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GI Cancer Risk Evaluation Program (GI CREP)

The Gastrointestinal Cancer Risk Evaluation Program (GI-CREP) offers information, evaluation, and follow-up for people who are at increased risk to develop gastrointestinal cancer due to a personal or family history of colon polyps ,colon cancer or other gastrointestinal cancers (pancreatic, stomach, esophageal, liver). It is also important to note that a personal or family history of genitourinary cancers (such as ovarian, bladder, kidney, and uterine cancer) also may contribute to an individual's risk assessment.

If you would like to schedule an appointment in our clinic, please contact the Gastroenterology Scheduling Office at (215) 349-8222

Download the New Patient Packet here.                       Download Frequently Asked Questions here.

Once you have completed the New Patient Packet to the best of your ability, please return via:

Email (preferred): GIGenetics@uphs.upenn.edu              Fax: (215) 349-5314, Attn: GI-CREP

Although most cancers happen by chance and occur at older ages, you may have an inherited risk of cancer in a family if you have:

  • Multiple relatives with the same type of cancer
  • Early age of diagnosis of colon polyps or colon cancer or another gastrointestinal cancer
  • Multiple relatives with colon polyps
  • Multiple relatives with different forms of cancer
  • Individuals who have more than one form of cancer

Penn's GI Cancer Risk Evaluation Program offers a team of experts in gastrointestinal medicine who are nationally recognized experts in the diagnosis and treatment of colon and other gastrointestinal cancers.  Our genetic counselors also have extensive experience in family history assessment, education and counseling for people with a personal/family history of cancer. During your initial visit our specialists help answer questions such as:

  • What is my level of risk for developing gastrointestinal cancer?
  • How can I protect myself?
  • What about my family members?
  • Would testing for the inherited forms of cancer be helpful?

Our specialists provide:

  • A review of your medical history
  • A physical examination and additional testing, as needed
  • Genetic counseling and genetic testing, when appropriate
  • Discussion of your personal risk and recommended risk-reduction strategies
  • A plan for ongoing monitoring for early detection and personal risk reduction
Attending Gastroenterologists: Genetic Counselors:
Anil Rustgi, MD Amanda Brandt, MS, LCGC
Bryson Katona, MD, PhD Dana Clark, MS, LCGC
Kirk Wangensteen, MD, PhD Danielle McKenna, MS, LCGC
  Jessica Long, MS, LCGC
  Jacquelyn Powers, MS, LCGC



University of Pennsylvania | Perelman School of Medicine