Mouse Phenotyping, Physiology and Metabolism Core - Staff

Joseph Baur, PhD

Joseph A. Baur, Ph.D., Director;

Dr. Baur earned his Ph.D. from the University of Texas Southwestern Medical Center in Dallas, Texas, where he studied mechanisms that limit the lifespan of cultured human cells under Drs. Jerry Shay and Woody Wright. He then moved to Harvard Medical School where he spent additional time training as a postdoctoral fellow with Dr. David Sinclair. There he developed a strong interest in the regulation of aging and metabolism by sirtuins, a conserved class of enzymes that regulate lifespan in lower organisms. He was the first to show that resveratrol, a small molecule with many effects, including activation of the sirtuin SIRT1, is able to improve insulin sensitivity and extend lifespan in obese mice. Current interests in The Baur Lab are centered around the metabolic pathways that mediate the effects of calorie restriction on health and longevity, including mTOR signaling and nicotinamide adenine dinucleotide (NAD) metabolism.

In addition to his primary appointment in the Department of Physiology, Dr. Baur is a member of Penn’s Institute for Diabetes, Obesity, and Metabolism, Institute on Aging, Center for Musculoskeletal Disorders, and Center for Excellence in Environmental Toxicology.


Will Quinn
Technical Director

Institute for Diabetes, Obesity, & Metabolism SCTR 1-154
3400 Civic Center Blvd, Building 421
Philadelphia, PA 19104-5160

(Core) 215-573-6331
(P): 215-573-1873
(Cell phone): 609-706-4407

Qiangwei Chu
Institute for Diabetes, Obesity, & Metabolism
1-154 SCTR
3400 Civic Center Blvd, Building 421
Philadelphia, PA 19104-5160

(P) 215-573-7502

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Mouse Phenotyping Core




The Baur Lab