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    Laura McLane and Mike Betts -Purified human CD8 T-cells were stained with a-T-bet (green), a-Lamin A (pink), and DAPI (blue) and imaged on a multilaser-based spinning disk confocal microscope (Zeiss). T-bet can be localized to both the nuclear and cytoplasmic compartments of specific subsets of human CD8 T-cells.

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    3D image of the inflamed meningeal membrane of a CX3CR1-GFP reporter mouse infected with Toxoplasma gondii. The dura mater that surrounds the brain is blue, blood vessels are labeled red and microglia and macrophages are green. Contributors for image are ChristophKonradt and Chris Hunter.

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    Time series of cells expressing GFP-tagged ebola viral protein VP40, pseudocolored as a fluorescence intensity heatmap. The contributors for image are: Gordon Ruthel, Xiaohong Liu, Ron Harty, and Bruce Freedman.

Autoimmunity

The Autoimmunity Program of the IFI promotes research into the derangements of immune tolerance and function that lead to autoinflammatory, autoimmune, and immunodeficient states. Examples of specific areas of interest include but are not limited to the study of: the development and loss of self-tolerance in both the innate and adaptive immune response, mechanisms of autoimmune organ damage, the relationships between autoimmunity and immunodeficiency, and therapeutic approaches to treat this group of diseases. The program supports research into basic mechansisms of immune function as well as translational studies in relevant disease states as diverse as lupus, psoriasis, multiple sclerosis, primary immunodeficiency, and pemphigus. We seek to encourage cross-divisional and cross-disciplinary collaborations in order to promote novel and far-reaching discoveries elucidating the mechanisms of autoimmune diseases.