Penn DRC Publications

DRC Publications (2006 - Present)

Insulin regulates adipocyte lipolysis via an Akt-independent signaling pathway. Choi SM, Tucker DF, Gross DN, Easton RM, DiPilato LM, Dean AS, Monks BR, Birnbaum MJ.Mol Cell Biol. 2010 Nov;30(21):5009-20. Epub 2010 Aug 23. PMID: 20733001

Disease-associated loci are significantly over-represented among genes bound by transcription factor 7-like 2 (TCF7L2) in vivo. Zhao J, Schug J, Li M, Kaestner KH, Grant SF.Diabetologia. 2010 Nov;53(11):2340-6. Epub 2010 Jul 17. PMID: 20640398

Transcriptional control of brown adipocyte development and thermogenesis. Seale P.Int J Obes (Lond). 2010 Oct;34 Suppl 1:S17-22. PMID: 20935660

Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase. Li C, Chen P, Palladino A, Narayan S, Russell LK, Sayed S, Xiong G, Chen J, Stokes D, Butt YM, Jones PM, Collins HW, Cohen NA, Cohen AS, Nissim I, Smith TJ, Strauss AW, Matschinsky FM, Bennett MJ, Stanley CA.J Biol Chem. 2010 Oct 8;285(41):31806-18. Epub 2010 Jul 29. PMID: 20670938

Targeted disruption of pancreatic-derived factor (PANDER, FAM3B) impairs pancreatic beta-cell function. Robert-Cooperman CE, Carnegie JR, Wilson CG, Yang J, Cook JR, Wu J, Young RA, Wolf BA, Burkhardt BR.Diabetes. 2010 Sep;59(9):2209-18. Epub 2010 Jun 21. PMID: 20566664

Characterization of the expression, localization, and secretion of PANDER in alpha-cells. Carnegie JR, Robert-Cooperman CE, Wu J, Young RA, Wolf BA, Burkhardt BR. Mol Cell Endocrinol. 2010 Aug 30;325(1-2):36-45. PMID: 20638985

E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha.Yin L, Joshi S, Wu N, Tong X, Lazar MA.Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11614-9. Epub 2010 Jun 7. PMID: 20534529
Akt2 is required for hepatic lipid accumulation in models of insulin resistance. Leavens KF, Easton RM, Shulman GI, Previs SF, Birnbaum MJ.Cell Metab. 2009 Nov;10(5):405-18. PMID: 19883618
The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity. Akpan I, Goncalves MD, Dhir R, Yin X, Pistilli EE, Bogdanovich S, Khurana TS, Ucran J, Lachey J, Ahima RS.Int J Obes (Lond). 2009 Nov;33(11):1265-73. Epub 2009 Aug 11. PMID: 19668253

Hypoxia-inducible factor 2 regulates hepatic lipid metabolism.Rankin EB, Rha J, Selak MA, Unger TL, Keith B, Liu Q, Haase VH.Mol Cell Biol. 2009 Aug;29(16):4527-38. Epub 2009 Jun 15. PMID: 19528226

Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas. Du A, Hunter CS, Murray J, Noble D, Cai CL, Evans SM, Stein R, May CL.Diabetes. 2009 Sep;58(9):2059-69. Epub 2009 Jun 5. PMID: 19502415

Amyloid and transplanted islets. Rickels MR, Collins HW, Naji A.N Engl J Med. 2008 Dec 18;359(25):2729; author reply 2729-31. PMID: 19092163

Effect of extracellular matrix and 3D morphogenesis on islet hormone gene expression by Ngn3-infected mouse pancreatic ductal epithelial cells. Boretti MI, Gooch KJ.Tissue Eng Part A. 2008 Dec;14(12):1927-37. PMID: 18694323

Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Rankin EB, Rha J, Unger TL, Wu CH, Shutt HP, Johnson RS, Simon MC, Keith B, Haase VH.Oncogene. 2008 Sep 11;27(40):5354-8. Epub 2008 May 19. PMID: 18490920

Divergent metabolic adaptations to intestinal parasitic nematode infection in mice susceptible or resistant to obesity. Wong T, Hildebrandt MA, Thrasher SM, Appleton JA, Ahima RS, Wu GD.Gastroenterology. 2007 Dec;133(6):1979-88. Epub 2007 Sep 14. PMID: 18054569

Acute insulin responses to glucose and arginine as predictors of beta-cell secretory capacity in human islet transplantation. Rickels MR, Naji A, Teff KL.Transplantation. 2007 Nov 27;84(10):1357-60. PMID:18049122

Evidence for allograft rejection in an islet transplant recipient and effect on beta-cell secretory capacity. Rickels MR, Kamoun M, Kearns J, Markmann JF, Naji A.J Clin Endocrinol Metab. 2007 Jul;92(7):2410-4. Epub 2007 May 8. PMID:17488791

Reduction of hepatosteatosis and lipid levels by an adipose differentiation-related protein antisense oligonucleotide. Imai Y, Varela GM, Jackson MB, Graham MJ, Crooke RM, Ahima RS.Gastroenterology. 2007 May;132(5):1947-54. Epub 2007 Feb 23. PMID: 17484887

Menstrual cycle effects on insulin sensitivity in women with type 1 diabetes: a pilot study. Trout KK, Rickels MR, Schutta MH, Petrova M, Freeman EW, Tkacs NC, Teff KL.Diabetes Technol Ther. 2007 Apr;9(2):176-82. PMID: 17425444

Transgene expression level and inherent differences in target gene activation determine the rate and fate of neurogenin3-mediated islet cell differentiation in vitro. Boretti MI, Gooch KJ.Tissue Eng. 2007 Apr;13(4):775-88. PMID: 17355210

Glycemic thresholds for activation of counterregulatory hormone and symptom responses in islet transplant recipients. Rickels MR, Schutta MH, Mueller R, Kapoor S, Markmann JF, Naji A, Teff KL.J Clin Endocrinol Metab. 2007 Mar;92(3):873-9. Epub 2006 Dec 27. PMID: 17192287

Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents. Hardy OT, Hohmeier HE, Becker TC, Manduchi E, Doliba NM, Gupta RK, White P, Stoeckert CJ Jr, Matschinsky FM, Newgard CB, Kaestner KH.Mol Endocrinol. 2007 Mar;21(3):765-73. Epub 2006 Dec 21. PMID: 17185391

Brain adipocytokine action and metabolic regulation. Ahima RS, Qi Y, Singhal NS, Jackson MB, Scherer PE.Diabetes. 2006 Dec;55 Suppl 2:S145-54. Review. PMID: 17130638

Induced cell clustering enhances islet beta cell formation from human cultures enriched for pancreatic ductal epithelial cells. Boretti MI, Gooch KJ.Tissue Eng. 2006 Apr;12(4):939-48. PMID: 16674305

Insulin sensitivity, glucose effectiveness, and free fatty acid dynamics after human islet transplantation for type 1 diabetes. Rickels MR, Naji A, Teff KL.J Clin Endocrinol Metab. 2006 Jun;91(6):2138-44. Epub 2006 Mar 28. PMID: 16569741

Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress. Sachdeva MM, Claiborn KC, Khoo C, Yang J, Groff DN, Mirmira RG, Stoffers DA.Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19090-5. Epub 2009 Oct 23. PMID: 19855005

Neonatal exendin-4 treatment reduces oxidative stress and prevents hepatic insulin resistance in intrauterine growth-retarded rats. Raab EL, Vuguin PM, Stoffers DA, Simmons RA.Am J Physiol Regul Integr Comp Physiol. 2009 Dec;297(6):R1785-94. Epub 2009 Oct 21. PMID: 19846744

Cyclin D2 protein stability is regulated in pancreatic beta-cells. He LM, Sartori DJ, Teta M, Opare-Addo LM, Rankin MM, Long SY, Diehl JA, Kushner JA.Mol Endocrinol. 2009 Nov;23(11):1865-75. Epub 2009 Jul 23. PMID: 19628581

Adaptive beta-cell proliferation is severely restricted with advanced age. Rankin MM, Kushner JA.Diabetes. 2009 Jun;58(6):1365-72. Epub 2009 Mar 5. PMID: 19265026

Circadian rhythm profiles in women with night eating syndrome. Goel N, Stunkard AJ, Rogers NL, Van Dongen HP, Allison KC, O'Reardon JP, Ahima RS, Cummings DE, Heo M, Dinges DF.J Biol Rhythms. 2009 Feb;24(1):85-94. PMID: 19150931

Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology. Alenghat T, Meyers K, Mullican SE, Leitner K, Adeniji-Adele A, Avila J, Bućan M, Ahima RS, Kaestner KH, Lazar MA.Nature. 2008 Dec 18;456(7224):997-1000. Epub 2008 Nov 26. PMID: 19037247

Untangling the glutamate dehydrogenase allosteric nightmare. Smith TJ, Stanley CA.Trends Biochem Sci. 2008 Nov;33(11):557-64. Epub 2008 Sep 24. Review. PMID: 18819805

Comparison of matrix metalloproteinase 9 and brain natriuretic peptide as clinical biomarkers in chronic heart failure. Vorovich EE, Chuai S, Li M, Averna J, Marwin V, Wolfe D, Reilly MP, Cappola TP.Am Heart J. 2008 Jun;155(6):992-7. Epub 2008 Feb 21. PMID: 18513509

Endothelial lipase is increased in vivo by inflammation in humans. Badellino KO, Wolfe ML, Reilly MP, Rader DJ.Circulation. 2008 Feb 5;117(5):678-85. Epub 2008 Jan 22. PMID: 18212282

The origin of islet-like cells in Drosophila identifies parallels to the vertebrate endocrine axis.Wang S, Tulina N, Carlin DL, Rulifson EJ.Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19873-8. Epub 2007 Dec 3. PMID: 18056636

Parvin-beta inhibits breast cancer tumorigenicity and promotes CDK9-mediated peroxisome proliferator-activated receptor gamma 1 phosphorylation. Johnstone CN, Mongroo PS, Rich AS, Schupp M, Bowser MJ, Delemos AS, Tobias JW, Liu Y, Hannigan GE, Rustgi AK.Mol Cell Biol. 2008 Jan;28(2):687-704. Epub 2007 Nov 12. PMID: 17998334

Gender difference in neural response to psychological stress. Wang J, Korczykowski M, Rao H, Fan Y, Pluta J, Gur RC, McEwen BS, Detre JA.Soc Cogn Affect Neurosci. 2007 Sep;2(3):227-39. PMID: 17873968

Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha. Gupta RK, Gao N, Gorski RK, White P, Hardy OT, Rafiq K, Brestelli JE, Chen G, Stoeckert CJ Jr, Kaestner KH.Genes Dev. 2007 Apr 1;21(7):756-69. PMID: 17403778

Value of electrocardiographic and ankle-brachial index abnormalities for prediction of coronary atherosclerosis in asymptomatic subjects with type 2 diabetes mellitus. Bagheri R, Schutta M, Cumaranatunge RG, Wolfe ML, Terembula K, Hoffman B, Schwartz S, Kimmel SE, Farouk S, Iqbal N, Reilly MP.Am J Cardiol. 2007 Apr 1;99(7):951-5. Epub 2007 Feb 14. PMID: 17398190

Accelerated mortality from hydrocephalus and pneumonia in mice with a combined deficiency of SPAG6 and SPAG16L reveals a functional interrelationship between the two central apparatus proteins. Zhang Z, Tang W, Zhou R, Shen X, Wei Z, Patel AM, Povlishock JT, Bennett J, Strauss JF 3rd.Cell Motil Cytoskeleton. 2007 May;64(5):360-76. PMID: 17323374

Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents. Hardy OT, Hohmeier HE, Becker TC, Manduchi E, Doliba NM, Gupta RK, White P, Stoeckert CJ Jr, Matschinsky FM, Newgard CB, Kaestner KH.Mol Endocrinol. 2007 Mar;21(3):765-73. Epub 2006 Dec 21. PMID: 17185391

A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. Li Y, Kao GD, Garcia BA, Shabanowitz J, Hunt DF, Qin J, Phelan C, Lazar MA.Genes Dev. 2006 Sep 15;20(18):2566-79. PMID: 16980585

HIV protease inhibitor-specific alterations in human adipocyte differentiation and metabolism. Kim RJ, Wilson CG, Wabitsch M, Lazar MA, Steppan CM.Obesity (Silver Spring). 2006 Jun;14(6):994-1002. PMID: 16861604

From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation. Sagen JV, Odili S, Bjørkhaug L, Zelent D, Buettger C, Kwagh J, Stanley C, Dahl-Jørgensen K, de Beaufort C, Bell GI, Han Y, Grimsby J, Taub R, Molven A, Søvik O, Njølstad PR, Matschinsky FM.Diabetes. 2006 Jun;55(6):1713-22. PMID: 16731834

Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice. Li C, Matter A, Kelly A, Petty TJ, Najafi H, MacMullen C, Daikhin Y, Nissim I, Lazarow A, Kwagh J, Collins HW, Hsu BY, Nissim I, Yudkoff M, Matschinsky FM, Stanley CA.J Biol Chem. 2006 Jun 2;281(22):15064-72. Epub 2006 Mar 30. PMID: 16574664

Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock. Yin L, Wang J, Klein PS, Lazar MA.Science. 2006 Feb 17;311(5763):1002-5. PMID: 16484495

Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase. Li C, Allen A, Kwagh J, Doliba NM, Qin W, Najafi H, Collins HW, Matschinsky FM, Stanley CA, Smith TJ.J Biol Chem. 2006 Apr 14;281(15):10214-21. Epub 2006 Feb 13. PMID: 16476731

Deficiency of SPAG16L causes male infertility associated with impaired sperm motility. Zhang Z, Kostetskii I, Tang W, Haig-Ladewig L, Sapiro R, Wei Z, Patel AM, Bennett J, Gerton GL, Moss SB, Radice GL, Strauss JF 3rd.Biol Reprod. 2006 Apr;74(4):751-9. Epub 2005 Dec 28. PMID: 16382026

Leucine regulation of glucokinase and ATP synthase sensitizes glucose-induced insulin secretion in pancreatic beta-cells. Yang J, Wong RK, Park M, Wu J, Cook JR, York DA, Deng S, Markmann J, Naji A, Wolf BA, Gao Z.Diabetes. 2006 Jan;55(1):193-201.