Welcome to the Feldser Lab at the University of Pennsylvania
Our lab is part of the Department of Cancer Biology and the Abramson Family Cancer Research Institute, two outstanding collectives of scientists working on diverse cancer related problems. Our work is dedicated to deconstructing the multistep process of tumorigenesis with the ultimate goal of developing potent strategies to eliminate cancer.
Histological view of a primary lung adenocarcinoma in the mouse. Advanced histological features include 1) multinucleate giant cells, 2) hyper chromatic nuclei, 3) prominent nucleoli, and 4) aberrant mitoses. The indicated mitotic figure in this image is being pulled in four directions and shows lagging chromosomes. This is a typical example of a moderately high grade tumor in our KrasG12D; p53LSL/LSL model.
RbTR alleles inactivate Rb gene function and report Rb gene expression. Fluorescence imaging reveals GFP expression levels reflect RbTR allele dosage.
Longitudinal bioluminescent imaging of a single mouse over time. Tumor cell abundance can be measured in vivo via luciferase based imaging platforms. We are utilizing this technology to study tumor regression due to defined genetic manipulations.