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Axonal de- and regeneration

In 1850 Waller described the process of injury induced nerved degeneration, which is now know as Wallerian degeneration. Recent research has revealed that axonal degeneration is a genetically controlled process, yet the molecular triggers and cellular mechanisms underlying axonal degeneration are not well understood. We have recently developed a zebrafish model for peripheral nerve injury which enables us to visualize in real time and in live intact animals the process of axonal degeneration. Using fluorescently tagged proteins, we are now investigating the cellular interaction between injured axons and neighboring cells, as well as the subcellular events within injured nerves.

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Rosenberg, A., Wolman, M, Franzini-Armstrong, C, Granato, M. In vivo macrophage-nerve interactions following peripheral nerve injury. 2012. J. Neuroscience (32), 4440-56. pdf and comment