NCI Program Project in Esophageal Carcinogenesis
Publications
The following is a list of publications by faculty member and is available for download in pdf format.
- Anil Rustgi, M.D.
- Meenhard Herlyn, D.V.M.
- J. Alan Diehl, Ph.D.
- Marcia Brose, M.D., Ph.D.
- Wafik El-Deiry, M.D., Ph.D.
- Jonathan Katz, M.D.
- Andres Klein-Szanto, M.D.
- John Lynch, M.D., Ph.D.
- Carlo Maley, Ph.D.
- Hiroshi Nakagawa, M.D., Ph.D.
Nakagawa H, Wang TC, Zukerberg L, Odze R, Togawa K, May GHW, Wilson J, Rustgi AK. The targeting of the cyclin D1 oncogene by an Epstein-Barr virus promoter in transgenic mice causes dysplasia in the tongue, esophagus and forestomach. Oncogene 1997; 14:1185-1190. [pdf]
Nakagawa H, Inomoto T, Rustgi AK. A CACCC box like cis-regulatory element of the Epstein-Barr virus ED-L2 promoter interacts with a nuclear transcriptional factor in tissue-specific squamous epithelia. J Biol Chem 272 1997;16688-16699. [pdf]
Jenkins TD, Nakagawa H, Rustgi AK. The keratinocyte specific Epstein-Barr virus ED-L2 promoter is regulated by phorbol 12-myristate 13-Acetate through two cis-regulatory elements containing e-box and Krüppel-like factor motifs. J Biol Chem 1997; 272:24433-24442. [pdf]
Yan YX, Nakagawa H, Lee MH, Rustgi AK. TGFa enhances cyclin D1 transcription through the binding of early-growth response protein to a cis-regulatory element in the cyclin D1 promoter. J Biol Chem 1997; 272:33181-33190. [pdf]
Mueller A, Odze R, Jenkins TD, Shahsesfaei A, Nakagawa H, Inomoto T, Rustgi AK. A transgenic mouse model with cyclin D1 overexpression results in cell cycle, epidermal growth factor receptor and p53 abnormalities. Cancer Research 1997; 57:5542-5549. [pdf]
Jenkins TD, Opitz OG, Okano J-I, Rustgi AK. Transactivation of the Human Keratin 4 and Epstein-Barr virus ED-L2 promoters by Gut-enriched Krüppel-like factor. J Biol Chem 1998; 273: 17, 10747-10754. [pdf]
Compton CC, Warland G, Nakagawa H, Opitz OG, Rustgi AK. Cellular characterization and successful transfection of serially subcultured normal human esophageal keratinocytes. J Cellular Phys 1998;177: 274-281. [pdf]
Ness S, Edelmann W, Jenkins TD, Liedtke W, Rustgi AK, Kucherlapati R. Mouse keratin 4 is necessary for internal epithelial integrity. J Biol Chem 1998; 273: 23904-23911. [pdf]
Opitz OG, Jenkins TD, Rustgi AK. Transcriptional regulation of the differentiation-linked human keratin 4 promoter is dependent upon esophageal-specific nuclear factors. J Biol Chem 1998; 73: 3912-23921. [pdf]
Jenkins TD, Mueller A, Odze R, Shahsafaei A, Zukerberg LR, Kent R, Stoner GD, Rustgi AK. Cyclin D1 overexpression combined with N-nitrosomethylbenzylamine increases dysplasia and cellular proliferation in murine esophageal squamous epithelium. Oncogene 1999; 18: 59-66. [pdf]
Brembeck FH, Opitz OG, Liebermann TA, Rustgi AK. Dual function of the epithelial specific ets transcription factor, ELF3, in modulating epithelial differentiation. Oncogene 2000; 19:1941-1949. [pdf]
Okano J, Opitz OG, Nakagawa H, Jenkins TD, Friedman S, Rustgi AK. The Kruppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact.. FEBS letters 2000; 473: 95-100. [pdf]
Opitz OG, Rustgi AK. Interaction between Sp1 and cell cycle regulatory proteins is important in transactivation of a differentiation-linked gene. Cancer Research 2000; 60: 2825-2830. [pdf]
Okano JI, Gaslightwala I, Birnbaum MJ, Rustgi AK, Hiroshi Nakagawa. Akt/Protein Kinase B isoforms are differentially regulated by epidermal growth factor stimulation. J Biol Chem 2000 Oct 6; 275(40): 30934-30942. [pdf]
Okano JI, Rustgi AK. Paclitaxel induces prolonged activation of the Ras/MEK/ERK pathway independently of activating the programmed cell-death machinery. J Biol Chem 2001; Jun 1; 276(22): 19555-19564. [pdf]
Opitz OG, Suliman Y, Hahn WC, Harada H, Blum HE, Rustgi AK. Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase independent mechanism. Journal of Clinical Investigation. 2001;108:725-732. (Commentary in Journal of Clinical Investigation and Nature Cancer Reviews). [pdf]
Suliman Y, Opitz OG, Avadhani A, Burns TF, El-Deiry WS, Wong D, Rustgi AK. p63 expression is associated with p53 loss in oral-esophageal epithelia of p53 deficient mice. Cancer Research 2001; 61: 6467-6473. [pdf]
O'Shaughnessy JA, Kelloff GJ, Gordon GB, Dannenberg AJ, Hong WK, Fabian CJ, Sigman CC, Bertagnolli MM, Stratton SP, Lam S, Nelson WG, Meyskens FL, Alberts DS, Follen M, Rustgi AK, Papadimitrakopoulou V, Scardino PT, Gazdar AF, Wattenberg LW, Sporn MB, Sakr WA, Lippman SM, Von Hoff DD. Treatment and prevention of intraepithelial neoplasia: an important target for accelerated new agent development : recommendations of the american association for cancer research task force on the treatment and prevention of intraepithelial neoplasia. Clin Cancer Res 2002; 8(2): 314-346. [pdf]
Opitz OG, Harada H, Suliman Y, Rhoades B, Sharpless NE, Kent R, Kopelovich L, Nakagawa H, Rustgi AK. A mouse genetic model of human oral-esophageal cancer. Journal of Clinical Investigation 2002: 110:761-769. [pdf]
Andl CD, Mizushima T, Nakagawa H, Oyama K, Harada H, Chruma K, Herlyn M, Rustgi AK. Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo. J Biol Chem 2003; 278(3):1824-1830.* [pdf]
Mizushima T, Nakagawa H, Rustgi AK. Wnt-1 but not EGF is required for b-Catenin-T cell factor dependent transcription in esophageal cancer. Cancer Research 2002; 62: 277-282. [pdf]
Okano J, Snyder L, Rustgi AK. Genetic alterations in esophageal cancer. Methods Mol Biol 2003; 222:131-145.
Harada H, Nakagawa N, Oyama K, Takaoka T, Andl C, Jacobmeier B, Enders GH, Opitz OG, Rustgi AK. Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation. Molecular Cancer Research 2003; 1:729-738. [pdf]
Fong LY, Mancini R, Nakagawa H, Rustgi AK, Huebner K. Combined cyclin D1 overexpression and zinc deficiency disrupts cell cycle and accelerates mouse forestomach carcinogenesis. Cancer Res 2003; 63: 4244-4252. [pdf]
Andl CD, Mizushima T, Oyama K, Bowser M, Nakagawa H, Rustgi AK. EGFR induced cell migration is mediated predominantly by the JAK/Stat pathway in primary esophageal keratinocytes. Am J Physiol Gastrointest Liver Physiol. 2004 Jul 29 (epub on-line) [pdf]
Kim SH, Kim K, Kwagh JG, Dicker DT, Herlyn M, Rustgi AK, Chen Y, El-Deiry WS. Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells. J Biol Chem 2004; Jun 28. [pdf]
Benzeno S, Lu F, Guo M, Herman JG, Barbash O, Zhang F, Klein PS, Rustgi AK, Diehl JA. Identification of mutations that disrupt phosphoryltaion-dependent nuclear export of cyclin D1. Oncogene 2006 May 29. Epub. [pdf]
Oyama K, Okawa T., Nakagawa H, Takaoka M, Andl CD, Kim SH, Klein-Szanto A, Diehl JA, Herlyn M, El-Deiry W, Rustgi AK. AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture. Oncogene 2006 October 9, Epub. [pdf]
Andl CD , Fargnoli B, Okawa T, Bowser M, Takaoka M, Nakagawa H, Klein-Szanto A, Hua X, Herlyn M, Rustgi AK. Coordinated functions of E-cadherin and TGF¾ receptor II in vitro and in vivo. Cancer Research 2006; 66(20) on-line. [pdf]
Lin D, Barbash O, Kumar S, Weber J, Harper W, Klein-Szanto A, Rustgi AK, Fuchs S, Diehl JA. Phosphorylation-dependent ubiquitination of cyclin D1 by the SCFFBX4-alphaBcrystallin complex. Molecular Cell 2006; 24(3): 355-366. [pdf]
Grandis JR, Carbone DP, Rustgi AK. Advances and challenges in aerodigestive epithelial cancer: meeting summary and research opportunities. Cancer Research 2007; 67(16):7556-7558. [pdf]
Okawa T, Michaylira CZ, Nakagawa H, Andl CD, Stairs DB, Johnstone CN, Klein-Szanto AJP, El-Deiry WS, Cukierman E, Herlyn M, Rustgi AK. The functional interplay between EGFR overexpression, hTER activation and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induce tumor development, invasion and differentiation. Genes & Development 2007; 21: 2788-2083. [pdf]
Harada H, Nakagawa H, Takaoka M, Lee J, Gimotty P, Herlyn M, Diehl AJ, Rustgi AK. Cleavage of MCM2 licensing proteins fosters senescence in human keratinocytes. Cell Cycle (in press).
Yang L, Dan HC, Sun M, Liu Q, Sun XM, Feldman RI, Hamilton AD, Polokoff M, Nicosia SV, Herlyn M, Sebti SM, Cheng JQ. Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer Res 2004; 64:4394-4399. [pdf]
Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, Venere M, Ditullio RA, Jr, Kastrinakis NG, Levy B, Kletsas D, Yoneta A, Herlyn M, Kittas C, Halazonetis TD. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005; 434:907-913. [pdf]
Liu Z-J, Xiao M, Balint K, Soma A, Pinnix CC, Capobianco AJ, Herlyn M. Inhibiton of endothelial cells growth by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requirtes MAML1. FASEB J 2006; 20(7): 1009-1011. [pdf]
Lioni M, Brafford P, Andl A, Rustgi A, El-Deiry W, Herlyn M, Smalley KSM. Dysregulation of Claudin-7 leads to loss of E-cadherin expression and the increased invasion of esophageal squamous cell carcinoma cells. Am. J. Pathol. 2007; 170: 709-721. [pdf]
Noma K, Smalley KS, Lioni M, Naomoto Y, Tankaka N, El-Deiry W, King AJ, Nakagawa H, Herlyn M. The Essential Role of Fibroblasts in Esophageal Squamous Cell Carcinoma-Induced Angiogenesis. Gastroenterology 2008; 134(7): 1981-1983. [pdf]
Lioni M, Noma K, Snyder A, Klein-Szanto A, Diehl JA, Rustgi AK, Herlyn M, Smalley KS. Bortezomib-Induces Apoptosis in Esophageal Squamous Cell Carcionma Cells through Activation of the p38 MAPK Pathway. Molecular Cancer Therapy 2008; 7(9); 2866-2875. [pdf]
Harada H, Nakagawa H, Takaoka M, Lee J, Gimotty P, Herlyn M, Diehl AJ, Rustgi AK. Cleavage of MCM2 licensing proteins fosters senescence in human keratinocytes. Cell Cycle (in press).
Rimerman RA, Gellert-Randleman A, Diehl JA. Wnt1 and MEK1 cooperate to promote cyclin D1 accumulation and cellular transformation. J Biol Chem 2000; 275:14736-14742. [pdf]
Alt JR, Cleveland JL, Hannink M, Diehl JA. Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. Genes & Dev 2000; 14:3102-3114. [pdf]
Alt JR, Gladden AB, Diehl JA. p21(Cip1) promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export. J Biol Chem 2002; 277:8517-8523. [pdf]
Diehl JA, Yang W, Rimerman RA, Xiao H, Emili A. Hsc70 Regulates Accumulation of Cyclin D1 and the Cyclin D1-Dependent Protein Kinase. Mol Cell Biol 2003; 23:1764-1774. [pdf]
Gladden AB, Diehl JA. The Cyclin D1-dependent kinase associates with the pre-replication complex and modulates RB.MCM7 binding. J Biol Chem 2003; 278:9754-9760. [pdf]
Lu F, Gladden AB, Diehl JA. An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene. Cancer Research 2003; 63:7056-7061. [pdf]
Benzeno S, Lu F, Guo M, Barbash O, Zhang F, Herman JG, Klein PS, Rustgi AK, Diehl JA. Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1. Oncogene 2006; Oct 12: 25(47): 6291-6303. [pdf]
Lin DI, Barbash O, Kumar KG, Weber JD, Harper JW, Klein-Szanto AJ, Rustgi AK, Fuchs Sy, Diehl JA. Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. Mol Cell 2006 Nov 3;24(3):355-366. [pdf]
Barbash O, Lin DI, Diehl JA. SCF Fbx4/alphaB-crystallin cyclin D1 ubiquitin ligase: a license to destroy. Cell Div 2007; Jan 15;2:2. [pdf]
Lin DI, Lessie MD, Gladden AB, Bassing CH, Wagner KU, Diehl JADisruption of cyclin D1 nuclear export and proteolysis accelerates mammary carcinogenesis. Oncogene 2008; 27:1231-1242. [pdf]
Aggarwal P, Lessie M, Lin DI, Gladden AD, Nuskey B, Goradia A, Wasik M, Klein-Szanto A, Rustgi A, Bassing C, Diehl JA. Nuclear Accumulation of Cyclin D1 During S-phase Inhibits Cul4-dependent Cdt1 Proteolysis and Triggers p53-dependent DNA Re-replication. Genes & Dev 2007; 21: 2908-2922. [pdf]
Barbash O, Zamfirova P, Lin DI, Chen LX, Yang K, Nakagawa H, Lu F, Rustgi AK, Diehl JA. Mutations in Fbx4 inhibit phosphorylation-dependent dimerization of the SCF-Fbx4 ligase and contribute to cyclin D1overexpression in human cancer. Cancer Cell 2008; 14:68-78. [pdf]
Barbash O, Diehl JA. SCF(Fbx4/alpha beta-crystallin) E3 ligase: when one is not enough. Cell Cycle (in press).
Harada H, Nakagawa H, Takaoka M, Lee J, Gimotty P, Herlyn M, Diehl AJ, Rustgi AK. Cleavage of MCM2 licensing proteins fosters senescence in human keratinocytes. Cell Cycle (in press).
Sparano A, Quesnelle KM, Kumar MS, Wang Y, Sylvester AJ, Feldman M, Sewell DA, Weinstein GS, Brose MS. Genome-wide profiling of oral squamous cell carcinoma by array-based comparative genomic hybridization. Laryngoscope 2006; 116(5): 735-741.
Vachani A, Nebozhyn M, Singhal S, Alila L, Wakeam E, Muschel R, Powell CA, Gaffney P, Singh B, Brose MS, Litlzky LA, Kucharczuk J, Kaiser LR, Marron JS, Showe MK, Albelda SM, Showe LC. A 10-gene classifier for distinguishing head and neck squamous cell carcinoma and lung squamous cell carcinoma. Clin Cancer Res 2007; 13(10): 2905-2915. [pdf]
O'Donnell RK, Mick R, Feldman M, Hino S, Wang Y, Brose MS, Muschel RJ. Distribution of dendritic cell subtypes in primary oral squamous cell carcinoma is inconsistent with a functional response. Cancer Lett 2007; 255(1): 145-152. [pdf]
Flaherty KT, Schiller J, Schuchter LM, Liu G, Tuveson DA, Redlinger M, Lathia C, Xia C, Petrenciuc O, Hingorani SR, Jacobetz MA, Van Belle PA, Elder D, Brose MS, Weber BL, Albertini MR, O'Dwyer PJ. A phase I trial of the oral, multikinase inhibitor sorafenib in combination with carboplatin and paclitaxel. Clinical Cancer Research 2008; 14(15): 4836-4842. [pdf]
Sheikh MS, Huang Y, Fernandez-Salas EA, El-Deiry WS, Friess H, Amundson S, Yin J, Meltzer SJ, Holbrook NJ, Fornace Jr. AJ. The antiapoptotic decoy receptor TRID/TRAIL R3 in a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract. Oncogene 18: 4153-4159, 1999. [pdf]
Kim K, Fisher MJ, Xu SQ, El-Deiry WS. Molecular determinants of response to TRAIL in killing of normal and cancer cells. Clinical Cancer Research, 6: 335-346, 2000. [pdf]
McDonald III ER, Chui PC, Martelli PF, Dicker DT, El-Deiry WS. Death domain mutagenesis of KILLER/DR5 reveals residues critical for apoptotic signaling. J Biol Chem, 276: 14939-14945, 2001. [pdf]
Meng RD, El-Deiry WS. P53-Independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-γ. Exp Cell Res. 262: 154-169, 2001. [pdf]
Fei P, Bernhard EJ, El-Deiry WS. Tissue specific induction of p53 targets in vivo. Can Res. 62: 7316-7327, 2001. [pdf]
Jin Z, McDonald III ER, Dicker DT, El-Deiry WS. Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis. J Biol Chem. 279: 35829-35839, 2004. [pdf]
Kim SH, Kim K, Kwagh JG, Dicker DT, Herlyn M, Rustgi AK, Chen Y, El-Deiry WS. Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells. J Biol Chem. 2004 Jun 28. [pdf]
Ricci MS, Jin Z, Dews M, Yu D, Thomas-Tikhonenko A, Dicker DT, El-Deiry WS. Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity. Mol & Chen Biol. 24.19: 8541-8555, 2004. [pdf]
Jin Z, El-Deiry WS. Overview of cell death signaling pathways. Can Biol & Therapy. 4.2: e50-e74, 2005. [pdf]
Mayes PA, Campbell L, Ricci MS, Plastaras JP, Dicker DT, El-Deiry WS. Modulation of TRAIL-induced tumor cell apoptosis in a hypoxic environment. Can Biol & Therapy. 4.10: 1068-1074, 2005. [pdf]
Jin Z, El-Deiry WS. Distinct Signaling Pathways in TRAIL - verses Tumor Necrosis Factor Induced Apoptosis. Mol & Cell Biol. 26.21: 8136-8148, 2006. [pdf]
Kim SH, Nakagawa H, Navaraj A, Naomoto Y, Klein-Szanto A, Rustgi AK, El-Deiry WS. Tumorigenic conversion of primary human esophageal epithelial cells using oncogene combinations in the absence of exogenous Ras. Cancer Research 2006; 66(21): 10415-10424. [pdf]
Katz JP, Perreault N, Goldstein BG, McNally SR, Silberg DG, Furth EE, Kaestner KH. Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach. Gastroenterology 2005: 128: 935-945. [pdf]
Yang Y, Goldstein BG, Chao H, Katz JP. KLF4 and KLF5 regulate proliferation, apoptosis, and invasion in esophageal cancer cells. Cancer Biology and Therapy 2005: 4: 1216-1221. [pdf]
Yang Y, Goldstein BG, Nakagawa H, Katz JP. Krüppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells. FASEB Journal 2007; 21: 543-550. [pdf]
Goldstein BG, Chao H, Yang Y, Yermolina Y, Tobias JW, Katz JP. Overexpression of Krüppel-like factor 5 in esophageal epithelia in vivo leads to increased proliferation in basal but not suprabasal cells. Am J Physiol Gastrointest Liver Physiol 2007: 292: G1784-1792. [pdf]
Crissey MA, Guo RJ, Fogt F, Li H, Katz JP, Silberg DG, Suh ER, Lynch JP. The homeodomain transcription factor Cdx1 does not behave as an oncogene in normal mouse intestine. Neoplasia 2008; 10:8-19. [pdf]
Andres Klein-Szanto Publications:
Liu SC, Bassi DE, Zhang SY, Holoran D, Conti CJ, Klein-Szanto AJP. Overexpression of cyclin D2 is associated with increased in vivo invasiveness of human squamous carcinoma cells. Mol Carcin 2002; 34: 131-139. [pdf]
Lopez de Cicco R, Bassie DE, Page RE, Klein-Szanto AJP. Furin expression in squamous cell carcinomas of the oral cavity and other sites evaluated by tissue microarray technology. Acta Odontol Latinoamer 2002; 15: 29-37.
Bassi DE, Mahloogi H, Lopez de Cicco R, Klein-Szanto AJP. Increased furin activity enhances the maligmant phenotype of human head and neck cancer cells. Am J Pathol 2003; 162: 439-447. [pdf]
Mahloogi H, González Guerrico AM, Lopez de Cicco R, Bassi DE, Goodrow T, Braunewell KH, Klein-Szanto AJP. Overexpression of the calcium sensor visinin-like protein-1 leads to a cAMP-mediated decrease of in vivo and in vitro growth and invasiveness of squamous cell carcinoma cells. Cancer Res 2003; 63: 4997-5004. [pdf]
Lopez de Cicco R, Watson JC, Bassi DE, Litwin S, Klein-Szanto AJP. Simultaneous expression of furin and vascular endothelial growth factor in human oral tongue squamous carcinoma progression. Clin Cancer Res 2004; 10: 4480-4488. [pdf]
Takaoka M, Harada H, Andl CD, Oyama K, Naomoto Y, Dempsey K, Klein-Szanto AJP, El-Deiry W, Grimberg A, Nakagawa H. Epidermal growth factor receptor regulates aberrant expression of insulin-like growth factor-binding protein 3. Cancer Res 2004; 64: 7711-7723. [pdf]
Gonzalez Guerrico AM, Jaffer ZM, Page RE, Braunewell KH, Chernoff J, Klein-Szanto AJP. Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells. Oncogene 2005; 24: 2307-2316. [pdf]
Bassi DE, Lopez de Cicco R, Cenna J, Cukierman E, Klein-Szanto AJP. PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression. Cancer Res 2005; 65: 7310-7319. [pdf]
Lopez de Cicco R, Bassi DE, Zucker S, Seidah NG, Klein-Szanto AJP. Human squamous carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin. Cancer Res 2005; 65: 7310-7319. [pdf]
Kim S, Nakagawa H, Navaraj A, Naomoto Y, Klein-Szanto AJP, Rustgi AK, El-Deiry WS. Tumorigenic conversion of primary human esophageal epithelial cells using oncogene combinations in the absence of exogenous Ras. Cancer Res 2006; 66: 10415-10424. [pdf]
Lin DI, Barbash O, Kumar KG, Weber JD, Harper JW, Klein-Szanto AJP, Rustgi AK, Fuchs Sy, Diehl JA. Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. Mol Cell 2006 Nov 3;24(3):355-366. [pdf]
Oyama K, Okawa T, Nakagawa H, Takaoka M, Andl CD, Kim S, Klein-Szanto AJP, Herlyn M, El-Deiry WS, Rustgi AK. AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture. Oncogene 2007; 26:2353-2364. [pdf]
Takaoka M, Kim SH, Okawa T, Michaylira C, Andl CD, Stairs D, Johnstone C, Rhoades B, Mitchell S, Lee J, Dezfuli A, Klein-Szanto AJP, El-Deiry WS, Nakagawa H. IGFBP-3 regulates esophageal tumor growth through IGF-dependent and independent mechanisms. Cancer Bio Ther 2007; 6: 534-540. [pdf]
Bassi DE, Klein-Szanto AJP. Carcinogen induced animal models of head and neck squamous cell cancer. Curr Prot Pharmacol 2007; 14:2.
Okawa T, Michaylira C, Nakagawa H, Andl C, Stairs D, Johnstone C, Klein-Szanto AJP, El-Diery W, Cukierman E, Herlyn M, Rustgi AK. The functional interplay between EGFR overexpression, hTERT activation and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induce tumor development, invasion and differentiation. Genes & Dev 2007; 21: 2788-2803. [pdf]
Aggarwal P, Lessie M, Lin DI, Gladden AD, Nuskey B, Goradia A, Wasik M, Klein-Szanto A, Rustgi A, Bassing C, Diehl JA. Nuclear Accumulation of Cyclin D1 During S-phase Inhibits Cul4-dependent Cdt1 Proteolysis and Triggers p53-dependent DNA Re-replication. Genes & Dev 2007; 21: 2908-2922. [pdf]
Xiao F, Crissey MS, Lynch JP, Silberg DG, Suh E. Intestinal metaplasia with high-salt diet induces epithelial prolifertion and alters cell composition in the gastric mucosa of mice. Cancer Bio Ther 2005; 4(6): 669-675. [pdf]
Kong J, Nakagawa H, Isariyawongse B, Funakoshi S, Silberg D, Rustgi AK, Lynch JP. Induction of intestinalization in human esophageal keratinocytes is a multi-step process. Carcinogenesis (in press).
Maley CC, Galipeau PC, Li X, Sanchez CA, Paulson TG, Reid BJ. Selectively advantageous mutations and hitchhikers in neoplasms: p16 lesions are selected in Barrett's esophagus. Cancer Res 2004; 64(10): 3414-3427. [pdf]
Maley CC, Galipeau PC, Li X, Sanchez CA, Paulson TG, Blount PL, Reid BJ. The combination of genetic instability and clonal expansion predicts progression to esophageal adenocarcinoma. Cancer Res 2004; 64(20): 7629-7633. [pdf]
Maley CC, Reid BJ. Natural selection in neoplastic progression of Barrett's esophagus. Semin Cancer Biol 2005; 15(6): 474-483. [pdf]
Maley CC, Galipeau PC, Finley JC, Wongsurawat VJ, Li X, Sanchez CA, Paulson TG, Blount PL, Risques RA, Rabinovitch PS, Reid BJ. Genetic clonal diversity predicts progression to esophageal adenocarcinoma. Nat Genet 2006; 38(4): 468-473. [pdf]
Maley CC, Rustgi AK. Barrett's esophagus and its progression to adenocarcinoma. J Natl Compr Canc Netw 2006; 4(4): 367-74.
Kelloff GJ, Lippman SM, Dannenberg AJ, Sigman CC, Pearce HL, Reid BJ, Szabo E, Jordan VC, Spitz MR, Mills GB, Papadimitrakopoulou VA, Lotan R, Aggarwal BB, Bresalier RS, Kim J, Arun B, Lu KH, Thomas ME, Rhodes HE, Brewer MA, Follen M, Shin DM, Parnes HL, Siegried JM, Evans AA, Blot WJ, Chow WH, Blount PL, Maley CC, Wang KK, Lam S, Lee JJ, Dubinett SM, Engstrom PF, Meyskens FL Jr, O'Shaughnessy J, Hawk ET, Levin B, Nelson WG, Hong WK, AACR Task Force on Cancer Prevention. Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer: a plan to move forward. Clin Cancer Res 2006; 12(12): 3661-3697. [pdf]
Chao DL, Maley CC, Wu X, Farrow DC, Galipeau PC, Sanchez CA, Paulson TG, Rabinovitch PS, Reid BJ, Spitz MR, Vaughan TL. Mutagen sensitivity and neoplastic progression in patients with Barrett's esophagus: a prospective analysis. Cancer Epidemiol Biomarkers Prev 2006; 15(10): 1935-1940. [pdf]
Maley CC. Multistage carcinogenesis in Barrett's esophagus. Cancer Lett 2007; 245(1-2): 22-32. [pdf]
Galipeau PC, Li X, Blount PL, Maley CC, Sanchez CA, Odze RD, Ayub K, Rabinovitch PS, Vaughan TL, Reid BJ. NSAIDs modulcate CDKN2A, TP53, and DNA content risk for progression to esphageal adenocarcionma. PLoS Med 2007; 4(2): e67. [pdf]
Hiroshi Nakagawa Publications:
Nakagawa H, Wang TC, Zukerberg L, Odze R, Togawa K, May GH, Wilson J, Rustgi AK. The targeting of the cyclin D1 oncogene by an Epstein-Barr virus promoter in transgenic mice causes dysplasia in the tongue, esophagus and forestomach. Oncogene 1997; 14: 1185-1190. [pdf]
Nakagawa H, Inomoto T, Rustgi AK. A CACCC box-like cis-regulatory element of the Epstein-Barr virus ED-L2 promoter interacts with a novel transcriptional factor in tissue-specific squamous epithelia. J Biol Chem 1997; 272: 16688-16699. [pdf]
Jenkins TD, Nakagawa H, Rustgi AK. The keratinocyte specific Epstein-Barr virus ED-L2 promoter is regulated by phorbol 12-myristate 13-Acetate through two cis-regulatory elements containing e-box and Krüppel-like factor motifs. J Biol Chem 1997; 272: 24433-24442. [pdf]
Mueller A, Odze R, Jenkins TD, Shahsesfaei A, Nakagawa H, Inomoto T, Rustgi AK. A transgenic mouse model with cyclin D1 overexpression results in cell cycle, epidermal growth factor receptor, and p53 abnormalities. Cancer Res 1997; 57: 5542-5549. [pdf]
Yan YX, Nakagawa H, Lee MH, Rustgi AK. Transforming growth factor-alpha enhances cyclin D1 transcription through the binding of early growth response protein to a cis-regulatory element in the cyclin D1 promoter. J Biol Chem 1997; 272: 33181-33190. [pdf]
Compton C, Garland W, Nakagawa H, Opitz O, Rustgi AK. Cellular characterization and successful transfection of serially subcultured normal human esophageal keratinocytes. Journal of Cellular Physiology 1998; 177: 274-281. [pdf]
Okano J, Opitz OG, Nakagawa H, Jenkins TD, Friedman SL, Rustgi AK. The Kruppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact. FEBS Lett 2000; 473: 95-100. [pdf]
Okano J, Gaslightwala I, Birnbaum MJ, Rustgi AK, Nakgawa H. Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation. J Biol Chem 2000; 275: 30934-30942. [pdf]
Mizushima T, Nakagawa H, Kamberov YG, Wilder EL, Klein PS, Rustgi AK. Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells. Cancer Res 2002; 62: 277-282. [pdf]
Opitz OG, Harada H, Suliman Y, Rhoades B, Sharpless NE, Kent R, Kopelovich L, Nakagawa H, Rustgi AK. A mouse genetic model of human oral-esophageal cancer. J. Clin Invest 2002; 110: 761-769. [pdf]
Andl CD, Mizushima T, Nakagawa H, Oyama K, Harada H, Chruma K, Herlyn M, Rustgi AK. Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo. J Biol Chem 2003; 278(3): 1824-1830. [pdf]
Fong LY, Mancini R, Nakagawa H, Rustgi AK, Huebner K. Combined cyclin D1 overexpression and zinc deficiency disrupts cell cycle and accelerates mouse forestomach carcinogenesis. Cancer Res 2003; 63: 4244-4252. [pdf]
Harada H, Nakagawa H, Oyama K, Takaoka M, Andl CD, Jacobmeier B, von Werder A, Enders GH, Opitz OG, Rustgi AK. Telomerase induces immortalization of human esophageal keratinocytes without p16INK4A inactivation. Molecular Cancer Research 2003; 1: 729-738. [pdf]
Kim K, Nakagawa H, Fei P, Rustgi AK, El-Deiry WS. Targeting Bcl-XL in esophageal squamous cancer to sensitize to chemotherapy plus TRAIL-induced apoptosis while normal epithelial cells are protected by blockade of caspase 9. Cell Death Diff 2004; 11: 583-587. [pdf]
Takaoka M, Harada H, Deramaudt TB, Oyama K, Andl CD, Johnstone CN, Rhoades B, Opitz OG, Nakagawa H. Ha-RasG12V induces senescence in primary and immortalized human esophageal keratinocytes with p53 dysfunction. Oncogene 2004; 23: 6760-6768. [pdf]
Andl CD, Mizushima T, Oyama K, Nakagawa H, Rustgi AK. EGFR induced cell migration is mediated predominantly by the JAK/Stat pathway in primary esophageal keratinocytes. American Journal of Physiology - Gastrointestinal and Liver Physiology 2004; 287: G1227-1237. [pdf]
Takaoka M, Harada H, Andl CD, Oyama K, Naomoto Y, Dempsey K, Klein-Szanto AJ, El-Deiry WS, Grimberg A, Nakagawa H. Epidermal growth factor receptor regulates aberrant expression of insulin-like growth factor binding protein-3. Cancer Research 2004; 64: 7711-7723. [pdf]
Takaoka M, Smith CE, Mashiba MK, Okawa T, Andl CD, El-Deiry WS, Nakagawa H. EGF-mediated regulation of insulin-like growth factor binding protein (IGFBP)-3 determines esophageal epithelial cellular response to IGF-I. Am J Physiol - Gastrointestinal and Liver Physiology 2006; 290: G404-416. [pdf]
Kobayashi M, Naomoto Y, Nobuhisa T, Okawa T, Takaoka M, Shirakawa Y, Yamatsuji T, Matsuoka J., Mizushima T, Matsuura H, Nakajima M, Nakagawa H, Rustgi AK, Tanaka N. Heparanase regulates esophageal keratinocyte differentiation through nuclear translocation and heparin sulfate cleavage. Differentiation 2006; 74(5): 235-243. [pdf]
Andl CD , Fargnoli B, Okawa T, Bowser M, Takaoka M, Nakagawa H, Klein-Szanto A, Hua X, Herlyn M, Rustgi AK. Coordinated functions of E-cadherin and TGFb receptor II in vitro and in vivo. Cancer Research 2006; 66(20): 9878-9885. [pdf]
Kim SH, Nakagawa H, Navaraj A, Naomoto Y, Klein-Szanto A, Rustgi AK, El-Deiry WS. Tumorigenic conversion of primary human esophageal epithelial cells using oncogene combinations in the absence of exogenous Ras. Cancer Research 2006; 66: 10415-10424. [pdf]
Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou LVF, Kolettas E, Niforou K, Zoumpourlis VC, Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, Sehested M, Andersen CL, Dyrskjot L, Orntoft T, Lukas J, Kittas C, Helleday T, Halazonetis TD, Bartek J, Gorgoulis V.G. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 2006; 444: 633-637. [pdf]
Oyama K, Okawa T, Nakagawa H, Takaoka M, Andl CD, Kim SH, Klein-Szanto A, Diehl JA, Herlyn M, El-Deiry W, Rustgi AK. AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture. Oncogene 2007; 26(16): 2353-2364. [pdf]
Yang Y, Goldstein BG, Nakagawa H, Katz JP. Krüppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells. FASEB J 2007; 21: 543-550. [pdf]
Takaoka M, Kim SH, Okawa T, Michaylira CZ, Stairs D, Johnstone CN, Andl CD, Rhoades B, Lee J, Klein-Szanto AJP, El-Deiry WS, Nakagawa H. IGFBP-3 regulates esophageal tumor growth through IGF-dependent and independent mechanisms. Cancer Biol Ther 2007; 6: 534-540. [pdf]
Okawa T, Michaylira CZ, Nakagawa H, Andl CD, Stairs DB, Johnstone CN, Klein-Szanto AJP, El-Deiry WS, Cukierman E, Herlyn M, Rustgi AK. The functional interplay between EGFR overexpression, hTER activation and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induce tumor development, invasion and differentiation. Genes & Development 2007; 21: 2788-2083. [pdf]
Harada H, Nakagawa H, Takaoka M, Lee J, Gimotty P, Herlyn M, Diehl AJ, Rustgi AK. Cleavage of MCM2 licensing proteins fosters senescence in human keratinocytes. Cell Cycle (in press).
Esophageal P01 Archive:
https://www-dev.bioinformatics.upenn.edu/p01/index.do