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Pharmacology Graduate Group Alumni of the University of Pennsylvania

 
2013-2014
 
 
 
MAHLET ABERA
 
 
 
Thesis Advisor:
Marcelo Kazanietz
 
 
Thesis Topic:
PKC isozymes in lung cancer development and therapy resistance
 
 
 
 
 
 
JESSE CARLIN
 
 
 
Thesis Advisor:
Teresa Reyes
 
 
Thesis Topic:
High fat diet affects the dopamine reward system: importance of sex and critical developmental periods.
 
       
 
EDWARD P. CHEN
 
 
 
Thesis Advisor:
Emer Smyth
 
 
Thesis Topic:
AUGMENTING ANTI-TUMOR IMMUNITY BY TARGETING MACROPHAGE COX-2 IN BREAST CANCER
 
 
 
 
 
 
COLIN GREINEDER
 
 
 
Thesis Advisor:
Vladimir Muzykantov
 
 
Thesis Topic:
Augmenting the Protein C Pathway with Endothelial Targeted Biotherapeutics: Strategies to Promote Partnering of TM and EPCR
 
 
 
 
 
 
HILARY MCCARREN
 
 
 
Thesis Advisor:
Max Kelz
 
 
Thesis Topic:
THE ROLE OF SLEEP-ACTIVE NEURONAL NUCLEI IN VOLATILE ANESTHETIC RESPONSE
 
       
 
MELISSA LOVE
 
 
 
Thesis Advisor:
Doron Greenbaum
 
 
Thesis Topic:
Explorations into host defense against Plasmodium falciparum: mechanistic and structure-function studies of antimalarial chemokines
 
       
 
ANIA WARCZYK PAYNE
 
 
 
Thesis Advisor:
Lewis Chodosh
 
 
Thesis Topic:
Role of Ceramide Kinase in Breast Cancer Progression
 
       
 
2012-2013
 
 
 
TRISHA AGRAWAL
   
 
Thesis Advisor:
Xiaolu Yang
 
 
Thesis Topic:
The Multifunctional Protein Daxx: Studies of its Biology and Regulation, and Discovery of a Novel Function
 
       
 
MICHAEL BREWER
 
 
 
Thesis Advisor:
Xiaolu Yang
 
 
Thesis Topic:
SUMO: A Heavy Player In A Complex World
 
       
 
GRAHAM CLINTHORNE
 
 
 
Thesis Advisor:
William DeGrado
 
 
Thesis Topic:
PhoQ: Structural and Mechanistic Investigations Into an Important Bacterial Sensor Kinase
 
 
 
 
 
 
ERIC DEUTSCH
 
 
 
Thesis Advisor:
David Lynch
 
 
Thesis Topic:
MEASURING BIOMARKERS OF FRIEDREICH ATAXIA: IMPLICATIONS FOR CLINICAL RESEARCH
 
 
 
 
 
 
MARY FALCONE
 
 
 
Thesis Advisor:
Caryn Lerman
 
 
Thesis Topic:
Influence of Individual Nicotine Metabolism Rate on Cognitive Effects of Nicotine Withdrawal
 
       
 
ALEXANDER FREY
 
 
 
Thesis Advisor:
Emer Smyth
 
 
Thesis Topic:
Characterization and Targeting of Thromboxane Receptor Dimerization: A Gateway to Novel Therapeutic Developments
 
 
 
   
 
GABRIEL KRIGSFELD
 
 
 
Thesis Advisor:
Ann Kennedy
 
 
Thesis Topic:
Radiation-induced death: Characterization of a novel mechanism
 
       
 
ALLISON LESHER
   
 
Thesis Advisor:
Wenchao Song
 
 
Thesis Topic:
Pathogenesis and Therapy of Complement-Mediated Kidney Disease in a Mouse Model
 
       
 
ROBERT LIN
 
 
 
Thesis Advisor:
Steven Siegel
 
 
Thesis Topic:
A day in the life of a schizophrenic BRAT rat: pharmacological perturbations of the vasopressin system
 
       
 
MARISSA MARTINEZ
 
 
 
Thesis Advisor:
Mortimer Poncz
 
 
Thesis Topic:
Increased fibrinolysis and establishment of fibrin clot viscoelastic properties are associated with pulmonary embolism
 
 
 
 
 
 
JACQUELINE MORRIS
 
 
 
Thesis Advisor:
James Eberwine
 
 
Thesis Topic:
The transcription factor Elk-1 is a marker of pathological states
 
 
 
 
 
 
NYAMEKYE OBENG-ADJEI
 
 
 
Thesis Advisor:
David Weiner
 
 
Thesis Topic:
Investigating and Manipulating Immune Responses to Hepatotropic Pathogens Using Synthetic DNA
 
 
 
 
 
 
CARLY SAYERS
 
 
 
Thesis Advisor:
Costas Koumenis
 
 
Thesis Topic:
The Integrated Stress Response Effector ATF4:  Characterization of a small molecule modulator of its expression and investigation of the role of ATF4 in metastasis
 
 
 
 
 
 
NATHANIEL SNYDER
 
 
 
Thesis Advisor:
Ian Blair
 
 
Thesis Topic:
Investigations of disposition, bioactivity, and metabolism of lipids through liquid chromatography-mass spectrometry
 
 
 
 
 
 
2011-2012
 
 
 
BOBBY BASU
 
 
 
Thesis Advisor:
Ian Blair
 
 
Thesis Topic:
SILEC: A new tool to study mitochondrial and metabolic disease
 
 
 
 
 
 
ANDREA HAMMONS
 
 
 
Thesis Advisor:
Alexander Steven Whitehead
 
 
Thesis Topic:
Genetic Polymorphisms and Antifolate Drug Treatment Alter Folate/Homocysteine Metabolism and Inflammatory Protein Profile
 
       
 
MICHAEL HARBUT
   
 
Thesis Advisor:
Doron Greenbaum
 
 
Thesis Topic:
CHEMICAL GENETIC APPROACHES FOR ASSESSING PROTEASE FUNCTION AND DRUG-TARGET POTENTIAL IN THE MALARIA PARASITE PLASMODIUM FALCIPARUM            
 
       
 
CYNTHIA KHOO
 
 
 
Thesis Advisor:
Doris Stoffers
 
 
Thesis Topic:
Insulin Biosynthesis and Beta Cell Survival Regulated by PDX1 Targets
 
       
 
KRYSTLE LANG KUHS
 
 
 
Thesis Advisor:
David Weiner
 
 
Thesis Topic:
Development of Novel Hepatitis C Virus DNA Vaccines
 
       
 
DANIEL LEUNG
   
 
Thesis Advisor:
Jim Delikatny
 
 
Thesis Topic:
MECHANISMS OF LIPID METABOLISM IN A PROSTATE CANCER CELL MODEL
 
       
 
MATTHEW MACDONALD
 
 
 
Thesis Advisor:
Chang-Gyu Hahn and Ian Blair
 
 
Thesis Topic:
Targeted Proteomics and Biochemical Fractionation: New Tools for Deciphering The Synapse in Schizophrenia
 
       
 
LINDSAY MCKENNA
 
 
 
Thesis Advisor:
Klaus Kaestner
 
 
Thesis Topic:
The role of miRNA and the transcription factor Hhex in the development and function of the pancreas
 
 
 
 
 
 
JENNIFER ONKSEN
   
 
Thesis Advisor:
Julie Blendy
 
 
Thesis Topic:
Role of hippocampal neurogenesis in the etiology and treatment of mood & anxiety disorders
 
       
 
SEBASTIAN RIECK
 
 
 
Thesis Advisor:
Klaus Kaestner
 
 
Thesis Topic:
The generation of fully functional beta-cells by proliferation: Lessons from pregnancy and HNF4alpha (MODY1)
 
 
 
 
 
 
ALEC SCHMAIER
 
 
 
Thesis Advisor:
Mark L. Kahn
 
 
Thesis Topic:
The evolution of platelet responses to collagen under conditions of hemodynamic flow
 
 
 
 
 
 
KEITH SCHUTSKY
 
 
 
Thesis Advisor:
Steven Thomas
 
 
Thesis Topic:
Role of Stress, Glucocorticoids & β-adrenergic Signaling in Aversive, Hippocampus-dependent Memory Retrieval
 
 
 
 
 
 
JAE-WON SHIN
 
 
 
Thesis Advisor:
Dennis Discher
 
 
Thesis Topic:
Sculpting blood cells with actomyosin forces: the central role of myosin-II in biophysical regulation of early hematopoiesis and megakaryocytopoiesis
 
       
 
CAROLYN ORBE SUMMERS
 
 
 
Thesis Advisor:
Alexander Steven Whitehead
 
 
Thesis Topic:
The Effects of Methotrexate and Genetic Polymorphisms on the
Folate/Homocysteine Pathway
 
 
 
 
 
 
LISA VUCHAK
 
 
 
Thesis Advisor:
Judy Meinkoth
 
 
Thesis Topic:
Role of Rap Signaling in the Regulation of ERK Activation and Cell-Cell Adhesion
 
 
 
 
 
 
ANGELA WEHR
 
 
 
Thesis Advisor:
Ian Blair
 
 
Thesis Topic:
LC-MS FOR PROTEIN BIOMARKER DISCOVERY IN PANCREATIC ADENOCARCINOMA
 
       
 
2010-2011
 
 
 
RUDY FUENTES
 
 
 
Thesis Advisor:
Mortimer Poncz
 
 
Thesis Topic:
Developing Novel Platelet-Based Targeting Strategies for Thrombolytics
 
 
 
 
 
 
J. BRANDON PARKER
 
 
 
Thesis Advisor:
Debabrata Chakravarti
 
 
Thesis Topic:
Characterization of THAP11 Mediated Transcriptional Repression in Colon Cancer Cells
 
 
 
 
 
 
TESHELL PONTEEN GREENE
 
 
 
Thesis Advisor:
Mortimer Poncz
 
 
Thesis Topic:
Understanding and Improving Platelet-Delivered Factor (F) VIII Hemostatic Efficacy
in Hemophilia A Mice
 
 
 
 
 
 
CONG WEI
 
 
 
Thesis Advisor:
Ian Blair
 
 
Thesis Topic:
The Role of 15-Lipoxygenase-1- and Cyclooxygenase-2-derived Lipid Mediators in Endothelial Cell Proliferation
 
       
 
NAN WU
 
 
 
Thesis Advisor:
Mitchell A. Lazar
 
 
Thesis Topic:
Nuclear Receptor Rev-erbalpha: A Transcriptional Link for Circadian Rhythm and Metabolism
 
 
 
 
 
 
ZHOU YU
 
 
 
Thesis Advisor:
Garret FitzGerald
 
 
Thesis Topic:
Lipoxygenase products, inhibition of COX-2 and cardiovascular diseases
 
 
 
 
 
 
2009-2010
 
 
 
MICHELLE COOK SANGAR
 
 
 
Thesis Advisor:
Narayan G. Avadhani
 
 
Thesis Topic:
Bimodal Targeting of Human Cytochrome P450 2D6 to Endoplasmic Reticulum and Mitochondria: Mechanistic and Metabolic Studies
 
 
 
 
 
 
CAROLINE PHELAN MURPHY
 
 
 
Thesis Advisor:
Mitchell A. Lazar
 
 
Thesis Topic:
Molecular and Structural Insights into Nuclear Hormone Receptor Repression Mediated by the Corepresor NCOR
 
 
 
 
 
 
JENNIFER SPAETHLING
 
 
 
Thesis Advisor:
David F. Meaney
 
 
Thesis Topic:
Signaling Leading to Calcium-Permeable AMPA Receptors and Their Role in Neuronal Loss Following Mechanical Injury
 
 
 
 
 
 
HONGBIN WANG
 
 
 
Thesis Advisor:
Marcelo Kazanietz
 
 
Thesis Topic:
The C1 Domain in Cancer Signaling Molecules:Regulation by Lipids and Protein-Protein Interactions
 
 
 
 
 
 
PETER BUCKLEY
 
 
 
Thesis Advisor:
James H. Eberwine,
 
 
Thesis Topic:
The Role of Retained Intron Sequences in Neuronal Dendritic MRNA
 
 
 
 
 
 
FRANCHESKA COLON-GONZALEZ
 
 
 
Thesis Advisor:
Marcelo G. Kazanietz
 
 
Thesis Topic:
Intra-and Inter-Molecular Interactions Regulate the Activity of the Rac-Gaps Alpha2-and Beta2-Chimaerins
 
 
 
 
 
 
JASON DRURY
 
 
 
Thesis Advisor:
Trevor M. Penning
 
 
Thesis Topic:
Expression, Characterization, and Structural Analysis of Human Liver Delta43Ketosteroid 5Beta-Reductase (AKR1D1) and its Disease-Related Mutant P133R
 
 
 
 
 
 
ERIN GRINER
 
 
 
Thesis Advisor:
Marcelo G. Kazanietz
 
 
Thesis Topic:
Investigating the Regulation and Function of the Rac-Gap Beta2-Chimaerin
 
 
 
 
 
 
MARIE HILDEBRANDT
 
 
 
Thesis Advisor:
Gary D. Wu
 
 
Thesis Topic:
The Role of Resistin Like Molecule Beta in Energy Homeostasis
 
 
 
 
 
 
ARMEN KARAMANIAN
 
 
 
Thesis Advisor:
Peter F. Davies
 
 
Thesis Topic:
Role of Claudin-5 and Hemodynamics in Endothelial Permeability and Susceptibility to Atheroclerosis
 
 
 
 
 
 
VICTOR KHOR
 
 
 
Thesis Advisor:
Wenchao Song
 
 
Thesis Topic:
The Role of Estrogen Sulfotransferase in Regulating Tissue Estrogen Sensitivity
 
 
Postdoc:
Postdoctoral Fellow, University of Pennsylvania
 
 
 
 
 
 
CHRISTOPHER REINA
 
 
 
Thesis Advisor:
Randall N. Pittman
 
 
Thesis Topic:
Characterizing the Role of the Polyglutamine Neurodegenerative Protein Ataxin-3 in the Cellular Response to Proteotoxic Stress
 
 
 
 
 
 
MARY ALLES ROBINSON
 
 
 
Thesis Advisor:
Otto, Cynthia M.
 
 
Thesis Topic:
 
 
 
 
 
 
 
JULIE L. WANG
 
 
 
Thesis Advisor:
Kung, Hank F.
 
 
Thesis Topic:
Development of Serotonin Transporter Brain Imaging Agents for Use in Positron Emission Tomography and Single Proton Emission Computed Tomography
 
 
 
 
 
 
YING YE
 
 
 
Thesis Advisor:
Chou, Margaret M.
 
 
Thesis Topic:
Regulation and Functions of Tre17/Ubiquitin-Specific Protease 6 (USP6) Oncogene in Aneurysmal Bone Cyst
 
 
 
 
 
 
2008-2009
 
 
 
DARRICK BALU
 
 
 
Thesis Advisor:
Lucki, Irwin
 
 
Thesis Topic:
Enhanced Sensitivity of the MRL/MPJ Mouse to the Neuroplastic and Behavioral Effects of Acute and Chronic Antidepressant Treatments
 
 
 
 
 
 
ANN-MARIE CHACKO
 
 
 
Thesis Advisor:
Kung, Hank F.
 
 
Thesis Topic:
The Molecular Imaging of Herpes Simplex Virus Type1 Thymidine Kinase Reporter Gene Expression: Novel[18F]Labeled Reporter Probes
 
 
 
 
 
 
EUGENE CICCIMARO
 
 
 
Thesis Advisor:
Blair, Ian A.
 
 
Thesis Topic:
The Absolute Quantification of Focal Adhesion Kinase Activation Loop Phosphorylation by Liquid Chromatography-Mass Spectrometry: A Biomarker of Src Kinase Activity
 
 
 
 
 
 
JESSICA CLECK
 
 
 
Thesis Advisor:
Blendy, Julie
 
 
Thesis Topic:
Alterations in Gene Expression at Key Points in the Addiction Cycle
 
 
 
 
 
 
BISEN DING
 
 
 
Thesis Advisor:
Muzykantov, Vladimir R.
 
 
Thesis Topic:
Protection Against Vascular Injury by Targeting Pro-Drugs to Endothelium
 
 
 
 
 
 
HOLLI KAWADLER
 
 
 
Thesis Advisor:
Yang, Xizolu
 
 
Thesis Topic:
The Role of Caspase-8 in T Cell Receptor Signaling
 
 
 
 
 
 
DAVID KIM
 
 
 
Thesis Advisor:
Song, Wenchao
 
 
Thesis Topic:
The Role of Complement Regulatory Proteins in Prevention of Cell Injury
 
 
 
 
 
 
DOMINICK LADDY
 
 
 
Thesis Advisor:
Weiner, David B.
 
 
Thesis Topic:
Vaccination Against Pathogenic Influenza with Synthetic Consensus DNA Antigens
 
 
 
 
 
 
ZHIYONG LU
 
 
 
Thesis Advisor:
Whitehead, Alexander Steven
 
 
Thesis Topic:
The Relationship Between Folate/Homocysteine Metabolism and Inflammatory Markers in Vitro and in Vivo
 
 
 
 
 
 
PATRICK MAYES
 
 
 
Thesis Advisor:
El-Deiry, Wafik S.
 
 
Thesis Topic:
The Mechanistic and Therapeutic Implications of Tumor Hypoxia in the Trail Signaling Pathway
 
 
 
 
 
 
MEREDITH MILLER
 
 
 
Thesis Advisor:
DeGrado, William F.
 
 
Thesis Topic:
Small Molecule Inhibitors of Integrin Alpha2Beta1 that Prevent Pathological Thrombus Formation Via an Allosteric Mechanism
 
 
 
 
 
 
JENNIFER OLIVER-KRASINSKI
 
 
 
Thesis Advisor:
Stoffers, Doris A.
 
 
Thesis Topic:
Novel Roles for PDX1 in the Endocrine Pancreas
 
 
 
 
 
 
AMY QUINN
 
 
 
Thesis Advisor:
Penning, Trevor M.
 
 
Thesis Topic:
Role of Aldo-Keto Reductase Enzymes in Polycyclic Aromatic Hydrocarbon Trans-Dihydrodiol Activation in Human Lung Cells
 
 
 
 
 
 
2007-2008
 
 
 
AMY EWING-KONDYRA
 
 
 
Thesis Advisor:
Chakravarti, Debabrata
 
 
Thesis Topic:
An Investigation of the Mechanisms Underlying N-Cor-Mediated Transcriptional Repression of Nuclear Receptor-Regulated Genes
 
 
 
 
 
 
ERIC KLEIN
 
 
 
Thesis Advisor:
Assoian, Richard K.
 
 
Thesis Topic:
Regulation of Cyclin D1 Expression by RAC, the Actin Cytoskeleton, and Extracellular Matrix Compliance
 
 
 
 
 
 
2006-2007
 
 
 
ALAN LAU
 
 
 
Thesis Advisor:
Chou, Margaret M.
 
 
Thesis Topic:
Non-Clathrin Endocytosis: Mechanisms of Regulating ARF6 and its Endocytic Pathway
 
 
 
 
 
 
RIJU RAY
 
 
 
Thesis Advisor:
Lerman, Caryn
 
 
Thesis Topic:
Effects of Atomoxetine on Nicotine Abstinence Symptoms
 
 
 
 
 
 
STEPHEN RUDNICK
 
 
 
Thesis Advisor:
Gewirtz, Alan M.
 
 
Thesis Topic:
Effects of Structure on Post-Transcriptional Gene Silencing
 
 
 
 
 
 
ELIZABETH SCHWARZBACH
 
 
 
Thesis Advisor:
Cohen, Akiva S.
 
 
Thesis Topic:
Investigating the Mechanisms Underlying Cognitive Impairments and Seizure Susceptibility Following Traumatic Brain Injury
 
 
 
 
 
 
ELIZABETH WESTGATE
 
 
 
Thesis Advisor:
FitzGerald, Garret A.
 
 
Thesis Topic:
Cardiovascular Rhythms and the Molecular Clock
 
 
 
 
 
 
PEIJUAN ZHU
 
 
 
Thesis Advisor:
Blair, Ian A.
 
 
Thesis Topic:
15Lipoxygenase-1Mediated Formation of Endogenous GSH-and RNA-Adducts and its Impact on GSH/GSSG Homeostasis in Monocytes/Macrophages
 
 
 
 
 
 
2005-2006
 
 
 
APHROTHITI FIKARIS
 
 
 
Thesis Advisor:
Meinkoth, Judy L.
 
 
Thesis Topic:
The Regulation of Cell Cycle Progression and Apoptosis in Thyroid Follicular Epithelial Cells
 
 
 
 
 
 
ALAINA FOURNIER
 
 
 
Thesis Advisor:
Assoian, Richard K.
 
 
Thesis Topic:
Rac-Dependent Regulation of Cyclin D1 Gene Expression by Integrins and E-Cadherin in Mammary Epithelial Cells
 
 
 
 
 
 
JULIE FRIEDLAND
 
 
 
Thesis Advisor:
Weaver, Valerie M.
 
 
Thesis Topic:
Spatial-Mechanical Regulation of the Small GTPase Rac in Mammary Epithelial Cell Survival and Apoptosis Resistance
 
 
 
 
 
 
RANA GUPTA
 
 
 
Thesis Advisor:
Kaestner, Klaus
 
 
Thesis Topic:
The Role of HNF-4alpha in the Pancreatic Beta-Cell
 
 
 
 
 
 
SARA KUTNEY
 
 
 
Thesis Advisor:
Chakravarti, Debabrata
 
 
Thesis Topic:
A Role for Inhat Proteins SET/TAF-IBeta and PP32 In Integrating Chromatin Hypoacetylation and Transcriptional Repression
 
 
 
 
 
 
KELLY ORLANDO
 
 
 
Thesis Advisor:
Pittman, Randall N.
 
 
Thesis Topic:
The Role of RHO Kinase in Preparing Apoptotic Corpses for Phagocytosis
 
 
 
 
 
 
LIYAN PANG
 
 
 
Thesis Advisor:
Poncz, Mortimer
 
 
Thesis Topic:
Maturation Stage-Specific Regulation of Megakaryopoiesis by Pointed Domain ETS Proteins
 
 
 
 
 
 
ADEMI SANTIAGO-WALKER
 
 
 
Thesis Advisor:
Meinkoth, Judy L.
 
 
Thesis Topic:
Isozyme-Specific Roles of Protein Kinase C in Thyroid Cells
 
 
 
 
 
 
ELISA WAXMAN
 
 
 
Thesis Advisor:
Lynch, David R.
 
 
Thesis Topic:
NMDA Receptor Biochemical and Activity-Dependent Regulation of P38 Mark and Glutamate Transporter EAAC1
 
 
 
 
 
 
ANASTASIA YOCUM
 
 
 
Thesis Advisor:
Blair, Ian A.
 
 
Thesis Topic:
Proteomic Approaches to the Discovery of Biomarkers and Pharmacological Targets
 
 
 
 
 
 
2004-2005
 
 
 
DAVID BAUMAN
 
 
 
Thesis Advisor:
Penning, Trevor M.
 
 
Thesis Topic:
Identification and Validation of Hydroxysteroid Dehydrogenases as Targets for Inhibitor Design in Human Prostate
 
 
 
 
 
 
KAREN BROWN
 
 
 
Thesis Advisor:
Whitehead, A.S.
 
 
Thesis Topic:
The Folate Metabolic Cycle: Genetic Modulation and Biological Consequences
 
 
 
 
 
 
BARRINGTON BURNETT
 
 
 
Thesis Advisor:
Pittman, Randall N.
 
 
Thesis Topic:
Characterizing the Role of the Polyglutamine Neurodegenerative Protein Ataxin-3 in the Ubiquitin-Proteasome Pathway
 
 
 
 
 
 
JAMES CROWLEY
 
 
 
Thesis Advisor:
Lucki, Irwin
 
 
Thesis Topic:
Pharmacogenomic Determinants of the Antidepressant-Like Effects of Citalopram in the Mouse Tail Suspension Test
 
 
 
 
 
 
KEITH FOURNIER
 
 
 
Thesis Advisor:
Robinson, Michael B.
 
 
Thesis Topic:
Intracellular Trafficking of the Neuronal Glutamate Transporter EAAC1
 
 
 
 
 
 
WENYING JIAN
 
 
 
Thesis Advisor:
Blair, Ian A.
 
 
Thesis Topic:
Lipid Peroxidation-Derived Endogenous DNA-and GSH-Adducts as Biomarkers of Oxidative Stress
 
 
 
 
 
 
ZHAOYU JIN
 
 
 
Thesis Advisor:
El-Deiry, Wafik S.
 
 
Thesis Topic:
The Regulation of Death Receptor-Mediated Apoptosis in Tumor Cells
 
 
 
 
 
 
MICHAEL POLLACK
 
 
 
Thesis Advisor:
Blair, Ian A.
 
 
Thesis Topic:
The Heptanone-Etheno-2'-Deoxycytidine Adduct: Stuctural Characterization and Translesion Synthesis
 
 
 
 
 
 
EDWARD WEINSTEIN
 
 
 
Thesis Advisor:
Rubin, Harvey
 
 
Thesis Topic:
Novel Approaches to Controlling Mycobacterium Tuberculosis Latency and Infection by Inhibiting the Electron Transport Chain
 
 
 
 
 
 
MICHELLE WILLIAMS
 
 
 
Thesis Advisor:
Blair, Ian A.
 
 
Thesis Topic:
Cyclooxygenase-2 Dependent Lipid Hydroperoxide-Induced DNA Damage
 
 
 
 
 
 
WU YIN
 
 
 
Thesis Advisor:
Birnbaum, Morris J.
 
 
Thesis Topic:
The Regulation of 5'AMP-Activated Protein Kinase by the Beta-Adrenergic Signaling Pathway in Adipocytes
 
 
 
 
 
 
2003-2004
 
 
 
BENJAMIN FRYER
 
 
 
Thesis Advisor:
Field, Jeffrey M.
 
 
Thesis Topic:
cGMP Dependent Protein Kinase (PKG) Phosphorylation of p21 Activated Kinase (PAK) at Serine 21 Regulates Nck/Pak Binding, VASP/Pak Association and Cell Morphology     
 
 
 
 
 
 
HONG-PING GUAN
 
 
 
Thesis Advisor:
Lazar, Mitchell A.
 
 
Thesis Topic:
A Futile Metabolic Cycle Activated in Adipocytes by Antidiabetic Agents
 
 
 
 
 
 
PAUL HAHN
 
 
 
Thesis Advisor:
Dunaief, Joshua L.
 
 
Thesis Topic:
Mechanisms of Cell Death in Retinal Degeneration: The Roles of Pro-Apoptotic BCL-2 Members, Bax and Bak, and of Iron Misregulation
 
 
 
 
 
 
RUI HONG
 
 
 
Thesis Advisor:
Chakravarti,Debabrata
 
 
Thesis Topic:
Characterization of Phospho-Protein pp32 and PCNA in Transcriptional Regulation      
 
 
 
 
 
 
YIQUN HUI
 
 
 
Thesis Advisor:
Funk, Colin
 
 
Thesis Topic:
Cysteinyl Leukotriene 2 Receptor Characterization
 
 
 
 
 
 
LEILAH MCNABB
 
 
 
Thesis Advisor:
Berrettini, Wade
 
 
Thesis Topic:
Analysis of the G-olf Locus on Human Chromosome 18 for a Role in Psychiatric Illness
 
 
 
 
 
 
ERIN NORRIS
 
 
 
Thesis Advisor:
Lee, Virginia Man-Yee
 
 
Thesis Topic:
Post-Translational Modifications of Alpha-Synuclein Protein by Oxidative and Nitrative Stress Mechanisms and Their Effects on the Pathogenesis of Synucleinopathies
 
 
 
 
 
 
SHERYL STEWART FLORES
 
 
 
Thesis Advisor:
Assoian, Richard K.
 
 
Thesis Topic:
Antimitogenesis by Prostacyclin Linked to Regulation of Skp2 Gene Expression
 
 
 
 
 
 
JONG YU
 
 
 
Thesis Advisor:
Lemmon, Mark A.
 
 
Thesis Topic:
Genome-Wide View of Membrane Targeting by Saccharomyces Cerevisiae Phox Homology (PX) and Pleckstrin Homology (PH) Domains
 
 
 
 
 
 
2002-2003
 
 
 
KUSHOL GUPTA
 
 
 
Thesis Advisor:
Loll, Patrick J.
 
 
Thesis Topic:
Structural Insights into the Mechanism and Inhibition of Prostaglandin H2 Synthase-1
 
 
 
 
 
 
NADIA GURVICH
 
 
 
Thesis Advisor:
Klein, Peter S.
 
 
Thesis Topic:
Histone Deacetylase is a Target of Valproic Acid-Mediated Cellular Differentiation
 
 
 
 
 
 
HALVOR JUUL
 
 
 
Thesis Advisor:
Dichter, Marc
 
 
Thesis Topic:
GABAa Receptor Subunit mRNA Expression and Pharmacology in Hippocampal Neurons Developint in Vitro
 
 
 
 
 
 
RYAN KRUGER
 
 
 
Thesis Advisor:
McCafferty, Dewey G.
 
 
Thesis Topic:
Sortase: Characterization, Substrate Specificity
 
 
 
 
 
 
FUSHENG LI
 
 
 
Thesis Advisor:
Pittman, Randall N.
 
 
Thesis Topic:
Effects of the polyglutamine neurodegenerative protein ataxin-3 on transcriptional regulation and the ubiquitin-proteasome pathway
 
 
 
 
 
 
JEFFREY MASUDA-ROBENS
 
 
 
Thesis Advisor:
Chou, Margaret M.
 
 
Thesis Topic:
The First Insights Into the TRE17 Oncogene: A Potential Link Between Actin Remodeling and Vesicular Trafficking
 
 
 
 
 
 
FANG ZHANG
 
 
 
Thesis Advisor:
Klein, Peter S.
 
 
Thesis Topic:
Regulation of Glycogen synthase Kinase-3 by the PC/AXIN Complex
 
 
 
 
 
 
2002-2001
 
 
 
JOANNA FUEYO
 
 
 
Thesis Advisor:
Weiser, Jeffrey Neal
 
 
Thesis Topic:
IN SILICO Discovery of Antimicrobial Targets
 
 
 
 
 
 
JESSICA WALCOTT
 
 
 
Thesis Advisor:
Merry, Diane E.
 
 
Thesis Topic:
Characterization of Cellular and Transgenic Models of Spinal and Bulbar Muscular Atrophy
 
 
 
 
 
 
2000-2001
 
 
 
ANTHONY BEVIVINO
 
 
 
Thesis Advisor:
Loll, Patrick J.
 
 
Thesis Topic:
BIOCHEMICAL CHARACTERIZATION OF THE NORMAL AND PATHOGENIC FORMS OF THE MJD1 GENE PRODUCT, ATAXIN-3
 
 
 
 
 
 
JOHN POWELL
 
 
 
Thesis Advisor:
Mousa, Shaker
 
 
Thesis Topic:
POTENTIAL ANGIOGENIC ACTIVITY AND BIOCHEMICAL MECHANISMS OF NEUTROPHIL ACTIVATING PROTEIN-2
 
 
 
 
 
 
CHRISTINA WILSON
 
 
 
Thesis Advisor:
Lee, Virginia
 
 
Thesis Topic:
MULTIPLE ROLES FOR PRESENILINS DEMONSTRATED BY CHARACTERIZATION OF PRESENILIN NULL CELLS
 
 
 
 
 
 
JING ZHANG
 
 
 
Thesis Advisor:
Granato, Michael
 
 
Thesis Topic:
THE ROLE OF THE ZEBRAFISH UNPLUGGED GENE IN MOTOR AXON PATHFINDING
 
 
 
 
 
 
1999-2000
 
 
 
CHEN, CATHERINE
 
 
 
Thesis Advisor:
Manning, David R.
 
 
Thesis Topic:
REGULATION OF G ALPHA-i PALMITOYLATION
 
 
 
 
 
 
DANA EMERY
 
 
 
Thesis Advisor:
McIntosh, Tracy K.
 
 
Thesis Topic:
INCREASED EXPRESSION OF GROWTH-RELATED PROTEINS AND HIPPOCAMPAL NEUROGENESIS IS BRAINS OF ADULT RATS FOLLOWING EXPERIMENTAL TRUMATIC BRAIN INJURY
 
 
 
 
 
 
JOHN HINES
 
 
 
Thesis Advisor:
Fluharty, Steven J.
 
 
Thesis Topic:
STRUCTURAL DETERMINANTS FOR FUNCTIONAL PROPERTIES OF ANGIOTENSIN II RECEPTORS
 
 
 
 
 
 
DEBORAH KNOBELMAN
 
 
 
Thesis Advisor:
Lucki, Irwin
 
 
Thesis Topic:
REGULATION OF EXTRACELLULAR CONCENTRATIONS OF SEROTONIN BY 5-HT 1A AND 5-HT 1B AUTORECEPTORS IN MICE
 
 
 
 
 
 
PETER O'BRIEN
 
 
 
Thesis Advisor:
Brass, Lawrence F.
 
 
Thesis Topic:
THE ROLE OF PROTEASE ACTIVATED RECEPTORS IN VASCULAR ENDOTHELIAL THROMBIN RESPONSES
 
 
 
 
 
 
JENNIFER PHILLIPS
 
 
 
Thesis Advisor:
Eberwine, James H.
 
 
Thesis Topic:
TRANSLIN: LOCALIZATION AND EVIDENCE FOR REGULATED NUCLEOCYTOPLASMIC SHUTTLING
 
 
 
 
 
 
ARTURO SAAVEDRA
 
 
 
Thesis Advisor:
Meinkoth, Judy L.
 
 
Thesis Topic:
CYCLIC AMP IN THE REGULATION OF CELL SURVIVAL
 
 
 
 
 
 
LORAINE SILVESTRO DIECKMANN
 
 
 
Thesis Advisor:
Axelsen, Paul H.
 
 
Thesis Topic:
FUNCTION AND STRUCTURE OF CECROPIN A
 
 
 
 
 
 
NICOLE STONE
 
 
 
Thesis Advisor:
Pittman, Randall N.
 
 
Thesis Topic:
MECHANISMS UNDERRLYING DYNAMIC MORPHOLOGICAL CHANGES DURING THE EXECUTION PHASE OF APOPTOSIS
 
 
 
 
 
 
HONGLIN ZHOU
 
 
 
Thesis Advisor:
Pittman, Randall N.
 
 
Thesis Topic:
REGULATION OF CELL SURVIVAL AND APOPTOSIS BY PHOSPHOINOSITIDE 3-KINASE/AKT PATHWAY
 
 
 
 
 
 
1998-1999
 
 
 
MICHAEL BURCZYNSKI
 
 
 
Thesis Advisor:
Penning, Trevor M.
 
 
Thesis Topic:
HUMAN ALDO-KETO REDUCTASES IN POLYCYCLIC AROMATIC HYDROCARBON ACTIVATION
 
 
 
 
 
 
LISA CASS
 
 
 
Thesis Advisor:
Meinkoth, Judy L.
 
 
Thesis Topic:
CYCLIC AMP SIGNALING IN THE HORMONAL CONTROL OF PROLIFERATION AND DIFFERENTIATION
 
 
 
 
 
 
MING HONG
 
 
 
Thesis Advisor:
Lee, Virginia Man-Yee
 
 
Thesis Topic:
MECHANISMS OF TAU PROTEIN DYSFUNCTION IN ALZHEIMER'S DISEASE AND OTHER NEURODEGENERATIVE TAUOPATHIES
 
 
 
 
 
 
HAICHING MA
 
 
 
Thesis Advisor:
Penning, Trevor M.
 
 
Thesis Topic:
THE DETERMINANTS OF COFACTOR AND SUBSTRATE SPECIFICITIES OF HYDROXYSTEROID DEHYDROGENASES
 
 
 
 
 
 
MATTHEW PEREZ
 
 
 
Thesis Advisor:
Pittman, Randall N.
 
 
Thesis Topic:
AGGREGATION AND NUCLEAR EXPRESSION OF THE SPINOCEREBELLAR ATAXIA TYPE 3 GENE PRODUCT, ATAXIN-3
 
 
 
 
 
 
MIECHELLE PLESCO O'BRIEN
 
 
 
Thesis Advisor:
Tew, Kenneth D.
 
 
Thesis Topic:
EXPRESSION AND FUNCTION OF THE GLUTATHIONE DETOXIFICATION PATHWAY AND THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN IN ANTICANCER DRUG RESISTANCE
 
 
 
 
 
 
DONNA WOULFE
 
 
 
Thesis Advisor:
Brass, Lawrence F.
 
 
Thesis Topic:
STRUCTURAL BASIS FOR THE SELECTIVITY OF THE REGULATOR OF G PROTEIN SIGNALLING, GAIP, FOR G ALPHA i FAMILY MEMBERS
 
 
 
 
 
 
HONGTAO ZHANG
 
 
 
Thesis Advisor:
Greene, Mark I.
 
 
Thesis Topic:
SIGNALLING PATHWAYS INVOLVED IN CELL TRANSFORMATION AND CONVERSION OF PHENOTYPE
 
 
 
 
 
 
1997-1998
 
 
 
KATHRYN WOHLPART
 
 
 
Thesis Advisor:
Molinoff, Perry B.
 
 
Thesis Topic:
Regulation of 5-HT2a Receptor Coupling and 5-HT2a Receptor mRNA in P11 Cells
 
 
 
 
 
 
MAURICIO REGINATO
 
 
 
Thesis Advisor:
Lazar, Mitchell A.
 
 
Thesis Topic:
Inhibitory Mechanisms Regulating Nuclear Hormone Receptor Action
 
 
 
 
 
 
1996-1997
 
 
 
NORIFUSA ANEGAWA
 
 
 
Thesis Advisor:
Lindstrom, Jon M.
 
 
Thesis Topic:
 
 
 
 
 
 
 
JOSEPH ERHARDT
 
 
 
Thesis Advisor:
Pittman, Randall N.
 
 
Thesis Topic:
p21(WAF1) and NFB42 in Neural Growth and Differentiation
 
 
 
 
 
 
ELFRIDA GRANT
 
 
 
Thesis Advisor:
Lynch, David
 
 
Thesis Topic:
Subunit Specificity and Modulation of N-Methyl-D-Aspartate Receptor Mediated Intracellular Calcium Responses
 
 
 
 
 
 
1996 - 1997
 
 
 
YVETTE BORDELON
 
 
 
Thesis Advisor:
Chesselet, Marie-Francoise
 
 
Thesis Topic:
Early Events Following an Excitotoxic Insult in Rat Striatum
 
 
 
 
 
 
BRIAN BROOKS
 
 
 
Thesis Advisor:
Fischbeck, Kenneth H.
 
 
Thesis Topic:
Characterization of Normal- and Expanded-Glutamine Repeat Androgen Receptors in a Neuronal Cell Line
 
 
 
 
 
 
DAVID BROUSSEAU
 
 
 
Thesis Advisor:
McGonigle, Paul
 
 
Thesis Topic:
Regulation of 5-HT 1A and 5-HT 2A Receptor mRNA and Protein Density in the Rat CNS: An Analysis using Quantitative In-situ Hybridization and Receptor Autoradiographic Techniques.
 
 
 
 
 
 
JENNIFER HEERDING
 
 
 
Thesis Advisor:
Steven J. Fluharty
 
 
Thesis Topic:
Elucidation of the Ligand Binding Domain of the Angiotensin Type 2 (AT2) Receptor
 
 
 
 
 
 
WESLIA HYNICKA
 
 
 
Thesis Advisor:
Randall N. Pittman
 
 
Thesis Topic:
Characterization of a cDNA Highly Enriched in CNS
 
 
 
 
 
 
SHELLY KENDRICK LENZ
 
 
 
Thesis Advisor:
Marc A. Dichter
 
 
Thesis Topic:
Pharmacological and Physiological Characterization of Recombinant and Native NMDA Receptors
 
 
 
 
 
 
CONRAD MESSAM
 
 
 
Thesis Advisor:
Randall N. Pittman
 
 
Thesis Topic:
Cellular and Biochemical Changes Occurring During Apoptosis of PC12 Cells
 
 
 
 
 
 
BRIAN SCHLEGEL
 
 
 
Thesis Advisor:
Trevor M. Penning
 
 
Thesis Topic:
Structural Determinants of Catalysis and Steroid Binding in 3alpha-Hydroxysteroid Dehydrogenase
 
 
 
 
 
 
XIN ZHANG
 
 
 
Thesis Advisor:
Mark Greene
 
 
Thesis Topic:
Sturctural and Functional Mapping of Immunoglobulin Domains
 
 
 
 
 
 
LISA DOWD
 
 
 
Thesis Advisor:
Michael B. Robinson
 
 
Thesis Topic:
Pharmacological Characterization and Second-Messenger Regulation of the Sodium-Dependent Glutamate Transporter Subtype, EAACI.
 
 
 
 
 
 
STEPHANIE FLAGG
 
 
 
Thesis Advisor:
James H. Eberwine
 
 
Thesis Topic:
Characterization of a Protein Interaction with the Proopiomelanocortin mRNA: An RNA Mutagenesis Analysis
 
 
 
 
 
 
SURESH NAIR
 
 
 
Thesis Advisor:
James H. Eberwine
 
 
Thesis Topic:
Molecular Correlates of Chronic Corticosterone Exposure in the Hippocampus
 
 
 
 
 
 
JANET VESSOTSKIE
 
 
 
Thesis Advisor:
Hank F. Kung
 
 
Thesis Topic:
Characterization of Iodinated Ligands for Dopamine D2-Like Receptors
 
 
 
 
 
 
1994 - 1995
 
 
 
YANXIANG CAO
 
 
 
Thesis Advisor:
James H. Eberwine
 
 
Thesis Topic:
Molecular Aspects of Aging in Hippocampal Neurons
 
 
 
 
 
 
PAUL FROHNA
 
 
 
Thesis Advisor:
Jeffrey N. Joyce
 
 
Thesis Topic:
The Developmental Plasticity of the Dopamine Systems of the Rodent Basal Ganglia: Effects of Neonatal 6-Hydroxydopamine Lesions
 
 
 
 
 
 
ANNEMARIE INGLIS
 
 
 
Thesis Advisor:
Randall N. Pittman
 
 
Thesis Topic:
Characterization of Plasminogen Activators in the Developing and Regenerating Rat Nervous System
 
 
 
 
 
 
HAEYOUNG KONG
 
 
 
Thesis Advisor:
Terry D. Reisine
 
 
Thesis Topic:
Identification of Ligand binding Determinants in the cloned Mouse Kappa and Delta Opiod Receptors
 
 
 
 
 
 
MUHAMMAD MUNIR
 
 
 
Thesis Advisor:
Paul McGonigle
 
 
Thesis Topic:
Mechanisms of Excitotoxicity in Human NT2-N Neurons
 
 
 
 
 
 
LAWRENCE REAGAN
 
 
 
Thesis Advisor:
Steven J. Fluharty
 
 
Thesis Topic:
Development of Polyclonal Antisera Selective for Angiotensin Type 2 (AT2) Receptors
 
 
 
 
 
 
YEONG-AN SHEU
 
 
 
Thesis Advisor:
Dolan Pritchett
 
 
Thesis Topic:
The Structural Study of the Serotornin-II Receptor and the Study of Signal Transduction
 
 
 
 
 
 
CORINNE SPENCER
 
 
 
Thesis Advisor:
James H. Eberwine
 
 
Thesis Topic:
Protein Interactions with a cis-Acting Element in the Coding Region of Proopiomelanocortin mRNA
 
 
 
 
 
 
JIE ZHONG
 
 
 
Thesis Advisor:
Perry B. Molinoff
 
 
Thesis Topic:
Expression and Regulation of NMDA Receptors
 
 
 
 
 
 
KAREN BLOCK
 
 
 
Thesis Advisor:
Mortimer Poncz
 
 
Thesis Topic:
Characterization of Regulatory Elements in the 5' - Flanking Region of the Gpiib Gene
 
 
 
 
 
 
ROBERT FERRY
 
 
 
Thesis Advisor:
Perry B. Molinoff
 
 
Thesis Topic:
Mechanisms of Regulation of 5-HT2A Receptors and Receptor mRNA in P11 Cells
 
 
 
 
 
 
LOUIS LITTMAN
 
 
 
Thesis Advisor:
Michael B. Robinson
 
 
Thesis Topic:
Evidence For The Expression Of Multiple Subtypes Of Excitatory Amino Acid Receptors Coupled To Phosphoinositide Hydrolysis In The Mammalian Central Nervous System;
 
 
 
 
 
 
FRANCIS SZELE
 
 
 
Thesis Advisor:
Marie-Francoise Chesselet
 
 
Thesis Topic:
Plasticity in the Striatum and Subependymal Layer of Adult Rats in Response to Cortical Lesions
 
 
 
 
 
 
SONGLI WANG
 
 
 
Thesis Advisor:
Randall N. Pittman
 
 
Thesis Topic:
Characterization of Early Molecular Events in Programmed Neuronal Cell Death
 
 
 
 
 
 
1992 - 1993
 
 
 
VIRGINIA BOUNDY
 
 
 
Thesis Advisor:
Perry B. Molinoff
 
 
Thesis Topic:
Development And Cfharacterization of Polyclonal Antibodies For The D2 and D3 Dopamine Receptors
 
 
 
 
 
 
NANETTE COCERO
 
 
 
Thesis Advisor:
Perry B. Molinoff
 
 
Thesis Topic:
Effects Of Partial Agonists On B-Adrenergic Receptors.
 
 
 
 
 
 
THERESA FILTZ
 
 
 
Thesis Advisor:
Perry B. Molinoff
 
 
Thesis Topic:
Paradoxical Regulation Of Dopamine Receptors In Transfected Cell Lines
 
 
 
 
 
 
KAREN LOUNSBURY
 
 
 
Thesis Advisor:
David R. Manning,
 
 
Thesis Topic:
Phosphorylation Of Gza By Protein KinaseC: Characterization In Human Platelets And Analysis By Site-Directed Mutagenesis
 
 
 
 
 
 
JOHN PAWLOWSKI
 
 
 
Thesis Advisor:
Trevor M. Penning
 
 
Thesis Topic:
Cloning, Expression and Site-Directed Mutagensis of the Rat Liver 3a-Hydroxysteroid Dehydrogenase
 
 
 
 
 
 
JED SHUMSKY
 
 
 
Thesis Advisor:
Irwin Lucki
 
 
Thesis Topic:
Differential Regulation of the Behavioral Effects of Chlordiazepoxide
 
 
 
 
 
 
ALISON GAGNON
 
 
 
Thesis Advisor:
Lawrence F. Brass
 
 
Thesis Topic:
G Proteins in Platelets: Identification and Role in Platelet Signal Transduction
 
 
 
 
 
 
MIN LI
 
 
 
Thesis Advisor:
Barry Wolfe
 
 
Thesis Topic:
Immunological and Pharmacological Studies on Subtypes of Muscarinic Cholinergic Receptors
 
 
 
 
 
 
KAREN RAYNOR
 
 
 
Thesis Advisor:
Terry D. Reisine
 
 
Thesis Topic:
Properties of Somatostatin Receptor Subtypes.
 
 
 
 
 
 
JOEL SCHACHTER
 
 
 
Thesis Advisor:
Barry Wolfe
 
 
Thesis Topic:
Regulation Of Phospholipase C Responses By Agents Which Alter.  The Cellular Cyclic AMP Profile.
 
 
 
 
 
 
1990 - 1991
 
 
 
KATHRYN IVINS
 
 
 
Thesis Advisor:
Perry B. Molinoff
 
 
Thesis Topic:
Studies Of Receptors For Dopamine And Serotonin In Novel Cell Lines
 
 
 
 
 
 
NEIL MARGOLIS
 
 
 
Thesis Advisor:
Terry D. Reisine
 
 
Thesis Topic:
Indentification And Characterization Of Nuclear Phosphoproteins Which May Be Involved In Proopiomelanocortin Gene Regulation.
 
 
 
 
 
 
SWAMINATHAN SUBRAMANIAM
 
 
 
Thesis Advisor:
Paul McGonigle
 
 
Thesis Topic:
Anatomical And Developmental Heterogeneity Of The Effects Of Polyamines On NMDA Receptor
 
 
 
 
 
 
STEPHEN WALL
 
 
 
Thesis Advisor:
Barry Wolfe
 
 
Thesis Topic:
Antibodies Selective For Subtypes Of Muscarinic Cholinergic Receptors: Studies On Receptor Distribution And Regulation
 
 
 
 
 
 
JONATHAN IVINS
 
 
 
Thesis Advisor:
Perry B. Molinoff
 
 
Thesis Topic:
Effects Of Cell-Cell Contact On Neuronal Growth Cones.
 
 
 
 
 
 
PETER VOS
 
 
 
Thesis Advisor:
Randall N. Pittman
 
 
Thesis Topic:
A Novel In Vitro System for Studying The Interactions Between Merkel Cells, Sensory Neurons, And Sympathetic Neurons
 
 
 
 
 
 
HUNG-LI WANG
 
 
 
Thesis Advisor:
Terry D. Reisine
 
 
Thesis Topic:
Somatostatin-14 And Somatostatin-28 Modulate Multiple Effector Systems In Cultured Rat Neocortical Neurons.