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Material Transfer Agreements
The Penn Vector Core provides materials to academic and other non-profit organizations under a Material Transfer Agreement (MTA). An MTA is required for the transfer of vectors as well as plasmids, cell lines, antibodies, animal models and all other biologicals.
If you do not know whether or not your laboratory currently holds an MTA for the materials requested, please email firstname.lastname@example.org
If your laboratory does not already hold a material transfer agreement (MTA) for the vectors requested, please complete one or more of the MTAs in the links below.
To complete an MTA:
Choose an MTA or MTAs associated with materials requested or anticipated to be requested. For a combination of materials, more than one MTA may be required.
AAV plasmids and vectors based on serotypes 1, 2, 5, 6, 6.2, 7, 8, 9, rh8, rh10, hu11, rh64 and certain others fall under the MTA for AAV, adenoviral vector or lentiviral vector materials* (template A).
A specific MTA template is required for the provision of AAV vectors for work involving domain antibodies. Additional MTAs are required for the transfer of lentiviral vectors pseudotyped with the Ebola glycoprotein envelopes.
(C) MTA for Ebola pseudotyped lentiviral vectors will be provided upon request.
*(HHMI investigators please contact the Vector Core for the HHMI specific AAV2/1 MTA template.)
To complete an MTA Exhibit :
For most of the MTAs listed above, an "Exhibit A" is included in which the following information is requested and for which our recommendations for completion are below:
Original Materials Requested: we recommend selecting as many serotypes and applications of interest for the materials requested to avoid further amendment to this MTA. Humans serotype 5 adenoviral vectors and VSVG pseudotyped lentiviral vectors as well as plasmid DNA may also be listed in MTA (A).
Summary of Research: we recommend listing as many genes/gene families of interest as well as applications of interest for the materials requested to avoid further amendment to your MTA
If additions to the Materials Requested or Summary of Research are needed, an MTA Amendment form may be used. Please note that an MTA (A) between UPenn and the requesting institution must already be in place to amend additional materials or workplans. For any questions about the form, please email email@example.com.
For investigators already holding an MTA (A) with UPenn, additional materials or applications may be amended to the existing agreement using the General MTA Amendment form. For investigators wishing to request vectors based on ORIGINAL MATERIALS provided by the Allen Institute, a separate MTA Amendment for Allen Institute Materials is required.
For completion of all MTAs and MTA Amendments:
The Principal Investigator and an authorized official from the institution (eg from the institution’s technology licensing or grants & contracts office) should sign where indicated on the MTA and attach the completed Summary of Work. Please note that the MTA should not be signed by students, postdoctoral researchers or fellows.
- A PDF of the partially executed (signed) MTA should be emailed to firstname.lastname@example.org
- If the institution requires hardcopies, please mail two partially executed copies to the following address: PENN VECTOR CORE, Attention: Julie Johnston, Vector Core Director, Gene Therapy Program, University of Pennsylvania, Suite 2000 - 125 S. 31st Street, Philadelphia, PA 19104
For requesting vectors based on Allen Institute materials: (see ‘To complete an MTA Amendment’)
The Penn Vector Core is pleased to provide vectors based on ORIGINAL MATERIALS distributed through Addgene or sent to us by generous investigators (see Catalog).
The vectors we generate are defined as MODIFICATIONS of the ORIGINAL MATERIALS as defined by the NIH and can be distributed only to investigators that hold an MTA with Upenn and the providing institution for the ORIGINAL MATERIAL.
To request vectors incorporating plasmid DNA obtained through Addgene we require either; (1) an MTA with a providing institution facilitated by Addgene, (2) an MTA directly from the providing institution, or (3) an email providing a statement of permission for use from the provider of the ORIGINAL MATERIAL.
Ideally the confirmation of MTA or permission of use should accompany the request, but if an MTA is not already held one can be obtained through Addgene by ordering the original material at a cost of $65 (plus shipping.)
MTA Definitions of MATERIALS and MODIFICATIONS
1. ORIGINAL MATERIAL: The material(s) are specifically described in EXHIBIT A of the MTA. ORIGINAL MATERIALS may include for example original plasmid DNA, vectors or cell lines.
2. PROGENY: Unmodified descendants from the ORIGINAL MATERIAL, including but not limited to, virus from virus, cell from cell, or organism from organism.
3. UNMODIFIED DERIVATIVES: Substances created by the RECIPIENT which constitute an unmodified functional subunit or product expressed by the ORIGINAL MATERIAL. Some examples include: subclones of unmodified cell lines, purified or fractionated subsets of the ORIGINAL MATERIAL, proteins expressed/encoded by DNA/RNA supplied by PENN, viral based vectors (assembled particles with or without genomes) generated from DNA/RNA supplied by PENN, or monoclonal antibodies secreted by a hybridoma cell line.
4. MODIFICATIONS: Substances created by the RECIPIENT which contain/incorporate the MATERIAL. Some examples include: crosses, breeding varieties, cell fusions, subclonings, viral based vectors generated from both DNA/RNA supplied by PENN and DNA/RNA provided by the RECIPIENT (eg. PENN AAV serotype vectors expressing genes provided by the RECIPIENT) etc.
5. MATERIAL: ORIGINAL MATERIAL, PROGENY, and UNMODIFIED DERIVATIVES. The MATERIAL shall not include: (a) MODIFICATIONS, or (b) other substances created by the RECIPIENT through the use of the MATERIAL which are not MODIFICATIONS, PROGENY, or UNMODIFIED DERIVATIVES.