BIOM 502: Molecular Basis of Disease

The main purpose of this course is to introduce students to the basic pathologic processes that underlie disease, and demonstrate how research about these mechanisms may lead to discoveries that further our understanding of the disease and / or can lead to innovations in treatment that are clinically relevant. By using a selected group of diseases, this course will demonstrate how research on the basic mechanisms of disease can go from “the bench to the bedside” and enhance clinical care.

Spring 2012 Syllabus

BIOM 503 - The Art of Making Modern Medicine

This course is designed for graduate students who are interested in translational biomedical research and/or the drug discovery/development process. This course is intended to provide an overview of how advancement in basic research is translated into new therapeutic interventions. The impact of “omics” technology on reforming the current drug discovery/development paradigm and its impact on personalized medicine will be discussed. Finally, students will see that drug discovery and development is a collaborative effort that requires strategic and critical thinking, decision-making, effective communication skills and team work.

Spring 2011 Syllabus

BIOM 600 - Cell Biology and Biochemistry

BIOM 600 is an intermediate level graduate course designed to introduce students to the molecular components and physiological mechanisms that underlie the structure and function of cells. The course is designed as an in-depth survey to cover general concepts central to the field of biochemistry and cell biology and to emphasize these concepts within the context of current scientific research questions and technical approaches. Lectures will focus on recent discoveries in contemporary cell biology involving (i) basic cellular biochemistry; (ii) mechanisms of membrance transport and excitability; (iii) intracellular compartmentalization and protein/vesicle targeting, organelle biogenesis; (iv) cytoskeletal arthitecture, cell motility and adhesion; and (v) molecular mechanisms of signal transduction. Efforts will be made to familiarize students with recent technical advances in molecular, biochemical, microscopic, spectroscopic, and electrophysiologic techniques.

CAMB 532: Human Physiology

This course will present a survey of the physiology of most of the major organ systems. It will integrate knowledge of cellular and molecular mechanisms into an understanding of function at the tissue, organ and organism levels. It will begin with a brief review of membrane physiology, followed by electrophysiology and signaling in nerve. Then, after a brief outline of neural control systems and their role in homeostasis, it will present motility and muscle, the cardiovascular system, respiration, the renal and gastrointestinal systems, and selected topics from the endocrine system. As well as providing a basis of integrative physiology for students in fields such as bioengineering and pharmacology, it should be of interest to students of cellular and molecular biology and genetic engineering who will need to appreciate the roles of specific systems and molecules at higher levels of organization. Offered fall semester.

CAMB 510 (IMUN 510):  Immunology for CAMB Students

The purpose of this course is to give a thorough grounding in Immunology to Cell and Molecular Biology graduate students with an emphasis on the role of the immune system in combating infectious and neoplastic disease and its role in immunopathological states such as transplantation rejection, autoimmunity and allergy.  This will be a required course for CAMB students in the Microbiology, Virology and Parasitology program and the Vaccine and Gene Therapy program, replacing Immune Mechanisms 506.  It may also be used as an elective by other CAMB students such as Cancer Biology and Cell Biology and Physiology.

The course is divided, by topic, into three parts. The first deals with innate and adaptive immune mechanisms, the structure, function, and molecular biology of antigen receptors and major histocompatibility complex molecules; the development and differentiation of lymphocytes and other hematopoietic cells involved in immunity and mechanisms of lymphocyte circulation and memory. The second part will cover the immune response in infection by bacteria, viruses and parasites and how this impacts on vaccine design and active immunization strategies. The course concludes by focusing on the immune system's role in pathological states such as cancer, allergy, graft rejection and auto-immunity.

The formal part of the course is comprised of two 1.5 hour lectures per week. In addition each week there will be an informal 1.5-hour meeting, on Fridays, which will be used to introduce the students to specialized techniques used to measure immune responses or to discuss topical issues relating to the application of immunological knowledge in fighting disease with emphasis on the primary literature in the field. There will be two exams. The first will be taken after part I and the second after part II and III of the course.The second exam will be distributed to the students two days before they are taken as closed-book essay exams, so they can plan which questions they will answer and how they will answer them.