Publications
2022
Baron, D.M., Fenton, A.R., Saez-Atienzar, S., Giampetruzzi, A., Sreeram, A., Shankaracharya, Keagle, P.J., Doocy, V.R., Smith, N.J., Danielson, E.W., et al. (2022). ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function. Cell reports 39, 110598. 10.1016/j.celrep.2022.110598.
Cason, S.E., and Holzbaur, E.L. (2022). Selective motor activation in organelle transport along axons. Nat Rev Mol Cell Biol.
Goldsmith, J., Ordureau, A., Harper, J.W., and Holzbaur, E.L.F. (2022). Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons. Neuron 110, 967-976 e968. 10.1016/j.neuron.2021.12.029.
Goldsmith, J., and Holzbaur, E.L.F. (2022). Proteomic profiling shows mitochondrial nucleoids are autophagy cargo in neurons: implications for neuron maintenance and neurodegenerative disease. Autophagy, 1-3. 10.1080/15548627.2022.2056865.
Masucci, E.M., Relich, P.K., Lakadamyali, M., Ostap, E.M., and Holzbaur, E.L.F. (2022). Microtubule dynamics influence the retrograde biased motility of kinesin-4 motor teams in neuronal dendrites. Mol Biol Cell 33, ar52. 10.1091/mbc.E21-10-0480.
2021
Aiken, J., and Holzbaur, E.L.F. (2021). Cytoskeletal regulation guides neuronal trafficking to effectively supply the synapse. Curr Biol 31, R633-R650. 10.1016/j.cub.2021.02.024.
Boecker, C.A., Goldsmith, J., Dou, D., Cajka, G.G., and Holzbaur, E.L.F. (2021). Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes. Curr Biol 31, 2140-2154 e2146. 10.1016/j.cub.2021.02.061.
Boecker, C.A., and Holzbaur, E.L.F. (2021). Hyperactive LRRK2 kinase impairs the trafficking of axonal autophagosomes. Autophagy 17, 2043-2045. 10.1080/15548627.2021.1936933.
Cason, S.E., Carman, P.J., Van Duyne, C., Goldsmith, J., Dominguez, R., and Holzbaur, E.L.F. (2021). Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway. J Cell Biol 220. 10.1083/jcb.202010179.
Fenton, A.R., Jongens, T.A., and Holzbaur, E.L.F. (2021). Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors. Nat Commun 12, 4578. 10.1038/s41467-021-24862-7.
Fenton, A.R., Jongens, T.A., and Holzbaur, E.L.F. (2021). Mitochondrial dynamics: Shaping and remodeling an organelle network. Curr Opin Cell Biol 68, 28-36. 10.1016/j.ceb.2020.08.014.
Goldsmith, J., and Holzbaur, E.L.F. (2020). Presynaptic Homeostatic Plasticity Staves off Neurodegenerative Pathophysiology up to a Tipping Point. Neuron 107, 6-8. 10.1016/j.neuron.2020.06.013.
Harding, O., Evans, C.S., Ye, J., Cheung, J., Maniatis, T., and Holzbaur, E.L.F. (2021). ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy. Proc Natl Acad Sci U S A 118. 10.1073/pnas.2025053118.
Masucci, E.M., Relich, P.K., Ostap, E.M., Holzbaur, E.L.F., and Lakadamyali, M. (2021). Cega: a single particle segmentation algorithm to identify moving particles in a noisy system. Mol Biol Cell 32, 931-941. 10.1091/mbc.E20-11-0744.
Moore, A.S., Coscia, S.M., Simpson, C.L., Ortega, F.E., Wait, E.C., Heddleston, J.M., Nirschl, J.J., Obara, C.J., Guedes-Dias, P., Boecker, C.A., et al. (2021). Actin cables and comet tails organize mitochondrial networks in mitosis. Nature 591, 659-664. 10.1038/s41586-021-03309-5.
Simpson, C.L., Tokito, M.K., Uppala, R., Sarkar, M.K., Gudjonsson, J.E., and Holzbaur, E.L.F. (2021). NIX initiates mitochondrial fragmentation via DRP1 to drive epidermal differentiation. Cell reports 34, 108689. 10.1016/j.celrep.2021.108689.
Strong, L.M., Chang, C., Riley, J.F., Boecker, C.A., Flower, T.G., Buffalo, C.Z., Ren, X., Stavoe, A.K., Holzbaur, E.L., and Hurley, J.H. (2021). Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy. eLife 10. 10.7554/eLife.70372.
2020
Boecker, C.A., Olenick, M.A., Gallagher, E.R., Ward, M.E., and Holzbaur, E.L.F. (2020). ToolBox: Live Imaging of intracellular organelle transport in induced pluripotent stem cell-derived neurons. Traffic 21, 138-155. 10.1111/tra.12701.
Evans, C.S., and Holzbaur, E.L. (2020). Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons. eLife 9. 10.7554/eLife.50260.
Evans, C.S., and Holzbaur, E.L.F. (2020). Lysosomal degradation of depolarized mitochondria is rate-limiting in OPTN-dependent neuronal mitophagy. Autophagy 16, 962-964. 10.1080/15548627.2020.1734330.
Evans, C.S., and Holzbaur, E.L.F. (2020). Quality Control in Neurons: Mitophagy and Other Selective Autophagy Mechanisms. Journal of molecular biology 432, 240-260. 10.1016/j.jmb.2019.06.031.
Goldsmith, J., and Holzbaur, E.L.F. (2020). Presynaptic Homeostatic Plasticity Staves off Neurodegenerative Pathophysiology up to a Tipping Point. Neuron 107, 6-8. 10.1016/j.neuron.2020.06.013.
Holzbaur, E.L.F. (2020). Mentoring in the time of Coronavirus. Mol Biol Cell 31, 2761-2762. 10.1091/mbc.E20-09-0597.
Lee, I.G., Cason, S.E., Alqassim, S.S., Holzbaur, E.L.F., and Dominguez, R. (2020). A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner. Nat Commun 11, 5695. 10.1038/s41467-020-19538-7.
Sase, S., Almad, A.A., Boecker, C.A., Guedes-Dias, P., Li, J.J., Takanohashi, A., Patel, A., McCaffrey, T., Patel, H., Sirdeshpande, D., et al. (2020). TUBB4A mutations result in both glial and neuronal degeneration in an H-ABC leukodystrophy mouse model. eLife 9. 10.7554/eLife.52986.
Stavoe, A.K.H., and Holzbaur, E.L.F. (2020). Neuronal autophagy declines substantially with age and is rescued by overexpression of WIPI2. Autophagy 16, 371-372. 10.1080/15548627.2019.1695401.
2019
Boecker, C.A., and Holzbaur, E.L. (2019). Vesicular degradation pathways in neurons: at the crossroads of autophagy and endo-lysosomal degradation. Current opinion in neurobiology 57, 94-101. 10.1016/j.conb.2019.01.005.
Evans, C.S., and Holzbaur, E.L.F. (2019). Autophagy and mitophagy in ALS. Neurobiology of disease 122, 35-40. 10.1016/j.nbd.2018.07.005.
Guedes-Dias, P., and Holzbaur, E.L.F. (2019). Axonal transport: Driving synaptic function. Science 366. 10.1126/science.aaw9997.
Hoshino, A., Wang, W.J., Wada, S., McDermott-Roe, C., Evans, C.S., Gosis, B., Morley, M.P., Rathi, K.S., Li, J., Li, K., et al. (2019). The ADP/ATP translocase drives mitophagy independent of nucleotide exchange. Nature 575, 375-379. 10.1038/s41586-019-1667-4.
Guedes-Dias, P., Nirschl, J.J., Abreu, N., Tokito, M.K., Janke, C., Magiera, M.M., and Holzbaur, E.L.F. (2019). Kinesin-3 Responds to Local Microtubule Dynamics to Target Synaptic Cargo Delivery to the Presynapse. Curr Biol 29, 268-282 e268. 10.1016/j.cub.2018.11.065.
Moore, A.S., and Holzbaur, E.L.F. (2019). Imaging the Dynamics of Mitophagy in Live Cells. Methods Mol Biol 1880, 601-610. 10.1007/978-1-4939-8873-0_39.
Olenick, M.A., Dominguez, R., and Holzbaur, E.L.F. (2019). Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes in neurons. J Cell Biol 218, 220-233. 10.1083/jcb.201805016.
Olenick, M.A., and Holzbaur, E.L.F. (2019). Dynein activators and adaptors at a glance. J Cell Sci 132. 10.1242/jcs.227132.