About the Mice Image
The mice featured on our website are three littermates generated by the injection of ES cells into mouse blastocysts. In laymen's terms, they are siblings born to the same surrogate mother, exihibiting different combinations of the same genetic mixture. While the coats of the middle and bottom mice reveal the contribution of both the ES cells (agouti) and their host embryos (black), the top shows no external evidence of any contribution from its ES cells.
These particular mice were created by our facility for research being conducted in the lab of Dr. John R. Stanley, Chairman of the Department of Dermatology in the University of Pennsylvania School of Medicine. A targeted mutation disrupted the Desmoglein 3 gene, resulting in a phenotype similar to Pemphigus Vulgaris. (J.Cell Biol. 137: 1091-1102, 1997).
Photograph by Todd Bauders