For additional ways to keep in touch, BGS maintains a Linkedin Group along with a Facebook page for Biomedical Graduate Studies Alumni. Please assist in keeping this alumni list below current by contacting the Pharmacology Graduate Group Coordinator with any current information on our graduates. Thank you.

Pharmacology Graduate Group Alumni of the University of Pennsylvania

2012-2013

GRAHAM CLINTHORNE

Thesis Advisor:

DeGrado, William

Thesis Topic:

PhoQ: Structural and Mechanistic Investigations Into an Important Bacterial Sensor Kinase

ERIC DEUTSCH

Thesis Advisor:

Lynch, David

Thesis Topic:

MEASURING BIOMARKERS OF FRIEDREICH ATAXIA: IMPLICATIONS FOR CLINICAL RESEARCH

MARY FALCONE

Thesis Advisor:

Caryn Lerman

Thesis Topic:

Influence of Individual Nicotine Metabolism Rate on Cognitive Effects of Nicotine Withdrawal

ALLISON LESHER

Thesis Advisor:

Song, Wenchao

Thesis Topic:

Pathogenesis and Therapy of Complement-Mediated Kidney Disease in a Mouse Model

ROBERT LIN

Thesis Advisor:

Siegel, Steven

Thesis Topic:

A day in the life of a schizophrenic BRAT rat: pharmacological perturbations of the vasopressin system

MARISSA MARTINEZ

Thesis Advisor:

Poncz, Mortimer

Thesis Topic:

Increased fibrinolysis and establishment of fibrin clot viscoelastic properties are associated with pulmonary embolism

JACQUELINE MORRIS

Thesis Advisor:

Eberwine, James

Thesis Topic:

The transcription factor Elk-1 is a marker of pathological states

NYAMEKYE OBENG-ADJEI

Thesis Advisor:

Weiner, David

Thesis Topic:

Investigating and Manipulating Immune Responses to Hepatotropic Pathogens Using Synthetic DNA

CARLY SAYERS

Thesis Advisor:

Koumenis, Costas

Thesis Topic:

The Integrated Stress Response Effector ATF4:  Characterization of a small molecule modulator of its expression and investigation of the role of ATF4 in metastasis

2011-2012

BOBBY BASU

Thesis Advisor:

Blair, Ian

Thesis Topic:

SILEC: A new tool to study mitochondrial and metabolic disease

ANDREA HAMMONS

Thesis Advisor:

Whitehead, Alexander Steven

Thesis Topic:

Genetic Polymorphisms and Antifolate Drug Treatment Alter Folate/Homocysteine Metabolism and Inflammatory Protein Profile

MICHAEL HARBUT

Thesis Advisor:

Greenbaum, Doron

Thesis Topic:

CHEMICAL GENETIC APPROACHES FOR ASSESSING PROTEASE FUNCTION AND DRUG-TARGET POTENTIAL IN THE MALARIA PARASITE PLASMODIUM FALCIPARUM            

CYNTHIA KHOO

Thesis Advisor:

Stoffers, Doris

Thesis Topic:

Insulin Biosynthesis and Beta Cell Survival Regulated by PDX1 Targets

KRYSTLE LANG KUHS

Thesis Advisor:

Weiner, David

Thesis Topic:

Development of Novel Hepatitis C Virus DNA Vaccines

DANIEL LEUNG

Thesis Advisor:

Delikatny, Jim

Thesis Topic:

MECHANISMS OF LIPID METABOLISM IN A PROSTATE CANCER CELL MODEL

MATTHEW MACDONALD

Thesis Advisor:

Hahn, Chang-Gyu and Blair, Ian

Thesis Topic:

Targeted Proteomics and Biochemical Fractionation: New Tools for Deciphering The Synapse in Schizophrenia

LINDSAY MCKENNA

Thesis Advisor:

Kaestner, Klaus

Thesis Topic:

The role of miRNA and the transcription factor Hhex in the development and function of the pancreas

JENNIFER ONKSEN

Thesis Advisor:

Blendy, Julie

Thesis Topic:

Role of hippocampal neurogenesis in the etiology and treatment of mood & anxiety disorders

SEBASTIAN RIECK

Thesis Advisor:

Kaestner, Klaus

Thesis Topic:

The generation of fully functional beta-cells by proliferation: Lessons from pregnancy and HNF4alpha (MODY1)

ALEC SCHMAIER

Thesis Advisor:

Kahn, Mark L.

Thesis Topic:

The evolution of platelet responses to collagen under conditions of hemodynamic flow

KEITH SCHUTSKY

Thesis Advisor:

Thomas, Steven

Thesis Topic:

Role of Stress, Glucocorticoids & β-adrenergic Signaling in Aversive, Hippocampus-dependent Memory Retrieval

JAE-WON SHIN

Thesis Advisor:

Dennis Discher

Thesis Topic:

Sculpting blood cells with actomyosin forces: the central role of myosin-II in biophysical regulation of early hematopoiesis and megakaryocytopoiesis

CAROLYN ORBE SUMMERS

Thesis Advisor:

Whitehead, Alexander Steven

Thesis Topic:

The Effects of Methotrexate and Genetic Polymorphisms on the
Folate/Homocysteine Pathway

LISA VUCHAK

Thesis Advisor:

Meinkoth, Judy

Thesis Topic:

Role of Rap Signaling in the Regulation of ERK Activation and Cell-Cell Adhesion

ANGELA WEHR

Thesis Advisor:

Blair, Ian

Thesis Topic:

LC-MS FOR PROTEIN BIOMARKER DISCOVERY IN PANCREATIC ADENOCARCINOMA

2010-2011

RUDY FUENTES

Thesis Advisor:

Poncz, Mortimer

Thesis Topic:

Developing Novel Platelet-Based Targeting Strategies for Thrombolytics

J. BRANDON PARKER

Thesis Advisor:

Chakravarti, Debabrata

Thesis Topic:

Characterization of THAP11 Mediated Transcriptional Repression in Colon Cancer Cells

TESHELL PONTEEN GREENE

Thesis Advisor:

Poncz, Mortimer

Thesis Topic:

Understanding and Improving Platelet-Delivered Factor (F) VIII Hemostatic Efficacy
in Hemophilia A Mice

CONG WEI

Thesis Advisor:

Blair, Ian

Thesis Topic:

The Role of 15-Lipoxygenase-1- and Cyclooxygenase-2-derived Lipid Mediators in Endothelial Cell Proliferation

NAN WU

Thesis Advisor:

Lazar, Mitchell A.

Thesis Topic:

Nuclear Receptor Rev-erbalpha: A Transcriptional Link for Circadian Rhythm and Metabolism

ZHOU YU

Thesis Advisor:

FitzGerald, Garret

Thesis Topic:

Lipoxygenase products, inhibition of COX-2 and cardiovascular diseases

2009-2010

MICHELLE COOK SANGAR

Thesis Advisor:

Avadhani, Narayan G.

Thesis Topic:

Bimodal Targeting of Human Cytochrome P450 2D6 to Endoplasmic Reticulum and Mitochondria: Mechanistic and Metabolic Studies

CAROLINE PHELAN MURPHY

Thesis Advisor:

Lazar, Mitchell A.

Thesis Topic:

Molecular and Structural Insights into Nuclear Hormone Receptor Repression Mediated by the Corepresor NCOR

JENNIFER SPAETHLING

Thesis Advisor:

Meaney, David F.

Thesis Topic:

Signaling Leading to Calcium-Permeable AMPA Receptors and Their Role in Neuronal Loss Following Mechanical Injury

HONGBIN WANG

Thesis Advisor:

Kazanietz, Marcelo

Thesis Topic:

The C1 Domain in Cancer Signaling Molecules:Regulation by Lipids and Protein-Protein Interactions

PETER BUCKLEY

Thesis Advisor:

Eberwine, James H.

Thesis Topic:

The Role of Retained Intron Sequences in Neuronal Dendritic MRNA

FRANCHESKA COLON-GONZALEZ

Thesis Advisor:

Kazanietz, Marcelo G.

Thesis Topic:

Intra-and Inter-Molecular Interactions Regulate the Activity of the Rac-Gaps Alpha2-and Beta2-Chimaerins

JASON DRURY

Thesis Advisor:

Penning, Trevor M.

Thesis Topic:

Expression, Characterization, and Structural Analysis of Human Liver Delta43Ketosteroid 5Beta-Reductase (AKR1D1) and its Disease-Related Mutant P133R

ERIN GRINER

Thesis Advisor:

Kazanietz, Marcelo G.

Thesis Topic:

Investigating the Regulation and Function of the Rac-Gap Beta2-Chimaerin

MARIE HILDEBRANDT

Thesis Advisor:

Wu, Gary D.

Thesis Topic:

The Role of Resistin Like Molecule Beta in Energy Homeostasis

ARMEN KARAMANIAN

Thesis Advisor:

Davies, Peter F.

Thesis Topic:

Role of Claudin-5 and Hemodynamics in Endothelial Permeability and Susceptibility to Atheroclerosis

VICTOR KHOR

Thesis Advisor:

Song, Wenchao

Thesis Topic:

The Role of Estrogen Sulfotransferase in Regulating Tissue Estrogen Sensitivity

Postdoc:

Postdoctoral Fellow, University of Pennsylvania

CHRISTOPHER REINA

Thesis Advisor:

Pittman, Randall N.

Thesis Topic:

Characterizing the Role of the Polyglutamine Neurodegenerative Protein Ataxin-3 in the Cellular Response to Proteotoxic Stress

MARY ALLES ROBINSON

Thesis Advisor:

Otto, Cynthia M.

Thesis Topic:

JULIE L. WANG

Thesis Advisor:

Kung, Hank F.

Thesis Topic:

Development of Serotonin Transporter Brain Imaging Agents for Use in Positron Emission Tomography and Single Proton Emission Computed Tomography

YING YE

Thesis Advisor:

Chou, Margaret M.

Thesis Topic:

Regulation and Functions of Tre17/Ubiquitin-Specific Protease 6 (USP6) Oncogene in Aneurysmal Bone Cyst

2008-2009

DARRICK BALU

Thesis Advisor:

Lucki, Irwin

Thesis Topic:

Enhanced Sensitivity of the MRL/MPJ Mouse to the Neuroplastic and Behavioral Effects of Acute and Chronic Antidepressant Treatments

ANN-MARIE CHACKO

Thesis Advisor:

Kung, Hank F.

Thesis Topic:

The Molecular Imaging of Herpes Simplex Virus Type1 Thymidine Kinase Reporter Gene Expression: Novel[18F]Labeled Reporter Probes

EUGENE CICCIMARO

Thesis Advisor:

Blair, Ian A.

Thesis Topic:

The Absolute Quantification of Focal Adhesion Kinase Activation Loop Phosphorylation by Liquid Chromatography-Mass Spectrometry: A Biomarker of Src Kinase Activity

JESSICA CLECK

Thesis Advisor:

Blendy, Julie

Thesis Topic:

Alterations in Gene Expression at Key Points in the Addiction Cycle

BISEN DING

Thesis Advisor:

Muzykantov, Vladimir R.

Thesis Topic:

Protection Against Vascular Injury by Targeting Pro-Drugs to Endothelium

HOLLI KAWADLER

Thesis Advisor:

Yang, Xizolu

Thesis Topic:

The Role of Caspase-8 in T Cell Receptor Signaling

DAVID KIM

Thesis Advisor:

Song, Wenchao

Thesis Topic:

The Role of Complement Regulatory Proteins in Prevention of Cell Injury

DOMINICK LADDY

Thesis Advisor:

Weiner, David B.

Thesis Topic:

Vaccination Against Pathogenic Influenza with Synthetic Consensus DNA Antigens

ZHIYONG LU

Thesis Advisor:

Whitehead, Alexander Steven

Thesis Topic:

The Relationship Between Folate/Homocysteine Metabolism and Inflammatory Markers in Vitro and in Vivo

PATRICK MAYES

Thesis Advisor:

El-Deiry, Wafik S.

Thesis Topic:

The Mechanistic and Therapeutic Implications of Tumor Hypoxia in the Trail Signaling Pathway

MEREDITH MILLER

Thesis Advisor:

DeGrado, William F.

Thesis Topic:

Small Molecule Inhibitors of Integrin Alpha2Beta1 that Prevent Pathological Thrombus Formation Via an Allosteric Mechanism

JENNIFER OLIVER-KRASINSKI

Thesis Advisor:

Stoffers, Doris A.

Thesis Topic:

Novel Roles for PDX1 in the Endocrine Pancreas

AMY QUINN

Thesis Advisor:

Penning, Trevor M.

Thesis Topic:

Role of Aldo-Keto Reductase Enzymes in Polycyclic Aromatic Hydrocarbon Trans-Dihydrodiol Activation in Human Lung Cells

2007-2008

AMY EWING-KONDYRA

Thesis Advisor:

Chakravarti, Debabrata

Thesis Topic:

An Investigation of the Mechanisms Underlying N-Cor-Mediated Transcriptional Repression of Nuclear Receptor-Regulated Genes

ERIC KLEIN

Thesis Advisor:

Assoian, Richard K.

Thesis Topic:

Regulation of Cyclin D1 Expression by RAC, the Actin Cytoskeleton, and Extracellular Matrix Compliance

2006-2007

ALAN LAU

Thesis Advisor:

Chou, Margaret M.

Thesis Topic:

Non-Clathrin Endocytosis: Mechanisms of Regulating ARF6 and its Endocytic Pathway

RIJU RAY

Thesis Advisor:

Lerman, Caryn

Thesis Topic:

Effects of Atomoxetine on Nicotine Abstinence Symptoms

STEPHEN RUDNICK

Thesis Advisor:

Gewirtz, Alan M.

Thesis Topic:

Effects of Structure on Post-Transcriptional Gene Silencing

ELIZABETH SCHWARZBACH

Thesis Advisor:

Cohen, Akiva S.

Thesis Topic:

Investigating the Mechanisms Underlying Cognitive Impairments and Seizure Susceptibility Following Traumatic Brain Injury

ELIZABETH WESTGATE

Thesis Advisor:

FitzGerald, Garret A.

Thesis Topic:

Cardiovascular Rhythms and the Molecular Clock

PEIJUAN ZHU

Thesis Advisor:

Blair, Ian A.

Thesis Topic:

15Lipoxygenase-1Mediated Formation of Endogenous GSH-and RNA-Adducts and its Impact on GSH/GSSG Homeostasis in Monocytes/Macrophages

2005-2006

APHROTHITI FIKARIS

Thesis Advisor:

Meinkoth, Judy L.

Thesis Topic:

The Regulation of Cell Cycle Progression and Apoptosis in Thyroid Follicular Epithelial Cells

ALAINA FOURNIER

Thesis Advisor:

Assoian, Richard K.

Thesis Topic:

Rac-Dependent Regulation of Cyclin D1 Gene Expression by Integrins and E-Cadherin in Mammary Epithelial Cells

JULIE FRIEDLAND

Thesis Advisor:

Weaver, Valerie M.

Thesis Topic:

Spatial-Mechanical Regulation of the Small GTPase Rac in Mammary Epithelial Cell Survival and Apoptosis Resistance

RANA GUPTA

Thesis Advisor:

Kaestner, Klaus

Thesis Topic:

The Role of HNF-4alpha in the Pancreatic Beta-Cell

SARA KUTNEY

Thesis Advisor:

Chakravarti, Debabrata

Thesis Topic:

A Role for Inhat Proteins SET/TAF-IBeta and PP32 In Integrating Chromatin Hypoacetylation and Transcriptional Repression

KELLY ORLANDO

Thesis Advisor:

Pittman, Randall N.

Thesis Topic:

The Role of RHO Kinase in Preparing Apoptotic Corpses for Phagocytosis

LIYAN PANG

Thesis Advisor:

Poncz, Mortimer

Thesis Topic:

Maturation Stage-Specific Regulation of Megakaryopoiesis by Pointed Domain ETS Proteins

ADEMI SANTIAGO-WALKER

Thesis Advisor:

Meinkoth, Judy L.

Thesis Topic:

Isozyme-Specific Roles of Protein Kinase C in Thyroid Cells

ELISA WAXMAN

Thesis Advisor:

Lynch, David R.

Thesis Topic:

NMDA Receptor Biochemical and Activity-Dependent Regulation of P38 Mark and Glutamate Transporter EAAC1

ANASTASIA YOCUM

Thesis Advisor:

Blair, Ian A.

Thesis Topic:

Proteomic Approaches to the Discovery of Biomarkers and Pharmacological Targets

2004-2005

DAVID BAUMAN

Thesis Advisor:

Penning, Trevor M.

Thesis Topic:

Identification and Validation of Hydroxysteroid Dehydrogenases as Targets for Inhibitor Design in Human Prostate

KAREN BROWN

Thesis Advisor:

Whitehead, A.S.

Thesis Topic:

The Folate Metabolic Cycle: Genetic Modulation and Biological Consequences

BARRINGTON BURNETT

Thesis Advisor:

Pittman, Randall N.

Thesis Topic:

Characterizing the Role of the Polyglutamine Neurodegenerative Protein Ataxin-3 in the Ubiquitin-Proteasome Pathway

JAMES CROWLEY

Thesis Advisor:

Lucki, Irwin

Thesis Topic:

Pharmacogenomic Determinants of the Antidepressant-Like Effects of Citalopram in the Mouse Tail Suspension Test

KEITH FOURNIER

Thesis Advisor:

Robinson, Michael B.

Thesis Topic:

Intracellular Trafficking of the Neuronal Glutamate Transporter EAAC1

WENYING JIAN

Thesis Advisor:

Blair, Ian A.

Thesis Topic:

Lipid Peroxidation-Derived Endogenous DNA-and GSH-Adducts as Biomarkers of Oxidative Stress

ZHAOYU JIN

Thesis Advisor:

El-Deiry, Wafik S.

Thesis Topic:

The Regulation of Death Receptor-Mediated Apoptosis in Tumor Cells

MICHAEL POLLACK

Thesis Advisor:

Blair, Ian A.

Thesis Topic:

The Heptanone-Etheno-2'-Deoxycytidine Adduct: Stuctural Characterization and Translesion Synthesis

EDWARD WEINSTEIN

Thesis Advisor:

Rubin, Harvey

Thesis Topic:

Novel Approaches to Controlling Mycobacterium Tuberculosis Latency and Infection by Inhibiting the Electron Transport Chain

MICHELLE WILLIAMS

Thesis Advisor:

Blair, Ian A.

Thesis Topic:

Cyclooxygenase-2 Dependent Lipid Hydroperoxide-Induced DNA Damage

WU YIN

Thesis Advisor:

Birnbaum, Morris J.

Thesis Topic:

The Regulation of 5'AMP-Activated Protein Kinase by the Beta-Adrenergic Signaling Pathway in Adipocytes

2003-2004

BENJAMIN FRYER

Thesis Advisor:

Field, Jeffrey M.

Thesis Topic:

cGMP Dependent Protein Kinase (PKG) Phosphorylation of p21 Activated Kinase (PAK) at Serine 21 Regulates Nck/Pak Binding, VASP/Pak Association and Cell Morphology     

HONG-PING GUAN

Thesis Advisor:

Lazar, Mitchell A.

Thesis Topic:

A Futile Metabolic Cycle Activated in Adipocytes by Antidiabetic Agents

PAUL HAHN

Thesis Advisor:

Dunaief, Joshua L.

Thesis Topic:

Mechanisms of Cell Death in Retinal Degeneration: The Roles of Pro-Apoptotic BCL-2 Members, Bax and Bak, and of Iron Misregulation

RUI HONG

Thesis Advisor:

Chakravarti,Debabrata

Thesis Topic:

Characterization of Phospho-Protein pp32 and PCNA in Transcriptional Regulation      

YIQUN HUI

Thesis Advisor:

Funk, Colin

Thesis Topic:

Cysteinyl Leukotriene 2 Receptor Characterization

LEILAH MCNABB

Thesis Advisor:

Berrettini, Wade

Thesis Topic:

Analysis of the G-olf Locus on Human Chromosome 18 for a Role in Psychiatric Illness

ERIN NORRIS

Thesis Advisor:

Lee, Virginia Man-Yee

Thesis Topic:

Post-Translational Modifications of Alpha-Synuclein Protein by Oxidative and Nitrative Stress Mechanisms and Their Effects on the Pathogenesis of Synucleinopathies

SHERYL STEWART FLORES

Thesis Advisor:

Assoian, Richard K.

Thesis Topic:

Antimitogenesis by Prostacyclin Linked to Regulation of Skp2 Gene Expression

JONG YU

Thesis Advisor:

Lemmon, Mark A.

Thesis Topic:

Genome-Wide View of Membrane Targeting by Saccharomyces Cerevisiae Phox Homology (PX) and Pleckstrin Homology (PH) Domains

2002-2003

KUSHOL GUPTA

Thesis Advisor:

Loll, Patrick J.

Thesis Topic:

Structural Insights into the Mechanism and Inhibition of Prostaglandin H2 Synthase-1

NADIA GURVICH

Thesis Advisor:

Klein, Peter S.

Thesis Topic:

Histone Deacetylase is a Target of Valproic Acid-Mediated Cellular Differentiation

HALVOR JUUL

Thesis Advisor:

Dichter, Marc

Thesis Topic:

GABAa Receptor Subunit mRNA Expression and Pharmacology in Hippocampal Neurons Developint in Vitro

RYAN KRUGER

Thesis Advisor:

McCafferty, Dewey G.

Thesis Topic:

Sortase: Characterization, Substrate Specificity

FUSHENG LI

Thesis Advisor:

Pittman, Randall N.

Thesis Topic:

Effects of the polyglutamine neurodegenerative protein ataxin-3 on transcriptional regulation and the ubiquitin-proteasome pathway

JEFFREY MASUDA-ROBENS

Thesis Advisor:

Chou, Margaret M.

Thesis Topic:

The First Insights Into the TRE17 Oncogene: A Potential Link Between Actin Remodeling and Vesicular Trafficking

FANG ZHANG

Thesis Advisor:

Klein, Peter S.

Thesis Topic:

Regulation of Glycogen synthase Kinase-3 by the PC/AXIN Complex

2002-2001

JOANNA FUEYO

Thesis Advisor:

Weiser, Jeffrey Neal

Thesis Topic:

IN SILICO Discovery of Antimicrobial Targets

JESSICA WALCOTT

Thesis Advisor:

Merry, Diane E.

Thesis Topic:

Characterization of Cellular and Transgenic Models of Spinal and Bulbar Muscular Atrophy

2000-2001

ANTHONY BEVIVINO

Thesis Advisor:

Loll, Patrick J.

Thesis Topic:

BIOCHEMICAL CHARACTERIZATION OF THE NORMAL AND PATHOGENIC FORMS OF THE MJD1 GENE PRODUCT, ATAXIN-3

JOHN POWELL

Thesis Advisor:

Mousa, Shaker

Thesis Topic:

POTENTIAL ANGIOGENIC ACTIVITY AND BIOCHEMICAL MECHANISMS OF NEUTROPHIL ACTIVATING PROTEIN-2

CHRISTINA WILSON

Thesis Advisor:

Lee, Virginia

Thesis Topic:

MULTIPLE ROLES FOR PRESENILINS DEMONSTRATED BY CHARACTERIZATION OF PRESENILIN NULL CELLS

JING ZHANG

Thesis Advisor:

Granato, Michael

Thesis Topic:

THE ROLE OF THE ZEBRAFISH UNPLUGGED GENE IN MOTOR AXON PATHFINDING

1999-2000

CHEN, CATHERINE

Thesis Advisor:

Manning, David R.

Thesis Topic:

REGULATION OF G ALPHA-i PALMITOYLATION

DANA EMERY

Thesis Advisor:

McIntosh, Tracy K.

Thesis Topic:

INCREASED EXPRESSION OF GROWTH-RELATED PROTEINS AND HIPPOCAMPAL NEUROGENESIS IS BRAINS OF ADULT RATS FOLLOWING EXPERIMENTAL TRUMATIC BRAIN INJURY

JOHN HINES

Thesis Advisor:

Fluharty, Steven J.

Thesis Topic:

STRUCTURAL DETERMINANTS FOR FUNCTIONAL PROPERTIES OF ANGIOTENSIN II RECEPTORS

DEBORAH KNOBELMAN

Thesis Advisor:

Lucki, Irwin

Thesis Topic:

REGULATION OF EXTRACELLULAR CONCENTRATIONS OF SEROTONIN BY 5-HT 1A AND 5-HT 1B AUTORECEPTORS IN MICE

PETER O'BRIEN

Thesis Advisor:

Brass, Lawrence F.

Thesis Topic:

THE ROLE OF PROTEASE ACTIVATED RECEPTORS IN VASCULAR ENDOTHELIAL THROMBIN RESPONSES

JENNIFER PHILLIPS

Thesis Advisor:

Eberwine, James H.

Thesis Topic:

TRANSLIN: LOCALIZATION AND EVIDENCE FOR REGULATED NUCLEOCYTOPLASMIC SHUTTLING

ARTURO SAAVEDRA

Thesis Advisor:

Meinkoth, Judy L.

Thesis Topic:

CYCLIC AMP IN THE REGULATION OF CELL SURVIVAL

LORAINE SILVESTRO DIECKMANN

Thesis Advisor:

Axelsen, Paul H.

Thesis Topic:

FUNCTION AND STRUCTURE OF CECROPIN A

NICOLE STONE

Thesis Advisor:

Pittman, Randall N.

Thesis Topic:

MECHANISMS UNDERRLYING DYNAMIC MORPHOLOGICAL CHANGES DURING THE EXECUTION PHASE OF APOPTOSIS

HONGLIN ZHOU

Thesis Advisor:

Pittman, Randall N.

Thesis Topic:

REGULATION OF CELL SURVIVAL AND APOPTOSIS BY PHOSPHOINOSITIDE 3-KINASE/AKT PATHWAY

1998-1999

MICHAEL BURCZYNSKI

Thesis Advisor:

Penning, Trevor M.

Thesis Topic:

HUMAN ALDO-KETO REDUCTASES IN POLYCYCLIC AROMATIC HYDROCARBON ACTIVATION

LISA CASS

Thesis Advisor:

Meinkoth, Judy L.

Thesis Topic:

CYCLIC AMP SIGNALING IN THE HORMONAL CONTROL OF PROLIFERATION AND DIFFERENTIATION

MING HONG

Thesis Advisor:

Lee, Virginia Man-Yee

Thesis Topic:

MECHANISMS OF TAU PROTEIN DYSFUNCTION IN ALZHEIMER'S DISEASE AND OTHER NEURODEGENERATIVE TAUOPATHIES

HAICHING MA

Thesis Advisor:

Penning, Trevor M.

Thesis Topic:

THE DETERMINANTS OF COFACTOR AND SUBSTRATE SPECIFICITIES OF HYDROXYSTEROID DEHYDROGENASES

MATTHEW PEREZ

Thesis Advisor:

Pittman, Randall N.

Thesis Topic:

AGGREGATION AND NUCLEAR EXPRESSION OF THE SPINOCEREBELLAR ATAXIA TYPE 3 GENE PRODUCT, ATAXIN-3

MIECHELLE PLESCO O'BRIEN

Thesis Advisor:

Tew, Kenneth D.

Thesis Topic:

EXPRESSION AND FUNCTION OF THE GLUTATHIONE DETOXIFICATION PATHWAY AND THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN IN ANTICANCER DRUG RESISTANCE

DONNA WOULFE

Thesis Advisor:

Brass, Lawrence F.

Thesis Topic:

STRUCTURAL BASIS FOR THE SELECTIVITY OF THE REGULATOR OF G PROTEIN SIGNALLING, GAIP, FOR G ALPHA i FAMILY MEMBERS

HONGTAO ZHANG

Thesis Advisor:

Greene, Mark I.

Thesis Topic:

SIGNALLING PATHWAYS INVOLVED IN CELL TRANSFORMATION AND CONVERSION OF PHENOTYPE

1997-1998

KATHRYN WOHLPART

Thesis Advisor:

Molinoff, Perry B.

Thesis Topic:

Regulation of 5-HT2a Receptor Coupling and 5-HT2a Receptor mRNA in P11 Cells

MAURICIO REGINATO

Thesis Advisor:

Lazar, Mitchell A.

Thesis Topic:

Inhibitory Mechanisms Regulating Nuclear Hormone Receptor Action

1996-1997

NORIFUSA ANEGAWA

Thesis Advisor:

Lindstrom, Jon M.

Thesis Topic:

JOSEPH ERHARDT

Thesis Advisor:

Pittman, Randall N.

Thesis Topic:

p21(WAF1) and NFB42 in Neural Growth and Differentiation

ELFRIDA GRANT

Thesis Advisor:

Lynch, David

Thesis Topic:

Subunit Specificity and Modulation of N-Methyl-D-Aspartate Receptor Mediated Intracellular Calcium Responses

1997

YVETTE BORDELON

Thesis Advisor:

Chesselet, Marie-Francoise

Thesis Topic:

Early Events Following an Excitotoxic Insult in Rat Striatum

BRIAN BROOKS

Thesis Advisor:

Fischbeck, Kenneth H.

Thesis Topic:

Characterization of Normal- and Expanded-Glutamine Repeat Androgen Receptors in a Neuronal Cell Line

DAVID BROUSSEAU

Thesis Advisor:

McGonigle, Paul

Thesis Topic:

Regulation of 5-HT 1A and 5-HT 2A Receptor mRNA and Protein Density in the Rat CNS: An Analysis using Quantitative In-situ Hybridization and Receptor Autoradiographic Techniques.

JENNIFER HEERDING

Thesis Advisor:

Fluharty, Steven J.

Thesis Topic:

Elucidation of the Ligand Binding Domain of the Angiotensin Type 2 (AT2) Receptor

WESLIA HYNICKA

Thesis Advisor:

Pittman, Randall N.

Thesis Topic:

Characterization of a cDNA Highly Enriched in CNS

SHELLY KENDRICK LENZ

Thesis Advisor:

Dichter,Marc A.

Thesis Topic:

Pharmacological and Physiological Characterization of Recombinant and Native NMDA Receptors

CONRAD MESSAM

Thesis Advisor:

Pittman, Randall N.

Thesis Topic:

Cellular and Biochemical Changes Occurring During Apoptosis of PC12 Cells

BRIAN SCHLEGEL

Thesis Advisor:

Penning, Trevor M.

Thesis Topic:

Structural Determinants of Catalysis and Steroid Binding in 3alpha-Hydroxysteroid Dehydrogenase

XIN ZHANG

Thesis Advisor:

Greene, Mark I

Thesis Topic:

Sturctural and Functional Mapping of Immunoglobulin Domains

1996

LISA DOWD

Thesis Advisor:

Robinson, Michael B.

Thesis Topic:

Pharmacological Characterization and Second-Messenger Regulation of the Sodium-Dependent Glutamate Transporter Subtype, EAACI.

STEPHANIE FLAGG

Thesis Advisor:

Eberwine, James H.

Thesis Topic:

Characterization of a Protein Interaction with the Proopiomelanocortin mRNA: An RNA Mutagenesis Analysis

SURESH NAIR

Thesis Advisor:

Eberwine, James H.

Thesis Topic:

Molecular Correlates of Chronic Corticosterone Exposure in the Hippocampus

JANET VESSOTSKIE

Thesis Advisor:

Kung, Hank F.

Thesis Topic:

Characterization of Iodinated Ligands for Dopamine D2-Like Receptors

1995

YANXIANG CAO

Thesis Advisor:

Eberwine, James H.

Thesis Topic:

Molecular Aspects of Aging in Hippocampal Neurons

PAUL FROHNA

Thesis Advisor:

Joyce, Jeffrey N.

Thesis Topic:

The Developmental Plasticity of the Dopamine Systems of the Rodent Basal Ganglia: Effects of Neonatal 6-Hydroxydopamine Lesions

ANNEMARIE INGLIS

Thesis Advisor:

Pittman, Randall N.

Thesis Topic:

Characterization of Plasminogen Activators in the Developing and Regenerating Rat Nervous System

HAEYOUNG KONG

Thesis Advisor:

Reisine,Terry D.

Thesis Topic:

Identification of Ligand binding Determinants in the cloned Mouse Kappa and Delta Opiod Receptors

MUHAMMAD MUNIR

Thesis Advisor:

McGonigle, Paul

Thesis Topic:

Mechanisms of Excitotoxicity in Human NT2-N Neurons

LAWRENCE REAGAN

Thesis Advisor:

Fluharty, Steven J.

Thesis Topic:

Development of Polyclonal Antisera Selective for Angiotensin Type 2 (AT2) Receptors

YEONG-AN SHEU

Thesis Advisor:

Pritchett, Dolan

Thesis Topic:

The Structural Study of the Serotornin-II Receptor and the Study of Signal Transduction

CORINNE SPENCER

Thesis Advisor:

Eberwine, James H.

Thesis Topic:

Protein Interactions with a cis-Acting Element in the Coding Region of Proopiomelanocortin mRNA

JIE ZHONG

Thesis Advisor:

Molinoff, Perry B.

Thesis Topic:

Expression and Regulation of NMDA Receptors

1994

KAREN BLOCK

Thesis Advisor:

Poncz, Mortimer

Thesis Topic:

Characterization of Regulatory Elements in the 5' - Flanking Region of the Gpiib Gene

ROBERT FERRY

Thesis Advisor:

Molinoff, Perry B.

Thesis Topic:

Mechanisms of Regulation of 5-HT2A Receptors and Receptor mRNA in P11 Cells

LOUIS LITTMAN

Thesis Advisor:

Robinson, Michael B.

Thesis Topic:

Evidence For The Expression Of Multiple Subtypes Of Excitatory Amino Acid Receptors Coupled To Phosphoinositide Hydrolysis In The Mammalian Central Nervous System;

FRANCIS SZELE

Thesis Advisor:

Chesselet, Marie-Francoise

Thesis Topic:

Plasticity in the Striatum and Subependymal Layer of Adult Rats in Response to Cortical Lesions

SONGLI WANG

Thesis Advisor:

Pittman, Randall N.

Thesis Topic:

Characterization of Early Molecular Events in Programmed Neuronal Cell Death

1993

VIRGINIA BOUNDY

Thesis Advisor:

Molinoff, Perry B.

Thesis Topic:

Development And Cfharacterization of Polyclonal Antibodies For The D2 and D3 Dopamine Receptors

NANETTE COCERO

Thesis Advisor:

Molinoff, Perry B.

Thesis Topic:

Effects Of Partial Agonists On B-Adrenergic Receptors.

THERESA FILTZ

Thesis Advisor:

Molinoff, Perry B.

Thesis Topic:

Paradoxical Regulation Of Dopamine Receptors In Transfected Cell Lines

KAREN LOUNSBURY

Thesis Advisor:

Manning, David R.

Thesis Topic:

Phosphorylation Of Gza By Protein KinaseC: Characterization In Human Platelets And Analysis By Site-Directed Mutagenesis

JOHN PAWLOWSKI

Thesis Advisor:

Penning, Trevor M.

Thesis Topic:

Cloning, Expression and Site-Directed Mutagensis of the Rat Liver 3a-Hydroxysteroid Dehydrogenase

JED SHUMSKY

Thesis Advisor:

Lucki, Irwin

Thesis Topic:

Differential Regulation of the Behavioral Effects of Chlordiazepoxide

1992

ALISON GAGNON

Thesis Advisor:

Brass, Lawrence F

Thesis Topic:

G Proteins in Platelets: Identification and Role in Platelet Signal Transduction

MIN LI

Thesis Advisor:

Wolfe, Barry

Thesis Topic:

Immunological and Pharmacological Studies on Subtypes of Muscarinic Cholinergic Receptors

KAREN RAYNOR

Thesis Advisor:

Reisine, Terry D.

Thesis Topic:

Properties of Somatostatin Receptor Subtypes.

JOEL SCHACHTER

Thesis Advisor:

Wolfe, Barry

Thesis Topic:

Regulation Of Phospholipase C Responses By Agents Which Alter.  The Cellular Cyclic AMP Profile.

1991

KATHRYN IVINS

Thesis Advisor:

Molinoff, Perry B.

Thesis Topic:

Studies Of Receptors For Dopamine And Serotonin In Novel Cell Lines

NEIL MARGOLIS

Thesis Advisor:

Reisine,Terry D.

Thesis Topic:

Indentification And Characterization Of Nuclear Phosphoproteins Which May Be Involved In Proopiomelanocortin Gene Regulation.

SWAMINATHAN SUBRAMANIAM

Thesis Advisor:

Paul McGonigle

Thesis Topic:

Anatomical And Developmental Heterogeneity Of The Effects Of Polyamines On NMDA Receptor

STEPHEN WALL

Thesis Advisor:

Wolfe, Barry

Thesis Topic:

Antibodies Selective For Subtypes Of Muscarinic Cholinergic Receptors: Studies On Receptor Distribution And Regulation

1990

JONATHAN IVINS

Thesis Advisor:

Molinoff, Perry B.

Thesis Topic:

Effects Of Cell-Cell Contact On Neuronal Growth Cones.

PETER VOS

Thesis Advisor:

Pittman, Randall N.

Thesis Topic:

A Novel In Vitro System for Studying The Interactions Between Merkel Cells, Sensory Neurons, And Sympathetic Neurons

HUNG-LI WANG

Thesis Advisor:

Reisine, Terry D.

Thesis Topic:

Somatostatin-14 And Somatostatin-28 Modulate Multiple Effector Systems In Cultured Rat Neocortical Neurons.