Welcome to the Penn Epigenetics Program

The Penn Epigenetics Program was established in 2009 by the Dean of Medicine to promote and develop basic research in chromatin biology and epigenetics, and to encourage collaborations between basic and clinical research in epigenetics. Toward this end, the Program offers monthly research meetings, sponsors seminars, organizes symposia, recruits faculty, galvanizes large program grants, and establishes technology cores, among other projects.
                                                                                                      Shelley L. Berger, Ph.D., Director
                                                                                                   Kenneth S. Zaret, Ph.D., Co-Director

New and Upcoming Events

UPCOMING EVENTS

Meetings for the Spring semester have been scheduled.  See the Program Events page for more details.  Next meeting is below.

June 14th, 2012, 4pm, TRC Building Room 11th floor, Rm. 146A

• Jason Kennerdell, Ph.D.
  • "Epigenetic regulation affects neurodegeneration and aging"
• Alexei Tulin, Ph.D.
  • "Reciprocal co-regulation of PARP-1 and nucleosomes"
    

BREAKING NEWS

From Dr. Mariusz Wasik's Lab:
with Qian Zhang:
IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK
http://www.uphs.upenn.edu/news/News_Releases/2011/08/lymphoma/
http://www.pnas.org/content/108/29/11977.abstract

From Dr. Ken Zaret's Lab:
Chengran, Xu, Ph.D. wrote:
Embryonic Cells: Predicting the Fate of Personalized Cells Next Step Toward New Therapies
http://www.sciencedaily.com/releases/2011/05/110519141605.htm

From Dr. Klaus Kaestner's Lab:
The nucleosome map of the mammalian liver
Zhaoyu Li, Jonathan Schug, Geetu Tuteja, Peter White and Klaus Kaaestner
http://www.ncbi.nlm.nih.gov/pubmed/21623366

From Dr. Mitchell Lazar's Lab:
A Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid Metabolism http://www.sciencemag.org/content/331/6022/1315.abstract

From Dr. Edward Morrisey's Lab:
Highly Efficient miRNA-Mediated Reprogramming of Mouse and Human Somatic Cells to Pluripotency
http://www.cell.com/cell-stem-cell/abstract/S1934-5909(11)00111-1

Information regarding the new NIH U54 "Epigenetics and Human Reproduction Center"
will be announced soon!

EPIGENETICS ROADMAP PROJECT

The Roadmap Project, sponsored by NIH, provides convergence of epigenomic data on this website:  More info can be found in our research section.