Wednesday July 25, 2012

7:00 – 7:50 AM

Continental Breakfast

7:50 – 8:05 AM

Program and Workshop Remarks

Rahim R. Rizi, Ph.D.

University of Pennsylvania

8:05 – 8:20 AM

Welcome Remarks

Mitchell Schnall, M.D.,Ph.D.

University of Pennsylvania

8:20 – 9:00 AM

Cancer Insights from NMR Studies of Yeast 
Metabolism

Robert Shulman, Ph.D.

Yale University

Session I

General Session
Moderator: Jerry Glickson, Ph.D.

9:00 – 9:35 AM

Systems Biology of the Mitochondria

Robert Balaban, Ph.D.

National Institutes of Health

9:35 – 9:50 AM

Refreshment Break

9:50 – 10:25 AM

Cancer Imaging and Metabolic Therapy

Chi Van Dang, M.D.,Ph.D.

University of Pennsylvania

10:25 – 11:00 AM

13C NMR Studies of Human Metabolism

Gerald Shulman, M.D.,Ph.D.

Yale University

11:00 – 11:35 AM

Imaging Disease Processes In Vivo: Uncommon Opportunities for Discovery

Cheryl L. Marks, Ph.D.

National Institutes of Health

11:35 – 12:00 PM

Discussion

12:00 – 12:45 PM

Lunch

Session II:

Translation from Preclinical to Clinic Study - Panel Session I

Validation, Harmonization, Standardization of Methodologies
Moderator: Huiming Zhang, Ph.D.

12:45 – 2:00 PM

Larry Clarke, NIH/NCI

Cheryl Marks, NIH/NCI

Chi Van Dang, University of Pennsylvania

Mitchell Schnall, University of Pennsylvania

Jonathan Murray, General Electric

C.T. Tan, Isotec Inc.

Session III:   

Graduate Student and Postdoctoral Presentations - Part I
Moderator: Stephen Kadlecek, Ph.D.

2:00 – 3:00 PM

Quantitative Markers of Real-time Cancer Metabolism Using Metabolic Activity Decomposition

Christine Leon

University of California San Francisco

Kinetic Modeling of Hyperpolarized 13C Pyruvate Metabolism in Tumors Using a Measured Arterial Input Function

Samira Kazan, Ph.D.

University of Sheffield, UK

Improved Quantitative Measures of Renal Pyruvate-to-Lactate Conversion using Diffusion Gradients

Jeremy Gordon

University of Wisconsin-Madison

Dynamic 13C-MRS Reveals Metabolic Markers of Metastatic and Non-Metastatic Phenotype in Two Isogenic Breast Cancer Cell Lines

Rui Simoes, Ph.D.

Memorial Sloan Kettering Cancer Center

Quantitative Metabolic Spectroscopy of Perfused Lungs Using Hyperpolarized [1-13C]Pyruvate

Sarmad Siddiqui

University of Pennsylvania

Quantification of pH in the Rat Thorax Using Hyperpolarized 13C-bicarbonate

Kundan Thind

Robarts Research Institute, Canada

Session IV:   

Applications of Carbon-13 in Metabolism - Part I
Moderator: R. Nick Bryan, M.D.,Ph.D.

3:00 – 3:35 PM

Hyperpolarized Carbon-13 MR Studies of Cancer in Preclinical Models and Initial Human Studies

Daniel Vigneron, Ph.D.

University of California San Francisco

3:35 – 4:00 PM

Investigation of Metabolism in the Diseased Heart Using Hyperpolarized MRI

Damian Tyler, Ph.D.

Oxford University, UK

4:00 – 4:25 PM

Sampling Strategies for Carbon-13 Metabolic Imaging

Ralph Hurd, Ph.D.

General Electric

4:25 – 4:50 PM

Hyperpolarized Metabolic Imaging of Rat C6 Glioma: Looking Beyond Lactate

Dirk Mayer, Ph.D.

SRI International

4:50 – 5:00 PM

Discussion

5:00 – 7:00 PM

Poster Session

5:00 – 7:00 PM

Reception

Thursday, July 26, 2012

(back to top)

7:15 – 8:15 AM

Continental Breakfast

Session V:   

Technological Advances in Hyperpolarized Carbon-13 - Part I
Moderator: Joachim Bargon, Ph.D.

8:15 – 8:45 AM

In Search of Long-T1 Biosensors

Dean Sherry, Ph.D.

University of Texas at Dallas

8:45 – 9:15 AM

Maintaining Hyperpolarization Using Singlet States

Malcolm H. Levitt, Ph.D.

Southampton University, UK

9:15 – 9:45 AM

Long-lived Spin States with Equivalent Spins

Warren S. Warren, Ph.D.

Duke University

9:45 – 10:00 AM

Discussion

10:00 – 10:15 AM

Refreshment Break

Session VI:

Metabolism and Metabolic Imaging - Part I
Moderator: Mitchell Schnall, M.D.,Ph.D.

10:15 – 10:45 AM

13C and 1H[13C] MRS Studies of Neuroenergetics and Neurotransmission

Douglas Rothman, Ph.D.

Yale University

10:45 – 11:15 AM

1H, 31P and 13C NMR Studies of Breast Cancer Metabolism

Jason A. Koutcher, M.D.,Ph.D.

Memorial Sloan Kettering Cancer Center

11:15 – 11:45 AM

Hyperpolarization of Liquids and Field Dependence of SABRE Experiments

Christian Griesinger, Ph.D.

Max Planck Institute for Biophysical Chemistry, Germany

11:45 – 12:00 PM

13C MRS Techniques for Studying the Turnover of Carboxylic and Amide Carbons in the Brain

Jun Shen, Ph.D.

National Institutes of Health

12:00 – 12:15 PM

Discussion

12:15 – 1:00 PM

Lunch

Session VII:   

Graduate Student and Postdoctoral Presentations - Part II
Moderator: Masaru Ishii, M.D.,Ph.D.

1:00 – 1:45 PM

Dynamic Metabolic Imaging of Rat Hearts at 9.4T using Spectral-Spatial Excitation and Single-Shot EPI

Andreas Sigfridsson, Ph.D.

ETH Zurich, Switzerland

Model Free Approach to Kinetic Analysis of Real-Time Hyperpolarised 13C MRS Data

Deborah Hill

The Institute of Cancer Research, UK

Construction and Advantages of DNP System at High Field

Mehrdad Pourfathi

University of Pennsylvania

Optimal Control Singlet State Storage of Hyperpolarized Compounds

Christoffer Laustsen

Aarhus University, Denmark

In Vivo Hyperpolarized Imaging of Hypoxia Inducible Factor-1 Activity in Murine Sarcoma

Ryan Davis

Duke University

Session VIII         

Translation from Preclinical to Clinic Study - Panel Session II

Resources, Dissemination, Training
Moderator : John Kurhanewicz, Ph.D.

1:45 – 3:00 PM

Dean Sherry, University of Texas at Dallas

Daniel Vigneron, University of California San Francisco

Damian Tyler, Oxford University, UK

Daniel Spielman, Stanford University

Rahim R. Rizi, University of Pennsylvania

Mark A. Rosen, University of Pennsylvania

Session IX

Applications of Carbon-13 in Metabolism - Part II
Moderator: Douglas Rothman, Ph.D.

3:00 – 3:35 PM

Hyperpolarized 13C MR of Prostate Cancer - From Cells to Man

John Kurhanewicz, Ph.D.

University of California San Francisco

3:35 – 4:00 PM

In Vivo Measurement of ALDH2 Activity in Rat Liver Ethanol Model Using Dynamic MRSI of Hyperpolarized [1-13C] Pyruvate

Daniel Spielman, Ph.D.

Stanford University

4:00 – 4:20 PM

13C-labeled Molecules as Markers of Cancer Therapy

Mikko Kettunen, Ph.D.

Cambridge University, UK

4:20 – 4:40 PM

Metabolic Imaging of Pulmonary Disorders with Polarized Carbon-13

Stephen Kadlecek, Ph.D.

University of Pennsylvania

4:40 – 4:55 PM

Technological Advances for Using Magnetic Resonance to Study Metabolism

Daniel J. Barabino, Ph.D.

Agilent Technologies Inc.

4:55 – 5:05 PM

Discussion

5:05 – 5:15 PM

Break

Session X: 

Lessons from Other Hyperpolarized Nuclei
Moderator: Kai Ruppert, Ph.D.

5:15 – 5:45 PM

Challenges in Quantification of Dissolved-Phase Xe-129 in the Lung

John P. Mugler, Ph.D.

University of Virginia

5:45 – 6:05 PM

Polarizing 129Xe with DNP Method

Nick Kuzma, Ph.D.

University of Pennsylvania

6:05 – 6:25 PM

Hyperpolarized Xe-129: A Very Useful Biophysical Probe

Ivan Dmochowski, Ph.D.

University of Pennsylvania

6:25 – 6:40 PM

Discussion

Friday July 27, 2012

(back to top)

7:00 – 8:00 AM

Continental Breakfast

Session XI: 

Metabolism and Metabolic Imaging - Part II
Moderator: Dean Sherry, Ph.D.

8:00 – 8:25 AM

High Resolution Functional Metabolic Imaging

Fahmeed Hyder, Ph.D.

Yale University

8:25 – 8:50 AM

Monitoring Human Metabolism with Stable Isotopes: Studying Children with Urea Cycle Defects

Marc Yudkoff, M.D.

Children’s Hospital of Philadelphia

8:50 – 9:15 AM

The Control of Hepatic Metabolism

Morris Birnbaum, M.D.,Ph.D.

University of Pennsylvania

9:15 – 9:30 AM

Discussion

9:30 – 9:45 AM

Break

Session XII:

Pulse Sequences and Hardware for NMR of Hyperpolarized Nuclei
Moderator: John P. Mugler, Ph.D.

9:45 – 10:05 AM

Strategies for Accelerating MR Spectroscopic Imaging

Stefan Posse, Ph.D.

University of New Mexico

10:05 – 10:25 AM

Metabolic Activity Decomposition with Stimulated-echoes: Principles and Validation

Peder Larson, Ph.D.

University of California San Francisco

10:25 – 10:45 AM

Multiband Spectral-Spatial RF Pulse Design for
Hyperpolarized C-13 Applications

Adam Kerr, Ph.D.

Stanford University

10:45 – 11:00 AM

Discussion

11:00 – 11:15 AM

Break

Session XIII:

Applications of Carbon-13 in Metabolism - Part III
Moderator: Warren S. Warren, Ph.D.

11:15 – 11:35 AM

Quantitative Measures of Kidney Metabolism Using 13C Pyruvate and Application in Obstructive Nephropathy

Sean Fain, Ph.D.

University of Wisconsin

11:35 – 11:55 AM

Substrate Competition Demonstrates Negligible Control of Hepatic PDH Flux

Matthew Merritt, Ph.D.

University of Texas - Southwestern

11:55 – 12:15 PM

Validation of the in-vivo Assessment of LDH-A Inhibition in Pancreatic Tumor Xenografts Using 13C-MRS of Hyperpolarized Pyruvate

Prasanta Dutta, Ph.D.

University of South Florida

12:15 – 12:30 PM

Discussion

12:30 – 1:30 PM

Lunch

Session XIV:

General Submission Presentations
Moderator: Sean Fain, Ph.D. , Matthew Merritt, Ph.D.

1:30 – 2:30 PM

Imaging the Metabolic Stress Response in Hepatocellular Carcinoma

Terence Gade, M.D.,Ph.D.

University of Pennsylvania

In Vivo Affordable Parahydrogen Induced Polarization

Shawn Wagner, Ph.D.

Cedars-Sinai Medical Center

Non-invasive Quantification of Intracellular Redox State in Tissue by Hyperpolarized 13C-NMR

Lin Li, Ph.D.

University of Pennsylvania

Effects of Tumour Oxygenation on 13C1-Pyruvate Metabolism

Steven Reynolds, Ph.D.

University of Sheffield, UK

Probing Tumor Early Response to Radiation Therapy Using Hyperpolarized [1-13C]Pyruvate in a Breast Cancer Model

Albert Chen, Ph.D.

General Electric

Singlet State of Nitrous Oxide

Rajat Ghosh, Ph.D.

University of Pennsylvania

2:30 – 2:45 PM

Discussion

Session XV:

Technological Advances in Hyperpolarized Carbon-13 - Part II
Moderator:

2:45 – 3:00 PM

Relaxometry of Hyperpolarized 13C-labelled Endogenous Compounds

Timothy Scholl, Ph.D.

Robarts Research Institute, Canada

3:00 – 3:15 PM

Solid-to-liquid State DNP of Large Molecules

Christian Hilty, Ph.D.

Texas A&M University

3:15 – 3:30 PM

On the Importance of Timing and Protocols in In Vivo Real-time Metabolic Studies Using 13C Hyperpolarized Substrates

Arnaud Comment, Ph.D.

École Fédérale de Lausanne, Switzerland

3:30 – 3:45 PM

PHIP Polarizing and Imaging Strategies for 13C-Lactate and 15N-Choline

Eduard Chekmenev, Ph.D.

Vanderbilt University

3:45 – 4:00 PM

Delineating Molecular and Metabolic Signatures of Disease via Contrast-enhanced Magnetic Resonance Imaging

Andrew Tsourkas, Ph.D.

University of Pennsylvania

4:00 – 4:15 PM

DB1 Melanoma Metabolic Network and Fluxome Revealed by Metabolic Modeling and 13C MRS/Bioreactor Technique

Alexander Shestov, Ph.D.

University of Minnesota

4:15 – 4:30 PM

Discussion

4:30 – 4:45 PM

Final Remarks
Rahim R. Rizi, Ph.D.
University of Pennsylvania