CAMB 530: Seminar in Cell Cycle and Cancer

This seminar course will focus on molecular events that regulate cell cycle transitions and their relevance to human cancer. Topics will include control of the G1/S and G2/M transitions, relationships between tumor suppressor genes such as p16, Rb, p53 or oncogenes such as cyclin D, cdc25A, MDM2 or c-myc and cell cycle control. Where appropriate, the focus will be on understanding regulation of cell cycle control through transcriptional induction of gene expression, protein associations, posttranslational modifications like phosphorylation or regulation of protein stability like ubiquitin degradation. Although achieving an improved understanding of mammalian cancer is a goal of the course, much of our knowledge of the cell cycle derives from work done in more genetically tractable organisms, such as yeasts, drosophila, and xenopus. Offered fall semester.

CAMB 542 (PHRM 542): Topics in Molecular Medicine

TiMM is planned as a once-weekly seminar course whose goal is to introduce students to the ways in which biomedical research can provide new insights into clinical medicine and, conversely, how knowledge of clinical disease impacts scientific discovery.

CAMB 630 : Topics in Human Genetics and Disease

Building on the foundations of the Human GenomeHapMap projects, our understanding of the basic concepts of Mendelian and non-Mendelian human genetic disease is proceeding at an unprecedented pace. This course will provide students with an overview of current problems and technical approaches in human genetics. Areas of focus will be analysis of disease mutations, chromosome rearrangements and disease, epigenetics, gene regulation and disease, human genomic variation and genomic applications to disease susceptibility. The format will be an advanced seminar course, with directed reading and student presentations. Offered fall semester.

Prerequisites: This course is designed for students with previous background in graduate level genetics, i.e., CAMB graduate students having taken CAMB 550, or students in MD/PhD, veterinary, genetic counseling or nursing programs with equivalent courses.

CAMB 609: Vaccines and Immune Therapeutics

Vaccination is perhaps the most successful medical intervention. The goal of this course is to expand on students' general understanding of the immune system and to focus this understanding towards the application of vaccination. Furthermore, the course will give the student a sense of how these principles are applied to vaccine and immune therapeutic development. The course covers basic science as well as the clinical, ethical, and political implications of modern vaccines.

Initial lectures review immune mechanisms believed to be responsible for vaccine-induced protection from disease. Subsequent lectures build on this background to explore the science of vaccines for diverse pathogens, including agents of bioterrorism as well as vaccines for cancer. An appreciation for the application of laboratory science to the clinical development of vaccines is provided in the next section of the course along with lectures, which focus on the ethical implications of vaccines in different situations. The financial implications of specific vaccines on the global community is one specific focus of this course.

The course is lecture style and has a required reading to provide the student background for the specific topic. Students are graded on course participation, a project, and a final written exam. The project is to propose in a written report a vaccine strategy for a current pathogen of importance that does not as yet have an effective vaccine. Strategies used should build on the material presented in the class lectures. The course is intended for graduate students or medical students in various MS, Ph.D., or MD/Ph.D. programs on the campus as well as local scientists and professionals in the community.

As a prerequisite students should have taken biology, biochemistry, or immunology courses at the advanced college level. 

CAMB 610: Molecular Basis of Gene Therapy

This is a team-taught, survey course that focuses on the basic science relevant to achieving efficient and effective gene transfer in animal models and humans for the treatment of disease. The course includes a unit devoted to a variety of vectors useful for gene transfer, with the remainder of the course devoted to the study of current gene therapy approaches using specific diseases as models. Prior background in biochemistry, cell biology, and molecular biology is essential. Aspects of organ system anatomy and physiology, virology and immunology that are relevant to the course material are included in the course. Because of the rapid movement in this field, specific topics vary somewhat from year to year. The course is designed for second year graduate students, however first year students may take the course with the course director's approval. Lecture format with discussion hours interspersed. There will be a take-home examination at the end of each of the three sections, each focusing on the material covered in that section. Offered fall semester.

CAMB 617: Emerging Infectious Diseases

Emerging Infectious Diseases will cover emerging viral, bacterial and parasitic organisms, with lectures being given by faculty from the Schools of Medicine, Veterinary Medicine, Dental Medicine, and Arts and Sciences. Epidemiology, immune responses to infection, vaccine and antimicrobial agents, and pathogenesis will all be discussed. The course format will include lectures by various faculty on Mondays and Wednesdays, with a discussion session held each Friday. Classes will be from 10 to 11 AM in Johnson 209. Each week will have a theme, and the lecturers for that week will organize the Friday discussion session. Evaluations will be based on a writing assignment and participation in the Friday small group sessions. Offered fall semester.

BIOL 513, GCB 513: Evolution in Cancer

Course Directors: Carlo Maley and Lauren Merlo

Cancers evolve by mutation and natural selection. This is the basis for both why we get cancer and why it so hard to cure. We will survey the cancer literature through the lens of evolutionary and ecological theory and review how that theory does and does not apply to cancer biology. This seminar is restricted to graduate students. This course is a graduate seminar course with both student and faculty presentations and discussions.

Prerequisite(s): Permission of the instructor. Preference is given to students who have completed CAMB 512 and medical students.

CAMB 590: Biology of Pathogens

A new course entitled "Topics in Microbiology, Virology & Parasitology: The Biology of Pathogens" is to be offered to first year MVP students three times per week for one hour over an eight week block in the fall semester. An exciting and unusual aspect of the course will be its integration of available information on viral, bacterial, and parasitic pathogens.

INSC 670: Current Topics in Neuropharmacology (PHRM 670)

Course Director: Jim Eberwine

Students critically review current topics in neuropharmacology literature, develop skills in oral presentation of scientific data and analysis of experimental results, and interact with faculty members working in fields associated with the topics discussed. The faculty members serve as experts in the areas discussed to provide perspectives or guide the discussions, but the emphasis is on efforts by the students. Typically, each session will employ a seminar format. The students are expected to critically read the designated papers and sufficient other references to place the paper in context, then clearly and critically present its results and conclusions and lead a round-table discussion with the other studetns. The course is designed to help students develop skills to independently and critically analyze scientific papers. Grading will depend on both the presentation of papers and the participation in class discussions.

PHRM 550: Advanced Topics in Neuropsychopharmacology (INSC576, PSYC750)

Instructors: Lucki and staff

Biological issues relevant to neuropsychiatric illnesses are covered in detail in four sections. The first section covers clinical aspects of major psychiatric disorders and includes some contact with patients. The second section presents the neuroanatomy of the limbic system. In the third section, emphasis is on the mechanisms of action of psychotropic drugs, including antidepressants, antipsychotics, anxiolytics, and stimulants.  The final section covers information relevant to understanding biological processes that may be abnormal in neuropsychiatric illnesses, such as stress, sleep, and circadian rhythms, as well as quantitative genetics.

Prerequisite(s): Permission of instructor. Meets two times per week.

PHRM 590: Molecular Toxicology: Chemical and Biological Mechanisms

Course Director: Trevor M. Penning

Exposures to foreign compounds (drugs, carcinogens, and pollutants) can disrupt normal cellular processes leading to toxicity. This course will focus on the molecular mechanisms by which environmental exposures lead to end-organ injury and to diseases of environmental etiology (neurodegenerative and lung diseases, reproduction disruption and cardiovascular injury). Students will learn the difficulties in modeling response to low-dose chronic exposures, how these exposures are influenced by metabolism and disposition, and how reactive intermediates alter the function of biomolecules. Mechanisms responsible for cellular damage, aberrant repair, and end-organ injury will be discussed. Students will learn about modern predictive molecular toxicology to classify toxicants, predict individual susceptibility and response to environmental triggers, and how to develop and validate biomarkers for diseases of environmental etiology. Students are expected to write a term paper on risk assessment on an environmental exposure using available TOXNET information.

Prerequisite(s): Pre-requisites: Must have taken or will take Fundamentals of Pharmacology concurrently.  Undergraduate course work in biochemistry and chemistry essential.  Exceptions allowed based on past course work.  Please consult with Course Director. 
Students: All 1st and 2nd year GGPS, CAMB, Neuro and BSTA students with required prerequisites; residents in Environmental and Occupational Health, and professional masters students (MPH and MTR).

PHRM 600: Medical Pharmacology

Instructors: Axelsen and staff

This course will review basic human physiology pertinent to drug action, and then focus on the mechanisms of action of the various classes of agents used in the therapy of human disease. It consists of lectures by an array of faculty with special interests and expertise in the topic being presented. Drug classes covered include: Neuropsychiatric drugs, cardiovascular and hematological drugs, anticancer drugs, antimicrobial drugs, endocrine and metabolic drugs.

Prerequisite(s): Permission of the instructor. Class meets four days a week.

PHRM 623: Fundamentals of Pharmacology

Instructors: David Manning and staff

This course is designed to introduce students to basic pharmacological concepts with special emphasis on the molecular actions of drugs.  Subject matter includes use of microcomputers to analyze pharmacological data.

Prerequisite(s): Permission of course director. Meets three times per week.