Publications

Amylin activates distributed CNS nuclei to control energy balance. Mietlicki-Baase EG, Hayes MR. Physiol Behav. 2014 Jan 28. pii: S0031-9384(14)00016-X. doi: 10.1016/j.physbeh.2014.01.013. [Epub ahead of print]
Intraduodenal milk protein concentrate augments the glycemic and food intake suppressive effects of DPP-IV inhibition. Olivos DR, McGrath LE, Turner CA, Montaubin O, Mietlicki-Baase EG, Hayes MR. Am J Physiol Regul Integr Comp Physiol. 2014 Feb;306(3):R157-63. doi: 10.1152/ajpregu.00358.2013. Epub 2013 Dec 18.
The food intake-suppressive effects of glucagon-like peptide-1 receptor signaling in the ventral tegmental area are mediated by AMPA/kainate receptors. Mietlicki-Baase EG, Ortinski PI, Rupprecht LE, Olivos DR, Alhadeff AL, Pierce RC, Hayes MR. Am J Physiol Endocrinol Metab. 2013 Dec 1;305(11):E1367-74. doi: 10.1152/ajpendo.00413.2013. Epub 2013 Oct 8.
Hindbrain GLP-1 receptor-mediated suppression of food intake requires a PI3K-dependent decrease in phosphorylation of membrane-bound Akt. Rupprecht LE, Mietlicki-Baase EG, Zimmer DJ, McGrath LE, Olivos DR, Hayes MR. Am J Physiol Endocrinol Metab. 2013 Sep;305(6):E751-9. doi: 10.1152/ajpendo.00367.2013. Epub 2013 Jul 30.
Amylin receptor signaling in the ventral tegmental area is physiologically relevant for the control of food intake. Mietlicki-Baase EG, Rupprecht LE, Olivos DR, Zimmer DJ, Alter MD, Pierce RC, Schmidt HD, Hayes MR. Neuropsychopharmacology. 2013 Aug;38(9):1685-97. doi: 10.1038/npp.2013.66. Epub 2013 Mar 8.
Donepezil, an acetylcholinesterase inhibitor, attenuates nicotine self-administration and reinstatement of nicotine seeking in rats. Kimmey BA, Rupprecht LE, Hayes MR, Schmidt HD. Addict Biol. 2012 Dec 12. doi: 10.1111/adb.12014. [Epub ahead of print]
Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance. Grill HJ, Hayes MR. Cell Metab. 2012 Sep 5;16(3):296-309. doi: 10.1016/j.cmet.2012.06.015. Epub 2012 Aug 16. Review.
Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency. De Jonghe BC, Hayes MR, Zimmer DJ, Kanoski SE, Grill HJ, Bence KK. Am J Physiol Endocrinol Metab. 2012 Sep 1;303(5):E644-51. doi: 10.1152/ajpendo.00009.2012. Epub 2012 Jul 3.
Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals. Kanoski SE, Zhao S, Guarnieri DJ, DiLeone RJ, Yan J, De Jonghe BC, Bence KK, Hayes MR, Grill HJ. Am J Physiol Endocrinol Metab. 2012 Aug 15;303(4):E496-503. doi: 10.1152/ajpendo.00205.2012. Epub 2012 Jun 12.
Galantamine, an Acetylcholinesterase Inhibitor and Positive Allosteric Modulator of Nicotinic Acetylcholine Receptors, Attenuates Nicotine Taking and Seeking in Rats. Hopkins TJ, Rupprecht LE, Hayes MR, Blendy JA, Schmidt HD. Neuropsychopharmacology. 2012 Sep;37(10):2310-21. doi: 10.1038/npp.2012.83. Epub 2012 Jun 6.
TrkB receptor signaling in the nucleus tractus solitarius mediates the food intake-suppressive effects of hindbrain BDNF and leptin. Spaeth AM, Kanoski SE, Hayes MR, Grill HJ. Am J Physiol Endocrinol Metab. 2012 May;302(10):E1252-60. Epub 2012 Feb 28.
Neuronal and intracellular signaling pathways mediating GLP-1 energy balance and glycemic effects. Hayes MR. Physiol Behav. 2012 Jun 6;106(3):413-6. Epub 2012 Feb 17.
Hindbrain leptin and glucagon-like-peptide-1 receptor signaling interact to suppress food intake in an additive manner. Zhao S, Kanoski SE, Yan J, Grill HJ, Hayes MR. Int J Obes (Lond). 2012 Jan 17. doi: 10.1038/ijo.2011.265. [Epub ahead of print]
The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide. Kanoski SE, Rupprecht LE, Fortin SM, De Jonghe BC, Hayes MR. Neuropharmacology. 2012 Apr;62(5-6):1916-27. Epub 2011 Dec 28.
GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake. Alhadeff AL, Rupprecht LE, Hayes MR. Endocrinology. 2012 Feb;153(2):647-58. Epub 2011 Nov 29.
Regulation of energy balance and body weight by the brain: a distributed system prone to disruption. Faulconbridge LF, Hayes MR. Psychiatr Clin North Am. 2011 Dec;34(4):733-45. Epub 2011 Oct 11.
The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1. Hayes MR, Kanoski SE, De Jonghe BC, Leichner TM, Alhadeff AL, Fortin SM, Arnold M, Langhans W, Grill HJ. Am J Physiol Regul Integr Comp Physiol. 2011 Nov;301(5):R1479-85. Epub 2011 Aug 17.
Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4. Kanoski SE, Fortin SM, Arnold M, Grill HJ, Hayes MR. Endocrinology. 2011 Aug;152(8):3103-12. Epub 2011 Jun 21.
Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in rats. Hayes MR, Kanoski SE, Alhadeff AL, Grill HJ. Obesity (Silver Spring). 2011 Jul;19(7):1342-9. doi: 10.1038/oby.2011.50. Epub 2011 Mar 17.
Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation. Hayes MR, Leichner TM, Zhao S, Lee GS, Chowansky A, Zimmer D, De Jonghe BC, Kanoski SE, Grill HJ, Bence KK. Cell Metab. 2011 Mar 2;13(3):320-30.
Role of the glucagon-like-peptide-1 receptor in the control of energy balance. Hayes MR, De Jonghe BC, Kanoski SE. Physiol Behav. 2010 Jul 14;100(5):503-10. Epub 2010 Mar 10. Review.
Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation. Hayes MR, Skibicka KP, Leichner TM, Guarnieri DJ, DiLeone RJ, Bence KK, Grill HJ. Cell Metab. 2010 Jan;11(1):77-83.
The nucleus tractus solitarius: a portal for visceral afferent signal processing, energy status assessment and integration of their combined effects on food intake. Grill HJ, Hayes MR. Int J Obes (Lond). 2009 Apr;33 Suppl 1:S11-5. Review.
Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling. Hayes MR, Bradley L, Grill HJ. Endocrinology. 2009 Jun;150(6):2654-9. Epub 2009 Mar 5.
Dorsal hindbrain 5'-adenosine monophosphate-activated protein kinase as an intracellular mediator of energy balance. Hayes MR, Skibicka KP, Bence KK, Grill HJ. Endocrinology. 2009 May;150(5):2175-82. Epub 2008 Dec 30.
Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation. Hayes MR, Skibicka KP, Grill HJ. Endocrinology. 2008 Aug;149(8):4059-68. Epub 2008 Apr 17.
Imaging obesity: fMRI, food reward, and feeding. Grill HJ, Skibicka KP, Hayes MR. Cell Metab. 2007 Dec;6(6):423-5.