• banner

    Laura McLane and Mike Betts -Purified human CD8 T-cells were stained with a-T-bet (green), a-Lamin A (pink), and DAPI (blue) and imaged on a multilaser-based spinning disk confocal microscope (Zeiss). T-bet can be localized to both the nuclear and cytoplasmic compartments of specific subsets of human CD8 T-cells.

  • banner

    3D image of the inflamed meningeal membrane of a CX3CR1-GFP reporter mouse infected with Toxoplasma gondii. The dura mater that surrounds the brain is blue, blood vessels are labeled red and microglia and macrophages are green. Contributors for image are ChristophKonradt and Chris Hunter.

  • banner

    Time series of cells expressing GFP-tagged ebola viral protein VP40, pseudocolored as a fluorescence intensity heatmap. The contributors for image are: Gordon Ruthel, Xiaohong Liu, Ron Harty, and Bruce Freedman.

Penn Institute for Immunology 2014 Catalyst Pilot Grant Program RFA
The Penn Institute for Immunology is announcing a Pilot Grant Program to foster competitive multi-investigator grant proposals. The specific scientific focus of pilot grant applications is non-restrictive, but applications that highlight the use of cutting edge technology, novel computation approaches, translation immunology or infectious disease are strongly encouraged. Importantly, pilot grants that are responsive to an upcoming RFA, future NIH Concept or other future funding mechanism (partial list included in Appendix) will be a priority. A specific plan should be articulated for how the pilot funding will position the investigator(s) to compete more effectively for a future multi-investigator application. The science remains a priority; however, it is important to emphasize the missing piece in preliminary data, etc. that this pilot grant will fill to enable a strong application.

Important Dates:
Submission deadline for full applications: May 15, 2014
Awards made by: June 16, 2014
It is anticipated that up to 2-3 pilots will be awarded. Applications may request up to $75,000 in support for one year.
Eligibility
All faculty members of the Penn IFI are invited to submit proposals.
Full applications must be submitted by email to Kaitlyn Piazza (kbaraldi@mail.med.upenn.edu) by 15 May 2014
Full Application Instructions:
A single PDF should include the following:
*Cover page: includes abstract of up to 250 words and list of approved or pending IACUC/IRB protocols [see attached cover page that should be included in each application].
*Application (Aims, Significance and Innovation, Preliminary Results and Experimental Design). Limited to two pages including all preliminary data (excluding references; references can be on additional pages).
*Applicants should include an additional half page section devoted to explaining how pilot funds will enable a strong, competitive application to a larger funding mechanism (e.g. multi-investigator NIH application)
*NIH biographical sketch for each investigator
*NIH other support for each investigator
*Budget and justification: one year, up to a maximum of $75,000; one page only
Award Terms
1) Awardees are required to inform the IFI in the event that the Pilot/Feasibility Project receives external funding during the project period.
2) A final progress report is due one month after the close of the project period. The report will contain a one-page synopsis of scientific progress and a list of resulting collaborations, publications, and grants.
3) Awardees will provide interim reports concerning other support, resulting publications, and research activities for the IFI annual retreat and continuation applications.
4) Awardees will also be required to present their work at the 2015 IFI Year in Review.  For additional information, please contact: Kaitlyn Piazza (kbaraldi@mail.med.upenn.edu)