Monday February 28, 2011

7:20-8:00 AM

Continental Breakfast

8:00-8:15 AM

Introductory Remarks

Rahim Rizi, Ph.D.

University of Pennsylvania

8:15-8:30 AM

Welcome Remarks

R. Nick Bryan, M.D., Ph.D.

University of Pennsylvania

Session I

Keynote Lectures - Part I

Moderator: Masaru Ishii, M.D., Ph.D.

8:30-8:45 AM

Opportunities in Lung Imaging:  An NHLBI Perspective

Thomas L. Croxton, M.D., Ph.D.

National Institutes of Health

8:45-9:25AM

Pulmonary gas exchange in health and disease: Implications for assessment by imaging methods

Peter D. Wagner,  M.D.

University of California, San Diego

9:25-10:05 AM

CT Phenotypes of the Lung for New Insights into Pathophysiologic Processes and Genetic Correlates

Eric A. Hoffman, Ph.D.

University of Iowa

10:05-10:20 AM

Discussion

10:20-10:35 AM

Break

Session II    

COPD Pathogenesis and Pulmonary Inflammation

Moderator: Steven M. Albelda, M.D.

10:35-11:05 AM

Molecular Mechanisms of COPD Pathogenesis

Jeanine D'Armiento, M.D., Ph.D.

Columbia University

11:05-11:35 AM

Functional Effects of Pulmonary Inflammation

Jose G. Venegas, Ph.D.

Harvard University

11:35-12:05 PM

Regional inflammation in VILI

João Batista Borges, M.D., Ph.D.

University Hospital of Uppsala, Sweden

12:05-12:25 PM

Pulmonary Functional Imaging and Its Apllication to Thoracic Radiation Oncology

Ramesh Rengan, M.D., Ph.D.

University of Pennsylvania

12:25-12:40 PM

Discussion

12:40-1:40 PM

Lunch

Session III:   

Graduate Student and Postdoctoral Presentations - Part I

Moderator:  Kiarash Emami

1:40-2:10 PM

DW imaging in rats using C2F6: ADC comparison between healthy and emphysematous lungs

Laura Carrero-Gonzalez

Boehringer Ingelheim Pharma, Germany

Imaging of Lung Micromechanics with Hyperpolarized Gas Diffusion MRI: Regional Compliance

Yi Xin

University of Pennsylvania

Noninvasive in vivo quantification of post-pneumonectomy compensatory lung growth in mice with hyperpolarized 3He diffusion MRI

Wei Wang

Washington University

Experimental demonstration of the influence of field strength and magnetic susceptibility on the ADC of 3He gas in human lungs

Juan Parra-Robles, Ph.D.

University of Sheffield, UK

Session IV:   

Asthma and Airways Disease

Moderators:  Reynold A. Panettieri, Jr.,  M.D. and Lawrence De Garavilla, Ph.D.

2:10-2:40 PM

Asthma: The Newest Challenges  

Reynold A. Panettieri, Jr., M.D.

University of Pennsylvania

2:40-3:00 PM

Imaging of Lung Structure and Function in Asthma

Sean B. Fain,  Ph.D.

University of Wisconsin

3:00-3:20 PM

Allergen-Induced Airway Inflammation in Murine Models: Immune Pathologies

Angela Haczku,  M.D., Ph.D.

University of Pennsylvania

3:20-3:40 PM

Quantitative Imaging of Specific Lung Ventilation with Hyperpolarized Gas MRI

Kiarash Emami

University of Pennsylvania

3:40-4:00 PM

Pulmonary Functional Imaging Using Hyperpolarized 3He

Mitchell S. Albert, Ph.D.

University of Massachusetts

4:00-4:15 PM

Discussion

4:15-4:35 PM

Break

Session V:      

Lung Function and Disease Models

Moderators:  Jose  G. Venegas, Ph.D. and James E. Baumgardner, M.D., Ph.D.

4:35-5:05 PM

Mechanical ventilation causes abdominal edema and inflammation in experimental sepsis

Göran Hedenstierna, M.D., Ph.D.

University Hospital of Uppsala, Sweden

5:05-5:25 PM

Dynamics of Cyclical Recruitment of Atelectasis: Insights from Gas Exchange

James E. Baumgardner, M.D., Ph.D.

Oscillogy LLC, Folsom, PA 

5:25-5:45 PM

Dynamics of Cyclical Recruitment of Atelectasis: Insights from dCT and EIT

Klaus Markstaller, M.D., Ph.D.

University of Vienna

5:45-6:05 PM

Quantitative Imaging of Regional Lung Function Using Synchrotron Radiation Computed Tomography: Present Status, Future Orientations

Sam Bayat, M.D., Ph.D.

CHU Nord, AMIENS, France

6:05-6:20 PM

Break

6:20-6:40 PM

Quantitative Imaging of Alveolar Recruitment Dynamics with Hyperpolarized Gas MRI During Mechanical Ventilation

Maurizio Cereda, M.D.

University of Pennsylvania

6:40-7:00 PM

Assessment of Lung Metabolism Activity by FDG-PET in Patients with Acute Lung Injury

Giacomo Bellani, M.D., Ph.D.

Università degli Studi di Milano-Bicocca, Italy

7:00-7:20 PM

Differential Lung Uptake of 99mTc-HMPAO and 99mTc-Duramycin in Two Rat Lung Injury Models

Anne V. Clough, Ph.D.

Marquette University

Tuesday March 1, 2011

(back to top)

7:00-7:40 AM

Continental Breakfast

Session VI         

Keynote Lectures - Part II

Moderator: Warren B. Gefter, M.D.

7:40-8:20 AM

The National Lung Screening Trial (NLST)

Mitchell Schnall, M.D., Ph.D.

University of Pennsylvania

8:20-9:00 AM

A Hard Day in the Life of a Soft Cell

Jeffrey J. Fredberg, Ph.D.

Harvard University

9:00-9:40 AM

New Insights into the Pathogenesis of COPD obtained by Micro-CT Examination of Human Lungs

James C. Hogg, M.D., Ph.D.

iCAPTURE Centre,St. Paul's Hospital, Vancouver, Canada

9:40-9:55 AM

Discussion

9:55-10:10 AM

Break

Session VII

COPD Biomarkers

Moderator: Eric A. Hoffman, Ph.D.

10:10-10:40 AM

Imaging Airway Heterogeneity: Signal or Noise

Robert H. Brown. M.D., M.P.H.

Johns Hopkins University

10:40-11:00 AM

Emerging Imaging Biomarkers in Emphysema

Jonathan Goldin M.D, Ph.D.

David Geffen School of Medicine

11:00-11:20 AM

Quantitative CT in COPD: Current Status, Future Needs

David A. Lynch, M.D.

National Jewish Hospital, Denver, CO

11:20-11:40 AM

Emphysema on CT Scan: Prevalence, Subtypes and Prognosis of a Distinct Disease

R. Graham Barr, M.D., DRPH

Columbia University

11:40-12:00 PM

Assessment of the Effect of Budesonide/Formoterol on Distal Airway Volume in COPD Patients Using HRCT and Lung Function Tests

Jan W. De Backer, Ph.D.

FluidDA NV, Belgium

12:00-12:15 PM

Discussion

12:15-1:15 PM

Lunch

Session VIII: 

Graduate Student and Postdoctoral Presentations - Part II

Moderator: Kiarash Emami

1:15-1:50 PM

A Novel Model of Dissolved Hyperpolarized 129Xe Dynamic for Simultaneous Quantification of Lung Structure and Function

Yulin V. Chang, Ph.D.

Washington University

Regional Ventilation Mapping of the Rat Lung using Hyperpolarized 129Xe Magnetic Resonance Imaging

Marcus J. Couch

Robarts Research Institute, Canada

Lung ventilation- and perfusion-weighted MRI by Fourier decomposition: Validation with hyperpolarized 3He-MRI and dynamic contrast-enhanced MRI in an animal experiment

Bauman Grzegorz, Ph.D.

German Cancer Research Center, Germany

An Improved Scheme for a Robust High Resolution Measurement of Alveolar Oxygen Tension in Human Lungs

Hooman Hamedani

University of Pennsylvania

Imaging V/Q in Pulmonary Hypertension with 3He and 1H MRI

Helen Marshall, Ph.D.

University of Sheffield, UK

Session IX: 

Lung Function and Structure from Hyperpolarized Gas MRI - Part I

Moderators: John P. Mugler, III, Ph.D. and Stephen Kadlecek, Ph.D.

1:50-2:20 PM

Breath-hold Chemical Shift Imaging with Hyperpolarized Xenon-129

John P. Mugler, III, Ph.D.

University of Virginia

2:20-2:40 PM

Progress in Hyperpolarized 129Xe MRI: From Mouse to Human

Bastiaan Driehuys, Ph.D.

Duke University

2:40-3:00 PM

Pulmonary Physiology with Hyperpolarized 129Xe

Samuel Patz, Ph.D.

Harvard Medical School

3:00-3:20 PM

Regional Measurement of O2 Tension in Both Small Animals and Human Subjects

Masaru Ishii, MD, Ph.D.

Johns Hopkins University

3:20-3:40 PM

Short Breath Hold PAO2 Mapping

Wilson Miller, Ph.D.

University of Virginia

3:40-4:00 PM

Detection of Acinar Microstructural Changes in Early Emphysema by In Vivo 3He Lung Morphometry

James D. Quirk, Ph.D.

Washington University 

4:00-4:15 PM

Discussion

4:15-4:35 PM

Break

Session X:

Polarization Methods

Moderators: William Hersman, Ph.D. and Bastiaan Driehuys, Ph.D.

4:35-4:55 PM

Hyperpolarized Xenon Production: From Laboratory Innovation to Clinical Trials

F. William Hersman, Ph.D.

University of New Hampshire

4:55-5:15 PM

Production and Use of Hyperpolarized Xenon for Lung Imaging: State of the Art and Future Directions

Nicholas N. Kuzma, Ph.D.

University of Pennsylvania

5:15-5:35 PM

Production of Hyperpolarized Liquids Under Continuous Flow Conditions

Kerstin Münnemann, Ph.D.

Max Planck Institute for Polymer Research

5:35-5:50 PM

Discussion

5:50-6:30 PM

Poster Session

Wednesday March 2, 2011

(back to top)

7:00-7:40 AM

Continental Breakfast

Session XI:

Keynote Lectures - Part III

Moderator: John Hansen-Flaschen, M.D.

7:40-8:20 AM

Murine Modeling of COPD

Jack A. Elias, M.D.

Yale University

8:20-9:00 AM

Imaging of the Lung for Clinical Phenotyping COPD

Robert A. Wise, M.D.

Johns Hopkins University

9:00-9:40 AM

COPDGene: Quantitative Imaging and Genetics for Therapeutic Development

James Crapo, M.D.

National Jewish Hospital

9:40-9:55 AM

Discussion

9:55-10:10 AM

Break

Session XII:                

Assessing the Lung with Proton MRI

Moderators: Per Åkeson, M.D., Ph.D. and Wilson Miller, Ph.D.

10:10-10:30 AM

Quantifying Regional Ventilation with Proton MRI

Kim Prisk, Ph.D.

University of  California, San Diego

10:30-10:50 AM

Dynamic MR Angiography of the Pulmonary Circulation

Parmede Vakil, Ph.D.

Northwestern University

10:50-11:10 AM

Physiological Insights into the Pulmonary Circulation Using Proton MRI

Susan R. Hopkins, M.D., Ph.D.

University of  California, San Diego

11:10-11:30 AM

Lung Proton MRI in Small Animals: Where Are We? Where Are We Going?

Yannick Cremillieux, Ph.D.

University of Bordeaux, France

11:30-11:50 AM

Calculatin of Parenchymal Tissue Mechanical Properties in Low Signal-to-Noise MRI Elastography

Kiaran McGee, Ph.D.

Mayo Clinic

11:50-12:05 PM

Discussion

12:05-1:05 PM

Lunch

Session XIII:

Graduate Student and Postdoctoral Presentations- Part III

Moderator: Kiarash Emami

1:05-1:35 PM

Non-invasive Assessment of Lung Status by Ventilation/Perfusion SPECT Imaging in a Murine Model of Long-term Cigarette Smoke Exposure

Brian Jobse

McMaster University, Canada

Imaging of Airway Remodeling in a Murine Model of Bronchial Hyper-responsiveness

Jennia Rajaei

University of Pennsylvania

Pulmonary 3He MRI of Pediatric Subjects with Risk Factors for Asthma

Robert Cadman, Ph.D.

University of Wisconsin–Madison

Assessment of lung morphology with steady state free precession (SSFP) MRI compared to computed tomography

Smitha Rajaram, Ph.D.

University of Sheffield, UK

Session XIV:

Lung Function and Structure from Hyperpolarized-Gas MRI - Part II

Moderator: Dmitriy Yablonskiy, Ph.D.

1:35-1:55 PM

Hyperpolarized Helium MRI in a Rat Model of Interstitial Lung Disease

Milton Rossman, M.D.

University of Pennsylvania

1:55-2:15 PM

Simultaneous Multinuclear MRI of the Lungs

Jim M. Wild, Ph.D.

University of Sheffield, UK

2:15-2:35 PM

Rodent Lung Imaging using Novel MRI and CT Approaches

Giles Santyr, Ph.D.

Robarts Research Institute, Canada

2:35-2:55 PM

Imaging Lung Microstructure in Normal Mice with Hyperpolarized 3He Diffusion MRI

Jason Woods, Ph.D.

Washington University

2:55-3:15 PM

Quantification of Lung Function in Humans Using Non-Equilibrium Xenon Uptake Spectroscopy (NEXUS)

Kai Ruppert, Ph.D.

University of Virginia

3:15-3:35 PM

Functional MRI of Obstructive Lung Disease Therapy: Research Hype or Clinically Relevant?

Grace Parraga, Ph.D.

Robarts Research Institute, Canada

3:35-3:50 PM

Discussion

3:50-4:10 PM

Break

Session XV:

Upcoming Techniques and Therapies

Moderator: Stephen Kadlecek, Ph.D.

4:10-4:30 PM

Nanodevices for Targeting Imaging Probes to the Pulmonary Vasculature

Vladimir Muzykantov, M.D., Ph.D.

University of Pennsylvania

4:30-4:50 PM

Reflectance Microscopy Techniques for 3-D Imaging of the Alveolar Structure

Carolin Unglert, M.S.

Harvard University

4:50–5:05 PM

Discussion

5:05-5:20 PM

Final Remarks

Rahim R. Rizi, Ph.D.

University of Pennsylvania

Adjournment