Publication describing a new C57BL6 knockin mouse that acknowledges Core personnel for design and construction of the targeting vector as well as electroporation of C57BL6 cells, karyotyping of the resulting ES clones and their expansion for injection into blastocysts

  • Chakkalakal SA, Zhang D, Culbert AL, Convente MR, Caron RJ, Wright AC, Maidment AD, Kaplan FS, Shore EM. An Acvr1 R206H knock-in mouse has fibrodysplasia ossificans progressiva. J Bone Miner Res. 2012 Aug;27(8):1746-56. doi: 10.1002/jbmr.1637. [Link]

Publication describing a new C57BL6 conditional knockout mouse that acknowledges Core personnel for electroporation of C57BL6 ES cells, karyotyping of the resulting ES clones and their expansion for injection into blastocysts

  • Song D, Lee FS. Mouse knockout of Iop1 reveals its essential role in mammalian cytosolic iron-sulfur protein biogenesis.J Biol Chem. 2011 Mar 2. [Link]

Publications describing new 129 knockin mice or new 129 conditional knockout mice that acknowledge the Core for electroporation of 129 ES cells, karyotyping of the resulting targeted ES clones and their expansion for injection into blastocysts

  • Miccio A, Wang Y, Hong W, Gregory GD, Wang H, Yu X, Choi JK, Shelat S, Tong W, Poncz M, Blobel GA NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. EMBO J. 2010 Jan 20;29(2):442-56. [Link]
  • Robert-Cooperman CE, Carnegie JR, Wilson CG, Yang J, Cook JR, Wu J, Young RA, Wolf BA, Burkhardt BR. Targeted disruption of pancreatic-derived factor (PANDER, FAM3B) impairs pancreatic beta-cell function. Diabetes. 2010 Sep;59(9):2209-18. Epub 2010 Jun 21. Erratum in: Diabetes. 2010 Dec;59(12):3257. [Link]
  • Wang D, Patel VV, Ricciotti E, Zhou R, Levin MD, Gao E, Yu Z, Ferrari VA, Lu MM, Xu J, Zhang H, Hui Y, Cheng Y, Petrenko N, Yu Y, FitzGerald GA. Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7548-52. Epub 2009 Apr 17. [Link]
  • Vardeh D, Wang D, Costigan M, Lazarus M, Saper CB, Woolf CJ, Fitzgerald GA, Samad TA. J Clin Invest. 2009 Feb;119(2):287-94. doi: 10.1172/JCI37098. COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice.Epub 2009 Jan 5. [Link]
  • Sun H, Gong S, Carmody RJ, Hilliard A, Li L, Sun J, Kong L, Xu L, Hilliard B, Hu S, Shen H, Yang X, Chen YH. TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis. Cell. 2008 May 2;133(3):415-26. [Link]
  • Saiki R, Lunceford AL, Shi Y, Marbois B, King R, Pachuski J, Kawamukai M, Gasser DL, Clarke CF. Am J Physiol Renal Physiol. 2008 Nov;295(5):F1535-44. Coenzyme Q10 supplementation rescues renal disease in Pdss2kd/kd mice with mutations in prenyl diphosphate synthase subunit 2. Epub 2008 Sep 10. [Link]
  • Peng M, Falk MJ, Haase VH, King R, Polyak E, Selak M, Yudkoff M, Hancock WW, Meade R, Saiki R, Lunceford AL, Clarke CF, Gasser DL. Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease. PLoS Genet. 2008 Apr 25;4(4):e1000061. [Link]

  • Select publications detailing the scientific expertise of Dr. Raabe, the Core and Laboratory Technical Director, in stem cell science

    • Raabe T and Wesselschmidt R. 2007 ‘Genetic manipulation of embryonic stem cells’ in: Human Stem Cell Manual: A Laboratory Guide. Edited by Jeanne Loring, Elsevier Press pp 267-88.
    • Yu Z, Raabe T, Hecht NB. 2005 MicroRNA Mirn122a reduces expression of the posttranscriptionally regulated germ cell transition protein 2 (Tnp2) messenger RNA (mRNA) by mRNA cleavage. Biol Reprod. 73(3):427-33. [Link]

    Select Publications detailing the scientific expertise of Core and Laboratory personnel in the regulation of mammalian and bacterial gene expression

    • Sherry B, Schmidtmayerova H, Zybarth G, Dubrovsky L, Raabe T, Bukrinsky M. 2000 Nitric oxide regulates MIP-1alpha expression in primary macrophages and T lymphocytes: implications for anti-HIV-1 response. Mol Med. 6:542-9. [Link]
    • Raabe T, Currie R, Bukrinsky M 1998 Relative contribution of transcription and translation to the induction of tumor necrosis factor by LPS. J. Biol. Chem. 273:974-980. [Link]
    • Bukrinsky M, Sherry B, Schmidtmayerova H, Raabe T, and Dubrovsky L 1997 Differential regulation by nitric oxide: Production of macrophage inflammatory protein. In HIV and Cytokines:, M. Guenounou (ed.). Les Editions INSERM, Paris, pp 89-97.
    • Schmidtmayerova H, Nottet H, Nuovo G, Raabe T, Flanagan C, Dubrovsky L, Gendelman H, Cerami A, Bukrinsky M, Sherry B 1996 Human immunodeficiency virus infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leucocytes into brain and lymphnodes. Proc. Natl. Acad. Sci. U.S.A. 93:700-704.[Link]
    • Raabe T, Murthy K, Manley J 1994 Poly (A) polymerase contains multiple functional domains. Mol. Cell. Biol. 14:2946-2957. [Link]
    • Raabe T, Bollum F, Manley J 1991 Primary structure and expression of bovine poly(A) polymerase. Nature 353: 229-234. [Link]
    • Raabe T, Jenny E, Meyer J 1988 A selection cartridge for rapid detection and analysis of spontaneous mutations including insertions of transposable elements in Enterobacteriaceae. Mol. Gen. Gent. 215:176-180. [Link]