The 2013 International Pulmonary Imaging Workshop




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Thursday | Friday | Saturday

Thursday May 16, 2013

7:00 – 7:50 AM

Continental Breakfast

7:50 – 8:05 AM

Introductory and Welcome Remarks

Rahim R. Rizi, Ph.D.

University of Pennsylvania

8:05 – 8:25 AM

Quantitative Molecular Imaging Biomarkers for Disease Management

David A. Mankoff, M.D.,Ph.D.

University of Pennsylvania


Session I : Keynote Lectures - Part I
Moderators: Jerry D. Glickson, Ph.D., Masaru Ishii, M.D.,Ph.D.

8:25 – 8:40 AM

Potential Contributions of Metabolic Imaging to Pulmonary Research

Thomas L. Croxton, M.D.,Ph.D.

National Institutes of Health

8:40 – 9:10 AM

Potential of NIRS for Measuring Respiratory Muscle Blood Flow and Metabolism

Peter D. Wagner, M.D.

University of California, San Diego

9:10 – 9:40 AM

Imaging of Reactive Oxygen Species Production during Lung Ischemia

Aron B. Fisher, M.D.

University of Pennsylvania

9:40 – 9:55 AM


9:55 – 10:10 AM



Session II : Molecular Imaging of Pulmonary Disorders - Part I
Moderator: Rahim R. Rizi, Ph.D.

10:10 – 10:35 AM

Challenges Associated with Molecular Imaging for Evaluating Molecular Pathways

Craig Malloy, M.D.

University of Texas, Southwestern

10:35 – 10:55 AM

Molecular Imaging of Pulmonary Fibrosis

Peter Caravan, Ph.D.

Harvard University

10:55 – 11:15 AM

Molecular Imaging of Inflammation in the Lungs

Timothy S. Blackwell, M.D.

University of Vanderbilt

11:15 – 11:35 AM

Imaging Lung Inflammation with Positron Emission Tomography

Delphine L. Chen, M.D.

Washington University

11:35 – 11:50 AM


11:50 AM – 12:50 PM



Session III : Graduate Student and Postdoctoral Presentations - Part I
Moderator: Kai Ruppert, Ph.D.

12:50 – 1:00 PM

Who Moved My Perfusion? The Early and Late Phase Pulmonary Response to Whole Lung Allergen Challenge

Vanessa J. Kelly, Ph.D.

Massachusetts General Hospital

1:00 – 1:10 PM

Reliability and Validity of Specific Ventilation Heterogeneity Estimation Obtained Using Specific Ventilation Imaging

Rui Carlos Sá, Ph.D.

University of  California, San Diego

1:10 – 1:20 PM

A Multiple-Breath 3He Wash-In Regimen to Reduce the Limitation of 3He PAO2-Imaging Due to Delayed Ventilation and Slow Filling

Hooman Hamedani

University of Pennsylvania

1:20 – 1:30 PM

Limitations and Pitfalls of HP Gas ADC Models of Alveolarization

Juan Parra-Robles, Ph.D.

University of Sheffield, United Kingdom

1:30 – 1:40 PM

19F Apparent Diffusion Coefficient MRI of Inert Fluorinated Gases in Human Lungs

Marcus Couch

Thunder Bay Regional Research Institute, Canada

1:40 – 1:50 PM

Effects of Ventilator Induced Lung Injury on Airspace Distension and Regional Ventilation in Rats Using Hyperpolarized MRI

Yi Xin

University of Pennsylvania

1:50 – 2:05 PM



Session IV : Molecular Imaging of Pulmonary Disorders - Part II
Moderator: Douglas L. Rothman Ph.D.

2:05 – 2:25 PM

Pyruvate Uptake and Metabolism in the Lung

Stephen J. Kadlecek, Ph.D.

University of Pennsylvania

2:25 – 2:45 PM

Anatomical, Functional and Metabolic MRI of Lung Injury Using Hyperpolarized Nuclei

Giles Santyr, Ph.D.

Robarts Research Institute, Canada

2:45 – 3:05 PM

Imaging of Lung Inflammation and Ventilation in Viral Induced Asthma Exacerbation

Sean B. Fain, Ph.D.

University of Wisconsin

3:05 – 3:20 PM


3:20 – 3:35 PM



Session V : Lung Structure and Disease Models - Part I
Moderators: Reynold A. Panettieri, Jr., M.D. and Jason Woods, Ph.D.

3:35 – 4:00 PM

Probing the Potential for Lung Growth in Adult Humans Using Hyperpolarized Noble Gas to Characterize Acinar Microstructure

James P. Butler, M.D.

Harvard University

4:00 – 4:20 PM

New Advances in Asthma

Reynold A. Panettieri, Jr., M.D.

University of Pennsylvania

4:20 – 4:40 PM

Intrapulmonary Aerosol Deposition with PET/CT: From Images to Tissue Dosing

José G. Venegas, Ph.D.

Harvard University

4:40 – 5:00 PM

Molecular Pathogenesis of COPD: A Guide to Functional Imaging

Jeanine D’Armiento, M.D.,Ph.D.

Columbia University

5:00 – 5:15 PM


5:15 – 5:35 PM

CT of COPD: Beyond Emphysema and Airway Measurement

Joon Beom Seo, M.D.

University of Ulsan, South Korea

5:35 – 5:55 PM

Three-dimensional Structure of the Rat Acinus

Johannes Schittny, Ph.D.

University of Bern, Switzerland

5:55 – 6:15 PM

Products of Elastin Degradation as Biomarkers in COPD

Gerard M. Turino, M.D.

Columbia University

6:15 – 6:35 PM

Pulmonary Inflammation during Acute Lung Injury Measured with PET

Marcos F. Vidal Melo, M.D.,Ph.D.

Harvard University

6:35 – 6:50 PM



Friday May 17, 2013

(back to top)

7:00 – 7:40 AM

Continental Breakfast


Session VI : Keynote Lectures - Part II
Moderator: Warren B. Gefter, M.D.

7:40 – 8:10 AM

Emerging Functional Measures of the Lung with Dual Energy CT

Eric A. Hoffman, Ph.D.

University of Iowa

8:10 – 8:40 AM

Propulsion and Navigation within the Advancing Monolayer Sheet

Jeffrey J. Fredberg, Ph.D.

Harvard University

8:40 – 9:10 AM

Micro CT Studies of Lung Pathology and Their Relationship to Histology and Gene Expression Profiling

James C. Hogg, M.D.,Ph.D.

St. Paul's Hospital, Canada

9:10 – 9:25 AM


9:25 – 9:40 AM



Sesson VII : Lung Structure and Disease Models - Part II
Moderator: John D. Newell, Jr., M.D.

9:40 – 10:05 AM

Image-based Subtypes of COPD

James D. Crapo, M.D.

National Jewish Health

10:05 – 10:30 AM

CT Imaging of the Airways

David P. Naidich, M.D.

New York University

10:30 – 10:55 AM

Acute Exacerbations of COPD and Imaging as a Predictor/Marker of Disease

Gerard Criner, M.D.

Temple University

10:55 – 11:15 AM

Lung Inflation, Airway Dilation, and Obstructive Lung Disease

Robert H. Brown, M.D.,M.P.H.

Johns Hopkins University

11:15 – 11:35 AM

Pulmonary Microvascular Blood Flow in COPD and Emphysema

R. Graham Barr, M.D.,Dr.P.H.

Columbia University

11:35 – 11:55 PM

Radiographic Heterogeneity in COPD

Meilan Han, M.D.

University of Michigan

11:55 AM – 12:10 PM


12:10 – 1:40 PM

Lunch & Poster Session


Session VIII : Lung Cancer
Moderator: Daniel H. Sterman, M.D.

1:40 – 2:10 PM

Update on CT Screening for Lung Cancer

Claudia I. Henschke, M.D., Ph.D.

Mount Sinai Hospital

2:10 – 2:30 PM

Using Paired Tissue and Serum Samples to Characterize Human Lung Cancer Metabolomics with Ex Vivo 1H HRMAS MRS

Leo L. Cheng, Ph.D.

Harvard University

2:30 – 2:50 PM

Imaging Proliferation in Non-small Cell Lung Cancer

Sharyn I. Katz, M.D.

University of Pennsylvania

2:50 – 3:00 PM


3:00 – 3:15 PM



Session IX : Lung Function and Structure Imaging - Part I
Moderator: Jim Wild, Ph.D.

3:15 – 3:40 PM

Advances in Regional Mapping of Gas Uptake in the Lung Using Hyperpolarized Xe-129 MRI

John P. Mugler, III, Ph.D.

University of Virginia

3:40 – 4:00 PM

In Vivo Lung Morphometry – Current Status and Future Perspectives

Dmitriy Yablonskiy, Ph.D.

Washington University

4:00 – 4:20 PM

Multi Nuclear MRI Measurements of Lung Function

Jim Wild, Ph.D.

University of Sheffield, United Kingdom

4:20 – 4:40 PM

New Advances in Pulmonary Functional MR Imaging Using Inert Gases

Mitchell Albert, Ph.D.

Thunder Bay Regional Research Institute, Canada

4:40 – 5:00 PM

Regional Reproducibility Study of Imaging of Alveolar Oxygen Tension

Masaru Ishii, M.D.,Ph.D.

Johns Hopkins University

5:00 – 5:10 PM


5:10 – 5:25 PM


Session X : Technological Advances in Polarized Gas MRI
Moderator: Samuel Patz, Ph.D.

5:25 – 5:45 PM

Design Considerations for a Portable MR Device to Measure Pulmonary Function

Samuel Patz, Ph.D.

Harvard University

5:45 – 6:05 PM

Further Increases in Production of Highly-polarized 129Xe

F. William Hersman, Ph.D.

University of New Hampshire

6:05 – 6:25 PM

High (~25-90%) 129Xe Hyperpolarization at High Xe Densities Using an ‘Open-Source’ Clinical-Scale Polarizer

Boyd Goodson, Ph.D.

Southern Illinois University

6:25 – 6:45 PM

Production and Use of Hyperpolarized Xenon for Lung Imaging: State of the Art and Future Directions

Nicholas N. Kuzma, Ph.D.

University of Pennsylvania

6:45 – 7:00 PM



Saturday May 18, 2013

(back to top)

7:00 – 7:40 AM

Continental Breakfast


Session XI : New Techniques for Lung Imaging
Moderator: Stephen Kadlecek, Ph.D.

7:40 – 8:00 AM

Optical Coherence Tomography and the Lung: Recent Advances and Future Direction

Melissa J. Suter, Ph.D.

Harvard University

8:00 – 8:20 AM

High-resolution Imaging of Airway Using Endoscopic OCT

Xingde Li, Ph.D.

Johns Hopkins University

8:20 – 8:40 AM

Temporal Dynamics in the Lung

G. Kim Prisk, Ph.D.

University of California, San Diego

8:40 – 9:00 AM

Ultrashort Repetition Time (UTR) MR Imaging of the Human Lung

G. Wilson Miller, Ph.D.

University of Virginia

9:00 – 9:10 AM


9:10 – 9:25 AM



Session XII : Lung Function and Structure Imaging - Part II
Moderator: John P. Mugler, III, Ph.D.

9:25 – 9:50 AM

Mesenchymal Stem(Stromal) Cells and Acute Lung Injury: Biology and Potential Clinical Treatment

Michael A. Matthay, M.D.

University of California, San Francisco

9:50 – 10:10 PM

Ventilator Induced Lung Injury – Insights from Hyperpolarized MRI

Maurizio F. Cereda, M.D.

University of Pennsylvania

10:10 – 10:30 AM

Advances in the Assessment of Lung Function Using Hyperpolarized Xenon-129

Kai Ruppert, Ph.D.

University of Virginia

10:30 – 10:50 AM

Using Hyper-CEST to Increase Hyperpolarized Xe-129 NMR Detection Sensitivity in Complex Structures

Ivan J. Dmochowski, Ph.D.

University of Pennsylvania

10:50 – 11:00 AM


11:00 – 11:15 AM


11:15 – 11:35 AM

Multi-breath Hyperpolarized Gas Imaging Protocols – Advances and New Possibilities

Kiarash Emami, Ph.D.

Polarean, Inc.

11:35 – 11:55 PM

Applications of 3He Lung Morphometry: Alveolar Recruitment and Regeneration

Jason Woods, Ph.D.

Cincinnati Children’s Hospital

11:55 AM – 12:15 PM

Emerging Clinical Applications of Hyperpolarized-gas MRI

Juliana M. Bueno, M.D.

University of Virginia

12:15 – 12:35 PM

Ventilation-perfusion Matching Measured with Proton MRI

Susan R. Hopkins, M.D.,Ph.D.

University of California, San Diego

12:35 – 12:45 PM


12:45 – 1:45 PM



Session XIII : Graduate Student and Postdoctoral Presentations - Part II
Moderator: TBA

1:45 – 1:55 PM

Normalized T1 Relaxation Time Mapping for Early Detection of Cystic Fibrosis Lung Disease

Chris A. Flask, Ph.D.

Case Western Reserve University

1:55 – 2:05 PM

High Resolution Imaging of Small Airway Lesions in the Early Stages of COPD in Paraffin Embedded Lung Tissue

Dragoș M. Vasilescu, Ph.D.

University of British Columbia, Canada

2:05 – 2:15 PM

Hypoxic Vasoconstrictive Response in Advanced Heterogeneous Emphysema – the VENT experience

Rahul G Argula, M.D.

University of South Carolina

2:15 – 2:25 PM

Metabolic Spectroscopy and Imaging of Lung Inflammation using Hyperpolarized 1-13C Pyruvate

Sarmad Siddiqui

University of Pennsylvania

2:25 – 2:35 PM

A Portable Low-Field System for Localized NMR Measurements

Mikayel Dabaghyan, Ph.D.

Mirtech Inc.

2:35 – 2:45 PM

Imaging Early Events in Experimental Acute Lung Injury

Rosana S. Rodrigues, M.D., Ph.D.

Federal University of Rio de Janeiro, Brazil

2:45 – 3:00 PM



Session XIV : Data Processing and Imaging Registration
Moderator: James C. Gee, Ph.D.

3:00 – 3:25 PM

Quantification of Changes in Lung Appearance and Configuration

James C. Gee, Ph.D.

University of Pennsylvania

3:25 – 3:45 PM

Anatomical Constraints for Segmenting Lungs with Severe Pathologies

S. Kevin Zhou, Ph.D.

Siemens Corporate Research

3:45 – 4:05 PM

Functional Chest CT Analysis

Eva van Rikxoort, Ph.D.

Radboud University Nijmegen, Netherland

4:05 – 4:25 PM

Advances in Pulmonary Image Registration

Nicholas J. Tustison, Ph.D.

University of Virginia

4:25 – 4:40 PM


4:40 – 4:55 PM



Session XV : Presentations from Submitted Abstracts
Moderator: Sean B. Fain, Ph.D.

4:55 – 5:10 PM

19F-Enhanced Magnetic Resonance Imaging of Pulmonary Function using Perfluoropropane in Human Subjects at 3T

Ahmed F. Halaweish, Ph.D.

Duke University

5:10 – 5:25 PM

In-Vivo 3He MRI and CFD Modeling of Respiratory Airflow Patterns

Kevin R. Minard, Ph.D.

Pacific Northwest National Laboratory

5:25 – 5:40 PM

In Vivo Measurement of Local Lung Ventilation in Healthy and Diseased Rats using 4DCT

Richard E. Jacob, Ph.D.

Pacific Northwest National Laboratory

5:40 – 5:50 PM


5:50 – 6:00 PM

Final Remarks

Rahim R. Rizi, Ph.D.