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GI Cancer Risk Evaluation Program (GI CREP)

Download the NEW PATIENT PACKET here. Once you have completed this to the best of your ability, please e-mail/fax back to GIGenetics@uphs.upenn.edu or 215-349-5314 (Attn: GI CREP).

Attending Gastroenterologists:
Anil Rustgi, MD
Bryson Katona, MD, PhD

Genetic Counselors:
Amanda Brandt, MS, LCGC
Dana Clark, MS, MS, LCGC
Danielle McKenna, MS, LCGC
Jessica Long, MS, LCGC
Jacquelyn Powers, MS, LCGC

Gastrointestinal cancers are common throughout the United States and the world.  Approximately 108,070 new cases of colon cancer and 40,740 new cases of rectal cancer will be diagnosed in the next year, according to the American Cancer Society.  Cancers that comprise other areas of the gastrointestinal tract such as esophagus, stomach, pancreas, and liver are prevalent as well.  Approximately 20-30% of colon cancer is familial meaning that there is a family history of one or more colon cancers in the family and approximately 10% of colon cancer is hereditary.  This means that we can identify the single genetic component that is putting a family at increased risk for colon and other gastrointestinal cancers.

Although most cancers happen by chance and occur at older ages, you may have an inherited risk of cancer in a family if you have:

  • Multiple relatives with the same type of cancer
  • Early age of diagnosis of colon polyps or colon cancer or another gastrointestinal cancer
  • Multiple relatives with colon polyps
  • Multiple relatives with different forms of cancer
  • Individuals who have more than one form of cancer

The GI Cancer Risk Evaluation Program offers information, evaluation, and follow-up for people who are at increased risk to develop gastrointestinal cancer due to a personal or family history of colon polyps, colon cancer, or other gastrointestinal cancers (pancreatic, stomach, esophageal, liver).  It is also important to note that a personal or family history of genitourinary cancers such as ovarian, bladder, kidney, and uterine cancer may contribute to an individual’s risk assessment.

Penn’s GI Cancer Risk Evaluation Program offers a team of experts in gastrointestinal medicine who are nationally recognized experts in the diagnosis and treatment of colon and other gastrointestinal cancers.  Our genetic counselors also have extensive experience in family history assessment, education and counseling for people with a family history of GI cancer.   Your GI Cancer Risk Evaluation team includes physicians and health care specialists from all needed specialties, including gastrointestinal medicine, hematology-oncology, medical genetics, radiation oncology, surgery, radiology, and pathology.  These specialists work as a team to provide comprehensive and coordinated care.

During your initial visit, our specialists help answer questions such as:

  • What is my level of risk for developing gastrointestinal cancer?
  • How can I protect myself?
  • What about my family members?
  • Would testing for the inherited forms of cancer be helpful?

Our specialists provide:

  • A review of your medical history
  • A physical examination and additional testing, as needed
  • Genetic counseling and genetic testing, when appropriate
  • Discussion of your personal risk and recommended risk-reduction strategies
  • A plan for ongoing monitoring for early detection and personal risk reduction

For physician's guide to Hereditary Colorectal Cancer Syndromes, please click here.

If you would like to know more about the known heritable colon cancer syndromes that we evaluate in our clinic then click here.


University of Pennsylvania | Perelman School of Medicine