MD (1991). University of Milan, Milan, Italy
7 Dulles HUP,
3400 Spruce Street,
University of Pennsylvania,
Philadelphia, PA 19104-6100
The goal of my research is to understand the mechanisms by which mechanical ventilation promotes - or prevents - severe acute respiratory distress syndrome (ARDS), with the ultimate purpose of developing more targeted lung protective strategies (including innovative modalities of mechanical ventilation and new drugs).
Characterized by diffuse inflammation of both lungs, ARDS is a hypoxic syndrome that has no specific treatment and causes patients to require mechanical (artificial) ventilation to survive: 64% of them will eventually die. Preventing severe ARDS could be the best way to reduce mortality. Since certain settings of the mechanical ventilator (i.e. volumes and pressures delivered to the patient) decrease survival in patients, we hypothesize that mechanical ventilation may also affect the propagation and evolution of pulmonary inflammation. The effect of ventilation may be additive or synergistic with those of pharmacological agents that modulate lung injury.
Using various animal models, we concentrate on the mechanisms that lead to topographical dissemination of initially localized or mild pulmonary inflammation (i.e. acid aspiration, extrapulmonary sepsis). The combined use of CT and hyperpolarized MRI allows us to obtain morphological and functional information on pulmonary responses to lung injury and mechanical ventilation.