HVTN 070
About the study
A Phase I clinical trial to evaluate the safety and immunogenicity of PENNVAX-B (gag, pol, env) given alone, with IL-12 DNA, or with a dose escalation of IL-15 DNA, in healthy, HIV-1 - uninfected adult participants.
Primary objectives:
To assess the safety and tolerability of a multigene HIV DNA vaccine (gag, pol, env) with or without co-administration of IL-12 DNA or IL-15 DNA in a cohort of HIV-uninfected healthy adults.
To evaluate the safety and tolerability of IL-15 DNA (escalating doses of 0.8 mg and 2 mg) with co-administration of 6 mg of a multigene HIV DNA vaccine (gag, pol, env).
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