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Gastrointestinal Cancer Genetics Program

Gastrointestinal Cancer Genetics Clinic

In the Gastrointestinal Cancer Genetics Clinic, we provide ongoing medical care for patients with hereditary gastrointestinal cancer or polyposis syndromes, including:

  • Lynch syndrome (also referred to as Hereditary Nonpolyposis Colorectal Cancer [HNPCC])
  • Familial adenomatous polyposis (FAP)
  • MUTYH-associated polyposis (MAP)
  • Peutz-Jeghers syndrome (PJS)
  • Juvenile polyposis syndrome (JPS)
  • Hereditary diffuse gastric cancer (HDGC)
  • Serrated polyposis syndrome (SPS)
  • Polymerase proofreading associated polyposis (PPAP)
  • Hereditary mixed polyposis syndrome (HMPS)
  • Colonic adenomatous polyposis of unknown etiology
  • Hereditary pancreatitis

We also help manage the gastrointestinal cancer risk associated with other hereditary cancer syndromes including:

  • Hereditary Breast and Ovarian Cancer syndrome
  • Li-Fraumeni syndrome
  • PTEN hamartoma tumor syndrome, including Cowden syndrome

Through our Gastrointestinal Cancer Genetics Clinic, patients receive counseling on the most current options for managing gastrointestinal cancer risk by expert physicians on the cutting edge of the field.  This is essential, since research and knowledge are advancing quickly in the field of hereditary gastrointestinal cancer and polyposis syndromes. In addition to medical management recommendations, patients may also obtain screening/surveillance tests and procedures, including:

  • Standard endoscopic procedures (including upper endoscopy and colonoscopy)
  • Advanced endoscopic procedures ([including device- assisted deep enteroscopy, endoscopic ultrasound ([EUS]), and endoscopic retrograde cholangio-pancreatography [([ERCP)]])
  • Advanced gastrointestinal imaging (including capsule endoscopy)
  • Radiologic imaging

As part of a world-class academic medical center, we have the ability to connect patients to a broad range of hightly skilled Penn Medicine specialists, including colorectal surgeons and medical oncologists.  Additionally, the Gastrointestinal Cancer Genetics Clinic may provide patients with opportunities to enlist in local and national research registries, as well as local and national clinical trials.

University of Pennsylvania | Perelman School of Medicine