Erin Zwak/Brodsky Lab & Penn Vet Imaging Core - Murine macrophages infected with Yersinia pseudo tuberculosis. Blue indicates the cell, red is a mitochondrial stain, green is a stain for Yersinia secreted effector proteins.
Claudio Giraudo - Polarization of lytic granules to the immunological synapse during the cytolytic process of human CD8 lymphocytes against cancer cells.
Gretchen Harms, Hunter lab - Stylized images of CD8+ T cells looking at differential localization of the transcription factor T-bet in mouse cells after infection with the parasite Toxoplasma gondii, using the Amnis ImageStream. In the cell in the first and third box, T-bet (red) does not co-localize with DAPI (blue), indicating that it is cytoplasmic, whereas in the cell in the second and fourth box, T-bet does co-localize with DAPI, indicating that it is nuclear. David Christian assisted in obtaining these images.
The IFI Cancer Immunology research program aims to advance the understanding of the immune system's role in neoplastic pathophysiology. Our work spans basic science discoveries, to translational medicine, to clinical care and epidemiology. A major goal is to utilize new insights of immune mechanisms to target malignant cells in relevant in vitro and animal model systems and in human clinical trials.
Cancer Program Highlights
The 1st Annual Abramson Cancer Center and Institute For Immunlogy Cancer Immunobiology Retreat took place on Thursday, December 18th from 9am-3pm in Smilow Rm 12-146. The retreat was a resounding success with 30 PI's participating.. The purpose of the retreat was to foster greater collaboration and interaction within the cancer immunology community at Penn.