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2016 Gail Gasser Lecture


Andrew B. Singleton, Ph.D.
NIH Distinguished Investigator
Laboratory of Neurogenetics
National Institutes of Health

"The Genetic Architecture of Parkinson Disease: Integrating data to provide novel insights"

Wednesday, October 12, 2016, 12:00 PM
Main Auditorium, Biomedical Research Building

Dr Singleton received his B.Sc. from the University of Sunderland, UK and his Ph.D. from the University of Newcastle upon Tyne, UK. Dr Singleton’s research initially focused on genetic determinants of dementia, in particular Alzheimer’s disease and dementia with Lewy bodies. His postdoctoral studies were spent at the Mayo Clinic in Jacksonville Florida. Dr Singleton moved to the National Institute on Aging at NIH Bethesda, MD in 2001 and became a principal investigator leading the Molecular Genetics Unit in 2002. In 2007 Dr Singleton became a tenured senior investigator at the National Institute on Aging, in 2008 he became the Chief of the Laboratory of Neurogenetics, and in 2016 he was named an NIH Distinguished Investigator.

Dr. Singleton has published more than 500 articles on a wide variety of topics. His laboratory comprises ~50 staff, including five principal investigators and 3 group leaders. His laboratory works on the genetic basis of neurological disorders including Parkinson's disease, Alzheimer’s disease, dystonia, ataxia, dementia with Lewy bodies, and amyotrophic lateral sclerosis. The goal of this research is to identify genetic variability that causes or contributes to disease and to use this knowledge to understand the molecular processes underlying disease.

Dr. Singleton currently serves on the scientific advisory board of the Michael J. Fox Foundation and the Lewy Body Dementia Association; he is a member of the editorial boards of Neurodegenerative Diseases, Neurogenetics, Movement Disorders, Brain (Associate Editor, Genetics), Lancet Neurology, the Journal of Parkinson’s Disease, NPJ Parkinson’s Disease, the Journal of Huntington’s Disease, and Annals of Neurology. Dr. Singleton was awarded the Boehringer Mannheim Research Award in 2005, the NIH Director’s Award in 2008, and the Annemarie Opprecht Award in 2008. In 2012 Dr. Singleton became the first person to win the Jay van Andel Award for Outstanding Achievement in Parkinson’s Disease Research.