J, Ayyaswamy PS, Eckmann DM. Temporal Multiscale Approach for Nanocarrier Motion with Simultaneous Adhesion and Hydrodynamic Interactions in Targeted Drug Delivery. Journal of Computational Physics. 2013; 244:252-263.

Ferrer MC, Hickok NJ, Eckmann DM, Composto RJ. Antibacterial Biomimetic Hybrid Films. Soft Matter. 2013; 8(8):2423-2431.

Ayyaswamy PS, Muzykantov V, Eckmann DM, Radhakrishnan R. Nanocarrier Hydrodynamics and Binding in Targeted Drug Delivery: Challenges in Numerical Modeling and Experimental Validation. Journal of Nanotechnology In Engineering and Medicine. 2013; 4(1):101011-1010115.

Ferrer MC, Sobolewski P, Composto RJ, Eckmann DM. Cellular Uptake and Intracellular Cargo Release From Dextran Based Nanogel Drug Carriers. Journal of Nanotechnology in Engineering and Medicine. 2013; 4(1):110021-110028.

Uma B, Radhakrishnan R, Eckmann DM, Ayyaswamy PS. A hybrid approach for the simulation of a nearly neutrally buoyant nanoparticle thermal motion in an incompressible Newtonian fluid medium. Journal of Heat Transfer. 2013; 135(1).

Lee HS, Stachelek SJ, Tomczyk N, Finley MJ, Composto RJ, Eckmann DM. Correlating macrophage morphology and cytokine production resulting from biomaterial contact. Journal of Biomedical Materials Research. Part A. 2013; 101(1):203-12.

Eckmann DM. Evidence Based Practice of Anesthesiology.3rd Edition ed. Fleisher LA, editor. Philadelphia, PA: Saunders; 2013. Chapter 36, Are there special techniques in obese patients?.

Lampe JW, Ayyaswamy PS, Eckmann DM. Proteins at Interfaces III. Horbett T, editor. Washington, DC: ACS Books; 2013. Chapter 18, Understanding the role of exogenous and endogenous surfactants in gas embolism. ; p.395-418.

 

2012

Ferrer MC, Ferrier RC Jr, Eckmann DM, Composto RJ. A facile route to synthesize nanogels doped with silver nanoparticles. Journal of Nanoparticle Research. 2012; 15:1323.

Lee HS, Yee MQ, Eckmann YY, Hickok NJ, Eckmann DM, Composto RJ. Reversible Swelling of Chitosan and Quaternary Ammonium Modified Chitosan Brush Layers: Effect of pH and Counter Anion Size and Functionality. Journal of Materials Chemistry. 2012; 22(37):19605-19616.

Uma B, Radhakrishnan R, Eckmann DM, Ayyaswamy PS. Nanocarrier-Cell Surface Adhesive and Hydrodynamic Interactions: Ligand-Receptor Bond Sensitivity Study. Journal of Nanotechnology in Engineering and Medicine. 2012; 3(3):310101-310108.

Uma B, Ayyaswamy PS, Radhakrishnan R, Eckmann DM. Fluctuating Hydrodynamics Approach for the Simulation of Nanoparticle Brownian Motion in a Newtonian Fluid. International Journal of Micro-Nano scale Transport. 2012; 3(1-2):13-20.

Uma B, Ayyaswamy PS, Radhakrishnan R, Eckmann DM. Modeling of a Nanoparticle Motion in a Newtonian Fluid: a Comparison Between Fluctuating Hydrodynamics and Generalized Langevin Procedures. Proc ASME Micro/Nanoscale Heat and Mass Transfer International Conference 2012; 2012:735-743.

Mukundakrishnan K, Ayyaswamy PS, Eckmann DM. Computational simulation of hematocrit effects on arterial gas embolism dynamics. Aviation, Space, and Environmental Medicine. 2012; 83(2):92-101.

Sobolewski P, Kandel J, Eckmann DM. Air bubble contact with endothelial cells causes a calcium-independent loss in mitochondrial membrane potential. PloS One. 2012; 7(10):e47254.

Muzykantov VR, Radhakrishnan R, Eckmann DM. Dynamic factors controlling targeting nanocarriers to vascular endothelium. Current Drug Metabolism. 2012; 13(1):70-81.

Uma B, Eckmann DM, Ayyaswamy PS, Radhakrishnan R. A hybrid formalism combining fluctuating hydrodynamics and generalized Langevin dynamics for the simulation of nanoparticle thermal motion in an incompressible fluid medium. Molecular Physics. 2012; 110(11-12):1057-1067.

Liu J, Agrawal NJ, Eckmann DM, Ayyaswamy PS, Radhakrishnan R. Innovations in Biomolecular Modeling and Simulation. Schlick T, editor. Cambridge, UK: Royal Society of Chemistry; 2012. Chapter 11, Top-down mesocale models and free energy calculations of multivalent protein-protein and protein-membrane interactions in nanocarrier adhesion and receptor trafficking; p.272-292.

 

2011

Eckmann DM. Intravital microscopy methods in microvascular blood flow and tissue oxygenation. Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc. 2011; 38(6):479-82.

Liao Z, Lampe JW, Ayyaswamy PS, Eckmann DM, Dmochowski IJ. Protein assembly at the air-water interface studied by fluorescence microscopy. Langmuir : the ACS Journal of Surfaces and Colloids. 2011; 27(21):12775-81.

Lee HS, Eckmann DM, Lee D, Hickok NJ, Composto RJ. Symmetric pH-dependent swelling and antibacterial properties of chitosan brushes. Langmuir : the ACS Journal of Surfaces and Colloids. 2011; 27(20):12458-65.

Klinger AL, Pichette B, Sobolewski P, Eckmann DM. Mechanotransductional basis of endothelial cell response to intravascular bubbles. Integrative Biology : Quantitative Biosciences From Nano to Macro. 2011; 3(10):1033-42.

Liu J, Bradley R, Eckmann DM, Ayyaswamy PS, Radhakrishnan R. Multiscale Modeling of Functionalized Nanocarriers in Targeted Drug Delivery. Current Nanoscience. 2011; 7(5):727-735.

Uma B, Swaminathan TN, Ayyaswamy PS, Eckmann DM, Radhakrishnan R. Generalized Langevin dynamics of a nanoparticle using a finite element approach: thermostating with correlated noise. The Journal of Chemical Physics. 2011; 135(11):114104.

Sobolewski P, Kandel J, Klinger AL, Eckmann DM. Air bubble contact with endothelial cells in vitro induces calcium influx and IP3-dependent release of calcium stores. American Journal of Physiology. Cell Physiology. 2011; 301(3):C679-86.

Swaminathan TN, Liu J, Balakrishnan U, Ayyaswamy PS, Radhakrishnan R, Eckmann DM. Dynamic factors controlling carrier anchoring on vascular cells. IUBMB Life. 2011; 63(8):640-7.

Liu J, Agrawal NJ, Calderon A, Ayyaswamy PS, Eckmann DM, Radhakrishnan R. Multivalent binding of nanocarrier to endothelial cells under shear flow. Biophysical Journal. 2011; 101(2):319-26.

Stachelek SJ, Finley MJ, Alferiev IS, Wang F, Tsai RK, Eckells EC, Tomczyk N, Connolly JM, Discher DE, Eckmann DM, Levy RJ. The effect of CD47 modified polymer surfaces on inflammatory cell attachment and activation. Biomaterials. 2011; 32(19):4317-26.

Uma B, Swaminathan TN, Radhakrishnan R, Eckmann DM, Ayyaswamy PS. Nanoparticle Brownian motion and hydrodynamic interactions in the presence of flow fields. Physics of Fluids. 2011; 23(7):73602-7360215.

Ombelli M, Costello L, Postle C, Anantharaman V, Meng QC, Composto RJ, Eckmann DM. Competitive protein adsorption on polysaccharide and hyaluronate modified surfaces. Biofouling. 2011; 27(5):505-18.

Tsai IY, Tomczyk N, Eckmann JI, Composto RJ, Eckmann DM. Human plasma protein adsorption onto dextranized surfaces: a two-dimensional electrophoresis and mass spectrometry study. Colloids and Surfaces. B, Biointerfaces. 2011; 84(1):241-52.

Calderon AJ, Bhowmick T, Leferovich J, Burman B, Pichette B, Muzykantov V, Eckmann DM, Muro S. Optimizing endothelial targeting by modulating the antibody density and particle concentration of anti-ICAM coated carriers. Journal of Controlled Release. 2011; 150(1):37-44. 

Calderon AJ, Baig M, Pichette B, Muzykantov V, Muro S, Eckmann DM. Effect of Glycocalyx on Drug Delivery Carriers Targeted to Endothelial Cells. International Journal of Transport Phenomena. 2011; 12(1-2):63-75. 

Lampe JW, Ayyaswamy PS, Eckmann DM. Using 3-D dense packing models to predict surface tension change due to protein adsorption. International Journal of Transport Phenomena. 2011; 12(3-4):283-300.

Tsai IY, Kuo CC, Tomczyk N, Stachelek SJ, Composto RJ, Eckmann DM. Human macrophage adhesion on polysaccharide patterned surfaces. Soft Matter. 2011; 7:3599-3606.

Kobayashi S, Crooks SD, Eckmann DM. In vitro surfactant mitigation of gas bubble contact-induced endothelial cell death. Undersea & Hyperbaric Medicine. 2011; 38(1):27-39.

 

2010

Swaminathan TN, Ayyaswamy PS, Eckmann DM. Surfactant properties differentially influence intravascular gas embolism mechanics. Annals of Biomedical Engineering. 2010; 38(12):3649-63.

Liu J, Weller GE, Zern B, Ayyaswamy PS, Eckmann DM, Muzykantov VR, Radhakrishnan R. Computational model for nanocarrier binding to endothelium validated using in vivo, in vitro, and atomic force microscopy experiments. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(38):16530-5.

Ferrer MC, Yang S, Eckmann DM, Composto RJ. Creating biomimetic polymeric surfaces by photochemical attachment and patterning of dextran. Langmuir : the ACS Journal of Surfaces and Colloids. 2010; 26(17):14126-34.

Lampe JW, Liao Z, Dmochowski IJ, Ayyaswamy PS, Eckmann DM. Imaging macromolecular interactions at an interface. Langmuir : the ACS Journal of surfaces and Colloids. 2010; 26(4):2452-9.

Swaminathan TN, Mukundakrishnan K, Ayyaswamy PS, Eckmann DM. Effect of a soluble surfactant on a finite sized bubble motion in a blood vessel. Journal of Fluid Mechanics. 2010; 642:509-539.

Eckmann DM. Essence of Anesthesia Practice. 3rd Edition ed. Fleisher LARoizen MD, editors. Philadelphia, PA: Elsevier; 2010. Gastric Bypass Stapling for Morbid Obesity.

 

2009

Eckmann DM. Polidocanol for endovenous microfoam sclerosant therapy. Expert Opinion On Investigational Drugs. 2009; 18(12):1919-27.

Mukundakrishnan K, Ayyaswamy PS, Eckmann DM. Bubble motion in a blood vessel: shear stress induced endothelial cell injury. Journal of Biomechanical Engineering. 2009; 131(7):074516.

Mukundakrishnan K, Eckmann DM, Ayyaswamy PS. Bubble motion through a generalized power-law fluid flowing in a vertical tube. Annals of the New York Academy of Sciences. 2009; 1161:256-67.

Calderon AJ, Muzykantov V, Muro S, Eckmann DM. Flow dynamics, binding and detachment of spherical carriers targeted to ICAM-1 on endothelial cells. Biorheology. 2009; 46(4):323-41. 

 Sinha AC, Eckmann DM. Miller’s Anesthesia. 7th Edition ed. Miller RD, editor. Philadelphia, PA: Elsevier; 2009. Chapter 64, Anesthesia for Bariatric Surgery.

 

2008

Mukundakrishnan K, Ayyaswamy PS, Eckmann DM. Finite-sized gas bubble motion in a blood vessel: non-Newtonian effects. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. 2008; 78(3 Pt 2):036303.

Eckmann DM. Evidence Based Practice of Anesthesiology. 2nd Edition ed. Fleisher LA, editor. Philadelphia, PA: Saunders; 2008. Are there special techniques in obese patients?

 

2007

Mukundakrishnan K, Quan S, Eckmann DM, Ayyaswamy PS. Numerical study of wall effects on buoyant gas-bubble rise in a liquid-filled finite cylinder. Physical review. E, Statistical, Nonlinear, and Soft Matter Physics. 2007; 76(3 Pt 2):036308. 

 

2006

Eckmann DM, Armstead SC. Influence of endothelial glycocalyx degradation and surfactants on air embolism adhesion. Anesthesiology. 2006; 105(6):1220-7.

Kobayashi S, Crooks S, Eckmann DM. Dose- and time-dependent liquid sclerosant effects on endothelial cell death. Dermatologic Surgery. 2006; 32(12):1444-52.

Sun Y, Chen J, Pruckmayr G, Baumgardner JE, Eckmann DM, Eckenhoff RG, Kelz MB. High throughput modular chambers for rapid evaluation of anesthetic sensitivity. BMC Anesthesiology. 2006; 6:13.

Eckmann DM. Air bubble growth in water. Anesthesiology. 2006; 105(5):1059; author reply 1059-60.

Ayyaswamy PS, Zhang J, Eckmann DM. Numerical modeling of the transport to an intravascular bubble in a tube with a soluble/insoluble surfactant. Annals of the New York Academy of Sciences. 2006; 1077:270-87.

Eckmann DM, Zhang J, Lampe J, Ayyaswamy PS. Gas embolism and surfactant-based intervention: implications for long-duration space-based activity. Annals of the New York Academy of Sciences. 2006; 1077:256-69.

Byrem WC, Armstead SC, Kobayashi S, Eckenhoff RG, Eckmann DM. A guest molecule-host cavity fitting algorithm to mine PDB for small molecule targets. Biochimica Et Biophysica Acta. 2006; 1764(8):1320-4.

Eckmann DM, Kobayashi S. Regarding "Stroke after varicose vein foam injection sclerotherapy". Journal of Vascular Surgery. 2006; 44(1):225; author reply 225-6.

Miksa D, Irish ER, Chen D, Composto RJ, Eckmann DM. Dextran functionalized surfaces via reductive amination: morphology, wetting, and adhesion. Biomacromolecules. 2006; 7(2):557-64.

Zhang J, Eckmann DM, Ayyaswamy PS. A front tracking method for a deformable intravascular axisymmetric bubble with a soluble surfactant. Journal of Computational Physics. 2006; 214:366-396.

 

2005

Eckmann DM, Armstead SC, Mardini F. Surfactants reduce platelet-bubble and platelet-platelet binding induced by in vitro air embolism. Anesthesiology. 2005; 103(6):1204-10.

Ombelli M, Composto RJ, Meng QC, Eckmann DM. A quantitative and selective chromatography method for determining coverages of multiple proteins on surfaces. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 2005; 826(1-2):198-205.

Eckmann DM, Kobayashi S, Li M. Microvascular embolization following polidocanol microfoam sclerosant administration. Dermatologic Surgery. 2005; 31(6):636-43.

 

2004

Suzuki A, Armstead SC, Eckmann DM. Surfactant reduction in embolism bubble adhesion and endothelial damage. Anesthesiology. 2004; 101(1):97-103.

Eckmann DM, Diamond SL. Surfactants attenuate gas embolism-induced thrombin production. Anesthesiology. 2004; 100(1):77-84.

 

2003

Sta Maria N, Eckmann DM. Model predictions of gas embolism growth and reabsorption during xenon anesthesia. Anesthesiology. 2003; 99(3):638-45.

Suzuki A, Eckmann DM. Embolism bubble adhesion force in excised perfused microvessels. Anesthesiology. 2003; 99(2):400-8.

Eckmann DM, Lomivorotov VN. Microvascular gas embolization clearance following perfluorocarbon administration. Journal of Applied Physiology. 2003; 94(3):860-8.

Eckmann DM. Variations in epidural catheter manufacture: implications for bending and stiffness. Regional Anesthesia and Pain Medicine. 2003; 28(1):37-42. 

Eckmann DM. The relationship between shear rate and vessel diameter. Anesthesia and Analgesia. 2003; 96:307-308.

 

2002

Ochroch EA, Eckmann DM. Clinical application of acoustic reflectometry in predicting the difficult airway. Anesthesia and Analgesia. 2002; 95(3):645-9, table of contents. 

Branger AB, Eckmann DM. Accelerated arteriolar gas embolism reabsorption by an exogenous surfactant. Anesthesiology. 2002; 96(4):971-9.

DeBisschop KM, Miksis MJ, Eckmann DM. Bubble rise in an inclined channel. Physics of Fluids. 2002; 14:93-106.

Cavanagh DP, Eckmann DM. The effects of a soluble surfactant on the interfacial dynamics of stationary bubbles in inclined tubes. Journal of Fluid Mechanics. 2002; 469:369-400.

Branger AB, Eckmann DM. Interfaces for the Twenty-First Century. Smith MK, Mikisi MJ,McFadden GB,Neitzel GP,Canright DR, editors. London: Imperial College Press; 2002. Manipulation of Intravascular Gas Embolism Dynamics with Exogenous Surfactants; p.244. 

Cavanagh DP, Eckmann DM. Interfaces for the Twenty-First Century. Smith MK, Mikisi MJ,McFadden GB,Neitzel GP,Canright DR, editors. London: Imperial College Press; 2002. Dynamic Effects of Surfactants on Stationary Bubbles in Liquid Flows; p.248. 

Eckmann DM. Interfaces for the Twenty-First Century. Smith MK, Mikisi MJ,McFadden GB,Neitzel GP,Canright DR, editors. London: Imperial College Press ; 2002. Soluble Surfactants and Contact Angle Dynamics; p.255.

 

2001

Branger AB, Lambertsen CJ, Eckmann DM. Cerebral gas embolism absorption during hyperbaric therapy: theory. Journal of Applied Physiology. 2001; 90(2):593-600.

Eckmann DM, Branger AB, Cavanagh DP. Wetting characteristics of aqueous surfactant-laden drops. Journal of Colloid and Interface Science. 2001; 242:386-394.

 

2000

Eckmann DM, Bowers S, Stecker M, Cheung AT. Hematocrit, volume expander, temperature, and shear rate effects on blood viscosity. Anesthesia and Analgesia. 2000; 91(3):539-45.

Eckmann DM. Transtracheal oxygen delivery. Critical Care Clinics. 2000; 16(3):463-72, vii.

Eckmann DM. Ventilatory support by tracheal gas insufflation and chest vibration during bronchoconstriction. Critical Care Medicine. 2000; 28(7):2533-9.

Eckmann DM, Branger AB, Cavanagh DP. Gas embolism. The New England Journal of Medicine. 2000; 342(26):2000-1; author reply 2001-2.

 

1999

Branger AB, Eckmann DM. Theoretical and experimental intravascular gas embolism absorption dynamics. Journal of Applied Physiology. 1999; 87(4):1287-95.

Cavanagh DP, Eckmann DM. Interfacial mechanics of stationary bubbles in flows in inclined tubes. Journal of Fluid Mechanics. 1999; 398:225-244.

 

1998

Eckmann DM, Swartz MA, Gavriely N, Glucksberg MR, Grotberg JB. Influence of intravenous perfluorocarbon administration on the dynamic behavior of lung surfactant. Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 1998; 26(4):359-66.

Cavanagh DP, Eckmann DM. Computational analysis of confined jet flow and mass transport in a blind tube. Journal of Biomechanical Engineering. 1998; 120(3):423-30.

Eckmann DM, Swartz MA, Glucksberg MR, Gavriely N, Grotberg JB. Perfluorocarbon induced alterations in pulmonary mechanics. Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 1998; 26(3):259-71.

Eckmann DM, Seligman I, Coté CJ, Hussong JW. Mucormycosis supraglottitis on induction of anesthesia in an immunocompromised host. Anesthesia and Analgesia. 1998; 86(4):729-30.

Eckmann DM. Bolus contaminant dispersion in oscillating flow in curved tubes. Journal of Biomechanical Engineering. 1998; 120(2):238-44.

 

1996

Eckmann DM, Glassenberg R, Gavriely N. Acoustic reflectometry and endotracheal intubation. Anesthesia and Analgesia. 1996; 83(5):1084-9.

Eckmann DM, Gavriely N. Chest vibration redistributes intra-airway CO2 during tracheal insufflation in ventilatory failure. Critical Care Medicine. 1996; 24(3):451-7.

 

1995

Gavriely N, Eckmann DM, Grotberg JB. Intra-airway gas transport during high-frequency chest vibration with tracheal insufflation in dogs. Journal of Applied Physiology. 1995; 79(1):243-50.

Eckmann DM, Gavriely N. Intra-airway CO2 distribution during airway insufflation in ventilatory failure. Journal of Applied Physiology. 1995; 78(2):546-54.

 

1992

Gavriely N, Eckmann D, Grotberg JB. Gas exchange by intratracheal insufflation in a ventilatory failure dog model. The Journal of Clinical Investigation. 1992; 90(6):2376-83.

 

1990

Eckmann DM, Grotberg JB. Experiments on transition to turbulence in oscillatory pipe flow. Journal of Fluid Mechanics. 1990; 222:329-350.

 

1988

Eckmann DM, Grotberg JB. Oscillatory flow and mass transport in a curved tube. Journal of Fluid Mechanics. 1988; 188:509-527.

PATENTS

Inventor: H.S. Lee, D.M. Eckmann, R.J. Composto and University of Pennsylvania “Antimicrobial polymer layers” US Patent App. 14/479,536 (Filed: Sep 8, 2014)