The Third International Workshop
on Metabolic Imaging


Download a PDF copy of the program brochure.

Wednesday | Thursday | Friday


Wednesday July 25, 2012

7:00 – 7:50 AM

Continental Breakfast

7:50 – 8:05 AM

Program and Workshop Remarks

Rahim R. Rizi, Ph.D.

University of Pennsylvania

8:05 – 8:20 AM

Welcome Remarks

Mitchell Schnall, M.D.,Ph.D.

University of Pennsylvania

8:20 – 9:00 AM

Cancer Insights from NMR Studies of Yeast 

Robert Shulman, Ph.D.

Yale University


Session I

General Session
Moderator: Jerry Glickson, Ph.D.

9:00 – 9:35 AM

Systems Biology of the Mitochondria

Robert Balaban, Ph.D.

National Institutes of Health

9:35 – 9:50 AM

Refreshment Break

9:50 – 10:25 AM

Cancer Imaging and Metabolic Therapy

Chi Van Dang, M.D.,Ph.D.

University of Pennsylvania

10:25 – 11:00 AM

13C NMR Studies of Human Metabolism

Gerald Shulman, M.D.,Ph.D.

Yale University

11:00 – 11:35 AM

Imaging Disease Processes In Vivo: Uncommon Opportunities for Discovery

Cheryl L. Marks, Ph.D.

National Institutes of Health

11:35 – 12:00 PM


12:00 – 12:45 PM



Session II:

Translation from Preclinical to Clinic Study - Panel Session I

Validation, Harmonization, Standardization of Methodologies
Moderator: Huiming Zhang, Ph.D.

12:45 – 2:00 PM

Larry Clarke, NIH/NCI


Cheryl Marks, NIH/NCI


Chi Van Dang, University of Pennsylvania


Mitchell Schnall, University of Pennsylvania


Jonathan Murray, General Electric


C.T. Tan, Isotec Inc.

Session III:   

Graduate Student and Postdoctoral Presentations - Part I
Moderator: Stephen Kadlecek, Ph.D.

2:00 – 3:00 PM

Quantitative Markers of Real-time Cancer Metabolism Using Metabolic Activity Decomposition


Christine Leon


University of California San Francisco


Kinetic Modeling of Hyperpolarized 13C Pyruvate Metabolism in Tumors Using a Measured Arterial Input Function


Samira Kazan, Ph.D.


University of Sheffield, UK


Improved Quantitative Measures of Renal Pyruvate-to-Lactate Conversion using Diffusion Gradients


Jeremy Gordon


University of Wisconsin-Madison


Dynamic 13C-MRS Reveals Metabolic Markers of Metastatic and Non-Metastatic Phenotype in Two Isogenic Breast Cancer Cell Lines


Rui Simoes, Ph.D.


Memorial Sloan Kettering Cancer Center


Quantitative Metabolic Spectroscopy of Perfused Lungs Using Hyperpolarized [1-13C]Pyruvate


Sarmad Siddiqui


University of Pennsylvania


Quantification of pH in the Rat Thorax Using Hyperpolarized 13C-bicarbonate


Kundan Thind


Robarts Research Institute, Canada

Session IV:   

Applications of Carbon-13 in Metabolism - Part I
Moderator: R. Nick Bryan, M.D.,Ph.D.

3:00 – 3:35 PM

Hyperpolarized Carbon-13 MR Studies of Cancer in Preclinical Models and Initial Human Studies

Daniel Vigneron, Ph.D.

University of California San Francisco

3:35 – 4:00 PM

Investigation of Metabolism in the Diseased Heart Using Hyperpolarized MRI

Damian Tyler, Ph.D.

Oxford University, UK

4:00 – 4:25 PM

Sampling Strategies for Carbon-13 Metabolic Imaging

Ralph Hurd, Ph.D.

General Electric

4:25 – 4:50 PM

Hyperpolarized Metabolic Imaging of Rat C6 Glioma: Looking Beyond Lactate

Dirk Mayer, Ph.D.

SRI International

4:50 – 5:00 PM


5:00 – 7:00 PM

Poster Session

5:00 – 7:00 PM



Thursday, July 26, 2012

(back to top)

7:15 – 8:15 AM

Continental Breakfast


Session V:   

Technological Advances in Hyperpolarized Carbon-13 - Part I
Moderator: Joachim Bargon, Ph.D.

8:15 – 8:45 AM

In Search of Long-T1 Biosensors

Dean Sherry, Ph.D.

University of Texas at Dallas

8:45 – 9:15 AM

Maintaining Hyperpolarization Using Singlet States

Malcolm H. Levitt, Ph.D.

Southampton University, UK

9:15 – 9:45 AM

Long-lived Spin States with Equivalent Spins

Warren S. Warren, Ph.D.

Duke University

9:45 – 10:00 AM


10:00 – 10:15 AM

Refreshment Break


Session VI:

Metabolism and Metabolic Imaging - Part I
Moderator: Mitchell Schnall, M.D.,Ph.D.

10:15 – 10:45 AM

13C and 1H[13C] MRS Studies of Neuroenergetics and Neurotransmission

Douglas Rothman, Ph.D.

Yale University

10:45 – 11:15 AM

1H, 31P and 13C NMR Studies of Breast Cancer Metabolism

Jason A. Koutcher, M.D.,Ph.D.

Memorial Sloan Kettering Cancer Center

11:15 – 11:45 AM

Hyperpolarization of Liquids and Field Dependence of SABRE Experiments

Christian Griesinger, Ph.D.

Max Planck Institute for Biophysical Chemistry, Germany

11:45 – 12:00 PM

13C MRS Techniques for Studying the Turnover of Carboxylic and Amide Carbons in the Brain

Jun Shen, Ph.D.

National Institutes of Health

12:00 – 12:15 PM


12:15 – 1:00 PM



Session VII:   

Graduate Student and Postdoctoral Presentations - Part II
Moderator: Masaru Ishii, M.D.,Ph.D.

1:00 – 1:45 PM

Dynamic Metabolic Imaging of Rat Hearts at 9.4T using Spectral-Spatial Excitation and Single-Shot EPI


Andreas Sigfridsson, Ph.D.


ETH Zurich, Switzerland


Model Free Approach to Kinetic Analysis of Real-Time Hyperpolarised 13C MRS Data


Deborah Hill


The Institute of Cancer Research, UK


Construction and Advantages of DNP System at High Field


Mehrdad Pourfathi


University of Pennsylvania


Optimal Control Singlet State Storage of Hyperpolarized Compounds


Christoffer Laustsen


Aarhus University, Denmark


In Vivo Hyperpolarized Imaging of Hypoxia Inducible Factor-1 Activity in Murine Sarcoma


Ryan Davis


Duke University

Session VIII         

Translation from Preclinical to Clinic Study - Panel Session II

Resources, Dissemination, Training
Moderator : John Kurhanewicz, Ph.D.

1:45 – 3:00 PM

Dean Sherry, University of Texas at Dallas


Daniel Vigneron, University of California San Francisco


Damian Tyler, Oxford University, UK


Daniel Spielman, Stanford University


Rahim R. Rizi, University of Pennsylvania


Mark A. Rosen, University of Pennsylvania

Session IX

Applications of Carbon-13 in Metabolism - Part II
Moderator: Douglas Rothman, Ph.D.

3:00 – 3:35 PM

Hyperpolarized 13C MR of Prostate Cancer - From Cells to Man

John Kurhanewicz, Ph.D.

University of California San Francisco

3:35 – 4:00 PM

In Vivo Measurement of ALDH2 Activity in Rat Liver Ethanol Model Using Dynamic MRSI of Hyperpolarized [1-13C] Pyruvate

Daniel Spielman, Ph.D.

Stanford University

4:00 – 4:20 PM

13C-labeled Molecules as Markers of Cancer Therapy

Mikko Kettunen, Ph.D.

Cambridge University, UK

4:20 – 4:40 PM

Metabolic Imaging of Pulmonary Disorders with Polarized Carbon-13

Stephen Kadlecek, Ph.D.

University of Pennsylvania

4:40 – 4:55 PM

Technological Advances for Using Magnetic Resonance to Study Metabolism

Daniel J. Barabino, Ph.D.

Agilent Technologies Inc.

4:55 – 5:05 PM


5:05 – 5:15 PM



Session X: 

Lessons from Other Hyperpolarized Nuclei
Moderator: Kai Ruppert, Ph.D.

5:15 – 5:45 PM

Challenges in Quantification of Dissolved-Phase Xe-129 in the Lung

John P. Mugler, Ph.D.

University of Virginia

5:45 – 6:05 PM



Polarizing 129Xe with DNP Method

Nick Kuzma, Ph.D.

University of Pennsylvania

6:05 – 6:25 PM



Hyperpolarized Xe-129: A Very Useful Biophysical Probe

Ivan Dmochowski, Ph.D.

University of Pennsylvania

6:25 – 6:40 PM



Friday July 27, 2012

(back to top)

7:008:00 AM

Continental Breakfast


Session XI: 

Metabolism and Metabolic Imaging - Part II
Moderator: Dean Sherry, Ph.D.

8:00 – 8:25 AM

High Resolution Functional Metabolic Imaging

Fahmeed Hyder, Ph.D.

Yale University

8:25 – 8:50 AM

Monitoring Human Metabolism with Stable Isotopes: Studying Children with Urea Cycle Defects

Marc Yudkoff, M.D.

Children’s Hospital of Philadelphia

8:50 – 9:15 AM

The Control of Hepatic Metabolism

Morris Birnbaum, M.D.,Ph.D.

University of Pennsylvania

9:15 – 9:30 AM


9:30 – 9:45 AM



Session XII:

Pulse Sequences and Hardware for NMR of Hyperpolarized Nuclei
Moderator: John P. Mugler, Ph.D.

9:45 – 10:05 AM

Strategies for Accelerating MR Spectroscopic Imaging

Stefan Posse, Ph.D.

University of New Mexico

10:05 – 10:25 AM

Metabolic Activity Decomposition with Stimulated-echoes: Principles and Validation

Peder Larson, Ph.D.

University of California San Francisco

10:25 – 10:45 AM

Multiband Spectral-Spatial RF Pulse Design for
Hyperpolarized C-13 Applications

Adam Kerr, Ph.D.

Stanford University

10:45 – 11:00 AM


11:00 – 11:15 AM


Session XIII:

Applications of Carbon-13 in Metabolism - Part III
Moderator: Warren S. Warren, Ph.D.

11:15 – 11:35 AM

Quantitative Measures of Kidney Metabolism Using 13C Pyruvate and Application in Obstructive Nephropathy

Sean Fain, Ph.D.

University of Wisconsin

11:35 – 11:55 AM


Substrate Competition Demonstrates Negligible Control of Hepatic PDH Flux

Matthew Merritt, Ph.D.

University of Texas - Southwestern

11:55 – 12:15 PM

Validation of the in-vivo Assessment of LDH-A Inhibition in Pancreatic Tumor Xenografts Using 13C-MRS of Hyperpolarized Pyruvate

Prasanta Dutta, Ph.D.

University of South Florida

12:15 – 12:30 PM


12:30 – 1:30 PM



Session XIV:

General Submission Presentations
Moderator: Sean Fain, Ph.D. , Matthew Merritt, Ph.D.

1:30 – 2:30 PM

Imaging the Metabolic Stress Response in Hepatocellular Carcinoma


Terence Gade, M.D.,Ph.D.


University of Pennsylvania


In Vivo Affordable Parahydrogen Induced Polarization


Shawn Wagner, Ph.D.


Cedars-Sinai Medical Center


Non-invasive Quantification of Intracellular Redox State in Tissue by Hyperpolarized 13C-NMR


Lin Li, Ph.D.


University of Pennsylvania


Effects of Tumour Oxygenation on 13C1-Pyruvate Metabolism


Steven Reynolds, Ph.D.


University of Sheffield, UK


Probing Tumor Early Response to Radiation Therapy Using Hyperpolarized [1-13C]Pyruvate in a Breast Cancer Model


Albert Chen, Ph.D.


General Electric


Singlet State of Nitrous Oxide


Rajat Ghosh, Ph.D.


University of Pennsylvania

2:30 – 2:45 PM



Session XV:

Technological Advances in Hyperpolarized Carbon-13 - Part II

2:45 – 3:00 PM


Relaxometry of Hyperpolarized 13C-labelled Endogenous Compounds

Timothy Scholl, Ph.D.

Robarts Research Institute, Canada

3:00 – 3:15 PM


Solid-to-liquid State DNP of Large Molecules

Christian Hilty, Ph.D.

Texas A&M University

3:15 – 3:30 PM


On the Importance of Timing and Protocols in In Vivo Real-time Metabolic Studies Using 13C Hyperpolarized Substrates

Arnaud Comment, Ph.D.

École Fédérale de Lausanne, Switzerland

3:30 – 3:45 PM

PHIP Polarizing and Imaging Strategies for 13C-Lactate and 15N-Choline

Eduard Chekmenev, Ph.D.

Vanderbilt University

3:45 – 4:00 PM

Delineating Molecular and Metabolic Signatures of Disease via Contrast-enhanced Magnetic Resonance Imaging

Andrew Tsourkas, Ph.D.

University of Pennsylvania

4:00 – 4:15 PM

DB1 Melanoma Metabolic Network and Fluxome Revealed by Metabolic Modeling and 13C MRS/Bioreactor Technique

Alexander Shestov, Ph.D.

University of Minnesota

4:15 – 4:30 PM


4:30 – 4:45 PM

Final Remarks
Rahim R. Rizi, Ph.D.
University of Pennsylvania